{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T14:39:31Z","timestamp":1771166371013,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["amjmed.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Medicine"],"published-print":{"date-parts":[[2001,2]]},"DOI":"10.1016\/s0002-9343(00)00700-2","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T15:48:54Z","timestamp":1027612134000},"page":"103-110","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":144,"title":["Enhanced oxidative susceptibility and reduced antioxidant content of metabolic precursors of small, dense low-density lipoproteins"],"prefix":"10.1016","volume":"110","author":[{"given":"Diane L","family":"Tribble","sequence":"first","affiliation":[]},{"given":"Manfredi","family":"Rizzo","sequence":"additional","affiliation":[]},{"given":"Alan","family":"Chait","sequence":"additional","affiliation":[]},{"given":"Diane M","family":"Lewis","sequence":"additional","affiliation":[]},{"given":"Patricia J","family":"Blanche","sequence":"additional","affiliation":[]},{"given":"Ronald M","family":"Krauss","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0002-9343(00)00700-2_BIB1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0022-2275(20)38178-5","article-title":"Identification of multiple subclasses of plasma low density lipoproteins in normal subjects","volume":"23","author":"Krauss","year":"1982","journal-title":"J Lipid Res"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB2","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S0022-2275(20)35367-0","article-title":"Heterogeneity of serum low density lipoproteins in normal human subjects","volume":"22","author":"Shen","year":"1981","journal-title":"J Lipid Res"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB3","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1001\/jama.1988.03410130125037","article-title":"Low density lipoprotein subclass and risk of myocardial infarction","volume":"260","author":"Austin","year":"1988","journal-title":"JAMA"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB4","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1161\/01.CIR.82.2.495","article-title":"Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk","volume":"82","author":"Austin","year":"1990","journal-title":"Circulation"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB5","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1001\/jama.1996.03540110036029","article-title":"A prospective study of triglyceride level, low-density lipoprotein particle diameter, and risk of myocardial infarction","volume":"276","author":"Stampfer","year":"1996","journal-title":"J Am Med Assoc"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB6","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1001\/jama.1996.03540110029028","article-title":"Association of small, dense lipoprotein particles with incidence of coronary artery disease in men and women","volume":"276","author":"Gardner","year":"1996","journal-title":"J Am Med Assoc"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB7","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1161\/01.CIR.95.1.69","article-title":"Small, dense low-density lipoprotein particles as a predictor of the risk of ischemic heart disease in men","volume":"95","author":"Lamarche","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB8","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0021-9150(94)90129-5","article-title":"Role of plasma triglyceride in the regulation of plasma low density lipoprotein (LDL) subfractions","volume":"106","author":"Griffin","year":"1994","journal-title":"Atherosclerosis"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB9","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1161\/01.ATV.11.2.298","article-title":"Enhanced susceptibility to in vitro oxidation of the dense low density lipoprotein subfraction in healthy subjects","volume":"11","author":"De Graaf","year":"1991","journal-title":"Arterioscler Thromb"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB10","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0021-9150(92)90255-F","article-title":"Variations in oxidative susceptibility among six low density lipoprotein subfractions of varying size and density","volume":"93","author":"Tribble","year":"1992","journal-title":"Atherosclerosis"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB11","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0022-2275(20)40756-4","article-title":"Dense low density lipoprotein subspecies with diminished oxidative resistance predominate in combined hyperlipidemia","volume":"34","author":"Dejager","year":"1993","journal-title":"J Lipid Res"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB12","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/0002-9343(93)90144-E","article-title":"Susceptibility of small, dense low-density lipoproteins to oxidative modification in subjects with the atherogenic lipoprotein phenotype pattern B","volume":"94","author":"Chait","year":"1993","journal-title":"Am J Med"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB13","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1073\/pnas.91.3.1183","article-title":"Oxidative susceptibility of low density lipoprotein subfractions is related to their ubiquinol-10 and alpha-tocopherol content","volume":"94","author":"Tribble","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB14","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1161\/01.ATV.14.4.557","article-title":"Effects of linoleate-enriched and oleate-enriched diets in combination with \u03b1-tocopherol on the susceptibility of LDL and LDL subfractions to oxidative modification in humans","volume":"14","author":"Reaven","year":"1994","journal-title":"Arterioscler Thromb"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB15","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/S0022-2275(20)40052-5","article-title":"Enhanced oxidative susceptibility of the surface monolayer in small, dense LDL may contribute to differences in copper-induced oxidation among LDL density subfractions","volume":"36","author":"Tribble","year":"1995","journal-title":"J Lipid Res"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB16","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0021-9150(94)05527-P","article-title":"Autoantibodies against malondialdehyde-modified LDL are elevated in subjects with an LDL subclass pattern B","volume":"115","author":"Jansen","year":"1995","journal-title":"Atherosclerosis"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB17","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1161\/01.ATV.15.11.2025","article-title":"Differing \u03b1-tocopherol oxidative lability and ascorbic acid sparing effects in buoyant and dense LDL","volume":"15","author":"Tribble","year":"1995","journal-title":"Arterioscler Thromb"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB18","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1161\/01.ATV.16.6.784","article-title":"Contribution of an in vivo oxidized LDL to LDL oxidation and its association with dense LDL subpopulations","volume":"16","author":"Sevanian","year":"1996","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB19","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1161\/01.CIR.99.4.591","article-title":"Antioxidant consumption and risk of coronary heart disease","volume":"99","author":"Tribble","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB20","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1097\/00041433-199405030-00007","article-title":"Metabolism of VLDL and LDL subclasses","volume":"5","author":"Griffin","year":"1994","journal-title":"Curr Opin