{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T22:48:26Z","timestamp":1774565306738,"version":"3.50.1"},"reference-count":24,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1995,9,1]],"date-time":"1995-09-01T00:00:00Z","timestamp":809913600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1995,9,1]],"date-time":"1995-09-01T00:00:00Z","timestamp":809913600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["amjmed.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Medicine"],"published-print":{"date-parts":[[1995,9]]},"DOI":"10.1016\/s0002-9343(99)80156-9","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T12:02:11Z","timestamp":1027598531000},"page":"249-254","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":437,"title":["Increased plasma serotonin in primary pulmonary hypertension"],"prefix":"10.1016","volume":"99","author":[{"given":"Philipe","family":"Herv\u00e9","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Marie","family":"Launay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Laur\u00e8ne","family":"Scrobohaci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Brenot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e9rald","family":"Simonneau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Petitpretz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrice","family":"Poubeau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Cerrina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Duroux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludovic","family":"Drouet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0002-9343(99)80156-9_BIB1","first-page":"513","article-title":"Etiologic mechanisms in primary pulmonary hypertension","author":"Voelkel","year":"1989"},{"key":"10.1016\/S0002-9343(99)80156-9_BIB2","series-title":"Pulmonary Hypertension","first-page":"115","article-title":"Diagnosis and management of primary pulmonary hypertension","author":"Weir","year":"1984"},{"key":"10.1016\/S0002-9343(99)80156-9_BIB3","first-page":"153","article-title":"Potential role of platelets in the pulmonary circulation","volume":"27","author":"Mlczoch","year":"1985","journal-title":"Cor Vasa"},{"key":"10.1016\/S0002-9343(99)80156-9_BIB4","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1172\/JCI111499","article-title":"Aggregating platelets contract isolated canine pulmonary arteries by releasing 5-hydroxytryptamine","volume":"74","author":"McGoon","year":"1984","journal-title":"J Clin Invest."},{"key":"10.1016\/S0002-9343(99)80156-9_BIB5","first-page":"L178","article-title":"Serotonin increases DNA synthesis in rat proximal and distal pulmonary vascular smooth muscle cells in culture","volume":"266","author":"Pitt","year":"1994","journal-title":"Am J Physiol."},{"issue":"1","key":"10.1016\/S0002-9343(99)80156-9_BIB6","first-page":"L46","article-title":"Serotonin produces both hyperplasia and hypertrophy of bovine pulmonary artery smooth muscle cells in culture","volume":"266","author":"Lee","year":"1994","journal-title":"Am J Physiol."},{"key":"10.1016\/S0002-9343(99)80156-9_BIB7","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/BF00561375","article-title":"Ketanserin treatment and serotonin in patients with primary and secondary Raynaud's phenomenon","volume":"35","author":"Marasini","year":"1988","journal-title":"Eur J Clin Pharmacol."},{"key":"10.1016\/S0002-9343(99)80156-9_BIB8","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1136\/ard.48.7.586","article-title":"Platelet serotonin in systemic sclerosis","volume":"48","author":"Klimiuk","year":"1989","journal-title":"Ann Rheum Dis."},{"key":"10.1016\/S0002-9343(99)80156-9_BIB9","first-page":"563","article-title":"Effect of fenfluramine on 5-hydroxytryptamine uptake and release by rat blood platelets","volume":"53","author":"Buczko","year":"1975","journal-title":"J Pharmacol."},{"key":"10.1016\/S0002-9343(99)80156-9_BIB10","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1136\/hrt.70.6.537","article-title":"Primary pulmonary hypertension and the appetite suppressant fenfluramine","volume":"70","author":"Brenot","year":"1993","journal-title":"Br Heart J."},{"key":"10.1016\/S0002-9343(99)80156-9_BIB11","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0002-9343(90)90111-P","article-title":"Primary pulmonary hypertension in patient with a familial storage pool disease: role of serotonin","volume":"89","author":"Herv\u00e9","year":"1990","journal-title":"Am J Med."