{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T09:32:25Z","timestamp":1769160745814,"version":"3.49.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2000,2,1]],"date-time":"2000-02-01T00:00:00Z","timestamp":949363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2000,2]]},"DOI":"10.1016\/s0002-9440(10)64764-5","type":"journal-article","created":{"date-parts":[[2011,1,28]],"date-time":"2011-01-28T05:02:45Z","timestamp":1296190965000},"page":"595-605","source":"Crossref","is-referenced-by-count":150,"title":["Carcinoembryonic Antigen Family Members CEACAM6 and CEACAM7 Are Differentially Expressed in Normal Tissues and Oppositely Deregulated in Hyperplastic Colorectal Polyps and Early Adenomas"],"prefix":"10.1016","volume":"156","author":[{"given":"Stefan","family":"Sch\u00f6lzel","sequence":"first","affiliation":[]},{"given":"Wolfgang","family":"Zimmermann","sequence":"additional","affiliation":[]},{"given":"Georg","family":"Schwarzkopf","sequence":"additional","affiliation":[]},{"given":"Fritz","family":"Grunert","sequence":"additional","affiliation":[]},{"given":"Brigitta","family":"Rogaczewski","sequence":"additional","affiliation":[]},{"given":"John","family":"Thompson","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0002-9440(10)64764-5_bib1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1046\/j.1365-2613.1997.280362.x","article-title":"The intestinal epithelial stem cell: the mucosal governor","volume":"78","author":"Potten","year":"1997","journal-title":"Int J Exp Pathol"},{"key":"10.1016\/S0002-9440(10)64764-5_bib2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0092-8674(00)81333-1","article-title":"Lessons from hereditary colorectal cancer","volume":"87","author":"Kinzler","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0002-9440(10)64764-5_bib3","first-page":"1776","article-title":"Down-regulation of carcinoembryonic antigen-family member 2 expression is an early event in colorectal tumorigenesis","volume":"57","author":"Thompson","year":"1997","journal-title":"Cancer Res"},{"key":"10.1016\/S0002-9440(10)64764-5_bib4","first-page":"2354","article-title":"Expression of CD66a (human C-CAM) and other members of adhesion molecules in human colorectal adenomas","volume":"57","author":"Nollau","year":"1997","journal-title":"Cancer Res"},{"key":"10.1016\/S0002-9440(10)64764-5_bib5","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0016-5107(97)70058-0","article-title":"Follow-up of patients with hyperplastic polyps of the large bowel","volume":"46","author":"Croizet","year":"1997","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/S0002-9440(10)64764-5_bib6","first-page":"5523","article-title":"Molecular determinants of dysplasia in colorectal lesions","volume":"54","author":"Jen","year":"1994","journal-title":"Cancer Res"},{"key":"10.1016\/S0002-9440(10)64764-5_bib7","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1159\/000217926","article-title":"Carcinoembryonic antigen in staging and follow-up of patients with solid tumors","volume":"16","author":"Ballesta","year":"1995","journal-title":"Tumor Biol"},{"key":"10.1016\/S0002-9440(10)64764-5_bib8","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0304-3835(88)90228-5","article-title":"Active production and membrane anchoring of carcinoembryonic antigen observed in normal colon mucosa","volume":"43","author":"Kuroki","year":"1988","journal-title":"Cancer Lett"},{"key":"10.1016\/S0002-9440(10)64764-5_bib9","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/jcla.1860050510","article-title":"Carcinoembryonic antigen gene family: molecular biology and clinical perspectives","volume":"5","author":"Thompson","year":"1991","journal-title":"J Clin Lab Anal"},{"key":"10.1016\/S0002-9440(10)64764-5_bib10","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1006\/excr.1999.4610","article-title":"Redefined nomenclature for members of the carcinoembryonic antigen family","volume":"252","author":"Beauchemin","year":"1999","journal-title":"Exp Cell Res"},{"key":"10.1016\/S0002-9440(10)64764-5_bib11","doi-asserted-by":"crossref","first-page":"10744","DOI":"10.1073\/pnas.90.22.10744","article-title":"Biliary glycoprotein, a potential human cell adhesion molecule, is down-regulated in colorectal