{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T21:36:46Z","timestamp":1774561006706,"version":"3.50.1"},"reference-count":76,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[1996,12,1]],"date-time":"1996-12-01T00:00:00Z","timestamp":849398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1996,12,1]],"date-time":"1996-12-01T00:00:00Z","timestamp":849398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Heart Journal"],"published-print":{"date-parts":[[1996,12]]},"DOI":"10.1016\/s0002-8703(96)90468-8","type":"journal-article","created":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T09:46:44Z","timestamp":1094032004000},"page":"1236-1243","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Endothelin-1: A scientist's curiosity, or a real player in ischemic heart disease?"],"prefix":"10.1016","volume":"132","author":[{"given":"Maurizio","family":"Cesari","sequence":"first","affiliation":[]},{"given":"Edoardo","family":"Pavan","sequence":"additional","affiliation":[]},{"given":"Alfredo","family":"Sacchetto","sequence":"additional","affiliation":[]},{"given":"Gian Paolo","family":"Rossi","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0002-8703(96)90468-8_BIB1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/332411a0","article-title":"A novel potent vasoconstrictor peptide produced by vascular endothelial cells","volume":"332","author":"Yanagisawa","year":"1988","journal-title":"Nature"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB2","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/0092-8674(94)90425-1","article-title":"ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1","volume":"78","author":"Xu","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1006\/bbrc.1995.1803","article-title":"Expression of the endothelin-converting enzyme gene in human tissues","volume":"211","author":"Rossi","year":"1995","journal-title":"Biochem Biophys Res Comm"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB4","doi-asserted-by":"crossref","first-page":"29794","DOI":"10.1074\/jbc.270.50.29794","article-title":"Organization of the gene encoding the human endothelin converting enzyme (ECE-1)","volume":"270","author":"Valdenaire","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB5","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1006\/bbrc.1996.0656","article-title":"Fine mapping of the human ECE gene by fluorescent in situ hybridization and radiation hybrids","volume":"221","author":"Albertin","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB6","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1172\/JCI117440","article-title":"Gene expression, localization, and characterization of endothelin A and B receptors in the human adrenal cortex","volume":"94","author":"Rossi","year":"1994","journal-title":"J Clin Invest"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB7","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2220\/biomedres.15.95","article-title":"In vitro autoradiographic demonstration of endothelin-1 binding sites in the human adrenal cortex","volume":"15","author":"Belloni","year":"1994","journal-title":"Biomed Res"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB8","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1056\/NEJM199508103330607","article-title":"Endothelins","volume":"333","author":"Levin","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB9","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0014-5793(91)80007-P","article-title":"Cloning and expression of human endothelin-1 receptor cDNA","volume":"287","author":"Hosoda","year":"1991","journal-title":"FEBS Lett"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB10","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/348730a0","article-title":"Cloning and expression of a cDNA encoding an endothelin receptor","volume":"348","author":"Arai","year":"1990","journal-title":"Nature"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB11","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0006-291X(91)91806-N","article-title":"Molecular cloning of a non-isopeptide selective human endothelin receptor","volume":"178","author":"Ogawa","year":"1991","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB12","first-page":"3185","article-title":"Cloning and functional expression of a vascular smooth muscle endothelin 1 receptor","volume":"88","author":"Lin","year":"1991"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB13","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1161\/01.RES.65.5.1193","article-title":"Effects of endothelin on the coronary vascular bed in open-chest dogs","volume":"65","author":"Clozel","year":"1989","journal-title":"Circ Res"},{"issue":"Suppl 5","key":"10.1016\/S0002-8703(96)90468-8_BIB14","doi-asserted-by":"crossref","first-page":"S193","DOI":"10.1097\/00005344-198900135-00054","article-title":"Effects of endothelin-1 on the rat isolated