{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T20:50:10Z","timestamp":1771015810722,"version":"3.50.1"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001677","name":"National Institute of Health","doi-asserted-by":"publisher","award":["R01-NS047592"],"award-info":[{"award-number":["R01-NS047592"]}],"id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"National Institute of Health","doi-asserted-by":"publisher","award":["P01-NS059560"],"award-info":[{"award-number":["P01-NS059560"]}],"id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Multiple Sclerosis Society (NMSS)","award":["RG 4549A4\/1"],"award-info":[{"award-number":["RG 4549A4\/1"]}]},{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-12-1-0457"],"award-info":[{"award-number":["W81XWH-12-1-0457"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.neuroimage.2014.06.009","type":"journal-article","created":{"date-parts":[[2014,6,16]],"date-time":"2014-06-16T16:05:15Z","timestamp":1402934715000},"page":"244-253","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Axonal transport rate decreased at the onset of optic neuritis in EAE mice"],"prefix":"10.1016","volume":"100","author":[{"given":"Tsen-Hsuan","family":"Lin","sequence":"first","affiliation":[]},{"given":"Joong Hee","family":"Kim","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3352-011X","authenticated-orcid":false,"given":"Carlos","family":"Perez-Torres","sequence":"additional","affiliation":[]},{"given":"Chia-Wen","family":"Chiang","sequence":"additional","affiliation":[]},{"given":"Kathryn","family":"Trinkaus","sequence":"additional","affiliation":[]},{"given":"Anne H.","family":"Cross","sequence":"additional","affiliation":[]},{"given":"Sheng-Kwei","family":"Song","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/j.neuroimage.2014.06.009_bb0005","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.mehy.2004.09.001","article-title":"Mitochondrial dysfunction plays a key role in progressive axonal loss in multiple sclerosis","volume":"64","author":"Andrews","year":"2005","journal-title":"Med. Hypotheses"},{"issue":"Suppl. 1","key":"10.1016\/j.neuroimage.2014.06.009_bb0010","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1016\/j.neuroimage.2007.04.053","article-title":"Role of neuronal activity and kinesin on tract tracing by manganese-enhanced MRI (MEMRI)","volume":"37","author":"Bearer","year":"2007","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0015","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1056\/NEJM199312093292403","article-title":"The effect of corticosteroids for acute optic neuritis on the subsequent development of multiple sclerosis. The Optic Neuritis Study Group","volume":"329","author":"Beck","year":"1993","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0020","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1001\/archopht.121.7.944","article-title":"High- and low-risk profiles for the development of multiple sclerosis within 10 years after optic neuritis","volume":"121","author":"Beck","year":"2003","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0025","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1084\/jem.20021603","article-title":"Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis","volume":"197","author":"Bettelli","year":"2003","journal-title":"J. Exp. Med."},{"issue":"Pt 6","key":"10.1016\/j.neuroimage.2014.06.009_bb0030","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1093\/brain\/123.6.1174","article-title":"Acute axonal injury in multiple sclerosis. Correlation with demyelination and inflammation","volume":"123","author":"Bitsch","year":"2000","journal-title":"Brain"},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0035","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1136\/jcp.35.3.365-b","article-title":"Double embedding in agar\/paraffin wax as an aid to orientation of mucosal biopsies","volume":"35","author":"Blewitt","year":"1982","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0040","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.neuroimage.2008.02.021","article-title":"MRI of optic neuritis in a rat model","volume":"41","author":"Boretius","year":"2008","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0045","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1523\/JNEUROSCI.4605-08.2009","article-title":"Axial diffusivity is the primary correlate of axonal injury in the experimental autoimmune encephalomyelitis spinal cord: A quantitative pixelwise analysis","volume":"29","author":"Budde","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0050","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.neuroimage.2008.01.002","article-title":"Evaluation of the retina and optic nerve in a rat model of chronic glaucoma using in vivo manganese-enhanced magnetic resonance imaging","volume":"40","author":"Chan","year":"2008","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0055","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.neuroimage.2010.07.015","article-title":"In vivo retinotopic mapping of superior colliculus using manganese-enhanced magnetic resonance imaging","volume":"54","author":"Chan","year":"2011","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0060","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1167\/iovs.11-8827","article-title":"Cell swelling contributes to thickening of low-dose N-methyl-d-aspartate-induced retinal edema","volume":"53","author":"Chen","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0065","first-page":"3085","article-title":"Acute visual function impairment in EAE is primarily caused by optic nerve inflammation as assessed by DBSI","volume":"20","author":"Chiang","year":"2012","journal-title":"Proc. Int. Soc. Magn. Reson. Med."