{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:54:06Z","timestamp":1773014046163,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,4,15]],"date-time":"2009-04-15T00:00:00Z","timestamp":1239753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the effect of supplemental prenatal folic acid, folic acid\u2013iron, folic acid\u2013iron\u2013zinc, and multiple micronutrients on maternal morbidity in rural Nepal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cluster\u2010randomized double\u2010masked controlled trial of pregnant women who received daily supplements from early pregnancy through 3\u00a0months post partum as per the treatment allocation. Women were interviewed at birth about labor and delivery complications and for 9\u00a0days post partum to obtain 24\u2010hour histories of morbidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 3986 (97.3%) women completed an interview regarding labor and delivery; morbidity history was available for 3564 (87.0%) women. Folic acid\u2013iron reduced the risk of postpartum hemorrhage (relative risk [RR] 0.59; 95% confidence interval [CI] 0.35\u20130.98). Risk of dysfunctional labor increased with multiple micronutrient supplementation (RR 1.28; 95% CI, 1.01\u20131.60), although preterm premature rupture of membrane decreased (RR 0.40; 95% CI, 0.21\u20130.79). Puerperal sepsis was lower in those receiving folic acid\u2013iron, folic acid\u2013iron\u2013zinc, and multiple micronutrients compared with controls (<jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prenatal folic acid\u2013iron supplementation reduced the risk of obstetric complications in this South Asian setting.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2009.03.040","type":"journal-article","created":{"date-parts":[[2009,4,16]],"date-time":"2009-04-16T08:16:18Z","timestamp":1239869778000},"page":"3-7","source":"Crossref","is-referenced-by-count":51,"title":["Effects of prenatal micronutrient supplementation on complications of labor and delivery and puerperal morbidity in rural Nepal"],"prefix":"10.1002","volume":"106","author":[{"given":"Parul","family":"Christian","sequence":"first","affiliation":[]},{"given":"Subarna K.","family":"Khatry","sequence":"additional","affiliation":[]},{"given":"Steven C.","family":"LeClerq","sequence":"additional","affiliation":[]},{"given":"Sanu Maiya","family":"Dali","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2009,4,15]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69386-0"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-112-3_21"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.01.068"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.318.7183.570"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/152.6.542"},{"issue":"11","key":"e_1_2_6_7_2","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1093\/jn\/130.11.2675","article-title":"Vitamin A or beta\u2010carotene supplementation reduces symptoms of illness in pregnant and lactating Nepali Women","volume":"130","author":"Christian P.","year":"2000","journal-title":"J Nutr."},{"issue":"3","key":"e_1_2_6_8_2","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1017\/S1368980000000367","article-title":"Vitamin A and causes of maternal mortality: association and biological plausibility","volume":"3","author":"Faisel H.","year":"2000","journal-title":"Public Health Nutr"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.3691.595"},{"key":"e_1_2_6_10_2","unstructured":"HakimiM. 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