{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:40:52Z","timestamp":1760204452050},"reference-count":58,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Regulatory Toxicology and Pharmacology"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.yrtph.2010.08.001","type":"journal-article","created":{"date-parts":[[2010,8,14]],"date-time":"2010-08-14T09:02:05Z","timestamp":1281776525000},"page":"360-368","source":"Crossref","is-referenced-by-count":23,"title":["The antipsychotics haloperidol and chlorpromazine increase bone metabolism and induce osteopenia in female rats"],"prefix":"10.1016","volume":"58","author":[{"given":"Takeshi","family":"Kunimatsu","sequence":"first","affiliation":[]},{"given":"Juki","family":"Kimura","sequence":"additional","affiliation":[]},{"given":"Hitoshi","family":"Funabashi","sequence":"additional","affiliation":[]},{"given":"Tadashi","family":"Inoue","sequence":"additional","affiliation":[]},{"given":"Takaki","family":"Seki","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/j.yrtph.2010.08.001_b0005","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0026-0495(98)90054-3","article-title":"Relative effects of prolactin excess and estrogen deficiency on bone in rats","volume":"47","author":"Adler","year":"1998","journal-title":"Metabolism"},{"key":"10.1016\/j.yrtph.2010.08.001_b0010","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/1097-0142(19870115)59:2<329::AID-CNCR2820590227>3.0.CO;2-S","article-title":"Serum bone gla-protein in multiple myeloma","volume":"59","author":"Bataille","year":"1987","journal-title":"Cancer"},{"key":"10.1016\/j.yrtph.2010.08.001_b0015","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1210\/edrv-6-4-564","article-title":"Dopamine: a prolactin-inhibiting hormone","volume":"6","author":"Ben-Jonathan","year":"1985","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.yrtph.2010.08.001_b0020","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1592\/phco.29.1.64","article-title":"Antipsychotic-induced hyperprolactinemia","volume":"29","author":"Bostwick","year":"2008","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.yrtph.2010.08.001_b0025","first-page":"449","article-title":"Regional analysis of bone mineral density in the distal femur and proximal tibia using peripheral quantitative computed tomography in the rat in vivo","volume":"58","author":"Breen","year":"1996","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.yrtph.2010.08.001_b0035","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S0140-6736(84)92506-6","article-title":"Serum bone gla-protein: a specific marker for bone formation in postmenopausal osteoporosis","volume":"8386","author":"Brown","year":"1984","journal-title":"Lancet"},{"key":"10.1016\/j.yrtph.2010.08.001_b0040","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1210\/endo-94-6-1704","article-title":"Plasma concentration of LH, FSH, prolactin, progesterone and estradiol-17beta throughout the 4-day estrous cycle of the rat","volume":"94","author":"Butcher","year":"1974","journal-title":"Endocrinology"},{"key":"10.1016\/j.yrtph.2010.08.001_b0045","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1359\/jbmr.080410","article-title":"Prevention of trabecular bone loss induced by estrogen deficiency by a selective p38alpha inhibitor","volume":"23","author":"Caverzasio","year":"2008","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.yrtph.2010.08.001_b0050","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1172\/JCI112234","article-title":"Estimation of bone turnover evaluated by 47 calcium kinetics: efficiency of serum bone gamma-carboxy-glutamic acid containing protein, serum alkaline phosphatase and urinary hydroxyproline excretion","volume":"76","author":"Charles","year":"1985","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yrtph.2010.08.001_b0055","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s004410050598","article-title":"Regulation of differentiation and keratin 10 expression by all-trans retinoic acid during the estrous cycle in the rat vaginal epithelium","volume":"284","author":"Chateau","year":"1996","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.yrtph.2010.08.001_b0060","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1046\/j.1365-2265.2000.00902.x","article-title":"Prolactinomas in aldolescents: persistent bone loss after 2years of prolactin normalisation","volume":"32","author":"Colao","year":"2000","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.yrtph.2010.08.001_b0065","series-title":"Osteoporosis: Etiology, Diagnosis, Management","first-page":"297","article-title":"Biochemical markers of bone turnover in osteoporosis","author":"Delmas","year":"1988"},{"key":"10.1016\/j.yrtph.2010.08.001_b0310","series-title":"Osteoporosis: Etiology, Diagnosis and Management","first-page":"319","article-title":"Biochemical markers for the assessment of bone turnover","author":"Delmas","year":"1995"},{"key":"10.1016\/j.yrtph.2010.08.001_b0075","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/BF02554970","article-title":"Cancellous bone resorption in the proximal ilium of the ovariectomized rats","volume":"46","author":"Devlin","year":"1990","journal-title":"Calcif. Tissue Int."