heart","volume":"13","author":"Baydoun","year":"1989","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB15","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1476-5381.1992.tb14304.x","article-title":"Modulation of vascular tone by endothelin-1: role of preload, endothelial integrity and concentration of endothelin-1","volume":"106","author":"Mehta","year":"1992","journal-title":"Br J Pharmacol"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB16","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/0006-291X(92)90826-7","article-title":"The endothelin ETB receptor mediates both vasodilation and vasoconstriction in vivo","volume":"186","author":"Clozel","year":"1992","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB17","first-page":"H339","article-title":"Lethal ischemia due to intracoronary endothelin in pigs","volume":"257","author":"Ezra","year":"1989","journal-title":"Am J Physiol"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB18","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/0002-9149(89)91055-2","article-title":"Influence of endothelin on human coronary arteries and localization of its binding sites","volume":"63","author":"Chester","year":"1989","journal-title":"Am J Cardiol"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB19","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1440-1681.1989.tb01551.x","article-title":"Endothelin is blood vessel selective: studies on a variety of human and dog vessels in vitro and on regional blood flow in the conscious rabbit","volume":"16","author":"Cocks","year":"1989","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB20","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/S0022-3565(25)10442-4","article-title":"Role of endothelin-1 and big endothelin-1 in modulating coronary vascular tone, contractile function and severity of ischemia in rat hearts","volume":"263","author":"Grover","year":"1992","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB21","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1093\/cvr\/24.11.879","article-title":"Myocardial ischaemia induced by endothelin in the intact rabbit: angiographic analysis","volume":"24","author":"Hirata","year":"1990","journal-title":"Cardiovasc Res"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB22","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/00005344-199402000-00006","article-title":"Effects of endothelin-1 at pathophysiologic concentrations on coronary perfusion and mechanical function of normal and postischemic myocardium","volume":"23","author":"Donckier","year":"1994","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB23","first-page":"S17","article-title":"Endothelin plasma levels in hypertensive patients with vascular disease","volume":"12","author":"Neild","year":"1994","journal-title":"J Hypertens Suppl"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB24","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1111\/j.1476-5381.1989.tb12592.x","article-title":"The pharmacological properties of the peptide, endothelin","volume":"97","author":"Eglen","year":"1989","journal-title":"Br J Pharmacol"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB25","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1016\/0024-3205(89)90406-2","article-title":"Endothelin: a potent vasoconstrictor associated with coronary vasospasm","volume":"44","author":"Kurihara","year":"1989","journal-title":"Life Sci"},{"issue":"suppl 8","key":"10.1016\/S0002-8703(96)90468-8_BIB26","first-page":"I","article-title":"Differential effect of endothelin on coronary conduit and resistance arteries","volume":"92","author":"Smith","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB27","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1111\/j.1476-5381.1993.tb13942.x","article-title":"Evidence for heterogeneity of endothelin receptor distribution in human coronary artery","volume":"110","author":"Godfraind","year":"1993","journal-title":"Br J Pharmacol"},{"issue":"Suppl 8","key":"10.1016\/S0002-8703(96)90468-8_BIB28","doi-asserted-by":"crossref","first-page":"S248","DOI":"10.1097\/00005344-199322008-00066","article-title":"Two subtypes of the endothelin receptor (ETA and ETB) mediate vasoconstriction in the perfused rat heart","volume":"22","author":"Balwierczak","year":"1993","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB29","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1161\/01.RES.74.1.105","article-title":"Potent vasoconstriction mediated by endothelin ETB receptors in canine coronary arteries","volume":"74","author":"Teerlink","year":"1994","journal-title":"Circ Res"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB30","doi-asserted-by":"crossref","first-page":"3312","DOI":"10.1161\/01.CIR.92.11.3312","article-title":"Endothelin at pathophysiological concentrations mediates coronary vasoconstriction via the endothelin-A receptor","volume":"92","author":"Cannan","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB31","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1161\/01.CIR.89.3.1203","article-title":"Both ETA and ETB receptors mediate contraction to endothelin-1 in human blood vessels","volume":"89","author":"Seo","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB32","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/0006-291X(91)91601-8","article-title":"Sarafatoxin S6C: an agonist which distinguishes between endothelin receptor subtypes","volume":"175","author":"Williams","year":"1991","journal-title":"Biochem Biophys Res Comm"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB33","series-title":"A quantitative radiographic analysis","first-page":"403","article-title":"Endothelin receptors in the human coronary artery, ventricle and atrium","volume":"348","author":"Bax","year":"1993"},{"issue":"suppl. 