{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T09:28:23Z","timestamp":1776072503793,"version":"3.50.1"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Department of the Navy"},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["NIA 037639"],"award-info":[{"award-number":["NIA 037639"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["NIA 043125"],"award-info":[{"award-number":["NIA 043125"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["NIMH 10031"],"award-info":[{"award-number":["NIMH 10031"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["NIMH 097464"],"award-info":[{"award-number":["NIMH 097464"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["NICHD 003352"],"award-info":[{"award-number":["NICHD 003352"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.neuroimage.2014.09.053","type":"journal-article","created":{"date-parts":[[2014,9,28]],"date-time":"2014-09-28T12:43:08Z","timestamp":1411908188000},"page":"323-333","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":161,"special_numbering":"C","title":["Optimization of a free water elimination two-compartment model for diffusion tensor imaging"],"prefix":"10.1016","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9254-8142","authenticated-orcid":false,"given":"Andrew R.","family":"Hoy","sequence":"first","affiliation":[]},{"given":"Cheng Guan","family":"Koay","sequence":"additional","affiliation":[]},{"given":"Steven R.","family":"Kecskemeti","sequence":"additional","affiliation":[]},{"given":"Andrew L.","family":"Alexander","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/j.neuroimage.2014.09.053_bb0005","first-page":"770","volume":"780","author":"Alexander","year":"2001"},{"key":"10.1016\/j.neuroimage.2014.09.053_bb0010","first-page":"316","volume":"4","author":"Alexander","year":"2007"},{"key":"10.1016\/j.neuroimage.2014.09.053_bb0015","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1002\/mrm.20274","article-title":"New modeling and experimental framework to characterize hindered and restricted water diffusion in brain white matter","volume":"52","author":"Assaf","year":"2004","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.neuroimage.2014.09.053_bb0025","first-page":"1","article-title":"Acquisition strategy to reduce cerebrospinal fluid partial volume effects for improved DTI tractography","volume":"00","author":"Baron","year":"2014","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.neuroimage.2014.09.053_bb0030","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0006-3495(94)80775-1","article-title":"MR diffusion tensor spectroscopy and imaging","volume":"66","author":"Basser","year":"1994","journal-title":"Biophys. J."},{"key":"10.1016\/j.neuroimage.2014.09.053_bb0035","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/nbm.782","article-title":"The basis of anisotropic water diffusion in the nervous system \u2014 a technical review","volume":"15","author":"Beaulieu","year":"2002","journal-title":"NMR Biomed."},{"key":"10.1016\/j.neuroimage.2014.09.053_bb0040","first-page":"2267","article-title":"Diffusion tensor tractography of the limbic system","volume":"26","author":"Concha","year":"2005","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.neuroimage.2014.09.053_bb0045","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jmr.2006.01.016","article-title":"Analytically exact correction scheme for signal extraction from noisy magnitude MR signals","volume":"179","author":"Koay","year":"2006","journal-title":"J. Magn. Reson."},{"key":"10.1016\/j.neuroimage.2014.09.053_bb0050","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jmr.2006.06.020","article-title":"A unifying theoretical and algorithmic framework for least squares methods of estimation in diffusion tensor imaging","volume":"182","author":"Koay","year":"2006","journal-title":"J. Magn. Reson."},{"key":"10.1016\/j.neuroimage.2014.09.053_bb0055","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1118\/1.3700166","article-title":"Sparse and optimal acquisition design for diffusion MRI and beyond","volume":"39","author":"Koay","year":"2012","journal-title":"Med. Phys."