{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T01:42:24Z","timestamp":1776130944396,"version":"3.50.1"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031935","name":"Xi&apos;an Jiaotong University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031935","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1707865"],"award-info":[{"award-number":["1707865"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.neuroimage.2026.121861","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:29:00Z","timestamp":1773361740000},"page":"121861","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Experimental evaluation of an integrated focused ultrasound and electroencephalography approach for developing activation-informed neuroimaging"],"prefix":"10.1016","volume":"330","author":[{"given":"Ye","family":"Yuan","sequence":"first","affiliation":[]},{"given":"Jun You","family":"Li","sequence":"additional","affiliation":[]},{"given":"Yongzhi","family":"Zhang","sequence":"additional","affiliation":[]},{"given":"Sonia E.","family":"Vader","sequence":"additional","affiliation":[]},{"given":"Tongsheng","family":"Zhang","sequence":"additional","affiliation":[]},{"given":"G\u00f6sta","family":"Ehnholm","sequence":"additional","affiliation":[]},{"given":"Jue","family":"Wang","sequence":"additional","affiliation":[]},{"given":"Nathan","family":"McDannold","sequence":"additional","affiliation":[]},{"given":"Yoshio","family":"Okada","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/j.neuroimage.2026.121861_bib0003","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.neuroimage.2004.08.011","article-title":"Confounding effects of anesthesia on functional activation in rodent brain: a study of halothane and \u03b1-chloralose anesthesia","volume":"24","author":"Austin","year":"2005","journal-title":"NeuroImage"},{"key":"10.1016\/j.neuroimage.2026.121861_bib53","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.neurol.2016.02.004","article-title":"Single and paired-pulse electrical stimulation during invasive EEG recordings","volume":"172","author":"Boulogne","year":"2016","journal-title":"Rev. Neurol."},{"key":"10.1016\/j.neuroimage.2026.121861_bib0005","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1146\/annurev-neuro-062111-150444","article-title":"Mechanisms of gamma oscillations","volume":"35","author":"Buzsaki","year":"2012","journal-title":"Ann. Rev. Neurosci."},{"key":"10.1016\/j.neuroimage.2026.121861_bib0006","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.tics.2010.09.001","article-title":"The functional role of cross-frequency coupling","volume":"14","author":"Canolty","year":"2010","journal-title":"Trends in Cog. Sci."},{"key":"10.1016\/j.neuroimage.2026.121861_bib0007","article-title":"Information for manufacturers seeking marketing clearance of diagnostic ultrasound systems and transducers","volume":"82","year":"2017","journal-title":"FIND"},{"key":"10.1016\/j.neuroimage.2026.121861_bib0008","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/nature10812","article-title":"Piezos are pore-forming subunits of mechanically activated channels","volume":"483","author":"Coste","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.neuroimage.2026.121861_bib0009","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jconrel.2018.02.027","article-title":"High-frequency, low-intensity ultrasound and microbubbles enhance nerve blockade","volume":"276","author":"Cullion","year":"2018","journal-title":"J. Control Release"},{"key":"10.1016\/j.neuroimage.2026.121861_bib0010","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1113\/jphysiol.1990.sp018080","article-title":"Paired-pulse depression of monosynaptic GABA-mediated inhibitory postsynaptic responses in rat hippocampus","volume":"424","author":"Davies","year":"1990","journal-title":"J. Physiol."},{"key":"10.1016\/j.neuroimage.2026.121861_bib0011","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1152\/physrev.00042.2018","article-title":"Sleep spindles : Mechanisms and functions","volume":"100","author":"Fernandez","year":"2020","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neuroimage.2026.121861_bib0012","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.neuron.2015.09.034","article-title":"Rhythms for cognition: communication through coherence","volume":"88","author":"Fries","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.neuroimage.2026.121861_bib0013","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/S0022-3565(24)37470-1","article-title":"Enhancement of \u03b3-aminobutyric acidA receptor activity by \u03b1-chloralose","volume":"285","author":"Garrett","year":"1998","journal-title":"J. Pharmacol Exp. Therap."