},{"issue":"Suppl. 3","key":"10.1016\/j.yrtph.2010.08.001_b0080","first-page":"10","article-title":"Hormonal side effects in women: typical versus atypical antipsychotic treatment","volume":"61","author":"Dickson","year":"2000","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.yrtph.2010.08.001_b0085","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1523\/JNEUROSCI.11-12-03727.1991","article-title":"D2 dopamine receptor activation of potassium channels in identified rat lactotrophs: whole-cell and single-channel recording","volume":"11","author":"Einhorn","year":"1991","journal-title":"J. Neurosci."},{"key":"10.1016\/j.yrtph.2010.08.001_b0090","doi-asserted-by":"crossref","first-page":"22919","DOI":"10.1016\/S0021-9258(18)54442-2","article-title":"Inhibitory control of prolactin and Pit-1 gene promoters by dopamine. Dual signaling pathways required for D2 receptor-regulated expression of the prolactin gene","volume":"266","author":"Elsholtz","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yrtph.2010.08.001_b0095","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.1523\/JNEUROSCI.19-09-03345.1999","article-title":"Tonic dopamine inhibition of L-type Ca2+ channel activity reduces alpha, 1D Ca2+ channel gene expression","volume":"19","author":"Fass","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.yrtph.2010.08.001_b0100","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.euroneuro.2003.12.001","article-title":"Effects of the classical antipsychotic haloperidol and atypical antipsychotic risperidone on weight gain, the estrous cycle and uterine weight in female rats","volume":"14","author":"Fell","year":"2004","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.yrtph.2010.08.001_b0105","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3109\/10408369109106867","article-title":"Osteocalcin: diagnostic methods and clinical applications","volume":"28","author":"Fottrell","year":"1991","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"10.1016\/j.yrtph.2010.08.001_b0110","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1677\/joe.1.05907","article-title":"Neonatal handling and reproductive function in female rats","volume":"184","author":"Gomes","year":"2005","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.yrtph.2010.08.001_b0115","first-page":"R310","article-title":"Effects of spaceflight on trabecular bone in rats","volume":"244","author":"Jee","year":"1983","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.yrtph.2010.08.001_b0120","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0306-4530(02)00112-9","article-title":"Elevated prolactin levels in patients with schizophrenia: mechanisms and related adverse events","volume":"28","author":"Halbreich","year":"2003","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.yrtph.2010.08.001_b0125","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1530\/rep.0.1260371","article-title":"Effect of hypothyroidism on hormone profiles in virgin, pregnant and lactating rats, and on lactation","volume":"126","author":"Hapon","year":"2003","journal-title":"Reproduction"},{"key":"10.1016\/j.yrtph.2010.08.001_b0315","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000054457","article-title":"Potentiation of prolactin secretion following lactotrope escape from dopamine action. II. Phosphorylation of the alpha (1) subunit of L-type, voltage-dependent calcium channels","volume":"70","author":"Hernandez","year":"1999","journal-title":"Neuroendocrinology"},{"issue":"11","key":"10.1016\/j.yrtph.2010.08.001_b0135","first-page":"2831","article-title":"Chronic intravenous toxicity studies of potassium clavulanate and BRL28500 in dogs","volume":"39","author":"Koyu","year":"1986","journal-title":"Jpn. J. Antibiot."},{"key":"10.1016\/j.yrtph.2010.08.001_b0145","first-page":"906","article-title":"Toxicological study of bromperidol (1st report) \u2013 subacute toxicological study in rats","volume":"15","author":"Horizoe","year":"1984","journal-title":"Iyakuhin Kenkyu (Jpn.)"},{"key":"10.1016\/j.yrtph.2010.08.001_b0150","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1176\/appi.ajp.161.4.756","article-title":"Alendronic acid for antipsychotic-related osteopenia","volume":"161","author":"Howes","year":"2004","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.yrtph.2010.08.001_b0155","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1176\/appi.ajp.162.1.162","article-title":"Osteoporosis in patients with schizophrenia","volume":"162","author":"Hummer","year":"2005","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.yrtph.2010.08.001_b0030","unstructured":"In-house data, 1976. Short-term Toxicity Study of Sulpiride in Rats: Summary of Results and Report of Findings."