},{"key":"10.1016\/j.neuroimage.2014.09.053_bb0060","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1016\/j.neuroimage.2011.08.043","article-title":"How and how not to correct for CSF-contamination in diffusion MRI","volume":"59","author":"Metzler-Baddeley","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuroimage.2014.09.053_bb0065","series-title":"Engineering Statistics","author":"Montgomery","year":"1987"},{"key":"10.1016\/j.neuroimage.2014.09.053_bb0070","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.mri.2009.05.003","article-title":"On high b diffusion imaging in the human brain: ruminations and experimental insights","volume":"27","author":"Mulkern","year":"2009","journal-title":"Magn. Reson. Imaging"},{"key":"10.1016\/j.neuroimage.2014.09.053_bb0075","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0166-2236(98)01261-2","article-title":"Extracellular space structure revealed by diffusion analysis","volume":"21","author":"Nicholson","year":"1998","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuroimage.2014.09.053_bb0085","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/mrm.22055","article-title":"Free water elimination and mapping from diffusion MRI","volume":"62","author":"Pasternak","year":"2009","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.neuroimage.2014.09.053_bb0080","first-page":"305","article-title":"Estimation of extracellular volume from regularized multi-shell diffusion MRI","volume":"15","author":"Pasternak","year":"2012","journal-title":"Med. Image Comput. Comput. Assist. Interv."},{"key":"10.1016\/j.neuroimage.2014.09.053_bb0090","doi-asserted-by":"crossref","first-page":"17365","DOI":"10.1523\/JNEUROSCI.2904-12.2012","article-title":"Excessive extracellular volume reveals a neurodegenerative pattern in schizophrenia onset","volume":"32","author":"Pasternak","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuroimage.2014.09.053_bb0095","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1002\/mrm.1910360612","article-title":"Toward a quantitative assessment of diffusion anisotropy","volume":"36","author":"Pierpaoli","year":"1996","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.neuroimage.2014.09.053_bb0100","series-title":"International Society for Magnetic Resonance in Medicine Meeting","first-page":"1215","article-title":"Removing CSF contamination in brain DT-MRIs by using a two-compartment tensor model","author":"Pierpaoli","year":"2004"},{"key":"10.1016\/j.neuroimage.2014.09.053_bb0105","series-title":"Cambridge NA Report NA2009\/06","article-title":"The BOBYQA algorithm for bound constrained optimization without derivatives","author":"Powell","year":"2009"},{"key":"10.1016\/j.neuroimage.2014.09.053_bb0110","doi-asserted-by":"crossref","first-page":"e48232","DOI":"10.1371\/journal.pone.0048232","article-title":"Parametric representation of multiple white matter fascicles from cube and sphere diffusion MRI","volume":"7","author":"Scherrer","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroimage.2014.09.053_bb0115","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0895-6111(00)00083-5","article-title":"Diffusion MRI: apparent diffusion coefficient (ADC) values in the normal brain and a classification of brain disorders based on ADC values","volume":"25","author":"Sener","year":"2001","journal-title":"Comput. Med. Imaging Graph."},{"key":"10.1016\/j.neuroimage.2014.09.053_bb0120","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/mrm.20605","article-title":"T1, T2 relaxation and magnetization transfer in tissue at 3T","volume":"54","author":"Stanisz","year":"2005","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.neuroimage.2014.09.053_bb0125","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1148\/radiology.177.2.2217777","article-title":"Echo-planar imaging of intravoxel incoherent motion","volume":"177","author":"Turner","year":"1990","journal-title":"Radiology"},{"key":"10.1016\/j.neuroimage.2014.09.053_bb0130","doi-asserted-by":"crossref","first-page":"3590","DOI":"10.1093\/brain\/awr307","article-title":"Quantification of increased cellularity during inflammatory demyelination","volume":"134","author":"Wang","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.neuroimage.2014.09.053_bb0140","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.neuroimage.2012.03.072","article-title":"NODDI: practical in vivo neurite orientation dispersion and density imaging of the human brain","volume":"61","author":"Zhang","year":"2012","journal-title":"Neuroimage"}],"container-title":["NeuroImage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053811914007952?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053811914007952?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T22:53:45Z","timestamp":1538175225000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053811914007952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":26,"alternative-id":["S1053811914007952"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroimage.2014.09.053","relation":{},"ISSN":["1053-8119"],"issn-type":[{"value":"1053-8119","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Optimization of a free water elimination two-compartment model for diffusion tensor imaging","name":"articletitle","label":"Article Title"},{"value":"NeuroImage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroimage.2014.09.053","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}