},{"key":"10.1016\/j.neuroimage.2026.121861_bib0014","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.neuron.2018.04.036","article-title":"Ultrasound produces extensive brain activation via a cochlear pathway","volume":"98","author":"Guo","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.neuroimage.2026.121861_bib0015","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.ultrasmedbio.2017.11.008","article-title":"Ketamine inhibits ultrasound stimulation-induced neuromodulation by blocking cortical neuron activity","volume":"44","author":"Han","year":"2018","journal-title":"Ultras. Med Biol."},{"key":"10.1016\/j.neuroimage.2026.121861_bib0016","series-title":"MEG-EEG Primer","author":"Hari","year":"2023"},{"key":"10.1016\/j.neuroimage.2026.121861_bib0017","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.neuroimage.2007.06.042","article-title":"Coupling between simultaneously recorded BOLD response and neuronal activity in the rat somatosensory cortex","volume":"39","author":"Huttunen","year":"2008","journal-title":"NeuroImage"},{"key":"10.1016\/j.neuroimage.2026.121861_bib0018","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.tins.2015.09.001","article-title":"Neural cross-frequency coupling: connecting architectures, mechanisms, and functions","volume":"38","author":"Hyafil","year":"2015","journal-title":"Trends Neuro. Sci."},{"key":"10.1016\/j.neuroimage.2026.121861_bib0019","series-title":"Brain Signals: Physics and Mathematics of MEG and EEG","author":"Ilmoniemi","year":"2019"},{"key":"10.1016\/j.neuroimage.2026.121861_bib0020","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s10548-009-0123-4","article-title":"Methodology for combined TMS and EEG","volume":"22","author":"Ilmoniemi","year":"2010","journal-title":"Brain Topog."},{"key":"10.1016\/j.neuroimage.2026.121861_bib0021","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1097\/00001756-199711100-00024","article-title":"Neuronal responses to magnetic stimulation reveal cortical reactivity and connectivity","volume":"8","author":"Ilmoniemi","year":"1997","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuroimage.2026.121861_bib0022","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1113\/jphysiol.1992.sp019086","article-title":"Enhancement of gamma-aminobutyric acid-activated Cl-currents in cultured rat hippocampal neurons by three volatile anaesthetics","volume":"449","author":"Jones","year":"1992","journal-title":"J. Physiol."},{"key":"10.1016\/j.neuroimage.2026.121861_bib0023","doi-asserted-by":"crossref","first-page":"4382","DOI":"10.1038\/s41467-024-48576-8","article-title":"Transcranial focused ultrasound to V5 enhances human visual motion brain-computer interface by modulating feature-based attention","volume":"15","author":"Kosnoff","year":"2024","journal-title":"Nat. Comm."},{"key":"10.1016\/j.neuroimage.2026.121861_bib0024","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nn.3620","article-title":"Transcranial focused ultrasound modulates the activity of primary somatosensory cortex in humans","volume":"17","author":"Legon","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuroimage.2026.121861_bib55","doi-asserted-by":"crossref","first-page":"103085","DOI":"10.1016\/j.isci.2021.103085","article-title":"MorphoSONIC: A morphologically structured intramembrane cavitation model reveals fiber-specific neuromodulation by ultrasound","volume":"24","author":"Lemaire","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.neuroimage.2026.121861_bib0025","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1152\/jn.00541.2018","article-title":"Focused ultrasound transiently increases membrane conductance in isolated crayfish axon","volume":"121","author":"Lin","year":"2019","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neuroimage.2026.121861_bib0026","article-title":"The role of neuronagivation in TMS-EEG studies: current applications and future perspectives","volume":"380","author":"Lioumis","year":"2022","journal-title":"J. Neursci. Methods"},{"key":"10.1016\/j.neuroimage.2026.121861_bib51","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.brs.2019.03.005","article-title":"Elimination of peripheral auditory pathway activation does not affect motor responses from ultrasound modulation","volume":"12","author":"Mahammadjavadi","year":"2019","journal-title":"Brain Stim"},{"key":"10.1016\/j.neuroimage.2026.121861_bib0027","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1152\/jn.1989.62.5.1018","article-title":"GABA as an inhibitory neurotransmitter in human cerebral cortex","volume":"62","author":"McCormick","year":"1989","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neuroimage.2026.121861_bib0028","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.jconrel.2024.06.036","article-title":"Cavitation monitoring, treatment strategy, and acoustic simulations of focused ultrasound blood-brain barrier disruption in patients with glioblastoma","volume":"372","author":"McDannold","year":"2024","journal-title":"J. Controlled Rel."