{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:28:23Z","timestamp":1768782503340,"version":"3.49.0"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015694","name":"Fondazione Cassa di Risparmio di Firenze","doi-asserted-by":"publisher","award":["B97G24000240005"],"award-info":[{"award-number":["B97G24000240005"]}],"id":[{"id":"10.13039\/501100015694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015694","name":"Fondazione Cassa di Risparmio di Firenze","doi-asserted-by":"publisher","award":["RICTD2025_2026-CUP"],"award-info":[{"award-number":["RICTD2025_2026-CUP"]}],"id":[{"id":"10.13039\/501100015694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["B53C22001810006"],"award-info":[{"award-number":["B53C22001810006"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["IR0000023"],"award-info":[{"award-number":["IR0000023"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020976","name":"LabEx BRAIN","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020976","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004434","name":"Universit\u00e0 degli Studi di Firenze","doi-asserted-by":"publisher","award":["464 del 02\/04\/2024"],"award-info":[{"award-number":["464 del 02\/04\/2024"]}],"id":[{"id":"10.13039\/501100004434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 MH117023"],"award-info":[{"award-number":["U01 MH117023"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["HORIZON-INFRA-2022-SERV-B-01"],"award-info":[{"award-number":["HORIZON-INFRA-2022-SERV-B-01"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["654148"],"award-info":[{"award-number":["654148"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004462","name":"Consiglio Nazionale delle Ricerche","doi-asserted-by":"publisher","award":["B53C24004790001"],"award-info":[{"award-number":["B53C24004790001"]}],"id":[{"id":"10.13039\/501100004462","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"HORIZON EUROPE Framework Programme","doi-asserted-by":"publisher","award":["2021\\u20132027"],"award-info":[{"award-number":["2021\\u20132027"]}],"id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.neuroimage.2025.121581","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T16:48:08Z","timestamp":1763657288000},"page":"121581","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Myelinated fiber labeling and orientation mapping of the human brain with light-sheet fluorescence microscopy"],"prefix":"10.1016","volume":"323","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0546-3157","authenticated-orcid":false,"given":"Michele","family":"Sorelli","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6545-0676","authenticated-orcid":false,"given":"Danila","family":"Di Meo","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5008-6580","authenticated-orcid":false,"given":"Samuel","family":"Bradley","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7793-4730","authenticated-orcid":false,"given":"Franco","family":"Cheli","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0341-9607","authenticated-orcid":false,"given":"Josephine","family":"Ramazzotti","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7262-2675","authenticated-orcid":false,"given":"Federica F.","family":"Caria","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5173-7606","authenticated-orcid":false,"given":"Laura","family":"Perego","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5348-8052","authenticated-orcid":false,"given":"Christophe","family":"Destrieux","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3208-1154","authenticated-orcid":false,"given":"Patrick R.","family":"Hof","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0675-3981","authenticated-orcid":false,"given":"Francesco S.","family":"Pavone","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3077-3904","authenticated-orcid":false,"given":"Giacomo","family":"Mazzamuto","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8464-7324","authenticated-orcid":false,"given":"Irene","family":"Costantini","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/j.neuroimage.2025.121581_b1","doi-asserted-by":"crossref","DOI":"10.1016\/j.media.2020.101760","article-title":"Analytical and fast fiber orientation distribution reconstruction in 3D-polarized light imaging","volume":"65","author":"Alimi","year":"2020","journal-title":"Med. Image Anal."