{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:11:30Z","timestamp":1770822690321,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2000,10,1]],"date-time":"2000-10-01T00:00:00Z","timestamp":970358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2000,10]]},"DOI":"10.1016\/s0002-9440(10)64624-x","type":"journal-article","created":{"date-parts":[[2011,1,28]],"date-time":"2011-01-28T05:02:54Z","timestamp":1296190974000},"page":"1097-1103","source":"Crossref","is-referenced-by-count":212,"title":["Mutation and Expression Analyses Reveal Differential Subcellular Compartmentalization of PTEN in Endocrine Pancreatic Tumors Compared to Normal Islet Cells"],"prefix":"10.1016","volume":"157","author":[{"given":"Aurel","family":"Perren","sequence":"first","affiliation":[]},{"given":"Paul","family":"Komminoth","sequence":"additional","affiliation":[]},{"given":"Parvin","family":"Saremaslani","sequence":"additional","affiliation":[]},{"given":"Claudia","family":"Matter","sequence":"additional","affiliation":[]},{"given":"Seraina","family":"Feurer","sequence":"additional","affiliation":[]},{"given":"Jacqueline A.","family":"Lees","sequence":"additional","affiliation":[]},{"given":"Philipp U.","family":"Heitz","sequence":"additional","affiliation":[]},{"given":"Charis","family":"Eng","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0002-9440(10)64624-X_bib1","first-page":"4682","article-title":"Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas","volume":"57","author":"Zhuang","year":"1997","journal-title":"Cancer Res"},{"key":"10.1016\/S0002-9440(10)64624-X_bib2","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0002-9440(10)65289-3","article-title":"Mutations and allelic deletions of the MEN1 gene are associated with a subset of sporadic endocrine pancreatic and neuroendocrine tumors and not restricted to foregut neoplasms","volume":"154","author":"Gortz","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1016\/S0002-9440(10)64624-X_bib3","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/BF02915125","article-title":"Identification of p53 gene mutations in gastrointestinal and pancreatic carcinoids by nonradioisotopic SSCA","volume":"64","author":"Lohmann","year":"1993","journal-title":"Virchows Arch B Cell Pathol"},{"key":"10.1016\/S0002-9440(10)64624-X_bib4","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/BF02896594","article-title":"Oncogene expression in endocrine pancreatic tumors","volume":"55","author":"Hofler","year":"1988","journal-title":"Virchows Arch B Cell Pathol"},{"key":"10.1016\/S0002-9440(10)64624-X_bib5","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1016\/S0002-9440(10)65495-8","article-title":"Genetic differences in endocrine pancreatic tumor subtypes detected by comparative genomic hybridization","volume":"155","author":"Speel","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1016\/S0002-9440(10)64624-X_bib6","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/ng0596-114","article-title":"Localization of the gene for Cowden disease to 10q22\u201323","volume":"13","author":"Nelen","year":"1996","journal-title":"Nat Genet"},{"key":"10.1016\/S0002-9440(10)64624-X_bib7","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1126\/science.275.5308.1943","article-title":"PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast and prostate cancer","volume":"275","author":"Li","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0002-9440(10)64624-X_bib8","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/ng0497-356","article-title":"Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers","volume":"15","author":"Steck","year":"1997","journal-title":"Nat Genet"},{"key":"10.1016\/S0002-9440(10)64624-X_bib9","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/ng0597-64","article-title":"Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome","volume":"16","author":"Liaw","year":"1997","journal-title":"Nat Genet"},{"key":"10.1016\/S0002-9440(10)64624-X_bib10","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/ng0897-333","article-title":"Germline mutations in PTEN are present in Bannayan-Zonana syndrome","volume":"16","author":"Marsh","year":"1997","journal-title":"Nat Genet"},{"key":"10.1016\/S0002-9440(10)64624-X_bib11","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1093\/hmg\/7.3.507","article-title":"Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation","volume":"7","author":"Marsh","year":"1998","journal-title":"Hum Mol Genet"},{"key":"10.1016\/S0002-9440(10)64624-X_bib12","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1093\/hmg\/8.8.1461","article-title":"PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome","volume":"8","author":"Marsh","year":"1999","journal-title":"Hum Mol Genet"},{"key":"10.1016\/S0002-9440(10)64624-X_bib13","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1093\/hmg\/9.5.765","article-title":"Germline and germline mosaic mutations associated with a Proteus-like syndrome of hemihypertrophy, lower limb asymmetry, arterio-venous malformations and lipomatosis","volume":"9","author":"Zhou","year":"2000","journal-title":"Hum Mol Genet"},{"key":"10.1016\/S0002-9440(10)64624-X_bib14","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/ng1097-143","article-title":"PTEN1 is frequently mutated in primary endometrial carcinomas","volume":"17","author":"Kong","year":"1997","journal-title":"Nat Genet"},{"key":"10.1016\/S0002-9440(10)64624-X_bib15","first-page":"3254","article-title":"PTEN