{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T12:17:38Z","timestamp":1784636258707,"version":"3.55.0"},"reference-count":98,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006469","name":"Fundo para o Desenvolvimento das Ci\u00eancias e da Tecnologia","doi-asserted-by":"publisher","award":["FDCT 0014\/2024\/RIB1"],"award-info":[{"award-number":["FDCT 0014\/2024\/RIB1"]}],"id":[{"id":"10.13039\/501100006469","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004733","name":"Universidade de Macau","doi-asserted-by":"publisher","award":["MYRG2022-00054-FHS"],"award-info":[{"award-number":["MYRG2022-00054-FHS"]}],"id":[{"id":"10.13039\/501100004733","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004733","name":"Universidade de Macau","doi-asserted-by":"publisher","award":["MYRG-GRG2023-00038-FHS-UMDF"],"award-info":[{"award-number":["MYRG-GRG2023-00038-FHS-UMDF"]}],"id":[{"id":"10.13039\/501100004733","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004733","name":"Universidade de Macau","doi-asserted-by":"publisher","award":["MYRG-GRG2024-00259-FHS"],"award-info":[{"award-number":["MYRG-GRG2024-00259-FHS"]}],"id":[{"id":"10.13039\/501100004733","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.neuroimage.2026.121926","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T13:18:12Z","timestamp":1776172692000},"page":"121926","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Neural-molecular signatures of insomnia: Insights from signed differential mapping and gene expression analysis"],"prefix":"10.1016","volume":"332","author":[{"given":"Ruisi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwen","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andriy","family":"Myachykov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan Tat","family":"Leong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyue","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheneryue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroimage.2026.121926_bib0001","series-title":"30th Anniversary meeting of the Associated Professional Sleep Societies","article-title":"Facial cues of tiredness: self-specific interpretive bias amongst individuals with insomnia","author":"Akram","year":"2016"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0002","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/jsr.12395","article-title":"Misperception of tiredness in young adults with insomnia","volume":"25","author":"Akram","year":"2016","journal-title":"J. Sleep Res."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0003","article-title":"Meta-analysis of voxel-based neuroimaging studies using seed-based d mapping with permutation of subject images (SDM-PSI)","volume":"59841","author":"Albajes-Eizagirre","year":"2019","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0004","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1523\/JNEUROSCI.3554-12.2013","article-title":"The convergence of maturational change and structural covariance in human cortical networks","volume":"33","author":"Alexander-Bloch","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0005","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.3390\/ijms20143537","article-title":"Genetic associations between voltage-gated calcium channels and psychiatric disorders","volume":"20","author":"Andrade","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.smrv.2023.101878","article-title":"Towards the neurobiology of insomnia: a systematic review of neuroimaging studies","author":"Aquino","year":"2024","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0007","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.neuroimage.2019.01.011","article-title":"A practical guide to linking brain-wide gene expression and neuroimaging data","volume":"189","author":"Arnatkevic\u0306i\u016bt\u0117","year":"2019","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0008","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1037\/bul0000053","article-title":"Sleep and mental disorders: a meta-analysis of polysomnographic research","volume":"142","author":"Baglioni","year":"2016","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0009","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyg.2019.00101","article-title":"Executive functions in insomnia disorder: a systematic review and exploratory meta-analysis","volume":"10","author":"Ballesio","year":"2019","journal-title":"Front. Psychol."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0018455","article-title":"Genetic and metabolic characterization of insomnia","volume":"6","author":"Ban","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0011","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00221-016-4772-8","article-title":"Sustained wakefulness and visual attention: moderation by chronotype","volume":"235","author":"Barclay","year":"2017","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0012","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1177\/1747021819895771","article-title":"Sleep duration, sleep variability, and impairments of visual attention","volume":"73","author":"Barclay","year":"2020","journal-title":"Q. J. Exp. Psychol."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0013","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Ser. B Methodol."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0014","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1111\/j.1467-8624.2010.01499.x","article-title":"A developmental perspective on executive function","volume":"81","author":"Best","year":"2010","journal-title":"Child Dev"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0015","doi-asserted-by":"crossref","DOI":"10.3389\/fnhum.2022.787079","article-title":"Inhibitory control and the structural parcelation of the right inferior frontal gyrus","volume":"16","author":"Boen","year":"2022","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0016","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jsmc.2019.10.002","article-title":"Insomnia and cognitive performance","volume":"15","author":"Brownlow","year":"2020","journal-title":"Sleep Med. Clin."