8","key":"10.1016\/S0002-8703(96)90468-8_BIB34","doi-asserted-by":"crossref","first-page":"S243","DOI":"10.1097\/00005344-199322008-00065","article-title":"Differential responsiveness of conduit and resistance coronary arteries to endothelin A and B receptor stimulation in anesthetized dogs","volume":"22","author":"Rigel","year":"1993","journal-title":"J Cardiovasc Pharmacol"},{"issue":"Suppl 3","key":"10.1016\/S0002-8703(96)90468-8_BIB35","doi-asserted-by":"crossref","first-page":"S376","DOI":"10.1097\/00005344-199506263-00112","article-title":"[3H] Bosentan binding to human coronary artery: functional correlates","volume":"26","author":"Dashwood","year":"1995","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB36","doi-asserted-by":"crossref","first-page":"S310","DOI":"10.1097\/00004872-198900076-00151","article-title":"Effects of endothelin on isolated ischaemic rat hearts during ramiprilat, bradykinin and indomethacin perfusion","volume":"7","author":"Linz","year":"1989","journal-title":"J Hypertens Suppl"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB37","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1159\/000188402","article-title":"Dissociation of selective renal venous plasma endothelin-1 activity and corresponding plasma renin activity in a patient with hypertension, severe stenosis of unilateral renal artery and ipsilaterally decreased renal function","volume":"68","author":"Takeda","year":"1994","journal-title":"Nephron"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB38","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1097\/00005344-199106000-00022","article-title":"Proarrhythmic activity of intracoronary endothelin in dogs: relation to the site of administration and to changes in regional flow","volume":"17","author":"Salvati","year":"1991","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB39","doi-asserted-by":"crossref","first-page":"16066","DOI":"10.1016\/S0021-9258(18)41966-7","article-title":"Polar secretion of endothelin-1 by cultured endothelial cells","volume":"267","author":"Wagner","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB40","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0140-6736(89)90813-1","article-title":"Modulation of coronary tone in acute myocardial infarction by endothelin","volume":"2","author":"Salminen","year":"1989","journal-title":"Lancet"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB41","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0140-6736(89)90303-6","article-title":"Increased plasma concentrations of endothelin-1 and big endothelin-1 in acute myocardial infarction","volume":"2","author":"Miyauchi","year":"1989","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/S0002-8703(96)90468-8_BIB42","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/BF02576230","article-title":"Increased endothelin plasma concentrations in patients with coronary artery disease or hyperlipoproteinemia without coronary events","volume":"193","author":"Arendt","year":"1993","journal-title":"Res Exp Med (Berl)"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB43","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1136\/hrt.72.5.436","article-title":"Raised plasma endothelin in unstable angina and non-Q wave myocardial infarction: relation to cardiovascular outcome","volume":"72","author":"Wieczorek","year":"1994","journal-title":"Br Heart J"},{"issue":"Suppl 3","key":"10.1016\/S0002-8703(96)90468-8_BIB44","first-page":"S376","article-title":"Endothelin-like immunoreactivity in atherosclerotic human coronary arteries","volume":"26","author":"Dashwood","year":"1993","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB45","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/S0140-6736(94)90571-1","article-title":"Increased tissue endothelin immunoreactivity in atherosclerotic lesions associated with acute coronary syndromes","volume":"344","author":"Zeiher","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB46","series-title":"A clue to the mechanism of increased vasoreactivity of the culprit lesion in unstable angina","first-page":"941","article-title":"Tissue endothelin-1 immunoreactivity in the active coronary atherosclerotic plaque","volume":"91","author":"Zeiher","year":"1995"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB47","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1161\/01.CIR.83.2.476","article-title":"Increased