},{"key":"10.1016\/S0002-9343(99)80156-9_BIB12","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1016\/0024-3205(83)90676-8","article-title":"A modified enzymatic isotopic microassay for serotonin (5-HT) using 5-HT-N-acetyl transferase partially purified from Drosophila","volume":"33","author":"Walker","year":"1983","journal-title":"Life Sci."},{"key":"10.1016\/S0002-9343(99)80156-9_BIB13","author":"Siegel","year":"1988"},{"key":"10.1016\/S0002-9343(99)80156-9_BIB14","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0272-5231(21)00604-3","article-title":"Lung serotonin metabolism","volume":"10","author":"Hart","year":"1989","journal-title":"Clin Chest Med."},{"key":"10.1016\/S0002-9343(99)80156-9_BIB15","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/0024-3205(87)90696-5","article-title":"Steady-state model for plasma free and platelet serotonin in man","volume":"41","author":"Anderson","year":"1987","journal-title":"Life Sci."},{"key":"10.1016\/S0002-9343(99)80156-9_BIB16","first-page":"608","article-title":"Removal of 5-hydroxytryptamine and norepinephrine from the pulmonary vascular space of man: influence of cardiopulmonary bypass and pulmonary arterial pressure on these processes","volume":"76","author":"Gillis","year":"1974","journal-title":"Surgery"},{"key":"10.1016\/S0002-9343(99)80156-9_BIB17","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1378\/chest.104.6.1690","article-title":"Platelet activation and fibrinopeptide formation in pulmonary hypertension","volume":"104","author":"Schulman","year":"1993","journal-title":"Chest."},{"key":"10.1016\/S0002-9343(99)80156-9_BIB18","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1056\/NEJM199207093270202","article-title":"An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension","volume":"327","author":"Christman","year":"1992","journal-title":"NEJM."},{"key":"10.1016\/S0002-9343(99)80156-9_BIB19","first-page":"A367","article-title":"Pulmonary metabolic function can serve as monitor for lung rejection","volume":"137","author":"Vasseur","year":"1988","journal-title":"Am Rev Respir Dis."},{"key":"10.1016\/S0002-9343(99)80156-9_BIB20","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1159\/000195509","article-title":"Pulmonary artery pressure in rats with hereditary platelet function defect","volume":"54","author":"Kentera","year":"1988","journal-title":"Respiration"},{"key":"10.1016\/S0002-9343(99)80156-9_BIB21","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1164\/ajrccm\/145.4_Pt_1.793","article-title":"Factors influencing the idiopathic development of pulmonary hypertension in the Fawn Hooded rat","volume":"145","author":"Sato","year":"1992","journal-title":"Am Rev Respir Dis."},{"key":"10.1016\/S0002-9343(99)80156-9_BIB22","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0041-008X(87)90001-9","article-title":"5-hydroxytryptamine and thromboxane in platelets from rats treated with monocrotaline pyrrhole","volume":"88","author":"Ganey","year":"1987","journal-title":"Toxicol Appl Pharmacol."},{"key":"10.1016\/S0002-9343(99)80156-9_BIB23","first-page":"A106","article-title":"The effects of contractile agonists on isolated pulmonary arterial and venous muscle preparations derived from patients with primary pulmonary hypertension","volume":"137","author":"Brink","year":"1988","journal-title":"Amer Rev Respir Dis."},{"key":"10.1016\/S0002-9343(99)80156-9_BIB24","first-page":"1929","article-title":"Paradoxical constriction to platelets by arteries from rat with pulmonary hypertension","volume":"260","author":"Ashmore","year":"1991","journal-title":"Am J Physiol."}],"container-title":["The American Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002934399801569?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002934399801569?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T08:13:10Z","timestamp":1757578390000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002934399801569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,9]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1995,9]]}},"alternative-id":["S0002934399801569"],"URL":"https:\/\/doi.org\/10.1016\/s0002-9343(99)80156-9","relation":{},"ISSN":["0002-9343"],"issn-type":[{"value":"0002-9343","type":"print"}],"subject":[],"published":{"date-parts":[[1995,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased plasma serotonin in primary pulmonary hypertension","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0002-9343(99)80156-9","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1995 Published by Excerpta Medica Inc.","name":"copyright","label":"Copyright"}]}}