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0070","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/S0140-6736(08)61620-7","article-title":"Multiple sclerosis","volume":"372","author":"Compston","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0075","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/glia.20112","article-title":"Sodium channels contribute to microglia\/macrophage activation and function in EAE and MS","volume":"49","author":"Craner","year":"2005","journal-title":"Glia"},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0080","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.neuroimage.2007.08.036","article-title":"Age-related decrease in axonal transport measured by MR imaging in vivo","volume":"39","author":"Cross","year":"2008","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0085","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1146\/annurev.neuro.31.061307.090711","article-title":"Role of axonal transport in neurodegenerative diseases","volume":"31","author":"De Vos","year":"2008","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0090","doi-asserted-by":"crossref","first-page":"3707","DOI":"10.1167\/iovs.08-1896","article-title":"Autoimmune optic neuritis in the common marmoset monkey: Comparison of visual evoked potentials with MRI and histopathology","volume":"49","author":"Diem","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0095","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/ana.20736","article-title":"Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients","volume":"59","author":"Dutta","year":"2006","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0100","doi-asserted-by":"crossref","first-page":"5585","DOI":"10.1523\/JNEUROSCI.5705-11.2012","article-title":"Preclinical retinal neurodegeneration in a model of multiple sclerosis","volume":"32","author":"Fairless","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0105","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1750-1326-7-29","article-title":"Oxidative stress inhibits axonal transport: Implications for neurodegenerative diseases","volume":"7","author":"Fang","year":"2012","journal-title":"Mol. Neurodegener."},{"issue":"Pt 3","key":"10.1016\/j.neuroimage.2014.06.009_bb0110","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1093\/brain\/120.3.393","article-title":"Axonal damage in acute multiple sclerosis lesions","volume":"120","author":"Ferguson","year":"1997","journal-title":"Brain"},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0115","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/ana.21668","article-title":"Role of n-type voltage-dependent calcium channels in autoimmune optic neuritis","volume":"66","author":"Gadjanski","year":"2009","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0120","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1093\/brain\/awl075","article-title":"Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70years of merits and culprits in experimental autoimmune encephalomyelitis research","volume":"129","author":"Gold","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0125","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1002\/nbm.1309","article-title":"MRI in experimental inflammatory and mitochondrial optic neuropathies","volume":"21","author":"Guy","year":"2008","journal-title":"NMR Biomed."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0130","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.neuroimage.2011.07.069","article-title":"Magnetic resonance imaging of the mouse visual pathway for in vivo studies of degeneration and regeneration in the CNS","volume":"59","author":"Haenold","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0135","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1093\/brain\/awh284","article-title":"A serial MRI study following optic nerve mean area in acute optic neuritis","volume":"127","author":"Hickman","year":"2004","journal-title":"Brain"},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0140","doi-asserted-by":"crossref","first-page":"5411","DOI":"10.1242\/jcs.02745","article-title":"The axonal transport of mitochondria","volume":"118","author":"Hollenbeck","year":"2005","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb9000","doi-asserted-by":"crossref","first-page":"49515","DOI":"10.1155\/IJBI\/2006\/49515","article-title":"A review on MR image intensity inhomogeneity correction","volume":"2006","author":"Hou","year":"2006","journal-title":"Int. J. Biomed. Imaging"},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0145","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/bja\/aet177","article-title":"Anaesthetic neurotoxicity and neuroplasticity: An expert group report and statement based on the BJA Salzburg