mutations and microsatellite instability in complex atypical hyperplasia, a precursor lesion to uterine endometrioid carcinoma","volume":"58","author":"Levine","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/S0002-9440(10)64624-X_bib16","first-page":"3935","article-title":"Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies","volume":"57","author":"Tashiro","year":"1997","journal-title":"Cancer Res"},{"key":"10.1016\/S0002-9440(10)64624-X_bib17","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1093\/jnci\/92.11.924","article-title":"Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers","volume":"92","author":"Mutter","year":"2000","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/S0002-9440(10)64624-X_bib18","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1038\/sj.onc.1201756","article-title":"PTEN mutations in gliomas and glioneuronal tumours","volume":"16","author":"D\u00fcrr","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/S0002-9440(10)64624-X_bib19","first-page":"29","article-title":"Mutation of the PTEN (MMAC1) tumour suppressor gene in a subset of glioblastomas but not in meningiomas with loss of chromosome arm 10q","volume":"58","author":"Bostr\u00f6m","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/S0002-9440(10)64624-X_bib20","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/S0002-9440(10)65227-3","article-title":"Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast","volume":"155","author":"Perren","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1016\/S0002-9440(10)64624-X_bib21","series-title":"Histological Typing of Endocrine Tumours","year":"2000"},{"key":"10.1016\/S0002-9440(10)64624-X_bib22","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/(SICI)1096-9896(199812)186:4<363::AID-PATH197>3.0.CO;2-W","article-title":"Clonal analysis of sporadic pancreatic endocrine tumours","volume":"186","author":"Perren","year":"1998","journal-title":"J Pathol"},{"key":"10.1016\/S0002-9440(10)64624-X_bib23","first-page":"922","article-title":"Detection of RET proto-oncogene point mutations in paraffin-embedded pheochromocytoma specimens by nonradioactive single-strand conformation polymorphism analysis and direct sequencing","volume":"145","author":"Komminoth","year":"1994","journal-title":"Am J Pathol"},{"key":"10.1016\/S0002-9440(10)64624-X_bib24","first-page":"5808","article-title":"PTEN suppresses breast cancer cell growth by phosphatase function-dependent G1 arrest followed by apoptosis","volume":"59","author":"Weng","year":"1999","journal-title":"Cancer Res"},{"key":"10.1016\/S0002-9440(10)64624-X_bib25","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/S0002-9440(10)65040-7","article-title":"Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors","volume":"156","author":"Gimm","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1016\/S0002-9440(10)64624-X_bib26","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/(SICI)1098-2264(199912)26:4<322::AID-GCC6>3.0.CO;2-#","article-title":"Fine structure deletion analysis of 10q22\u201324 demonstrates novel regions of loss and suggests that sporadic follicular thyroid adenomas and follicular thyroid carcinomas develop along distinct parallel neoplastic pathways","volume":"26","author":"Yeh","year":"1999","journal-title":"Gene Chromsom Cancer"},{"key":"10.1016\/S0002-9440(10)64624-X_bib27","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1126\/science.280.5369.1614","article-title":"Inhibition of cell migration, spreading and focal adhesions by tumor suppressor PTEN","volume":"280","author":"Tamura","year":"1998","journal-title":"Science"},{"key":"10.1016\/S0002-9440(10)64624-X_bib28","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1523\/JNEUROSCI.20-04-01404.2000","article-title":"A role for nuclear PTEN in neuronal differentiation","volume":"20","author":"Lachyankar","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/S0002-9440(10)64624-X_bib29","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0005-2760(98)00146-5","article-title":"Phospholipid signalling in the nucleus","volume":"1436","author":"D'Santos","year":"1998","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/S0002-9440(10)64624-X_bib30","doi-asserted-by":"crossref","first-page":"27943","DOI":"10.1074\/jbc.274.39.27943","article-title":"Agonists cause nuclear translocation of phosphotidylinositol 3-kinase gamma. A Gbeta-gamma-dependent pathway that requires p110-gamma amino terminus","volume":"274","author":"Metjian","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/S0002-9440(10)64624-X_bib31","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1006\/bbrc.1998.9787","article-title":"Phosphotidylinositol 3-kinase in HL-60 nuclei is bound to the nuclear matrix and increases during granulocyte differentiation","volume":"253","author":"Marchisio","year":"1998","journal-title":"Biochem Biophys Res Commun"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000294401064624X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000294401064624X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T04:46:30Z","timestamp":1637210790000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000294401064624X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,10]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,10]]}},"alternative-id":["S000294401064624X"],"URL":"https:\/\/doi.org\/10.1016\/s0002-9440(10)64624-x","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2000,10]]}}}