Lipid"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB21","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1161\/01.ATV.6.1.79","article-title":"Presence of multiple subpopulations of lipoproteins of intermediate density in normal subjects","volume":"6","author":"Musliner","year":"1986","journal-title":"Arteriosclerosis"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB22","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1161\/01.CIR.94.9.2146","article-title":"Predominance of dense low-density lipoprotein particles predicts angiographic benefit of therapy in the Stanford Coronary Risk Intervention Project","volume":"94","author":"Miller","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB23","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1093\/clinchem\/20.4.470","article-title":"Enzymatic determination of total serum cholesterol","volume":"20","author":"Allain","year":"1974","journal-title":"Clin Chem"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB24","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/clinchem\/31.2.217","article-title":"Comparison of improved precipitation methods for quantification of high density lipoprotein cholesterol","volume":"31","author":"Warnick","year":"1985","journal-title":"Clin Chem"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB25","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0022-2275(20)38178-5","article-title":"Identification of multiple subclasses of plasma low density lipoproteins in normal humans","volume":"23","author":"Krauss","year":"1982","journal-title":"J Lipid Res"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB26","unstructured":"Lindgren FT, Jensen LC, Hatch FT. The isolation and quantitative analysis of lipoproteins. In: Nelson GJ, ed. Blood Lipids and Lipoproteins: Quantitation, Composition and Metabolism. New York: Wiley-Interscience; 1972:181\u2013174."},{"key":"10.1016\/S0002-9343(00)00700-2_BIB27","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0022-2275(20)38678-8","article-title":"Autooxidation of human low density lipoprotein","volume":"28","author":"Esterbauer","year":"1987","journal-title":"J Lipid Res"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB28","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0378-4347(88)80009-4","article-title":"Determination of coenzyme Q10, alpha-tocopherol and cholesterol in biological samples by coupled-column liquid chromatography with coulometric and ultraviolet detection","volume":"425","author":"Edlund","year":"1988","journal-title":"J Chromatog"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB29","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/0003-2697(78)90586-9","article-title":"A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples","volume":"87","author":"Markwell","year":"1978","journal-title":"Ann Biochem"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB30","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S0021-9258(18)70226-3","article-title":"Phosphorus assay in column chromatography","volume":"234","author":"Bartlett","year":"1959","journal-title":"J Biol Chem"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB31","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0009-8981(77)90287-X","article-title":"The determination of total cholesterol in serum by gas-liquid chromatography compared with two other methods","volume":"74","author":"Hindriks","year":"1977","journal-title":"Clin Chim Acta"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB32","doi-asserted-by":"crossref","first-page":"3542","DOI":"10.1161\/01.ATV.17.12.3542","article-title":"Lipoprotein heterogeneity and apolipoprotein B metabolism","volume":"17","author":"Packard","year":"1997","journal-title":"Arterioscler Thromb"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB33","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/S0022-2275(20)41629-3","article-title":"Discrete subspecies of human LDL are heterogeneous in their interaction with the cellular LDL receptor","volume":"32","author":"Nigon","year":"1991","journal-title":"J Lipid Res"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB34","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1161\/01.ATV.16.6.794","article-title":"Differences in receptor binding of LDL subfractions","volume":"16","author":"Campos","year":"1996","journal-title":"Arterioscler Thromb"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB35","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1161\/01.ATV.7.4.408","article-title":"Metabolism of human intermediate and very low density lipoprotein subfractions from normal and dysbetalipoproteinemic plasma. In vivo studies in rat","volume":"7","author":"Musliner","year":"1987","journal-title":"Arteriosclerosis"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB36","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0021-9150(94)90140-6","article-title":"Hepatic lipase and lipoprotein lipase are not major determinants of the low density lipoprotein subclass pattern in human subjects with coronary heart disease","volume":"107","author":"Jansen","year":"1994","journal-title":"Atherosclerosis"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB37","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1161\/01.ATV.12.12.1496","article-title":"LDL-subclass phenotypes, and triglyceride metabolism in non-insulin-dependent diabetes","volume":"12","author":"Feingold","year":"1992","journal-title":"Arterioscler Thromb"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB38","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1021\/bi00173a028","article-title":"Fatty acid composition of LDL influences its susceptibility to autooxidation","volume":"33","author":"Thomas","year":"1994","journal-title":"Biochemistry"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB39","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0014-5793(94)80242-4","article-title":"LDL oxidizability by copper correlates to its initial ubiquinol-10, and polyunsaturated fatty acid content","volume":"341","author":"Kontush","year":"1994","journal-title":"FEBS lett"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB40","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1016\/S0022-2275(20)35354-2","article-title":"Content of antioxidants, preformed lipid hydroperoxides, and cholesterol as predictors of the susceptibility of human LDL to metal ion-dependent and -independent oxidation","volume":"34","author":"Frei","year":"1993","journal-title":"J Lipid Res"},{"key":"10.1016\/S0002-9343(00)00700-2_BIB41","doi-asserted-by":"crossref","first-page":"58S","DOI":"10.1016\/S0002-9343(98)00213-7","article-title":"Triglycerides and atherogenic lipoproteins","volume":"105","author":"Krauss","year":"1998","journal-title":"Am J Med"}],"container-title":["The American Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002934300007002?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002934300007002?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T07:30:07Z","timestamp":1757575807000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002934300007002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,2]]}},"alternative-id":["S0002934300007002"],"URL":"https:\/\/doi.org\/10.1016\/s0002-9343(00)00700-2","relation":{},"ISSN":["0002-9343"],"issn-type":[{"value":"0002-9343","type":"print"}],"subject":[],"published":{"date-parts":[[2001,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhanced oxidative susceptibility and reduced antioxidant content of metabolic precursors of small, dense low-density lipoproteins","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0002-9343(00)00700-2","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2001 Excerpta Medica Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}