{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:44:47Z","timestamp":1783633487724,"version":"3.55.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[1999,12,1]],"date-time":"1999-12-01T00:00:00Z","timestamp":944006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[1999,12]]},"DOI":"10.1016\/s0002-9440(10)65497-1","type":"journal-article","created":{"date-parts":[[2011,1,28]],"date-time":"2011-01-28T00:02:45Z","timestamp":1296172965000},"page":"1803-1809","source":"Crossref","is-referenced-by-count":61,"title":["Analysis of E-Cadherin in Diffuse-Type Gastric Cancer Using a Mutation-Specific Monoclonal Antibody"],"prefix":"10.1016","volume":"155","author":[{"given":"Karl-Friedrich","family":"Becker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Kremmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Eulitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Handschuh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Schuhmacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut E.","family":"Gabbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Ochiai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Setsuo","family":"Hirohashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"H\u00f6fler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/S0002-9440(10)65497-1_bib1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0955-0674(96)80110-4","article-title":"Cadherins and catenins in development","volume":"8","author":"Huber","year":"1996","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/S0002-9440(10)65497-1_bib2","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1126\/science.275.5307.1752","article-title":"\u03b2-catenin as oncogene: the smoking gun","volume":"275","author":"Peifer","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0002-9440(10)65497-1_bib3","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1126\/science.2006419","article-title":"Cadherin cell adhesion receptors as a morphogenetic regulator","volume":"251","author":"Takeichi","year":"1991","journal-title":"Science"},{"key":"10.1016\/S0002-9440(10)65497-1_bib4","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0002-9440(10)65575-7","article-title":"Inactivation of the E-cadherin-mediated cell adhesion system in human cancers","volume":"153","author":"Hirohashi","year":"1998","journal-title":"Am J Pathol"},{"key":"10.1016\/S0002-9440(10)65497-1_bib5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0304-419X(94)90003-5","article-title":"Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness","volume":"1198","author":"Birchmeier","year":"1994","journal-title":"Biochem Biophys Acta Rev Cancer"},{"key":"10.1016\/S0002-9440(10)65497-1_bib6","first-page":"2185","article-title":"Expression of E- and P-cadherin in gastric carcinomas","volume":"51","author":"Shimoyama","year":"1991","journal-title":"Cancer Res"},{"key":"10.1016\/S0002-9440(10)65497-1_bib7","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/BF00190559","article-title":"Immunohistochemical evaluation of \u03b1-catenin expression in human gastric cancer","volume":"424","author":"Matsui","year":"1994","journal-title":"Virchows Arch"},{"key":"10.1016\/S0002-9440(10)65497-1_bib8","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/(SICI)1097-0215(19960621)69:3<184::AID-IJC6>3.0.CO;2-W","article-title":"Prognostic value of E-cadherin expression in 413 gastric carcinomas","volume":"69","author":"Gabbert","year":"1996","journal-title":"Int J Cancer"},{"key":"10.1016\/S0002-9440(10)65497-1_bib9","first-page":"1690","article-title":"E-cadherin expression in primary and metastatic gastric cancer: down-regulation correlates with cellular dedifferentiation and glandular disintegration","volume":"53","author":"Mayer","year":"1993","journal-title":"Cancer Res"},{"key":"10.1016\/S0002-9440(10)65497-1_bib10","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1073\/pnas.91.5.1858","article-title":"E-cadherin gene mutations in human gastric carcinoma cell lines","volume":"91","author":"Oda","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0002-9440(10)65497-1_bib11","first-page":"3845","article-title":"E-cadherin gene mutations provide clues to diffuse type gastric carcinomas","volume":"54","author":"Becker","year":"1994","journal-title":"Cancer Res"},{"key":"10.1016\/S0002-9440(10)65497-1_bib12","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1111\/j.1349-7006.1996.tb03125.x","article-title":"Inactivation of the E-cadherin gene in primary gastric carcinomas and gastric carcinoma cell lines","volume":"87","author":"Tamura","year":"1996","journal-title":"Jpn J Cancer Res"},{"key":"10.1016\/S0002-9440(10)65497-1_bib13","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1111\/j.1349-7006.1996.tb02109.x","article-title":"E-cadherin gene mutations in signet ring cell carcinoma of the stomach","volume":"87","author":"Muta","year":"1996","journal-title":"Jpn J Cancer