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0017","article-title":"Gene ontology resource: enriching a GOld mine","volume":"49","author":"Carbon","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0018","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.neuroimage.2004.12.007","article-title":"The talairach coordinate of a point in the MNI space: how to interpret it","volume":"25","author":"Chau","year":"2005","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biopsycho.2013.12.016","article-title":"Increased insula coactivation with salience networks in insomnia","volume":"97","author":"Chen","year":"2014","journal-title":"Biol. Psychol."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0020","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/hbm.23843","article-title":"Reproducibility of R-fMRI metrics on the impact of different strategies for multiple comparison correction and sample sizes","volume":"39","author":"Chen","year":"2018","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0021","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1007\/s11682-021-00567-9","article-title":"Abnormal functional connectivity of the salience network in insomnia","volume":"16","author":"Cheng","year":"2022","journal-title":"Brain Imag. Behav."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0022","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1038\/nn.4406","article-title":"Activity flow over resting-state networks shapes cognitive task activations","volume":"19","author":"Cole","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0023","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.876","article-title":"Rest but busy: aberrant resting-state functional connectivity of triple network model in insomnia","volume":"8","author":"Dong","year":"2018","journal-title":"Brain Behav."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0024","doi-asserted-by":"crossref","DOI":"10.1111\/jsr.13928","article-title":"Hyperarousal in insomnia disorder: current evidence and potential mechanisms","volume":"32","author":"Dressle","year":"2023","journal-title":"J. Sleep Res."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0025","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.5665\/sleep.2952","article-title":"Neural correlates of working memory performance in primary insomnia","volume":"36","author":"Drummond","year":"2013","journal-title":"Sleep"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0026","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s00406-022-01485-7","article-title":"Distinct functional brain abnormalities in insomnia disorder and obstructive sleep apnea","volume":"273","author":"Duan","year":"2023","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0027","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1016\/j.neuroimage.2011.09.017","article-title":"Activation likelihood estimation meta-analysis revisited","volume":"59","author":"Eickhoff","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0028","doi-asserted-by":"crossref","first-page":"3508","DOI":"10.1093\/cercor\/bhw157","article-title":"The human brainnetome atlas: a new brain atlas based on connectional architecture","volume":"26","author":"Fan","year":"2016","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.smrv.2021.101569","article-title":"Functional connectivity changes in insomnia disorder: a systematic review","volume":"61","author":"Fasiello","year":"2022","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0030","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.smrv.2011.03.008","article-title":"Insomnia and daytime cognitive performance: a meta-analysis","volume":"16","author":"Fortier-Brochu","year":"2012","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0031","doi-asserted-by":"crossref","first-page":"9673","DOI":"10.1073\/pnas.0504136102","article-title":"The human brain is intrinsically organized into dynamic, anticorrelated functional networks","volume":"102","author":"Fox","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0032","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1126\/science.aad6469","article-title":"Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap","volume":"359","author":"Gandal","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0033","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1073\/pnas.96.6.3314","article-title":"Spatial attention affects brain activity in human primary visual cortex","volume":"96","author":"Gandhi","year":"1999","journal-title":"Proc. Natl. Acad. Sci"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0034","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1176\/appi.ajp.2019.19050560","article-title":"Multimodal abnormalities of brain structure and function in major depressive disorder: a meta-analysis of neuroimaging studies","volume":"177","author":"Gray","year":"2020","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0035","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/ng.3888","article-title":"Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits","volume":"49","author":"Hammerschlag","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0036","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1093\/cercor\/bhy049","article-title":"Functional segregation of the right inferior frontal gyrus: evidence from coactivation-based parcellation","volume":"29","author":"Hartwigsen","year":"2019","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0037","series-title":"Springer Handbook of Bio-\/Neuroinformatics","first-page":"1111","article-title":"The allen brain atlas","author":"Hawrylycz","year":"2014"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0038","doi-asserted-by":"crossref","first-page":"103","DOI":"10.33069\/cim.2020.0021","article-title":"Brain activation changes in insomnia: a review of functional magnetic resonance imaging studies","volume":"2","author":"Hwang","year":"2020","journal-title":"Chronobiol. Med."