Seminar","volume":"111","author":"Jevtovic-Todorovic","year":"2013","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0150","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1369\/jhc.2008.952002","article-title":"Class III beta-tubulin is a component of the mitotic spindle in multiple cell types","volume":"56","author":"Jouhilahti","year":"2008","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0155","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1093\/bja\/82.3.402","article-title":"Isoflurane inhibits neuronal Ca2+ channels through enhancement of current inactivation","volume":"82","author":"Kameyama","year":"1999","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0160","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1093\/brain\/124.6.1114","article-title":"Distribution of a calcium channel subunit in dystrophic axons in multiple sclerosis and experimental autoimmune encephalomyelitis","volume":"124","author":"Kornek","year":"2001","journal-title":"Brain"},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0165","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.neuroimage.2003.07.009","article-title":"In vivo tracing of major rat brain pathways using manganese-enhanced magnetic resonance imaging and three-dimensional digital atlasing","volume":"20","author":"Leergaard","year":"2003","journal-title":"Neuroimage"},{"issue":"2","key":"10.1016\/j.neuroimage.2014.06.009_bb9010","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/hbm.10109","article-title":"A wavelet-based approximation of surface coil sensitivity profiles for correction of image intensity inhomogeneity and parallel imaging reconstruction","volume":"19","author":"Lin","year":"2003","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0170","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/nbm.3073","article-title":"Manganese-enhanced MRI (MEMRI) via topical loading of Mn(2+) significantly impairs mouse visual acuity: A comparison with intravitreal injection","volume":"27","author":"Lin","year":"2014","journal-title":"NMR Biomed."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0175","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1093\/brain\/awq179","article-title":"Functional role of brain-derived neurotrophic factor in neuroprotective autoimmunity: Therapeutic implications in a model of multiple sclerosis","volume":"133","author":"Linker","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0180","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1002\/nbm.2808","article-title":"Manganese-enhanced MRI optic nerve tracking: Effect of intravitreal manganese dose on retinal toxicity","volume":"25","author":"Luo","year":"2012","journal-title":"NMR Biomed."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0185","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.neuron.2009.01.030","article-title":"Miro1 is a calcium sensor for glutamate receptor-dependent localization of mitochondria at synapses","volume":"61","author":"Macaskill","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0190","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1002\/jnr.23019","article-title":"Estrogen treatment prevents gray matter atrophy in experimental autoimmune encephalomyelitis","volume":"90","author":"MacKenzie-Graham","year":"2012","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0195","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.bbadis.2009.07.002","article-title":"Is multiple sclerosis a mitochondrial disease?","volume":"1802","author":"Mao","year":"2010","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0200","first-page":"1813","article-title":"Pictorial review of glutamate excitotoxicity: Fundamental concepts for neuroimaging","volume":"22","author":"Mark","year":"2001","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0205","doi-asserted-by":"crossref","first-page":"e10561","DOI":"10.1371\/journal.pone.0010561","article-title":"Mitochondrial superoxide contributes to blood flow and axonal transport deficits in the Tg2576 mouse model of Alzheimer's disease","volume":"5","author":"Massaad","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0210","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nrn3380","article-title":"Axonal transport deficits and neurodegenerative diseases","volume":"14","author":"Millecamps","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0215","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1038\/emboj.2013.59","article-title":"beta-Tubulin mutations that cause severe neuropathies disrupt axonal transport","volume":"32","author":"Niwa","year":"2013","journal-title":"EMBO J."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0225","doi-asserted-by":"crossref","first-page":"7249","DOI":"10.1523\/JNEUROSCI.0095-11.2011","article-title":"Myelination and axonal electrical activity modulate the distribution and motility of mitochondria at CNS nodes of Ranvier","volume":"31","author":"Ohno","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0230","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/jmri.22284","article-title":"Manganese transport in the rat optic nerve evaluated with spatial- and time-resolved magnetic resonance imaging","volume":"32","author":"Olsen","year":"2010","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0220","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0165-5728(97)00203-8","article-title":"Optic neuritis in chronic relapsing experimental allergic encephalomyelitis in Biozzi ABH mice: Demyelination and fast axonal transport changes in disease","volume":"82","author":"O'Neill","year":"1998","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0235","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1177\/1352458509107015","article-title":"Revision of the risk of secondary leukaemia after mitoxantrone in multiple sclerosis populations is required","volume":"15","author":"Pascual","year":"2009","journal-title":"Mult. Scler."