{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:20:26Z","timestamp":1770823226388,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2001,1]]},"DOI":"10.1016\/s0002-9440(10)63959-4","type":"journal-article","created":{"date-parts":[[2011,1,28]],"date-time":"2011-01-28T00:02:54Z","timestamp":1296172974000},"page":"207-214","source":"Crossref","is-referenced-by-count":68,"title":["Molecular Cytogenetic Comparison of Apocrine Hyperplasia and Apocrine Carcinoma of the Breast"],"prefix":"10.1016","volume":"158","author":[{"given":"Chris","family":"Jones","sequence":"first","affiliation":[]},{"given":"Stefania","family":"Damiani","sequence":"additional","affiliation":[]},{"given":"Dagan","family":"Wells","sequence":"additional","affiliation":[]},{"given":"Ranbir","family":"Chaggar","sequence":"additional","affiliation":[]},{"given":"Sunil R.","family":"Lakhani","sequence":"additional","affiliation":[]},{"given":"Vincenzo","family":"Eusebi","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0002-9440(10)63959-4_bib1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/00125480-199705000-00001","article-title":"Apocrine differentiation in breast epithelium","volume":"4","author":"Eusebi","year":"1997","journal-title":"Adv Anat Pathol"},{"key":"10.1016\/S0002-9440(10)63959-4_bib2","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s004280050089","article-title":"Apocrine epithelium of the breast: does it result from metaplasia?","volume":"431","author":"Viacava","year":"1997","journal-title":"Virchows Arch"},{"key":"10.1016\/S0002-9440(10)63959-4_bib3","series-title":"Rosen's Breast Pathology","first-page":"67","article-title":"Benign papillary tumours","author":"Rosen","year":"1997"},{"key":"10.1016\/S0002-9440(10)63959-4_bib4","first-page":"91","article-title":"Apocrine differentiation in invasive carcinoma of the breast","volume":"3","author":"Losi","year":"1995","journal-title":"Appl Immunohistochem"},{"key":"10.1016\/S0002-9440(10)63959-4_bib5","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0046-8177(87)80169-7","article-title":"Apocrine cystic metaplasia: subgross pathology and prevalence in cancer-associated versus random autopsy breasts","volume":"18","author":"Wellings","year":"1987","journal-title":"Hum Pathol"},{"key":"10.1016\/S0002-9440(10)63959-4_bib6","series-title":"Problems in breast pathology","author":"Azzopardi","year":"1979"},{"key":"10.1016\/S0002-9440(10)63959-4_bib7","first-page":"1791","article-title":"Association of cyst type with risk factors for breast cancer and relapse rate in women with gross cystic disease of the breast","volume":"52","author":"Naldoni","year":"1992","journal-title":"Cancer Res"},{"key":"10.1016\/S0002-9440(10)63959-4_bib8","first-page":"239","article-title":"Breast gross cystic disease fluid analysis. I. Isolation and radioimmunoassay for a major component protein","volume":"62","author":"Haagensen","year":"1979","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/S0002-9440(10)63959-4_bib9","first-page":"29","article-title":"Detection of PIP-GCDFP-15 gene expression in apocrine epithelium of the breast and salivary glands","volume":"2","author":"Pagani","year":"1994","journal-title":"Appl Immunohistochem"},{"key":"10.1016\/S0002-9440(10)63959-4_bib10","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/BF00197548","article-title":"PIP\/GCDFP-15 gene expression and apocrine differentiation in carcinomas of the breast","volume":"425","author":"Pagani","year":"1994","journal-title":"Virchows Arch"},{"key":"10.1016\/S0002-9440(10)63959-4_bib11","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/BF01534877","article-title":"The gene for prolactin-inducible protein (PIP), uniquely expressed in exocrine organs, maps to chromosome 7","volume":"15","author":"Myal","year":"1989","journal-title":"Somat Cell Mol Genet"},{"key":"10.1016\/S0002-9440(10)63959-4_bib12","first-page":"25A","article-title":"Down regulation of bcl2, ER, PR associated with AR expression is triggered by apocrine differentiation of mammary epithelium [Abstract]","volume":"9","author":"Tavassoli","year":"1996","journal-title":"Mod Pathol"},{"key":"10.1016\/S0002-9440(10)63959-4_bib13","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/path.1711150405","article-title":"Apocrine metaplasia in