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The development of new immunotherapy strategies and effective biomarkers of response and resistance is urgently needed. Recently, high-throughput bulk and single-cell gene expression profiling technologies have generated valuable resources. However, these resources are not well organized and systematic analysis is difficult. Here, we present TIGER, a tumor immunotherapy gene expression resource, which contains bulk transcriptome data of 1508 tumor samples with clinical immunotherapy outcomes and 11,057 tumor\/normal samples without clinical immunotherapy outcomes, as well as single-cell transcriptome data of 2,116,945 immune cells from 655 samples. TIGER provides many useful modules for analyzing collected and user-provided data. Using the resource in TIGER, we identified a tumor-enriched subset of CD4+ T cells. Patients with melanoma with a higher signature score of this subset have a significantly better response and survival under immunotherapy. We believe that TIGER will be helpful in understanding anti-tumor immunity mechanisms and discovering effective biomarkers. TIGER is freely accessible at http:\/\/tiger.canceromics.org\/.<\/jats:p>","DOI":"10.1016\/j.gpb.2022.08.004","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T02:29:46Z","timestamp":1661740186000},"page":"337-348","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":92,"title":["TIGER: A Web Portal of Tumor Immunotherapy Gene Expression Resource"],"prefix":"10.1093","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6641-6426","authenticated-orcid":false,"given":"Zhihang","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oncology in South China, Cancer Center, Collaborative Innovation Center for Cancer Medicine, School of Life Sciences, Sun Yat-sen University , Guangzhou 510060 , 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China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1261-7716","authenticated-orcid":false,"given":"Hongwan","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China, Cancer Center, Collaborative Innovation Center for Cancer Medicine, School of Life Sciences, Sun Yat-sen University , Guangzhou 510060 , China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3529-5657","authenticated-orcid":false,"given":"Zongping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital) , Hangzhou 310016 , China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0519-461X","authenticated-orcid":false,"given":"Penghui","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China, Cancer Center, Collaborative Innovation Center for Cancer Medicine, School of Life Sciences, Sun Yat-sen University , Guangzhou 510060 , China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4161-1292","authenticated-orcid":false,"given":"Jian","family":"Ren","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China, Cancer Center, Collaborative Innovation Center for Cancer Medicine, School of Life Sciences, Sun Yat-sen University , Guangzhou 510060 , China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9630-0793","authenticated-orcid":false,"given":"An","family":"Zhao","sequence":"additional","affiliation":[{"name":"Experimental Research Center, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital) , Hangzhou 310016 , China"},{"name":"Institute of Cancer and Basic Medicine (IBMC), Chinese Academy of Sciences , Hangzhou 310000 , China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2492-2689","authenticated-orcid":false,"given":"Zhixiang","family":"Zuo","sequence":"additional","affiliation":[{"name":"State Key Laboratory 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Published by Elsevier B.V. and Science Press on behalf of Beijing Institute of Genomics, Chinese Academy of Sciences \/ China National Center for Bioinformation and Genetics Society of China.","name":"copyright","label":"Copyright"}]}}