},{"issue":"11","key":"10.1016\/j.neuroimage.2025.121581_b2","doi-asserted-by":"crossref","first-page":"4483","DOI":"10.1364\/BOE.6.004483","article-title":"Label-free near-infrared reflectance microscopy as a complimentary tool for two-photon fluorescence brain imaging","volume":"6","author":"Allegra Mascaro","year":"2015","journal-title":"Biomed. Opt. Express"},{"issue":"2","key":"10.1016\/j.neuroimage.2025.121581_b3","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.neuroimage.2010.08.075","article-title":"A novel approach to the human connectome: ultra-high resolution mapping of fiber tracts in the brain","volume":"54","author":"Axer","year":"2011","journal-title":"NeuroImage"},{"issue":"7","key":"10.1016\/j.neuroimage.2025.121581_b4","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1038\/jcbfm.2013.46","article-title":"Assessing white matter ischemic damage in dementia patients by measurement of myelin proteins","volume":"33","author":"Barker","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"12","key":"10.1016\/j.neuroimage.2025.121581_b5","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1038\/s41592-019-0582-9","article-title":"ilastik: interactive machine learning for (bio)image analysis","volume":"16","author":"Berg","year":"2019","journal-title":"Nature Methods"},{"issue":"5","key":"10.1016\/j.neuroimage.2025.121581_b6","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1152\/jn.01023.2004","article-title":"Polytrodes: high-density silicon electrode arrays for large-scale multiunit recording","volume":"93","author":"Blanche","year":"2005","journal-title":"J. Neurophysiol."},{"issue":"4","key":"10.1016\/j.neuroimage.2025.121581_b7","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol."},{"issue":"1","key":"10.1016\/j.neuroimage.2025.121581_b8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroimage.2012.06.042","article-title":"Examining brain microstructure using structure tensor analysis of histological sections","volume":"63","author":"Budde","year":"2012","journal-title":"NeuroImage"},{"key":"10.1016\/j.neuroimage.2025.121581_b9","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.neurobiolaging.2016.05.014","article-title":"Age-related changes in the function and structure of the peripheral sensory pathway in mice","volume":"45","author":"Canta","year":"2016","journal-title":"Neurobiol. Aging"},{"issue":"1","key":"10.1016\/j.neuroimage.2025.121581_b10","doi-asserted-by":"crossref","first-page":"14629","DOI":"10.1038\/s41598-024-65092-3","article-title":"Deep learning-based localization algorithms on fluorescence human brain 3D reconstruction: a comparative study using stereology as a reference","volume":"14","author":"Checcucci","year":"2024","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.neuroimage.2025.121581_b11","doi-asserted-by":"crossref","first-page":"8038","DOI":"10.1038\/s41598-021-86092-7","article-title":"Autofluorescence enhancement for label-free imaging of myelinated fibers in mammalian brains","volume":"11","author":"Costantini","year":"2021","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.neuroimage.2025.121581_b12","doi-asserted-by":"crossref","first-page":"5251","DOI":"10.1364\/BOE.10.005251","article-title":"In-vivo and ex-vivo optical clearing methods for biological tissues","volume":"10","author":"Costantini","year":"2019","journal-title":"Biomed. Opt. Express"},{"issue":"6","key":"10.1016\/j.neuroimage.2025.121581_b13","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1364\/BOE.415555","article-title":"Large-scale, cell-resolution volumetric mapping allows layer-specific investigation of human brain cytoarchitecture","volume":"12","author":"Costantini","year":"2021","journal-title":"Biomed. Opt. Express"},{"issue":"41","key":"10.1016\/j.neuroimage.2025.121581_b14","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adg3844","article-title":"A cellular resolution atlas of Broca\u2019s area","volume":"9","author":"Costantini","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.neuroimage.2025.121581_b15","series-title":"Neural Imaging and Sensing 2025, Vol. 13303","article-title":"Cyto- and myeloarchitectonics characterization of human cortex and brainstem with light sheet fluorescence microscopy","author":"Costantini","year":"2025"},{"issue":"203","key":"10.1016\/j.neuroimage.2025.121581_b16","article-title":"Optical clearing and labeling for light-sheet fluorescence microscopy in large-scale human brain imaging","author":"Di Meo","year":"2024","journal-title":"JoVE (J. Vis. Exp.)"