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0240","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1006\/nimg.2002.1075","article-title":"Tracing odor-induced activation in the olfactory bulbs of mice using manganese-enhanced magnetic resonance imaging","volume":"16","author":"Pautler","year":"2002","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0245","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1002\/mrm.1910400515","article-title":"In vivo neuronal tract tracing using manganese-enhanced magnetic resonance imaging","volume":"40","author":"Pautler","year":"1998","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0250","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1093\/brain\/aws100","article-title":"Limiting multiple sclerosis related axonopathy by blocking Nogo receptor and CRMP-2 phosphorylation","volume":"135","author":"Petratos","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0255","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/71555","article-title":"Glutamate excitotoxicity in a model of multiple sclerosis","volume":"6","author":"Pitt","year":"2000","journal-title":"Nat. Med."},{"issue":"Pt 12","key":"10.1016\/j.neuroimage.2014.06.009_bb0260","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1093\/brain\/120.12.2149","article-title":"Nitric oxide donors reversibly block axonal conduction: Demyelinated axons are especially susceptible","volume":"120","author":"Redford","year":"1997","journal-title":"Brain"},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0265","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.visres.2005.09.006","article-title":"The visual evoked potential in the mouse\u2014Origins and response characteristics","volume":"46","author":"Ridder","year":"2006","journal-title":"Vision Res"},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0270","doi-asserted-by":"crossref","first-page":"7881","DOI":"10.1523\/JNEUROSCI.23-21-07881.2003","article-title":"Glutamate decreases mitochondrial size and movement in primary forebrain neurons","volume":"23","author":"Rintoul","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0275","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1093\/brain\/awg070","article-title":"A function of myelin is to protect axons from subsequent injury: Implications for deficits in multiple sclerosis","volume":"126","author":"Rodriguez","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0280","doi-asserted-by":"crossref","first-page":"6849","DOI":"10.1523\/JNEUROSCI.20-18-06849.2000","article-title":"Neurofilaments are transported rapidly but intermittently in axons: Implications for slow axonal transport","volume":"20","author":"Roy","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0285","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0896-6273(02)00718-3","article-title":"Magnetic resonance imaging of neuronal connections in the macaque monkey","volume":"34","author":"Saleem","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0290","series-title":"Roots to research: A vertical development of mathematical problems","author":"Sally","year":"2007"},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0295","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0300","first-page":"82","article-title":"Optic neuritis: A review","volume":"16","author":"Shams","year":"2009","journal-title":"Int. MS J."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0305","doi-asserted-by":"crossref","first-page":"4060","DOI":"10.1167\/iovs.04-0554","article-title":"Myelin\/oligodendrocyte glycoprotein-specific T-cells induce severe optic neuritis in the C57BL\/6 mouse","volume":"45","author":"Shao","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0310","doi-asserted-by":"crossref","first-page":"e13463","DOI":"10.1371\/journal.pone.0013463","article-title":"Hyperglycemia induces oxidative stress and impairs axonal transport rates in mice","volume":"5","author":"Sharma","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0315","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0166-2236(03)00199-1","article-title":"Does neurofilament phosphorylation regulate axonal transport?","volume":"26","author":"Shea","year":"2003","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0320","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/nbm.945","article-title":"Manganese-enhanced magnetic resonance imaging (MEMRI): Methodological and practical considerations","volume":"17","author":"Silva","year":"2004","journal-title":"NMR Biomed."