{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T18:13:20Z","timestamp":1776104000474,"version":"3.50.1"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"EU-FP7","award":["HEALTH-F2-2012-279017"],"award-info":[{"award-number":["HEALTH-F2-2012-279017"]}]},{"name":"BrainPath","award":["FP7-PEOPLE-2013-IAPP -612360"],"award-info":[{"award-number":["FP7-PEOPLE-2013-IAPP -612360"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.neuroimage.2015.12.044","type":"journal-article","created":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T08:16:15Z","timestamp":1451463375000},"page":"54-62","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"special_numbering":"C","title":["Glucose consumption of inflammatory cells masks metabolic deficits in the brain"],"prefix":"10.1016","volume":"128","author":[{"given":"Heiko","family":"Backes","sequence":"first","affiliation":[]},{"given":"Maureen","family":"Walberer","sequence":"additional","affiliation":[]},{"given":"Anne","family":"Ladwig","sequence":"additional","affiliation":[]},{"given":"Maria A.","family":"Rueger","sequence":"additional","affiliation":[]},{"given":"Bernd","family":"Neumaier","sequence":"additional","affiliation":[]},{"given":"Heike","family":"Endepols","sequence":"additional","affiliation":[]},{"given":"Mathias","family":"Hoehn","sequence":"additional","affiliation":[]},{"given":"Gereon R.","family":"Fink","sequence":"additional","affiliation":[]},{"given":"Michael","family":"Schroeter","sequence":"additional","affiliation":[]},{"given":"Rudolf","family":"Graf","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/j.neuroimage.2015.12.044_bb0005","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.2967\/jnumed.110.085266","article-title":"Whiskers area as extracerebral reference tissue for quantification of rat brain metabolism using (18)F-FDG PET: application to focal cerebral ischemia","volume":"52","author":"Backes","year":"2011","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.neuroimage.2015.12.044_bb0010","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/glia.10144","article-title":"Visualising microglial activation in vivo","volume":"40","author":"Banati","year":"2002","journal-title":"Glia"},{"key":"10.1016\/j.neuroimage.2015.12.044_bb0015","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s11068-004-0515-7","article-title":"Mitochondria in activated microglia in vitro","volume":"33","author":"Banati","year":"2004","journal-title":"J. Neurocytol."},{"key":"10.1016\/j.neuroimage.2015.12.044_bb0020","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1097\/00004647-199611000-00001","article-title":"Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain","volume":"16","author":"Bittar","year":"1996","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neuroimage.2015.12.044_bb0025","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.neuroimage.2004.01.016","article-title":"Fast and robust registration of PET and MR images of human brain","volume":"22","author":"C\u00edzek","year":"2004","journal-title":"NeuroImage"},{"key":"10.1016\/j.neuroimage.2015.12.044_bb0030","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/npp.2012.255","article-title":"Microglia, amyloid, and glucose metabolism in Parkinson's disease with and without dementia","volume":"38","author":"Edison","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroimage.2015.12.044_bb0035","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3389\/fneur.2015.00081","article-title":"The ischemic environment drives microglia and macrophage function","volume":"6","author":"Fumagalli","year":"2015","journal-title":"Front. Neurol."},{"key":"10.1016\/j.neuroimage.2015.12.044_bb0040","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1161\/01.STR.0000113692.38574.57","article-title":"Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging","volume":"35","author":"Gerriets","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.neuroimage.2015.12.044_bb0045","doi-asserted-by":"crossref","unstructured":"Graeber, M.B., 2010. Changing face of microglia. Sci. (New York, NY) 330, 783\u2013788.","DOI":"10.1126\/science.1190929"},{"key":"10.1016\/j.neuroimage.2015.12.044_bb0050","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00401-009-0622-0","article-title":"Microglia: biology and pathology","volume":"119","author":"Graeber","year":"2010","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neuroimage.2015.12.044_bb0055","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1161\/01.STR.17.2.246","article-title":"Polymorphonuclear leukocyte accumulation in brain regions with low blood flow during the early postischemic period","volume":"17","author":"Hallenbeck","year":"1986","journal-title":"Stroke"},{"key":"10.1016\/j.neuroimage.2015.12.044_bb0060","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1038\/jcbfm.1994.120","article-title":"Dynamic penumbra demonstrated by sequential multitracer PET after middle cerebral artery occlusion in