},{"key":"10.1016\/j.neuroimage.2026.121861_bib0029","doi-asserted-by":"crossref","first-page":"19113","DOI":"10.1073\/pnas.1312691110","article-title":"Cellular organization of cortical barrel columns is whisker-specific","volume":"47","author":"Meyer","year":"2013","journal-title":"PNAS"},{"key":"10.1016\/j.neuroimage.2026.121861_bib0030","article-title":"Transcranial ultrasound neuromodulation of the thalamic visual pathway in a large animal model and the dose-response relationship with MR-ARFI","volume":"12","author":"Mohammadjavadi","year":"2022","journal-title":"Nat. Comm\/Scie. Rep."},{"key":"10.1016\/j.neuroimage.2026.121861_bib0031","series-title":"Fifty Years of Magnetoencephalography: Beginnings, Technical Advances and Applications","first-page":"35","article-title":"Physiological bases of magnetoencephalography and electroencephalography","author":"Okada","year":"2020"},{"key":"10.1016\/j.neuroimage.2026.121861_bib0032","doi-asserted-by":"crossref","unstructured":"Palva JM, Palva S, Kaila K. (2005). Phase synchrony among neuronal oscillations in the.","DOI":"10.1523\/JNEUROSCI.4250-04.2005"},{"key":"10.1016\/j.neuroimage.2026.121861_bib54","article-title":"Intramembrane cavitation as a predictive bio-piezoelectric mechanism for ultrasonic brain stimulation","volume":"4","author":"Plaksin","year":"2014","journal-title":"Phys. Rev. X"},{"key":"10.1016\/j.neuroimage.2026.121861_bib56","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0077115","article-title":"Dynamic response of model lipid membranes to ultrasonic radiation force","volume":"8","author":"Prieto","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroimage.2026.121861_bib0033","article-title":"Integration of focused ultrasound and dynamic imaging control system for targeted neuro-modulation","volume":"417","author":"Raghunath","year":"2025","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.neuroimage.2026.121861_bib0034","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1002\/hbm.22016","article-title":"Assessing cortical network properties using TMS-EEG","volume":"34","author":"Rogasch","year":"2013","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.neuroimage.2026.121861_bib0035","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.neuron.2018.05.009","article-title":"Ultrasonic neuromodulation causes widespread cortical activation via an indirect auditory mechanism","volume":"98","author":"Sato","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.neuroimage.2026.121861_bib0036","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1016\/j.ultrasmedbio.2020.06.003","article-title":"Direct activation of cortical neurons in the primary somatosensory cortex of the rat in vivo using focused ultrasound","volume":"46","author":"Tripathi","year":"2020","journal-title":"Ultrasound Med. Biol.,"},{"key":"10.1016\/j.neuroimage.2026.121861_bib0037","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.neuron.2010.05.008","article-title":"Transcranial pulsed ultrasound stimulates intact brain circuits","volume":"66","author":"Tufail","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.neuroimage.2026.121861_bib0038","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1038\/nprot.2011.371","article-title":"Ultrasonic neuromodulation by brain stimulation with transcranial ultrasound","volume":"6","author":"Tufail","year":"2011","journal-title":"Nat. Protocol."