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With these demands, it is now critical to understand the fundamental regulatory mechanism for aging and longevity in mammals. Our studies on the mammalian NAD\u2010dependent deacetylase SIRT1 and nicotinamide phosphoribosyltransferase (NAMPT)\u2010mediated systemic NAD biosynthesis led us to propose a comprehensive model for the systemic regulatory network connecting metabolism and aging, termed the \u201cNAD World\u201d. In this article, I will discuss the importance of SIRT1 and NAMPT\u2010mediated NAD biosynthesis in the NAD World and the system dynamics of this hierarchical network for the connection between metabolism and aging.<\/jats:p>","DOI":"10.1016\/j.febslet.2011.04.060","type":"journal-article","created":{"date-parts":[[2011,5,7]],"date-time":"2011-05-07T20:27:53Z","timestamp":1304800073000},"page":"1657-1662","source":"Crossref","is-referenced-by-count":98,"title":["Dissecting systemic control of metabolism and aging in the NAD World: The importance of SIRT1 and NAMPT\u2010mediated NAD biosynthesis"],"prefix":"10.1002","volume":"585","author":[{"given":"Shin-ichiro","family":"Imai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,5,5]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Carone G. and Costello D. (2006) Can Europe afford to grow old? 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