{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T06:02:26Z","timestamp":1770271346101,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T00:00:00Z","timestamp":1711324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271954"],"award-info":[{"award-number":["82271954"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971576"],"award-info":[{"award-number":["81971576"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020732","name":"Innovative Research Team of High-level Local University in Shanghai","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018920","name":"Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2009900\/2022YFC2009905"],"award-info":[{"award-number":["2022YFC2009900\/2022YFC2009905"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.neuroimage.2024.120588","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T07:34:52Z","timestamp":1711438492000},"page":"120588","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["PENCIL imaging: A novel approach for neuromelanin sensitive MRI in Parkinson's disease"],"prefix":"10.1016","volume":"291","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3221-5909","authenticated-orcid":false,"given":"Peng","family":"Liu","sequence":"first","affiliation":[]},{"given":"Xinhui","family":"Wang","sequence":"additional","affiliation":[]},{"given":"Youmin","family":"Zhang","sequence":"additional","affiliation":[]},{"given":"Pei","family":"Huang","sequence":"additional","affiliation":[]},{"given":"Zhijia","family":"Jin","sequence":"additional","affiliation":[]},{"given":"Zenghui","family":"Cheng","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7114-5731","authenticated-orcid":false,"given":"Yongsheng","family":"Chen","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8782-2773","authenticated-orcid":false,"given":"Qiuyun","family":"Xu","sequence":"additional","affiliation":[]},{"given":"Kiarash","family":"Ghassaban","sequence":"additional","affiliation":[]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[]},{"given":"Shengdi","family":"Chen","sequence":"additional","affiliation":[]},{"given":"Naying","family":"He","sequence":"additional","affiliation":[]},{"given":"Fuhua","family":"Yan","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4965-7954","authenticated-orcid":false,"given":"E. Mark","family":"Haacke","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/j.neuroimage.2024.120588_bib0001","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1093\/brain\/awaa216","article-title":"Spatiotemporal changes in substantia nigra neuromelanin content in Parkinson's disease","volume":"143","author":"Biondetti","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.neuroimage.2024.120588_bib0002","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.mri.2017.10.005","article-title":"STrategically acquired gradient echo (STAGE) imaging, part I: creating enhanced T1 contrast and standardized susceptibility weighted imaging and quantitative susceptibility mapping","volume":"46","author":"Chen","year":"2018","journal-title":"Magn. Reson. ImAging"},{"key":"10.1016\/j.neuroimage.2024.120588_bib0003","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1093\/brain\/122.8.1437","article-title":"The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson's disease","volume":"122","author":"Damier","year":"1999","journal-title":"Brain"},{"key":"10.1016\/j.neuroimage.2024.120588_bib0004","doi-asserted-by":"crossref","first-page":"491","DOI":"10.3233\/JPD-171135","article-title":"Substantia nigra neuromelanin as an imaging biomarker of disease progression in Parkinson's disease","volume":"7","author":"Fabbri","year":"2017","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.neuroimage.2024.120588_bib0005","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1002\/mds.26201","article-title":"Automated neuromelanin imaging as a diagnostic biomarker for Parkinson's disease","volume":"30","author":"Castellanos","year":"2015","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neuroimage.2024.120588_bib0006","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1002\/mds.22340","article-title":"Movement disorder society UPDRS revision task force. Movement disorder society-sponsored revision of the unified Parkinson's disease rating scale (MDS-UPDRS): scale presentation and clinimetric testing results","volume":"23","author":"Goetz","year":"2008","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neuroimage.2024.120588_bib0007","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1002\/mds.28531","article-title":"Longitudinal changes in neuromelanin MRI signal in parkinson's disease: a progression marker","volume":"36","author":"Gaurav","year":"2021","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neuroimage.2024.120588_bib0008","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s00702-017-1688-9","article-title":"Neuromelanin MRI is useful for monitoring motor complications in Parkinson's and PARK2 disease","volume":"124","author":"Hatano","year":"2017","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.neuroimage.2024.120588_bib0009","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.mri.2019.09.006","article-title":"STrategically acquired Gradient Echo (STAGE) imaging, part III: technical advances and clinical applications of a rapid multi-contrast multi-parametric brain imaging method","volume":"65","author":"Haacke","year":"2020","journal-title":"Magn. Reson. ImAging"},{"key":"10.1016\/j.neuroimage.2024.120588_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2021.117810","article-title":"Imaging iron and neuromelanin simultaneously using a single 3D gradient echo magnetization transfer sequence: combining neuromelanin, iron and the nigrosome-1 sign as complementary imaging biomarkers in early stage Parkinson's disease","volume":"230","author":"He","year":"2021","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuroimage.2024.120588_bib0011","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/jmri.28414","article-title":"Application of neuromelanin MR imaging in Parkinson disease","volume":"57","author":"He","year":"2023","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.neuroimage.2024.120588_bib0012","first-page":"196","article-title":"Neuromelanin imaging and dopaminergic loss in Parkinson's disease","volume":"22","author":"Isaias","year":"2016","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neuroimage.2024.120588_bib0013","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1002\/hbm.25770","article-title":"Automatic detection of neuromelanin and iron in the midbrain nuclei using a magnetic resonance imaging-based brain template","volume":"43","author":"Jin","year":"2022","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.neuroimage.2024.120588_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2022.119814","article-title":"Diagnosing Parkinson's disease by combining neuromelanin and iron imaging features using an automated midbrain template approach","volume":"266","author":"Jokar","year":"2023","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuroimage.2024.120588_bib0015","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.neuroimage.2009.06.012","article-title":"In vivo mapping of the human locus coeruleus","volume":"47","author":"Keren","year":"2009","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuroimage.2024.120588_bib0016","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.neulet.2016.09.011","article-title":"A longitudinal study of neuromelanin-sensitive magnetic resonance imaging in Parkinson's disease","volume":"28","author":"Matsuura","year":"2016","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuroimage.2024.120588_bib0017","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neuroimage.2018.04.047","article-title":"Quantifying iron content in magnetic resonance imaging","volume":"15","author":"Ghassaban","year":"2019","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuroimage.2024.120588_bib0018","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41531-024-00631-3","article-title":"Diagnostic utility of 7T neuromelanin imaging of the substantia nigra in Parkinson's disease","volume":"10","author":"Lakhani","year":"2024","journal-title":"NPJ. Parkinsons Dis."},{"key":"10.1016\/j.neuroimage.2024.120588_bib0019","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s12264-017-0183-5","article-title":"Biomarkers for Parkinson's disease: recent advancement","volume":"33","author":"Lotankar","year":"2017","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.neuroimage.2024.120588_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2020.116935","article-title":"Optimizing neuromelanin contrast in the substantia nigra and locus coeruleus using a magnetization transfer contrast prepared 3D gradient recalled echo sequence","volume":"218","author":"Liu","year":"2020","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuroimage.2024.120588_bib0021","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/brain\/97.1.489","article-title":"Lipoprotein pigments\u2013their relationship to ageing in the human nervous system. II. The melanin content of pigmented nerve cells","volume":"97","author":"Mann","year":"1974","journal-title":"Brain"},{"key":"10.1016\/j.neuroimage.2024.120588_bib0022","doi-asserted-by":"crossref","first-page":"205","DOI":"10.2463\/mrms.7.205","article-title":"Visualization of neuromelanin in the Substantia nigra and locus ceruleus at 1.5T using a 3D-gradient echo sequence with magnetization transfer contrast","volume":"7","author":"Nakane","year":"2008","journal-title":"Magn. Reson. Med. Sci."},{"key":"10.1016\/j.neuroimage.2024.120588_bib0023","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1002\/mds.28417","article-title":"Neuromelanin-sensitive magnetic resonance imaging using DANTE pulse","volume":"36","author":"Oshima","year":"2021","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neuroimage.2024.120588_bib0024","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/mds.26424","article-title":"MDS clinical diagnostic criteria for Parkinson's disease","volume":"30","author":"Postuma","year":"2015","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neuroimage.2024.120588_bib0025","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1111\/ene.13573","article-title":"Three-dimensional neuromelanin-sensitive magnetic resonance imaging of the substantia nigra in Parkinson's