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0039","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s11325-019-02001-3","article-title":"Effect-size seed-based d mapping of resting-state fMRI for persistent insomnia disorder","volume":"24","author":"Jiang","year":"2020","journal-title":"Sleep Breath"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0040","article-title":"KEGG: integrating viruses and cellular organisms","volume":"49","author":"Kanehisa","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0041","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3390\/brainsci7030023","article-title":"Hyperarousal and beyond: new insights to the pathophysiology of insomnia disorder through functional neuroimaging studies","volume":"7","author":"Kay","year":"2017","journal-title":"Brain Sci"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0042","first-page":"28","article-title":"Comorbid insomnia and psychiatric disorders","volume":"15","author":"Khurshid","year":"2018","journal-title":"Innov. Clin. Neurosci."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0043","doi-asserted-by":"crossref","first-page":"14496","DOI":"10.1523\/JNEUROSCI.4004-09.2009","article-title":"Investigating the functional heterogeneity of the default mode network using coordinate-based meta-analytic modeling","volume":"29","author":"Laird","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0044","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1385\/NI:3:1:065","article-title":"BrainMap","volume":"3","author":"Laird","year":"2005","journal-title":"Neuroinformatics"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0045","doi-asserted-by":"crossref","first-page":"47","DOI":"10.33069\/cim.2022.0014","article-title":"Is insomnia a brain disorder arising from aberrant brain structure, brain function, or both?","volume":"4","author":"Lee","year":"2022","journal-title":"Chronobiol. Med."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0046","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1186\/s12888-016-1075-3","article-title":"Insomnia and the risk of depression: a meta-analysis of prospective cohort studies","volume":"16","author":"Li","year":"2016","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0047","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1159\/000443372","article-title":"Abnormal Neural Network of primary insomnia: evidence from spatial Working Memory task fMRI","volume":"75","author":"Li","year":"2016","journal-title":"Eur. Neurol."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0048","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1111\/biom.12817","article-title":"Quantifying publication bias in meta-analysis","volume":"74","author":"Lin","year":"2018","journal-title":"Biometrics"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0049","doi-asserted-by":"crossref","first-page":"e656","DOI":"10.1016\/j.wneu.2020.08.058","article-title":"Anatomy and white matter connections of the inferior temporal gyrus","volume":"143","author":"Lin","year":"2020","journal-title":"World Neurosurg."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0050","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3390\/brainsci6040064","article-title":"Genetic pathways to insomnia","volume":"6","author":"Lind","year":"2016","journal-title":"Brain Sci."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.smrv.2021.101437","article-title":"The heritability of insomnia: systematic review and meta-analysis of twin studies","volume":"58","author":"Madrid-Valero","year":"2021","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0052","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/S1053-8119(03)00169-1","article-title":"An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets","volume":"19","author":"Maldjian","year":"2003","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0053","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2022.104659","article-title":"Six actions to improve detection of critical features for neuroimaging coordinate-based meta-analysis preparation","volume":"137","author":"Manuello","year":"2022","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0054","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.72129","article-title":"Standardizing workflows in imaging transcriptomics with the abagen toolbox","volume":"10","author":"Markello","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0055","doi-asserted-by":"crossref","first-page":"9604","DOI":"10.1073\/pnas.1820754116","article-title":"Cortical patterning of abnormal morphometric similarity in psychosis is associated with brain expression of schizophrenia-related genes","volume":"116","author":"Morgan","year":"2019","journal-title":"Proc. Natl. Acad. Sci"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0056","article-title":"Insomnia disorder","volume":"1","author":"Morin","year":"2015","journal-title":"Nat. Rev. Dis. Primer"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0057","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jsmc.2022.03.003","article-title":"Epidemiology of insomnia: prevalence, course, risk factors, and public health burden","volume":"17","author":"Morin","year":"2022","journal-title":"Sleep Med. Clin."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0058","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.neubiorev.2017.11.012","article-title":"Ten simple rules for neuroimaging meta-analysis","volume":"84","author":"M\u00fcller","year":"2018","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0059","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.neuroimage.2003.09.069","article-title":"The neural basis of executive function in working memory: an fMRI study based on individual differences","volume":"21","author":"Osaka","year":"2004","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0060","doi-asserted-by":"crossref","DOI":"10.1111\/jsr.13868","article-title":"Potential genetic and epigenetic mechanisms in insomnia: a systematic review","volume":"32","author":"Palagini","year":"2023","journal-title":"J. Sleep Res."