carcinomas","volume":"90","author":"Neumaier","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0002-9440(10)64764-5_bib12","first-page":"2375","article-title":"Inhibition of colonic tumor cell growth by biliary glycoprotein","volume":"11","author":"Kunath","year":"1995","journal-title":"Oncogene"},{"key":"10.1016\/S0002-9440(10)64764-5_bib13","first-page":"190","article-title":"Tumor suppressive role of an androgen-regulated epithelial cell adhesion molecule (C-CAM) in prostate carcinoma cell revealed by sense and antisense approaches","volume":"55","author":"Hsieh","year":"1995","journal-title":"Cancer Res"},{"key":"10.1016\/S0002-9440(10)64764-5_bib14","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1159\/000217923","article-title":"Molecular cloning and expression of carcinoembryonic antigen gene family members","volume":"16","author":"Thompson","year":"1995","journal-title":"Tumor Biol"},{"key":"10.1016\/S0002-9440(10)64764-5_bib15","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1128\/IAI.65.6.2353-2361.1997","article-title":"Differential recognition of members of the carcinoembryonic antigen family by Opa variants of Neisseria gonorrhoeae","volume":"65","author":"Bos","year":"1997","journal-title":"Infect Immun"},{"key":"10.1016\/S0002-9440(10)64764-5_bib16","first-page":"907","article-title":"Specificity and epitope localization of CD66\/CD67 mAb. Leucocyte Typing. V. White Cell Differentiation Antigens, vol 1","author":"Grunert","year":"1995"},{"key":"10.1016\/S0002-9440(10)64764-5_bib17","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/ijc.2910550222","article-title":"Determination of the specificities of monoclonal antibodies recognizing members of the CEA family using a panel of transfectants","volume":"55","author":"Daniel","year":"1993","journal-title":"Int J Cancer"},{"key":"10.1016\/S0002-9440(10)64764-5_bib18","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/ijc.1985.36.3.357","article-title":"Two CEA, and three NCA species, although distinguishable by monoclonal antibodies, have nearly identical peptide patterns","volume":"36","author":"Grunert","year":"1985","journal-title":"Int J Cancer"},{"key":"10.1016\/S0002-9440(10)64764-5_bib19","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/ijc.2910550223","article-title":"A polymerase chain reaction assay for the specific identification of transcripts encoded by individual carcinoembryonic antigen (CEA) gene family members","volume":"55","author":"Thompson","year":"1993","journal-title":"Int J Cancer"},{"key":"10.1016\/S0002-9440(10)64764-5_bib20","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0143-4004(77)90002-9","article-title":"Highly specific monoclonal antibody demonstrates that pregnancy-specific glycoprotein (PSG) is limited to syncytio-trophoblast in human early and term placenta","volume":"18","author":"Zhou","year":"1997","journal-title":"Placenta"},{"key":"10.1016\/S0002-9440(10)64764-5_bib21","doi-asserted-by":"crossref","first-page":"32924","DOI":"10.1016\/S0021-9258(20)30079-X","article-title":"CGM2, a member of the carcinoembryonic antigen gene family is down-regulated in colorectal carcinomas","volume":"269","author":"Thompson","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/S0002-9440(10)64764-5_bib22","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0968-0004(00)89051-9","article-title":"The turning point in genome research","volume":"20","author":"Boguski","year":"1995","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/S0002-9440(10)64764-5_bib23","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/255714a0","article-title":"Nonspecific cross-reacting antigen as a marker for human polymorphs, macrophages and monocytes","volume":"255","author":"Burtin","year":"1975","journal-title":"Nature"},{"key":"10.1016\/S0002-9440(10)64764-5_bib24","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/0014-2964(75)90171-1","article-title":"Carcinoembryonic antigen (CEA) and related antigens in blood cells and haematopoietic tissues","volume":"11","author":"Bordes","year":"1975","journal-title":"Eur J Cancer"},{"key":"10.1016\/S0002-9440(10)64764-5_bib25","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1177\/172460089300800407","article-title":"Immunohistochemical detection of carcinoembryonic antigen (CEA) in non-neoplastic lung disease","volume":"8","author":"Abbona","year":"1993","journal-title":"Int J Biol