Res"},{"key":"10.1016\/S0002-9440(10)65497-1_bib14","first-page":"459","article-title":"E-cadherin gene mutations provide a genetic basis for the phenotypic divergence of mixed gastric carcinomas","volume":"79","author":"Machado","year":"1999","journal-title":"Lab Invest"},{"key":"10.1016\/S0002-9440(10)65497-1_bib15","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/(SICI)1098-1004(1998)12:4<226::AID-HUMU2>3.0.CO;2-D","article-title":"Mutations of the human E-cadherin (CDH1) gene","volume":"12","author":"Berx","year":"1998","journal-title":"Hum Mutat"},{"key":"10.1016\/S0002-9440(10)65497-1_bib16","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1083\/jcb.113.1.173","article-title":"E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells","volume":"113","author":"Frixen","year":"1991","journal-title":"J Cell Biol"},{"key":"10.1016\/S0002-9440(10)65497-1_bib17","first-page":"2128","article-title":"Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas","volume":"49","author":"Shimoyama","year":"1989","journal-title":"Cancer Res"},{"key":"10.1016\/S0002-9440(10)65497-1_bib18","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1006\/viro.1995.1157","article-title":"Rat monoclonal antibodies differentiating between the Epstein-Barr virus nuclear antigens 2A (EBNA2A) and 2B (EBNA2B)","volume":"208","author":"Kremmer","year":"1995","journal-title":"Virology"},{"key":"10.1016\/S0002-9440(10)65497-1_bib19","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1089\/hyb.1.1982.1.257","article-title":"Monoclonal antibodies specific for rat IgG1, IgG2a, and IgG2b subclasses, and kappa chain monotypic and allotypic determinants: reagents for use with rat monoclonal antibodies","volume":"1","author":"Springer","year":"1982","journal-title":"Hybridoma"},{"key":"10.1016\/S0002-9440(10)65497-1_bib20","doi-asserted-by":"crossref","first-page":"4301","DOI":"10.1038\/sj.onc.1202790","article-title":"Tumor-associated E-cadherin mutations alter cellular morphology, decrease cellular adhesion, and increase cellular motility","volume":"8","author":"Handschuh","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/S0002-9440(10)65497-1_bib21","doi-asserted-by":"crossref","first-page":"5787","DOI":"10.1073\/pnas.81.18.5787","article-title":"Linear organization of the liver cell adhesion molecule L-CAM","volume":"81","author":"Cunningham","year":"1984","journal-title":"Proc Acad Sci USA"},{"key":"10.1016\/S0002-9440(10)65497-1_bib22","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1177\/39.6.1709656","article-title":"Antigen retrieval in formalin-fixed, paraffin-embedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections","volume":"39","author":"Shi","year":"1991","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/S0002-9440(10)65497-1_bib23","doi-asserted-by":"crossref","first-page":"6107","DOI":"10.1002\/j.1460-2075.1995.tb00301.x","article-title":"E-cadherin is a tumour\/invasion suppressor gene mutated in human lobular breast cancers","volume":"14","author":"Berx","year":"1995","journal-title":"EMBO J"},{"key":"10.1016\/S0002-9440(10)65497-1_bib24","first-page":"1919","article-title":"E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain","volume":"13","author":"Berx","year":"1996","journal-title":"Oncogene"},{"key":"10.1016\/S0002-9440(10)65497-1_bib25","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1111\/j.1349-7006.1994.tb02902.x","article-title":"Point mutation of the E-cadherin gene in invasive lobular carcinoma of the breast","volume":"85","author":"Kanai","year":"1994","journal-title":"Jpn J Cancer Res"},{"key":"10.1016\/S0002-9440(10)65497-1_bib26","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/(SICI)1097-0215(19970106)70:1<32::AID-IJC5>3.0.CO;2-7","article-title":"E-cadherin gene alterations are rare events in thyroid tumors","volume":"70","author":"Soares","year":"1997","journal-title":"Int J Cancer"},{"key":"10.1016\/S0002-9440(10)65497-1_bib27","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/ng0594-98","article-title":"Mutations of the E-cadherin gene in human gynecologic cancers","volume":"7","author":"Risinger","year":"1994","journal-title":"Nat Genet"},{"key":"10.1016\/S0002-9440(10)65497-1_bib28","first-page":"1972","article-title":"Mechanisms of inactivation of E-cadherin in breast cancer cell lines","volume":"58","author":"Hiraguri","year":"1998","journal-title":"Cancer Res"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010654971?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010654971?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,8]],"date-time":"2019-06-08T01:15:56Z","timestamp":1559956556000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944010654971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,12]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1999,12]]}},"alternative-id":["S0002944010654971"],"URL":"https:\/\/doi.org\/10.1016\/s0002-9440(10)65497-1","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[1999,12]]}}}