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0061","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.859440","article-title":"Improved functional organization in patients with primary insomnia after individually-targeted transcranial magnetic stimulation","volume":"16","author":"Qi","year":"2022","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0062","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/2045-5380-2-6","article-title":"Meta-analytic methods for neuroimaging data explained","volume":"2","author":"Radua","year":"2012","journal-title":"Biol. Mood Anxiety Disord."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0063","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1192\/bjp.bp.108.055046","article-title":"Voxel-wise meta-analysis of grey matter changes in obsessive\u2013compulsive disorder","volume":"195","author":"Radua","year":"2009","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0064","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.eurpsy.2011.04.001","article-title":"A new meta-analytic method for neuroimaging studies that combines reported peak coordinates and statistical parametric maps","volume":"27","author":"Radua","year":"2012","journal-title":"Eur. Psychiatry"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0065","first-page":"462","article-title":"A general approach for combining voxel-based meta-analyses conducted in different neuroimaging modalities","volume":"20","author":"Radua","year":"2013","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0066","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2014.00013","article-title":"Anisotropic kernels for coordinate-based meta-analyses of neuroimaging studies","volume":"5","author":"Radua","year":"2014","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0067","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1146\/annurev-neuro-071013-014030","article-title":"The brain\u2019s default mode network","volume":"38","author":"Raichle","year":"2015","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0068","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.smrv.2017.05.002","article-title":"The role of sleep in regulating structural plasticity and synaptic strength: implications for memory and cognitive function","volume":"39","author":"Raven","year":"2018","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0069","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/wps.20050","article-title":"The DSM-5: classification and criteria changes","volume":"12","author":"Regier","year":"2013","journal-title":"World Psychiatry"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.smrv.2023.101821","article-title":"Convergent abnormality in the subgenual anterior cingulate cortex in insomnia disorder: a revisited neuroimaging meta-analysis of 39 studies","volume":"71","author":"Reimann","year":"2023","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0071","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S1474-4422(15)00021-6","article-title":"The neurobiology, investigation, and treatment of chronic insomnia","volume":"14","author":"Riemann","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0072","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1378\/chest.14-0970","article-title":"International classification of sleep disorders-third edition","volume":"146","author":"Sateia","year":"2014","journal-title":"Chest"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0073","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s11920-020-01173-0","article-title":"Affect and arousal in insomnia: through a lens of neuroimaging studies","volume":"22","author":"Schiel","year":"2020","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0074","doi-asserted-by":"crossref","DOI":"10.3389\/fnhum.2023.1133367","article-title":"The role of the salience network in cognitive and affective deficits","volume":"17","author":"Schimmelpfennig","year":"2023","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0075","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.tins.2012.09.005","article-title":"The allen human brain atlas: comprehensive gene expression mapping of the human brain","volume":"35","author":"Shen","year":"2012","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0076","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s11325-017-1575-5","article-title":"fMRI brain activation in patients with insomnia disorder during a working memory task","volume":"22","author":"Son","year":"2018","journal-title":"Sleep Breath"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0077","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1034\/j.1399-5618.2000.020302.x","article-title":"Neuroimaging in bipolar disorder","volume":"2","author":"Strakowski","year":"2000","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0078","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.smrv.2018.07.004","article-title":"A lack of consistent brain alterations in insomnia disorder: an activation likelihood estimation meta-analysis","volume":"42","author":"Tahmasian","year":"2018","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0079","doi-asserted-by":"crossref","first-page":"5142","DOI":"10.1002\/hbm.24746","article-title":"Practical recommendations to conduct a neuroimaging meta-analysis for neuropsychiatric disorders","volume":"40","author":"Tahmasian","year":"2019","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0080","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/s41588-018-0333-3","article-title":"Genome-wide analysis of insomnia in 1331,010 individuals identifies new risk loci and functional pathways","volume":"51","author":"Jansen","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0081","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1089\/brain.2021.0129","article-title":"Time-of-day effects in resting-State functional Magnetic resonance imaging: changes in effective connectivity and blood oxygenation level dependent signal","volume":"12","author":"Vaisvilaite","year":"2022","journal-title":"Brain Connect."