Markers"},{"key":"10.1016\/S0002-9440(10)64764-5_bib26","first-page":"992","article-title":"CD66 Family Workshop Panel Report. Leucocyte Typing. VI. White Cell Differentiation Antigens","author":"Skubitz","year":"1997"},{"key":"10.1016\/S0002-9440(10)64764-5_bib27","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/1523-1747.ep12327258","article-title":"Glycoproteins of the carcinoembryonic antigen (CEA) family are expressed in sweat and sebaceous glands of human fetal and adult skin","volume":"106","author":"Metze","year":"1996","journal-title":"J Invest Dermatol"},{"key":"10.1016\/S0002-9440(10)64764-5_bib28","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s004030050221","article-title":"Hair cycle-dependent expression of a nonspecific cross-reacting antigen (NCA)-50\/90-like molecule on follicular keratinocytes","volume":"289","author":"Honda","year":"1997","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/S0002-9440(10)64764-5_bib29","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1111\/j.1349-7006.1990.tb02527.x","article-title":"Detection of mRNAs of carcinoembryonic antigen and nonspecific cross-reacting antigen genes in colorectal adenomas and carcinomas by in situ hybridization","volume":"81","author":"Higashide","year":"1990","journal-title":"Jpn J Cancer Res"},{"key":"10.1016\/S0002-9440(10)64764-5_bib30","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1159\/000217718","article-title":"Predominant expression of mRNA coding for nonspecific cross-reacting antigen in colorectal carcinomas","volume":"12","author":"Chi","year":"1991","journal-title":"Tumor Biol"},{"key":"10.1016\/S0002-9440(10)64764-5_bib31","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1093\/jnci\/82.5.380","article-title":"Carcinoembryonic antigen as a selective enhancer of colorectal cancer metastasis","volume":"82","author":"Hostetter","year":"1990","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/S0002-9440(10)64764-5_bib32","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/BF01753839","article-title":"Metastatic potential of human colorectal carcinoma SW1222 cells transfected with cDNA encoding carcinoembryonic antigen","volume":"12","author":"Hashino","year":"1994","journal-title":"Clin Exp Metastasis"},{"key":"10.1016\/S0002-9440(10)64764-5_bib33","series-title":"Cell Adhesion and Communication Mediated by the CEA Family: Basic and Clinical Perspectives","first-page":"141","article-title":"Contributions of the human CEA family to malignant transformation","author":"Stanners","year":"1998"},{"key":"10.1016\/S0002-9440(10)64764-5_bib34","series-title":"Cell Adhesion and Communication Mediated by the CEA Family: Basic and Clinical Perspectives","first-page":"99","article-title":"CEA family members are expressed on hematopoietic cells and their possible role in cell adhesion and signaling","author":"Grunert","year":"1998"},{"key":"10.1016\/S0002-9440(10)64764-5_bib35","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0167-5699(92)90136-U","article-title":"Multichain immune recognition receptors: similarities in structure and signaling pathways","volume":"13","author":"Keegan","year":"1992","journal-title":"Immunol Today"},{"key":"10.1016\/S0002-9440(10)64764-5_bib36","doi-asserted-by":"crossref","first-page":"19535","DOI":"10.1016\/S0021-9258(17)32202-0","article-title":"Bile acid efflux mediated by the rat liver canalicular bile acid transporter\/ecto-ATPase protein requires serine 503 phosphorylation and is regulated by tyrosine 488 phosphorylation","volume":"269","author":"Sippel","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/S0002-9440(10)64764-5_bib37","doi-asserted-by":"crossref","first-page":"8809","DOI":"10.1074\/jbc.271.15.8809","article-title":"Cloning and characterization of a functional promoter of the rat pp120 gene, encoding a substrate of the insulin receptor tyrosine kinase","volume":"271","author":"Najjar","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/S0002-9440(10)64764-5_bib38","first-page":"1649","article-title":"Association of pp60\/c-src with biliary glycoprotein (CD66a), an adhesion molecule of the carcinoembryonic antigen family downregulated in colorectal carcinomas","volume":"11","author":"Br\u00fcmmer","year":"1995","journal-title":"Oncogene"},{"key":"10.1016\/S0002-9440(10)64764-5_bib39","doi-asserted-by":"crossref","first-page":"5382","DOI":"10.4049\/jimmunol.155.11.5382","article-title":"CD66 