plasma level of endothelin-1 and coronary spasm induction in patients with vasospastic angina pectoris","volume":"83","author":"Toyooka","year":"1991","journal-title":"Circulation"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB48","series-title":"A new mechanism of vasospasm?","first-page":"188","article-title":"Threshold concentrations of endothelin-1 potentiate contractions to norepinephrine and serotonin in human arteries","volume":"82","author":"Yang","year":"1990"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB49","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/0002-9149(91)90484-3","article-title":"Increased plasma level of endothelin-1-like immunoreactivity during coronary spasm in patients with coronary spastic angina","volume":"68","author":"Matsuyama","year":"1991","journal-title":"Am J Cardiol"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB50","first-page":"118","article-title":"Myocardial ischemia and local endothelin-1 production","volume":"15","author":"Velasco","year":"1994","journal-title":"Eur Heart J"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB51","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/344114a0","article-title":"Endothelin in myocardial infarction","volume":"344","author":"Watanabe","year":"1990","journal-title":"Nature"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB52","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1093\/cvr\/27.8.1482","article-title":"Release of endothelin from the porcine heart after short term coronary artery occlusion","volume":"27","author":"Tonnessen","year":"1993","journal-title":"Cardiovasc Res"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB53","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/0006-291X(89)91799-3","article-title":"Ischaemia causes externalization of endothelin-1 binding sites in rat cardiac membranes","volume":"164","author":"Liu","year":"1989","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB54","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1097\/00005344-199206000-00014","article-title":"Effects of nisoldipine upon vasoconstrictor responses and binding of endothelin-1 in ischemic and reperfused rat hearts","volume":"19","author":"Watts","year":"1992","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB55","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/0022-2828(91)90186-P","article-title":"Effects of endothelin-1 in the isolated heart in ischemia\/reperfusion and hypoxia\/reoxygenation injury","volume":"23","author":"Neubauer","year":"1991","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB56","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/cvr\/27.1.121","article-title":"Intravenous adenosine suppresses cardiac release of endothelin after myocardial ischaemia and reperfusion","volume":"27","author":"Velasco","year":"1993","journal-title":"Cardiovasc Res"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB57","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1161\/01.RES.69.2.370","article-title":"Contribution of endogenous endothelin to the extension of myocardial infarct size in rats","volume":"69","author":"Watanabe","year":"1991","journal-title":"Circ Res"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB58","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1093\/cvr\/27.9.1613","article-title":"The endothelin-1 receptor antagonist BQ-123 reduces infarct size in a canine model of coronary occlusion and reperfusion","volume":"27","author":"Grover","year":"1993","journal-title":"Cardiovasc Res"},{"issue":"suppl 8","key":"10.1016\/S0002-8703(96)90468-8_BIB59","first-page":"I","article-title":"Endogenous endothelin increases myocardial infarct size","volume":"92","author":"Hagar","year":"1995","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/S0002-8703(96)90468-8_BIB60","first-page":"I","article-title":"Cardioprotective action of endothelin-1 during ischemia","volume":"88","author":"Velasco","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB61","first-page":"30A","article-title":"Endothelins protect the ischemic myocardium","author":"Velasco","year":"1994","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB62","first-page":"869","article-title":"Role of endogenous endothelin in myocardial and coronary endothelial injury after ischaemia and reperfusion in rats: studies with bosentan, a mixed ETA-ETB antagonist","volume":"113","author":"Richard","year":"1994"},{"issue":"suppl 8","key":"10.1016\/S0002-8703(96)90468-8_BIB63","first-page":"I","article-title":"Endothelin A receptor antagonism by PD 156707 does not reduce infarct size following coronary artery occlusion\/reperfusion in pigs","volume":"92","author":"Mertz","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB64","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1476-5381.1994.tb13032.x","article-title":"The effects of the endothelin ETA receptor