},{"key":"10.1016\/j.neuroimage.2025.121581_b17","series-title":"Quantitative cytoarchitectural phenotyping of deparaffinized human brain tissues","author":"Di Meo","year":"2024"},{"issue":"4","key":"10.1016\/j.neuroimage.2025.121581_b18","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nmeth1036","article-title":"Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain","volume":"4","author":"Dodt","year":"2007","journal-title":"Nature Methods"},{"issue":"5","key":"10.1016\/j.neuroimage.2025.121581_b19","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1177\/38.5.2110209","article-title":"Double-labeling of tissue containing the carbocyanine dye DiI for immunocytochemistry","volume":"38","author":"Elberger","year":"1990","journal-title":"J. Histochem. Cytochem."},{"issue":"5","key":"10.1016\/j.neuroimage.2025.121581_b20","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.bpj.2011.01.031","article-title":"In vivo imaging of myelin in the vertebrate central nervous system using third harmonic generation microscopy","volume":"100","author":"Farrar","year":"2011","journal-title":"Biophys. J."},{"key":"10.1016\/j.neuroimage.2025.121581_b21","series-title":"Medical Image Computing and Computer-Assisted Intervention \u2014 MICCAI\u201998, Vol. 1496","first-page":"130","article-title":"Multiscale vessel enhancement filtering","author":"Frangi","year":"1998"},{"issue":"2","key":"10.1016\/j.neuroimage.2025.121581_b22","doi-asserted-by":"crossref","first-page":"277","DOI":"10.4103\/1673-5374.375318","article-title":"Myelin histology: a key tool in nervous system research","volume":"19","author":"Garc\u00eda-Garc\u00eda","year":"2024","journal-title":"Neural Regen. Res."},{"issue":"7","key":"10.1016\/j.neuroimage.2025.121581_b23","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1016\/j.bpj.2017.07.033","article-title":"Lipid order degradation in autoimmune demyelination probed by polarized coherent Raman microscopy","volume":"113","author":"Gasecka","year":"2017","journal-title":"Biophys. J."},{"key":"10.1016\/j.neuroimage.2025.121581_b24","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.91979","article-title":"Expansion-assisted selective plane illumination microscopy for nanoscale imaging of centimeter-scale tissues","volume":"12","author":"Glaser","year":"2025","journal-title":"eLife"},{"issue":"11","key":"10.1016\/j.neuroimage.2025.121581_b25","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1038\/s41587-020-0560-x","article-title":"Rapid image deconvolution and multiview fusion for optical microscopy","volume":"38","author":"Guo","year":"2020","journal-title":"Nature Biotechnol."},{"issue":"10","key":"10.1016\/j.neuroimage.2025.121581_b26","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1038\/nn.4107","article-title":"ScaleS: an optical clearing palette for biological imaging","volume":"18","author":"Hama","year":"2015","journal-title":"Nature Neurosci."},{"issue":"1\u20132","key":"10.1016\/j.neuroimage.2025.121581_b27","doi-asserted-by":"crossref","first-page":"115","DOI":"10.18054\/pb.v125i1-2.24860","article-title":"Tissue optical clearing methods for microscopy: A review of their application in neuroscience","volume":"125","author":"Hamer","year":"2023","journal-title":"Period. Biol."},{"issue":"1","key":"10.1016\/j.neuroimage.2025.121581_b28","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1146\/annurev-neuro-070918-050357","article-title":"Light-sheet microscopy in neuroscience","volume":"42","author":"Hillman","year":"2019","journal-title":"Annu. Rev. Neurosci."},{"issue":"9","key":"10.1016\/j.neuroimage.2025.121581_b29","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0166-2236(89)90040-4","article-title":"Dil and DiO: versatile fluorescent dyes for neuronal labelling and pathway tracing","volume":"12","author":"Honig","year":"1989","journal-title":"Trends Neurosci."},{"issue":"2","key":"10.1016\/j.neuroimage.2025.121581_b30","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/cercor\/7.2.166","article-title":"Myelin patterns in V1 and V2 of normal and monocularly enucleated monkeys","volume":"7","author":"Horton","year":"1997","journal-title":"Cerebral Cortex"},{"issue":"4","key":"10.1016\/j.neuroimage.2025.121581_b31","doi-asserted-by":"crossref","first-page":"R1105","DOI":"10.1152\/ajpregu.00535.2005","article-title":"Effect of chronic continuous or intermittent hypoxia and reoxygenation on cerebral capillary density and myelination","volume":"290","author":"Kanaan","year":"2006","journal-title":"Am. J. Physiol.