disease","volume":"25","author":"Prasad","year":"2018","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.neuroimage.2024.120588_bib0026","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.neuroimage.2017.07.045","article-title":"High-resolution in vivo imaging of human locus coeruleus by magnetization transfer MRI at 3T and 7T","volume":"168","author":"Priovoulos","year":"2018","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuroimage.2024.120588_bib0027","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1097\/01.wnr.0000227984.84927.a7","article-title":"Neuromelanin magnetic resonance imaging of locus ceruleus and substantia nigra in Parkinson's disease","volume":"17","author":"Sasaki","year":"2006","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuroimage.2024.120588_bib0028","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1148\/radiol.2016160662","article-title":"In vivo assessment of brainstem depigmentation in Parkinson disease: potential as a severity marker for multicenter studies","volume":"283","author":"Schwarz","year":"2017","journal-title":"Radiology"},{"key":"10.1016\/j.neuroimage.2024.120588_bib0029","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41531-018-0047-3","article-title":"Neuromelanin detection by magnetic resonance imaging (MRI) and its promise as a biomarker for Parkinson's disease","volume":"10","author":"Sulzer","year":"2018","journal-title":"NPJ Parkinsons Dis."},{"key":"10.1016\/j.neuroimage.2024.120588_bib0030","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1002\/mrm.26584","article-title":"Contrast mechanisms associated with neuromelanin-MRI","volume":"78","author":"Trujillo","year":"2017","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.neuroimage.2024.120588_bib0031","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1007\/s00234-017-1911-2","article-title":"Pool size ratio of the substantia nigra in Parkinson's disease derived from two different quantitative magnetization transfer approaches","volume":"59","author":"Trujillo","year":"2017","journal-title":"Neuroradiology"},{"key":"10.1016\/j.neuroimage.2024.120588_bib0032","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20180037","article-title":"Quantifying changes in nigrosomes using quantitative susceptibility mapping and neuromelanin imaging for the diagnosis of early-stage Parkinson's disease","volume":"91","author":"Takahashi","year":"2018","journal-title":"Br. J. Radiol."},{"key":"10.1016\/j.neuroimage.2024.120588_bib0033","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.neuroimage.2019.06.049","article-title":"Quantitative magnetization transfer imaging of the human locus coeruleus","volume":"200","author":"Trujillo","year":"2019","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuroimage.2024.120588_bib0035","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.mri.2017.10.006","article-title":"STrategically acquired gradient echo (STAGE) imaging, part II: correcting for RF inhomogeneities in estimating T1 and proton density","volume":"46","author":"Wang","year":"2018","journal-title":"Magn. Reson. ImAging"},{"key":"10.1016\/j.neuroimage.2024.120588_bib0036","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1007\/s00429-019-01858-0","article-title":"Magnetic resonance imaging of noradrenergic neurons","volume":"224","author":"Watanabe","year":"2019","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.neuroimage.2024.120588_bib0037","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00702-020-02295-8","article-title":"Substantia nigra neuromelanin magnetic resonance imaging in patients with different subtypes of Parkinson disease","volume":"128","author":"Wang","year":"2021","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.neuroimage.2024.120588_bib0038","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1002\/mds.27502","article-title":"Life span pigmentation changes of the substantia nigra detected by neuromelanin-sensitive MRI","volume":"33","author":"Xing","year":"2018","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neuroimage.2024.120588_bib0039","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0014-5793(01)03269-0","article-title":"The absolute concentration of nigral neuromelanin, assayed by a new sensitive method, increases throughout the life and is dramatically decreased in Parkinson's disease","volume":"510","author":"Zecca","year":"2002","journal-title":"FEBS Lett."}],"container-title":["NeuroImage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053811924000831?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053811924000831?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T01:08:43Z","timestamp":1731632923000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053811924000831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":38,"alternative-id":["S1053811924000831"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroimage.2024.120588","relation":{},"ISSN":["1053-8119"],"issn-type":[{"value":"1053-8119","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PENCIL imaging: A novel approach for neuromelanin sensitive MRI in Parkinson's disease","name":"articletitle","label":"Article Title"},{"value":"NeuroImage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroimage.2024.120588","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120588"}}