antagonist, FR 139317, on infarct size in a rabbit model of acute myocardial ischemia and reperfusion","volume":"112","author":"McMurdo","year":"1994","journal-title":"Br J Pharmacol"},{"issue":"3","key":"10.1016\/S0002-8703(96)90468-8_BIB65","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1161\/01.RES.71.3.631","article-title":"Endothelin reverses the effects of acidosis on the intracellular Ca2+ transient and contractility in ferret myocardium","volume":"71","author":"Wang","year":"1992","journal-title":"Circ Res"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB66","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1476-5381.1990.tb14699.x","article-title":"Endothelin-1 inhibits platelet aggregation in vivo: a study with 111indium-labelled platelets","volume":"99","author":"Thiemermann","year":"1990","journal-title":"Br J Pharmacol"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB67","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/0049-3848(90)90163-7","article-title":"Endothelin and platelet function","volume":"57","author":"Ohlstein","year":"1990","journal-title":"Thromb Res"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB68","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1475-097X.1990.tb00450.x","article-title":"Endothelin does not affect aggregation of human platelets","volume":"10","author":"Edlund","year":"1990","journal-title":"Clin Physiol"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB69","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0014-2999(88)90273-7","article-title":"Endothelin inhibits ex vivo platelet aggregation in the rabbit","volume":"158","author":"Thiemermann","year":"1988","journal-title":"Eur J Pharmacol"},{"issue":"Suppl 8","key":"10.1016\/S0002-8703(96)90468-8_BIB70","doi-asserted-by":"crossref","first-page":"S199","DOI":"10.1097\/00005344-199322008-00054","article-title":"The snake venom peptide sarafotoxin S6b inhibits repetitive platelet thrombus formation in the stenosed canine coronary artery","volume":"22","author":"Leadley","year":"1993","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB71","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/0002-9149(93)90178-F","article-title":"Effect of percutaneous transluminal coronary angioplasty on circulating endothelin levels","volume":"72","author":"Ameli","year":"1993","journal-title":"Am J Cardiol"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB72","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/0735-1097(94)90104-X","article-title":"Endothelin-1 in patients with coronary heart disease undergoing cardiac catheterization","volume":"24","author":"Montalescot","year":"1994","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB73","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/0002-8703(93)90421-5","article-title":"Release of immunoreactive endothelin from the heart during percutaneous transluminal coronary angioplasty","volume":"126","author":"Malatino","year":"1993","journal-title":"Am Heart J"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB74","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/0026-0495(91)90021-N","article-title":"Circulating immunoreactive endothelin in patients undergoing percutaneous transluminal coronary angioplasty","volume":"40","author":"Tahara","year":"1991","journal-title":"Metabolism"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB75","first-page":"H2259","article-title":"Role of endothelin-1 in neointima formation after endothelial removal in rabbit carotid arteries","volume":"267","author":"Azuma","year":"1994","journal-title":"Am J Physiol"},{"key":"10.1016\/S0002-8703(96)90468-8_BIB76","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/0002-8703(95)90370-4","article-title":"Endothelin and endothelin antagonism: roles in cardiovascular health and disease","volume":"130","author":"Tamirisa","year":"1995","journal-title":"Am Heart J"}],"container-title":["American Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870396904688?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870396904688?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T05:09:40Z","timestamp":1757567380000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002870396904688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,12]]},"references-count":76,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1996,12]]}},"alternative-id":["S0002870396904688"],"URL":"https:\/\/doi.org\/10.1016\/s0002-8703(96)90468-8","relation":{},"ISSN":["0002-8703"],"issn-type":[{"value":"0002-8703","type":"print"}],"subject":[],"published":{"date-parts":[[1996,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endothelin-1: A scientist's curiosity, or a real player in ischemic heart disease?","name":"articletitle","label":"Article Title"},{"value":"American Heart Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0002-8703(96)90468-8","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1996 Published by Mosby, Inc.","name":"copyright","label":"Copyright"}]}}