-Regul. Integr. Comp. Physiol."},{"issue":"4","key":"10.1016\/j.neuroimage.2025.121581_b32","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.cell.2020.01.028","article-title":"Mapping the fine-scale organization and plasticity of the brain vasculature","volume":"180","author":"Kirst","year":"2020","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.neuroimage.2025.121581_b33","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1097\/00005072-195312040-00008","article-title":"A method for the combined staining of cells and fibers in the nervous system","volume":"12","author":"Kl\u00fcver","year":"1953","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"4","key":"10.1016\/j.neuroimage.2025.121581_b34","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0301-0082(00)00019-8","article-title":"Current concepts in neuroanatomical tracing","volume":"62","author":"K\u00f6bbert","year":"2000","journal-title":"Prog. Neurobiol."},{"issue":"1","key":"10.1016\/j.neuroimage.2025.121581_b35","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00401-016-1653-y","article-title":"An updated histological classification system for multiple sclerosis lesions","volume":"133","author":"Kuhlmann","year":"2017","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neuroimage.2025.121581_b36","series-title":"Quantitative imaging of three-dimensional fiber orientation in the human brain via two illumination angles using polarization-sensitive optical coherence tomography","author":"Liu","year":"2023"},{"key":"10.1016\/j.neuroimage.2025.121581_b37","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2021.118627","article-title":"Quantification of volumetric morphometry and optical property in the cortex of human cerebellum at micrometer resolution","volume":"244","author":"Liu","year":"2021","journal-title":"NeuroImage"},{"issue":"2","key":"10.1016\/j.neuroimage.2025.121581_b38","doi-asserted-by":"crossref","DOI":"10.1002\/VIW.20230046","article-title":"Tissue clearing and its applications in human tissues: A review","volume":"5","author":"Mai","year":"2024","journal-title":"View"},{"key":"10.1016\/j.neuroimage.2025.121581_b39","series-title":"Biophotonics Congress: Biomedical Optics Congress 2018","article-title":"Software tools for efficient processing of high-resolution 3D images of macroscopic brain samples","author":"Mazzamuto","year":"2018"},{"key":"10.1016\/j.neuroimage.2025.121581_b40","series-title":"Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXX, Vol. 12385","first-page":"10","article-title":"High-speed light-sheet microscopy imaging and data post-processing using custom hardware and software solutions","author":"Mazzamuto","year":"2023"},{"key":"10.1016\/j.neuroimage.2025.121581_b41","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.neuroimage.2017.06.001","article-title":"Evaluating fibre orientation dispersion in white matter: Comparison of diffusion MRI, histology and polarized light imaging","volume":"157","author":"Mollink","year":"2017","journal-title":"NeuroImage"},{"issue":"2","key":"10.1016\/j.neuroimage.2025.121581_b42","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.jneumeth.2012.06.015","article-title":"FluoroMyelin\u2122 Red is a bright, photostable and non-toxic fluorescent stain for live imaging of myelin","volume":"209","author":"Monsma","year":"2012","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.neuroimage.2025.121581_b43","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.neuroimage.2017.11.060","article-title":"Developing 3D microscopy with clarity on human brain tissue: Towards a tool for informing and validating MRI-based histology","volume":"182","author":"Morawski","year":"2018","journal-title":"NeuroImage"},{"issue":"4","key":"10.1016\/j.neuroimage.2025.121581_b44","doi-asserted-by":"crossref","DOI":"10.1117\/1.NPh.2.4.041404","article-title":"Comprehensive optical and data management infrastructure for high-throughput light-sheet microscopy of whole mouse