cats","volume":"14","author":"Heiss","year":"1994","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neuroimage.2015.12.044_bb0065","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1006\/nimg.1996.0066","article-title":"Simplified reference tissue model for PET receptor studies","volume":"4","author":"Lammertsma","year":"1996","journal-title":"NeuroImage"},{"key":"10.1016\/j.neuroimage.2015.12.044_bb0070","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1212\/WNL.0b013e3182635645","article-title":"Increased PK11195 PET binding in the cortex of patients with MS correlates with disability","volume":"79","author":"Politis","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.neuroimage.2015.12.044_bb0075","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/nrn3722","article-title":"Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease","volume":"15","author":"Prinz","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuroimage.2015.12.044_bb0080","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/intimm\/dxs110","article-title":"Hypoxia-mediated regulation of macrophage functions in pathophysiology","volume":"25","author":"Riboldi","year":"2013","journal-title":"Int. Immunol."},{"key":"10.1016\/j.neuroimage.2015.12.044_bb0085","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1038\/sj.jcbfm.9600500","article-title":"Imaging brain inflammation with [(11)C]PK11195 by PET and induction of the peripheral-type benzodiazepine receptor after transient focal ischemia in rats","volume":"27","author":"Rojas","year":"2007","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neuroimage.2015.12.044_bb0090","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1093\/brain\/awl094","article-title":"Increased thalamic neurodegeneration following ischaemic cortical stroke in osteopontin-deficient mice","volume":"129","author":"Schroeter","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.neuroimage.2015.12.044_bb0095","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/jcbfm.2009.36","article-title":"Neuroinflammation extends brain tissue at risk to vital peri-infarct tissue: a double tracer [11C]PK11195- and [18F]FDG-PET study","volume":"29","author":"Schroeter","year":"2009","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neuroimage.2015.12.044_bb0100","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s00109-011-0724-8","article-title":"Hypoxia: a double-edged sword of immunity","volume":"89","author":"Sica","year":"2011","journal-title":"J. Mol. Med. (Berl)"},{"key":"10.1016\/j.neuroimage.2015.12.044_bb0105","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/1098-1136(200103)33:3<256::AID-GLIA1024>3.0.CO;2-J","article-title":"Dynamics of microglial activation: a confocal time-lapse analysis in hippocampal slices","volume":"33","author":"Stence","year":"2001","journal-title":"Glia"},{"key":"10.1016\/j.neuroimage.2015.12.044_bb0110","series-title":"[BOOK] Brain maps III: structure of the rat brain","author":"Swanson","year":"2003"},{"key":"10.1016\/j.neuroimage.2015.12.044_bb0115","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1161\/STROKEAHA.110.598821","article-title":"Imaging of microglia activation in stroke","volume":"42","author":"Thiel","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.neuroimage.2015.12.044_bb0120","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1161\/STROKEAHA.111.624551","article-title":"Potential of early [(18)F]-2-fluoro-2-deoxy-D-glucose positron emission tomography for identifying hypoperfusion and predicting fate of tissue in a rat embolic stroke model","volume":"43","author":"Walberer","year":"2012","journal-title":"Stroke"},{"key":"10.1016\/j.neuroimage.2015.12.044_bb0125","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/ana.410140605","article-title":"Disturbance of oxidative metabolism of glucose in recent human cerebral infarcts","volume":"14","author":"Wise","year":"1983","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuroimage.2015.12.044_bb0130","article-title":"Hypoxia induces autophagic cell death through hypoxia-inducible factor 1\u03b1 in microglia","volume":"9","author":"Yang","year":"2014","journal-title":"PLoS One"}],"container-title":["NeuroImage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105381191501157X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105381191501157X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T02:08:53Z","timestamp":1567476533000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S105381191501157X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":26,"alternative-id":["S105381191501157X"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroimage.2015.12.044","relation":{},"ISSN":["1053-8119"],"issn-type":[{"value":"1053-8119","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glucose consumption of inflammatory cells masks metabolic deficits in the brain","name":"articletitle","label":"Article Title"},{"value":"NeuroImage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroimage.2015.12.044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}