cystic hyperplastic mastopathy. Histochemical and ultrastructural observations","volume":"115","author":"Ahmed","year":"1975","journal-title":"J Pathol"},{"key":"10.1016\/S0002-9440(10)63959-4_bib14","first-page":"231","article-title":"An atlas of subgross pathology of the human breast with special reference to possible precancerous lesions","volume":"55","author":"Wellings","year":"1975","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/S0002-9440(10)63959-4_bib15","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/modpathol.3880004","article-title":"Immunohistochemical analysis of Ki-67, p53, p21 and p27 in benign and malignant apocrine lesions of the breast: its correlation to histologic findings in 43 cases","volume":"13","author":"Moriya","year":"2000","journal-title":"Mod Pathol"},{"key":"10.1016\/S0002-9440(10)63959-4_bib16","first-page":"409","article-title":"Sweat carcinoma of the breast","volume":"39","author":"Dawson","year":"1932","journal-title":"Edinburgh Med J"},{"key":"10.1016\/S0002-9440(10)63959-4_bib17","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1097\/00000658-194501000-00002","article-title":"Comparative studies of cancerous versus non-cancerous breasts","volume":"12","author":"Foote","year":"1945","journal-title":"Ann Surg"},{"key":"10.1016\/S0002-9440(10)63959-4_bib18","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1749-6632.1990.tb17812.x","article-title":"Significance of apocrine metaplasia in mammary carcinogenesis. A preliminary morphological and immunohistochemical study","volume":"586","author":"T\u00f3th","year":"1990","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/S0002-9440(10)63959-4_bib19","series-title":"Breast carcinoma. Risk and Detection","first-page":"83","article-title":"Apocrine epithelium","author":"Haagensen","year":"1981"},{"key":"10.1016\/S0002-9440(10)63959-4_bib20","first-page":"1055","article-title":"Relation between component parts of fibrocystic disease complex and breast cancer","volume":"61","author":"Page","year":"1978","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/S0002-9440(10)63959-4_bib21","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1016\/S0140-6736(98)06408-3","article-title":"Risk of breast cancer in women with palpable breast cysts: a prospective study. Edinburgh Breast Group","volume":"353","author":"Dixon","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/S0002-9440(10)63959-4_bib22","first-page":"29","article-title":"Papillary apocrine change of the breast\u2014cancer risk indicator?","volume":"5","author":"Page","year":"1996","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/S0002-9440(10)63959-4_bib23","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1136\/bmj.314.7085.925","article-title":"Cohort study of association of risk of breast cancer with cyst type in women with gross cystic disease of the breast","volume":"315","author":"Bruzzi","year":"1997","journal-title":"BMJ"},{"key":"10.1016\/S0002-9440(10)63959-4_bib24","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/j.1365-2559.1988.tb02030.x","article-title":"Apocrine carcinoma and apocrine metaplasia","volume":"13","author":"Yates","year":"1988","journal-title":"Histopathology"},{"key":"10.1016\/S0002-9440(10)63959-4_bib25","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/BF01605456","article-title":"Immunohistochemical study of neu protein overexpression in clinging in situ duct carcinoma of the breast","volume":"422","author":"De Potter","year":"1993","journal-title":"Virchows Archiv A Pathol Anat Hisopathol"},{"key":"10.1016\/S0002-9440(10)63959-4_bib26","first-page":"223","article-title":"Long term follow up of in situ carcinoma of the breast","volume":"11","author":"Eusebi","year":"1994","journal-title":"Semin Diagn Pathol"},{"key":"10.1016\/S0002-9440(10)63959-4_bib27","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/0046-8177(94)90273-9","article-title":"Ductal carcinoma in situ of the breast with apocrine cytology: definition of a borderline category","volume":"25","author":"O'Malley","year":"1994","journal-title":"Hum Pathol"},{"key":"10.1016\/S0002-9440(10)63959-4_bib28","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1136\/jcp.48.8.737","article-title":"Apocrine adenosis: a precursor of aggressive breast