brains","volume":"2","author":"M\u00fcllenbroich","year":"2015","journal-title":"Neurophotonics"},{"issue":"6","key":"10.1016\/j.neuroimage.2025.121581_b45","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.cell.2015.11.025","article-title":"Simple, scalable proteomic imaging for high-dimensional profiling of intact systems","volume":"163","author":"Murray","year":"2015","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.neuroimage.2025.121581_b46","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s40246-021-00368-7","article-title":"Single-cell transcriptome identifies molecular subtype of autism spectrum disorder impacted by de novo loss-of-function variants regulating glial cells","volume":"15","author":"Nassir","year":"2021","journal-title":"Hum. Genom."},{"issue":"1","key":"10.1016\/j.neuroimage.2025.121581_b47","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/s42003-022-03390-0","article-title":"3D molecular phenotyping of cleared human brain tissues with light-sheet fluorescence microscopy","volume":"5","author":"Pesce","year":"2022","journal-title":"Commun. Biol."},{"issue":"4","key":"10.1016\/j.neuroimage.2025.121581_b48","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.cell.2014.10.010","article-title":"iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging","volume":"159","author":"Renier","year":"2014","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.neuroimage.2025.121581_b49","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.neuron.2020.06.010","article-title":"Selective neuronal vulnerability in Alzheimer\u2019s disease: A network-based analysis","volume":"107","author":"Roussarie","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.neuroimage.2025.121581_b50","doi-asserted-by":"crossref","DOI":"10.3389\/fnana.2021.752234","article-title":"Comparison of different tissue clearing methods for three-dimensional reconstruction of human brain cellular anatomy using advanced imaging techniques","volume":"15","author":"Scardigli","year":"2021","journal-title":"Front. Neuroanat."},{"issue":"1","key":"10.1016\/j.neuroimage.2025.121581_b51","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s42003-023-04536-4","article-title":"Efficient 3D light-sheet imaging of very large-scale optically cleared human brain and prostate tissue samples","volume":"6","author":"Schueth","year":"2023","journal-title":"Commun. Biol."},{"issue":"8","key":"10.1016\/j.neuroimage.2025.121581_b52","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/s41592-021-01208-1","article-title":"Universal autofocus for quantitative volumetric microscopy of whole mouse brains","volume":"18","author":"Silvestri","year":"2021","journal-title":"Nature Methods"},{"issue":"1","key":"10.1016\/j.neuroimage.2025.121581_b53","doi-asserted-by":"crossref","first-page":"4160","DOI":"10.1038\/s41598-023-30953-w","article-title":"Fiber enhancement and 3D orientation analysis in label-free two-photon fluorescence microscopy","volume":"13","author":"Sorelli","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuroimage.2025.121581_b54","series-title":"Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XXIII, Vol. 13323","article-title":"Automated 3D quantitative cyto- and myeloarchitectural analysis of human brain fluorescence microscopy reconstructions","author":"Sorelli","year":"2025"},{"issue":"1","key":"10.1016\/j.neuroimage.2025.121581_b55","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3109\/10520295709111391","article-title":"A Sudan Black B myelin stain for peripheral nerves","volume":"32","author":"Stilwell","year":"1957","journal-title":"Stain. Technol."},{"issue":"2\u20134","key":"10.1016\/j.neuroimage.2025.121581_b56","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/cpe.938","article-title":"Distributed computing in practice: the Condor experience","volume":"17","author":"Thain","year":"2005","journal-title":"Concurr. Comput.: Pr. Exp."},{"issue":"3","key":"10.1016\/j.neuroimage.2025.121581_b57","article-title":"Physical and chemical mechanisms of tissue optical clearing","volume":"24","author":"Tingting","year":"2021","journal-title":"iScience"},{"issue":"4","key":"10.1016\/j.neuroimage.2025.121581_b58","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/s41592-020-0792-1","article-title":"Machine learning analysis of whole mouse brain vasculature","volume":"17","author":"Todorov","year":"2020","journal-title":"Nature Methods"},{"issue":"2","key":"10.1016\/j.neuroimage.2025.121581_b59","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/s41583-019-0250-1","article-title":"Tissue clearing and its applications in neuroscience","volume":"21","author":"Ueda","year":"2020","journal-title":"Nature Rev. Neurosci."