},{"issue":"Suppl. 1","key":"10.1016\/j.yrtph.2010.08.001_b0320","first-page":"SP167","article-title":"Collaborative work on evaluation of ovarian toxicity. 16. Effects of 2 or 4weeks repeated dose studies and fertility study of chlorpromazine hydrochloride in rats","volume":"34","author":"Izumi","year":"2008","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.yrtph.2010.08.001_b0165","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0378-4347(93)80365-B","article-title":"Assay of pyridinium crosslinks in serum using narrow-bone ion-paired reversed-phase high-performance liquid chromatography","volume":"612","author":"James","year":"1993","journal-title":"J. Chromatogr."},{"issue":"9","key":"10.1016\/j.yrtph.2010.08.001_b0175","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.4088\/JCP.v67n0909","article-title":"Prevalence of bone mineral density loss in Korean patients with schizophrenia: a cross-sectional study","volume":"67","author":"Jung","year":"2006","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.yrtph.2010.08.001_b0180","doi-asserted-by":"crossref","first-page":"385","DOI":"10.4088\/JCP.v69n0307","article-title":"Antipsychotic-induced hyperprolactinemia inhibits the hypothalamo-pituitary-gonadal axis and reduces bone mineral density in male patients with schizophrenia","volume":"69","author":"Kishimoto","year":"2008","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.yrtph.2010.08.001_b0185","doi-asserted-by":"crossref","first-page":"12007","DOI":"10.1016\/S0021-9258(17)32674-1","article-title":"G(i) alpha 2- and G(0) alpha-mediated signaling in the Pit-1-dependent inhibition of the prolactin gene promoter. Control of transcription by dopamine D2 receptors","volume":"269","author":"Lew","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yrtph.2010.08.001_b0190","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S8756-3282(96)00317-1","article-title":"Time course of femoral neck osteopenia in ovariectomized rats","volume":"20","author":"Li","year":"1997","journal-title":"Bone"},{"key":"10.1016\/j.yrtph.2010.08.001_b0195","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/0896-6273(92)90273-G","article-title":"Differential G protein-mediated coupling of D2 dopamine receptors to K+ and Ca2+ currents in rat anterior pituitary cells","volume":"8","author":"Liedo","year":"1992","journal-title":"Neuron"},{"key":"10.1016\/j.yrtph.2010.08.001_b0200","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/01926230601156260","article-title":"The rat mammary gland: morphologic changes as an indicator of systemic hormonal purturbations induced by xenobiotics","volume":"35","author":"Lucas","year":"2007","journal-title":"Toxicol. Pathol."},{"issue":"Suppl. 4","key":"10.1016\/j.yrtph.2010.08.001_b0205","first-page":"56","article-title":"Prolactin elevation with antipsychotic medications: mechanism of action and clinical consequences","volume":"63","author":"Maguire","year":"2002","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.yrtph.2010.08.001_b0210","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/BF02555043","article-title":"Bone marrow fat content in relation to bone remodeling and serum chemistry in intact and ovariectomized dogs","volume":"46","author":"Martin","year":"1990","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.yrtph.2010.08.001_b0215","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/8756-3282(91)90011-7","article-title":"Relationship between marrow fat and bone turnover in ovariectomized and intact rats","volume":"12","author":"Martin","year":"1991","journal-title":"Bone"},{"key":"10.1016\/j.yrtph.2010.08.001_b0220","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/00003086-197110000-00021","article-title":"Osteoporosis and the replacement of cell populations of the marrow by adipose tissue","volume":"80","author":"Meunier","year":"1971","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.yrtph.2010.08.001_b0225","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/ar.1092360303","article-title":"Long-term osteopenic changes in cancellous bone structure in ovariectomized rats","volume":"236","author":"Miller","year":"1993","journal-title":"Anat. Rec."