cancer?","volume":"48","author":"Wells","year":"1995","journal-title":"J Clin Pathol"},{"key":"10.1016\/S0002-9440(10)63959-4_bib29","first-page":"309","article-title":"Immunohistochemical study of ras and myc oncoproteins in apocrine breast lesions with and without papillomatosis","volume":"13","author":"Agnantis","year":"1992","journal-title":"Eur J Gynaeocol Oncol"},{"key":"10.1016\/S0002-9440(10)63959-4_bib30","first-page":"129","article-title":"Detection of allelic imbalance indicates that a proportion of mammary hyperplasia of usual type are clonal, neoplastic proliferations","volume":"74","author":"Lakhani","year":"1996","journal-title":"Lab Invest"},{"key":"10.1016\/S0002-9440(10)63959-4_bib31","first-page":"1083","article-title":"Loss of heterozygosity is detected at chromosomes 1p35-36 (NB), 3p25 (VHL), 16p13 (TSC2\/PKD1), and 17p13 (TP53) in microdissected apocrine carcinomas of the breast","volume":"12","author":"Lininger","year":"1999","journal-title":"Mod Pathol"},{"key":"10.1016\/S0002-9440(10)63959-4_bib32","first-page":"167","article-title":"Ductal carcinoma in situ: a proposal for a new classification","volume":"11","author":"Holland","year":"1994","journal-title":"Semin Diagn Pathol"},{"key":"10.1016\/S0002-9440(10)63959-4_bib33","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1365-2559.1991.tb00229.x","article-title":"Pathological prognostic factors in breast cancer. 1. The value of histological grade in breast cancer: experience from a large study with long-term follow-up","volume":"19","author":"Elston","year":"1991","journal-title":"Histopathology"},{"key":"10.1016\/S0002-9440(10)63959-4_bib34","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1177\/29.4.6166661","article-title":"The use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase technique","volume":"29","author":"Hsu","year":"1981","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/S0002-9440(10)63959-4_bib35","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/BF01675295","article-title":"In situ hybridization methods for the detection of somatostatin mRNA in tissue sections using antisense RNA probes","volume":"18","author":"Hoefler","year":"1986","journal-title":"Histochem J"},{"key":"10.1016\/S0002-9440(10)63959-4_bib36","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1093\/nar\/27.4.1214","article-title":"Detailed chromosomal and molecular genetic analysis of single cells by whole genome amplification and comparative genomic hybridization","volume":"27","author":"Wells","year":"1999","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/S0002-9440(10)63959-4_bib37","first-page":"532","article-title":"Apocrine carcinoma of the breast","volume":"123","author":"Eusebi","year":"1986","journal-title":"Am J Pathol"},{"key":"10.1016\/S0002-9440(10)63959-4_bib38","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1097\/00000478-199107000-00010","article-title":"Is cystic disease related to breast cancer?","volume":"15","author":"Haagensen","year":"1991","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/S0002-9440(10)63959-4_bib39","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1136\/jcp.52.11.838","article-title":"Immunohistochemical localisation of androgen receptor in apocrine metaplasia and apocrine adenosis of the breast: relation to oestrogen and progesterone receptors","volume":"52","author":"Selim","year":"1999","journal-title":"J Clin Pathol"},{"key":"10.1016\/S0002-9440(10)63959-4_bib40","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1002\/(SICI)1096-9896(199903)187:4<396::AID-PATH286>3.0.CO;2-L","article-title":"Comparative genomic hybridization of ductal carcinoma in situ of the breast-evidence of multiple genetic pathways","volume":"187","author":"Buerger","year":"1999","journal-title":"J Pathol"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010639594?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010639594?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T01:56:06Z","timestamp":1543974966000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944010639594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2001,1]]}},"alternative-id":["S0002944010639594"],"URL":"https:\/\/doi.org\/10.1016\/s0002-9440(10)63959-4","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2001,1]]}}}