},{"issue":"6441","key":"10.1016\/j.neuroimage.2025.121581_b60","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1126\/science.aav8130","article-title":"Single-cell genomics identifies cell type\u2013specific molecular changes in autism","volume":"364","author":"Velmeshev","year":"2019","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.neuroimage.2025.121581_b61","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13041-017-0314-y","article-title":"Neuroscience in the third dimension: shedding new light on the brain with tissue clearing","volume":"10","author":"Vigouroux","year":"2017","journal-title":"Mol. Brain"},{"key":"10.1016\/j.neuroimage.2025.121581_b62","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.neuroimage.2017.10.012","article-title":"as-PSOCT: Volumetric microscopic imaging of human brain architecture and connectivity","volume":"165","author":"Wang","year":"2018","journal-title":"NeuroImage"},{"issue":"1","key":"10.1016\/j.neuroimage.2025.121581_b63","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s13073-016-0355-3","article-title":"Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer\u2019s disease","volume":"8","author":"Wang","year":"2016","journal-title":"Genome Med."},{"issue":"6","key":"10.1016\/j.neuroimage.2025.121581_b64","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1038\/s41596-021-00502-8","article-title":"Tutorial: practical considerations for tissue clearing and imaging","volume":"16","author":"Weiss","year":"2021","journal-title":"Nat. Protoc."},{"issue":"1","key":"10.1016\/j.neuroimage.2025.121581_b65","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3109\/10408369309084665","article-title":"The structure and function of central nervous system myelin","volume":"30","author":"Williams","year":"1993","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"issue":"45","key":"10.1016\/j.neuroimage.2025.121581_b66","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2106143118","article-title":"A near-infrared AIE fluorescent probe for myelin imaging: From sciatic nerve to the optically cleared brain tissue in 3D","volume":"118","author":"Wu","year":"2021","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"4","key":"10.1016\/j.neuroimage.2025.121581_b67","doi-asserted-by":"crossref","DOI":"10.1117\/1.NPh.7.4.045005","article-title":"Improving the characterization of ex vivo human brain optical properties using high numerical aperture optical coherence tomography by spatially constraining the confocal parameters","volume":"7","author":"Yang","year":"2020","journal-title":"Neurophotonics"},{"key":"10.1016\/j.neuroimage.2025.121581_b68","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2022.119146","article-title":"Post mortem mapping of connectional anatomy for the validation of diffusion MRI","volume":"256","author":"Yendiki","year":"2022","journal-title":"NeuroImage"},{"issue":"9","key":"10.1016\/j.neuroimage.2025.121581_b69","doi-asserted-by":"crossref","DOI":"10.1093\/cercor\/bhae362","article-title":"Segmentation of supragranular and infragranular layers in ultra-high-resolution 7t ex vivo mri of the human cerebral cortex","volume":"34","author":"Zeng","year":"2024","journal-title":"Cerebral Cortex"}],"container-title":["NeuroImage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053811925005841?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053811925005841?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T11:51:07Z","timestamp":1768737067000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053811925005841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":69,"alternative-id":["S1053811925005841"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroimage.2025.121581","relation":{},"ISSN":["1053-8119"],"issn-type":[{"value":"1053-8119","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Myelinated fiber labeling and orientation mapping of the human brain with light-sheet fluorescence microscopy","name":"articletitle","label":"Article Title"},{"value":"NeuroImage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroimage.2025.121581","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"121581"}}