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0340","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S1474-4422(02)00102-3","article-title":"The role of nitric oxide in multiple sclerosis","volume":"1","author":"Smith","year":"2002","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0335","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/ana.96","article-title":"Electrically active axons degenerate when exposed to nitric oxide","volume":"49","author":"Smith","year":"2001","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0325","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.3171\/jns.2003.98.5.1072","article-title":"Amyloid beta accumulation in axons after traumatic brain injury in humans","volume":"98","author":"Smith","year":"2003","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0330","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.neuroimage.2007.01.046","article-title":"In vivo axonal transport rates decrease in a mouse model of Alzheimer's disease","volume":"35","author":"Smith","year":"2007","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0345","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1016\/j.neuroimage.2003.07.005","article-title":"Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia","volume":"20","author":"Song","year":"2003","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0350","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1523\/JNEUROSCI.3887-04.2005","article-title":"Breakdown of axonal synaptic vesicle precursor transport by microglial nitric oxide","volume":"25","author":"Stagi","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0355","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jns.2005.03.031","article-title":"General mechanisms of axonal damage and its prevention","volume":"233","author":"Stys","year":"2005","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0360","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s11910-009-0060-3","article-title":"Axonal degeneration in multiple sclerosis: The mitochondrial hypothesis","volume":"9","author":"Su","year":"2009","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0365","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.nbd.2007.06.011","article-title":"Selective vulnerability of cerebral white matter in a murine model of multiple sclerosis detected using diffusion tensor imaging","volume":"28","author":"Sun","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0370","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1002\/jmri.21504","article-title":"Manganese-enhanced MRI of the rat visual pathway: Acute neural toxicity, contrast enhancement, axon resolution, axonal transport, and clearance of Mn(2+)","volume":"28","author":"Thuen","year":"2008","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0375","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev.neuro.30.051606.094313","article-title":"Multiple sclerosis: An immune or neurodegenerative disorder?","volume":"31","author":"Trapp","year":"2008","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0380","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0306-4522(02)00070-2","article-title":"In vivo manganese-enhanced magnetic resonance imaging reveals connections and functional properties of the songbird vocal control system","volume":"112","author":"Van der Linden","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0390","doi-asserted-by":"crossref","first-page":"3590","DOI":"10.1093\/brain\/awr307","article-title":"Quantification of increased cellularity during inflammatory demyelination","volume":"134","author":"Wang","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0385","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1111\/j.1460-9568.2012.08258.x","article-title":"Decreased axonal transport rates in the Tg2576 APP transgenic mouse: Improvement with the gamma-secretase inhibitor MRK-560 as detected by manganese-enhanced MRI","volume":"36","author":"Wang","year":"2012","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0395","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1002\/nbm.937","article-title":"Functional mapping of neural pathways in rodent brain in vivo using manganese-enhanced three-dimensional magnetic resonance imaging","volume":"17","author":"Watanabe","year":"2004","journal-title":"NMR Biomed."},{"key":"10.1016\/j.neuroimage.2014.06.009_bb0400","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nrn2023","article-title":"Axonal conduction and injury in multiple sclerosis: The role of sodium channels","volume":"7","author":"Waxman","year":"2006","journal-title":"Nat. Rev. Neurosci."}],"container-title":["NeuroImage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053811914004868?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053811914004868?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,11]],"date-time":"2019-08-11T11:29:00Z","timestamp":1565522940000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053811914004868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":82,"alternative-id":["S1053811914004868"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroimage.2014.06.009","relation":{},"ISSN":["1053-8119"],"issn-type":[{"value":"1053-8119","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Axonal transport rate decreased at the onset of optic neuritis in EAE mice","name":"articletitle","label":"Article Title"},{"value":"NeuroImage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroimage.2014.06.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}