family members are associated with tyrosine kinase activity in human neutrophils","volume":"155","author":"Skubitz","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/S0002-9440(10)64764-5_bib40","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/sj.onc.1200888","article-title":"Association of biliary glycoprotein with protein tyrosine phosphatase SHP-1 in malignant colon epithelial cells","volume":"14","author":"Beauchemin","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/S0002-9440(10)64764-5_bib41","series-title":"Cell Adhesion and Communication Mediated by the CEA Family: Basic and Clinical Perspectives","first-page":"121","article-title":"Signal transduction mediated by the CEA family","author":"Dr\u00e1ber","year":"1998"},{"key":"10.1016\/S0002-9440(10)64764-5_bib42","first-page":"3569","article-title":"Regulation of cell numbers in the mammalian gastrointestinal tract: the importance of apoptosis","volume":"119","author":"Hall","year":"1992","journal-title":"J Cell Sci"},{"key":"10.1016\/S0002-9440(10)64764-5_bib43","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1083\/jcb.119.3.493","article-title":"Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation","volume":"119","author":"Gavrieli","year":"1992","journal-title":"J Cell Biol"},{"key":"10.1016\/S0002-9440(10)64764-5_bib44","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1136\/gut.37.6.819","article-title":"In situ detection of enterocytic apoptosis in normal colonic mucosa and in familial adenomatous polyposis","volume":"37","author":"Str\u00e4ter","year":"1995","journal-title":"Gut"},{"key":"10.1016\/S0002-9440(10)64764-5_bib45","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/(SICI)1096-9896(199610)180:2<152::AID-PATH649>3.0.CO;2-Y","article-title":"Apoptosis of crypt epithelial cells in ulcerative colitis","volume":"180","author":"Iwamoto","year":"1996","journal-title":"J Pathol"},{"key":"10.1016\/S0002-9440(10)64764-5_bib46","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S0016-5085(97)70091-X","article-title":"CD95 (APO-1\/Fas)-mediated apoptosis in colon epithelial cells: a possible role in ulcerative colitis","volume":"113","author":"Str\u00e4ter","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/S0002-9440(10)64764-5_bib47","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1083\/jcb.134.4.1089","article-title":"Early detachment of colon carcinoma cells during CD95(APO-1\/Fas)-mediated apoptosis. 1. De-adhesion from hyaluronate by shedding of CD44","volume":"134","author":"G\u00fcnthert","year":"1996","journal-title":"J Cell Biol"},{"key":"10.1016\/S0002-9440(10)64764-5_bib48","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/ijc.2910570314","article-title":"Expression of APO-1 (CD95), a member of the NGF\/TNF receptor superfamily, in normal and neoplastic colon epithelium","volume":"57","author":"M\u00f6ller","year":"1994","journal-title":"Int J Cancer"},{"key":"10.1016\/S0002-9440(10)64764-5_bib49","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/S0016-5085(96)70003-3","article-title":"Inward growth of colonic adenomatous polyps","volume":"111","author":"Moss","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/S0002-9440(10)64764-5_bib50","first-page":"1811","article-title":"Inhibition of apoptosis during development of colorectal cancer","volume":"55","author":"Bedi","year":"1995","journal-title":"Cancer Res"},{"key":"10.1016\/S0002-9440(10)64764-5_bib51","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s004280050076","article-title":"Proliferation and apoptosis in proliferative lesions of the colon and rectum","volume":"431","author":"Kikuchi","year":"1997","journal-title":"Virchows Arch"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010647645?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010647645?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T00:33:03Z","timestamp":1685925183000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944010647645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,2]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,2]]}},"alternative-id":["S0002944010647645"],"URL":"https:\/\/doi.org\/10.1016\/s0002-9440(10)64764-5","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2000,2]]}}}