},{"key":"10.1016\/j.yrtph.2010.08.001_b0230","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1007\/BF02405340","article-title":"Marrow changes in paraplegic patients","volume":"36","author":"Minaire","year":"1984","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.yrtph.2010.08.001_b0235","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0306-4530(02)00129-4","article-title":"Hyperprolactinemia and bone mineral density: the potential impact of antipsychotic agents","volume":"28","author":"Naidoo","year":"2003","journal-title":"Psychoendocrinology"},{"key":"10.1016\/j.yrtph.2010.08.001_b0240","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s774-002-8442-7","article-title":"Altered bone turnover in chlorpromazine-challenged rats and its effect on 1alpha-hydroxyvitamin D3 administration in vivo","volume":"20","author":"Oh-ie","year":"2002","journal-title":"J. Bone Miner. Metab."},{"key":"10.1016\/j.yrtph.2010.08.001_b0245","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/01.jcp.0000150223.31007.e0","article-title":"Antipsychotic drugs \u2013 a new risk factor for osteoporosis in young women with schizophrenia?","volume":"25","author":"O\u2019Keane","year":"2005","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.yrtph.2010.08.001_b0250","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1177\/0269881107088439","article-title":"Antipsychotic-induced hyperprolactinemia, hypogonadism and osteoporosis in the treatment of schizophrenia","volume":"22","author":"O\u2019Keane","year":"2008","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.yrtph.2010.08.001_b0255","series-title":"Collagen in Health and Disease","first-page":"160","article-title":"Turnover and crosslinking of collagen","author":"Robbins","year":"1982"},{"key":"10.1016\/j.yrtph.2010.08.001_b0265","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/1043-2760(92)90129-O","article-title":"Urinary pyridinium crosslinks of collagen. Specific markers of bone resorption in metabolic bone disease","volume":"3","author":"Seibel","year":"1992","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.yrtph.2010.08.001_b0270","first-page":"2571","article-title":"Role of prolactin in regulating gonadotropin secretion and gonad function in female rats","volume":"39","author":"Smith","year":"1980","journal-title":"Fed. Proc."},{"key":"10.1016\/j.yrtph.2010.08.001_b0275","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00223-004-0224-8","article-title":"Enhanced marrow adipogenesis and bone resorption in estrogen-deprived rats treated with the PPARgamma agonist BRL49653 (rosiglitazone)","volume":"75","author":"Sottile","year":"2004","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.yrtph.2010.08.001_b0280","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1440-1681.1980.tb00079.x","article-title":"Maintenance of pseudopregnancy by prolactin in indomethacin treated rats","volume":"7","author":"Tan","year":"1980","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"Suppl. 1","key":"10.1016\/j.yrtph.2010.08.001_b0285","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2131\/jts.13.SupplementI_91","article-title":"Six-month chronic subcutaneous toxicity study of cefodizime sodium in rats","volume":"13","author":"Wada","year":"1988","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.yrtph.2010.08.001_b0290","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1677\/joe.0.1070127","article-title":"Single nephron function during prolactin-induced pseudopregnancy in the rat","volume":"107","author":"Walker","year":"1985","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.yrtph.2010.08.001_b0295","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1210\/endo-118-3-1237","article-title":"Effects of hyperprolactinemia on estrous cyclicity, serum luteinizing hormone, prolactin, estradiol, and progesterone concentrations, and catecholamine activity in microdissected brain areas","volume":"118","author":"Wise","year":"1986","journal-title":"Endocrinology"},{"key":"10.1016\/j.yrtph.2010.08.001_b0300","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/BF02556007","article-title":"Long-term effects of ovariectomy and aging on the rats\u2019 skeleton","volume":"45","author":"Wronski","year":"1989","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.yrtph.2010.08.001_b0305","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/8756-3282(89)90067-7","article-title":"Time course of vertebral osteopenia in ovariectomized rats","volume":"10","author":"Wronski","year":"1989","journal-title":"Bone"}],"container-title":["Regulatory Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230010001285?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230010001285?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T17:38:17Z","timestamp":1636133897000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0273230010001285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":58,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0273230010001285"],"URL":"https:\/\/doi.org\/10.1016\/j.yrtph.2010.08.001","relation":{},"ISSN":["0273-2300"],"issn-type":[{"value":"0273-2300","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}