},{"key":"10.1016\/j.neuroimage.2026.121861_bib0039","doi-asserted-by":"crossref","first-page":"e3511","DOI":"10.1371\/journal.pone.0003511","article-title":"Remote excitation of neuronal circuits using low-intensity, low-frequency ultrasound","volume":"3","author":"Tyler","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.neuroimage.2026.121861_bib0041","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.neuron.2006.09.020","article-title":"Neural synchrony in brain disorders: relevance for cognitive dysfunction and pathophysiology","volume":"52","author":"Uhlhaas","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.neuroimage.2026.121861_bib0042","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.neuron.2012.09.004","article-title":"Neuronal dynamics and neuropsychiatric disorders: toward a translational paradigm for dysfunctional large-scale networks","volume":"75","author":"Uhlhaas","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.neuroimage.2026.121861_bib0043","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202101950","article-title":"Ultrasound mediated cellular deflection results in cellular depolarization","volume":"9","author":"Vasan","year":"2022","journal-title":"Adv. Sci."},{"key":"10.1016\/j.neuroimage.2026.121861_bib0044","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1111\/j.1528-1167.2008.01939.x","article-title":"Single and repetitive paired-pulse suppression: a parametric analysis and assessement of usefulness in epilepsy research","volume":"50","author":"Waldbaum","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuroimage.2026.121861_bib0045","doi-asserted-by":"crossref","first-page":"5312","DOI":"10.1523\/JNEUROSCI.20-14-05312.2000","article-title":"Properties and plasticity of paired-pulse depression at a central synapse","volume":"20","author":"Waldeck","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuroimage.2026.121861_bib0046","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41467-022-28040-1","article-title":"Focused ultrasound excites cortical neurons via mechanosensitive calcium accumulation and ion channel amplification","volume":"13","author":"Yoo","year":"2022","journal-title":"Nat. Comm."},{"key":"10.1016\/j.neuroimage.2026.121861_bib0047","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1474923","article-title":"Anesthetc spindles serve as EEG markers of the depth variations in anesthesia induced by multifarious general anesthetics in mouse experiments","volume":"15","author":"You","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.neuroimage.2026.121861_bib0048","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1016\/j.ultrasmedbio.2022.05.028","article-title":"Effects of osmolarity on ultrasound-induced membrane depolarization in isolated crayfish motor axon","volume":"48","author":"Yu","year":"2022","journal-title":"Ultrasound Med & Biol"},{"key":"10.1016\/j.neuroimage.2026.121861_bib52","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1016\/j.ultrasmedbio.2023.08.016","article-title":"Ultrasound-induced membrane hyperpolarization in motor axons and muscle fibers of the crayfish neuromuscular junction","volume":"49","author":"Yu","year":"2023","journal-title":"Ultrasound Med. Biol."},{"key":"10.1016\/j.neuroimage.2026.121861_bib0049","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1038\/s41467-021-22743-7","article-title":"Intrinsic functional neuron-type selectivity of transcranial focused ultrasound neuromodulation","volume":"12","author":"Yu","year":"2021","journal-title":"Nat. Comm."},{"key":"10.1016\/j.neuroimage.2026.121861_bib0050","doi-asserted-by":"crossref","DOI":"10.1080\/19336950.2024.2355123","article-title":"The activation thresholds and inactivation kinetics of poking-evoked PIEZO1 and PIEZO2 currents are sensitive to subtle variations in mechanical stimulation parameters","volume":"18","author":"Zeitzschel","year":"2024","journal-title":"CHANNELS"},{"key":"10.1016\/j.neuroimage.2026.121861_bib57","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2300291120","article-title":"The mechanosensitive ion channel Piezo1 contributes to ultrasound neuromodulation","volume":"120","author":"Zhu","year":"2023","journal-title":"PNAS"}],"container-title":["NeuroImage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053811926001783?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053811926001783?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:45:32Z","timestamp":1776127532000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053811926001783"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":53,"alternative-id":["S1053811926001783"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroimage.2026.121861","relation":{},"ISSN":["1053-8119"],"issn-type":[{"value":"1053-8119","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Experimental evaluation of an integrated focused ultrasound and electroencephalography approach for developing activation-informed neuroimaging","name":"articletitle","label":"Article Title"},{"value":"NeuroImage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroimage.2026.121861","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"121861"}}