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0082","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1152\/physrev.00046.2019","article-title":"Brain mechanisms of insomnia: new perspectives on causes and consequences","volume":"101","author":"Van Someren","year":"2021","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0083","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1007\/s00330-016-4680-0","article-title":"Increased insular connectivity with emotional regions in primary insomnia patients: a resting-state fMRI study","volume":"27","author":"Wang","year":"2017","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0084","article-title":"Is the insula linked to sleep? A systematic review and narrative synthesis","volume":"8","author":"Wang","year":"2022","journal-title":"Heliyon"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0085","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1038\/s41588-022-01124-w","article-title":"Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways","volume":"54","author":"Watanabe","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0086","doi-asserted-by":"crossref","first-page":"9105","DOI":"10.1073\/pnas.1601745113","article-title":"Adolescence is associated with genomically patterned consolidation of the hubs of the human brain connectome","volume":"113","author":"Whitaker","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0087","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0169-7439(01)00155-1","article-title":"PLS-regression: a basic tool of chemometrics","volume":"58","author":"Wold","year":"2001","journal-title":"Chemom. Intell. Lab. Syst."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0088","article-title":"Explore structural and functional brain changes in insomnia disorder: a PRISMA-compliant whole brain ALE meta-analysis for multimodal MRI","volume":"99","author":"Wu","year":"2020","journal-title":"Medicine"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0089","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1002\/hbm.24550","article-title":"Multimodal neuroimaging analysis reveals age-associated common and discrete cognitive control constructs","volume":"40","author":"Yang","year":"2019","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0090","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1007\/s11325-024-03002-7","article-title":"Increased functional connectivity within the salience network in patients with insomnia","volume":"28","author":"Yin","year":"2024","journal-title":"Sleep Breath"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0091","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1046\/j.1432-1327.2001.01866.x","article-title":"Genomic organization of the human phosphodiesterase PDE11A gene","volume":"268","author":"Yuasa","year":"2001","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0092","doi-asserted-by":"crossref","first-page":"5387","DOI":"10.1002\/hbm.26443","article-title":"Association between gene expression and functional-metabolic architecture in parkinson\u2019s disease. Hum","volume":"44","author":"Zang","year":"2023","journal-title":"Brain Mapp"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0093","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1017\/S0033291723003434","article-title":"Similarity and difference in large-scale functional network alternations between behavioral addictions and substance use disorder: a comparative meta-analysis","volume":"54","author":"Zeng","year":"2024","journal-title":"Psychol. Med."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0094","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2024.111209","article-title":"Gene expression is associated with brain function of insomnia disorder, rather than brain structure","volume":"136","author":"Zhang","year":"2025","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0095","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/15622975.2025.2503938","article-title":"Altered cerebral functional activity and its associated genetic profiles underlying chronic insomnia disorder before and after treatment","volume":"26","author":"Zhang","year":"2025","journal-title":"World J. Biol. Psychiatry"},{"key":"10.1016\/j.neuroimage.2026.121926_bib0096","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.sleep.2024.10.021","article-title":"The association between insomnia and cognitive decline: a scoping review","volume":"124","author":"Zhang","year":"2024","journal-title":"Sleep Med."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0097","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuroimage.2026.121926_bib0098","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2023.1135995","article-title":"Functional connectivity changes are correlated with sleep improvement in chronic insomnia patients after rTMS treatment","volume":"17","author":"Zhu","year":"2023","journal-title":"Front. Neurosci."}],"container-title":["NeuroImage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053811926002417?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053811926002417?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T15:51:08Z","timestamp":1780588268000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053811926002417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":98,"alternative-id":["S1053811926002417"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroimage.2026.121926","relation":{},"ISSN":["1053-8119"],"issn-type":[{"value":"1053-8119","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neural-molecular signatures of insomnia: Insights from signed differential mapping and gene expression analysis","name":"articletitle","label":"Article Title"},{"value":"NeuroImage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroimage.2026.121926","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"121926"}}