{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T22:42:09Z","timestamp":1772750529113,"version":"3.50.1"},"reference-count":58,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":4214,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biophysical Journal"],"published-print":{"date-parts":[[2002,1]]},"DOI":"10.1016\/s0006-3495(02)75379-4","type":"journal-article","created":{"date-parts":[[2009,1,6]],"date-time":"2009-01-06T12:49:34Z","timestamp":1231246174000},"page":"120-132","source":"Crossref","is-referenced-by-count":128,"title":["Simulations of Cell-Surface Integrin Binding to Nanoscale-Clustered Adhesion Ligands"],"prefix":"10.1016","volume":"82","author":[{"given":"Darrell J.","family":"Irvine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerri-Ann","family":"Hue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne M.","family":"Mayes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda G.","family":"Griffith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0006-3495(02)75379-4_bib1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/PL00000864","article-title":"Cell-matrix contact structures","volume":"58","author":"Adams","year":"2001","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/S0006-3495(02)75379-4_bib2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0031-6997(24)01359-0","article-title":"Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobin-cell adhesion molecules, and cadherins","volume":"50","author":"Aplin","year":"1998","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/S0006-3495(02)75379-4_bib3","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1016\/S0021-9258(18)53809-6","article-title":"Cell- and heparin-binding domains of the hexabrachion arm identified by teascin expression proteins","volume":"268","author":"Aukhil","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0006-3495(02)75379-4_bib4","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/(SICI)1097-4636(20000605)50:3<331::AID-JBM6>3.0.CO;2-T","article-title":"Polymer latexes for controlling cell adhesion and receptor-mediated interactions","volume":"50","author":"Banerjee","year":"2000","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/S0006-3495(02)75379-4_bib5","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/S0006-3495(84)84252-6","article-title":"Cell adhesion: competition between nonspecific repulsion and specific binding","volume":"45","author":"Bell","year":"1984","journal-title":"Biophys. J."},{"key":"10.1016\/S0006-3495(02)75379-4_bib6","series-title":"Monte Carlo Simulations in Statistical Physics: An Introduction","author":"Binder","year":"1997"},{"key":"10.1016\/S0006-3495(02)75379-4_bib7","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1146\/annurev.cellbio.12.1.463","article-title":"Focal adhesions, contractility, and signaling","volume":"12","author":"Burridge","year":"1996","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/S0006-3495(02)75379-4_bib8","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/S0006-3495(98)74074-3","article-title":"Measuring two-dimensional receptor-ligand binding kinetics by micropipette","volume":"75","author":"Chesla","year":"1998","journal-title":"Biophys. J."},{"key":"10.1016\/S0006-3495(02)75379-4_bib9","doi-asserted-by":"crossref","first-page":"31447","DOI":"10.1074\/jbc.272.50.31447","article-title":"Fibronectin type III repeats mediate RGD-independent adhesion and signaling through activated \u03b21 integrins","volume":"272","author":"Chi-Rosso","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0006-3495(02)75379-4_bib10","doi-asserted-by":"crossref","first-page":"10622","DOI":"10.1021\/ja00148a003","article-title":"Molecular origins of the slow streptavidin-biotin dissociation kinetics","volume":"117","author":"Chilkoti","year":"1995","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/S0006-3495(02)75379-4_bib11","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1146\/annurev.biochem.66.1.823","article-title":"The molecular structure of cell adhesion molecules","volume":"66","author":"Chothia","year":"1997","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/S0006-3495(02)75379-4_bib12","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1126\/science.7716514","article-title":"Integrins and signal transduction pathways: the road taken","volume":"1995","author":"Clark","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0006-3495(02)75379-4_bib13","doi-asserted-by":"crossref","first-page":"21612","DOI":"10.1074\/jbc.270.37.21612","article-title":"Requirement for the synergy site for cell adhesion to fibronectin depends on the activation state of integrin \u03b15\u03b21","volume":"270","author":"Danen","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0006-3495(02)75379-4_bib14","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/0014-4827(89)90290-5","article-title":"(Arg-Gly-Asp)N-albumin conjugates as model substratum for integrin-mediated cell-adhesion","volume":"182","author":"Danilov","year":"1989","journal-title":"Exp. Cell. Res."},{"key":"10.1016\/S0006-3495(02)75379-4_bib15","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1046\/j.1365-2133.2000.03262.x","article-title":"Dexamethasone-induced healing of chronic leg ulcers in a patient with defective organization of the extracellular matrix of fibronectin","volume":"142","author":"de Panfilis","year":"2000","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/S0006-3495(02)75379-4_bib16","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1098\/rspb.1988.0038","article-title":"The reaction-limited kinetics of membrane-to-surface detachment","volume":"234","author":"Dembo","year":"1988","journal-title":"Proc. R. Soc. Lond. B."},{"key":"10.1016\/S0006-3495(02)75379-4_bib17","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1083\/jcb.107.4.1385","article-title":"Fibronectin receptor exhibits high lateral mobility in embryonic locomoting cells but is immobile in focal contacts and fibrillar streaks in stationary cells","volume":"107","author":"Duband","year":"1988","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0006-3495(02)75379-4_bib18","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.1103\/PhysRevLett.79.3018","article-title":"Observed substrate topography-mediated lateral patterning of diblock copolymer films","volume":"79","author":"Fasolka","year":"1997","journal-title":"Phys. Rev. Lett."},{"key":"10.1016\/S0006-3495(02)75379-4_bib19","doi-asserted-by":"crossref","first-page":"17106","DOI":"10.1016\/S0021-9258(19)47346-8","article-title":"Monoclonal antibodies to ligand-occupied conformers of integrin \u03b1IIb\u03b23 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function","volume":"266","author":"Frelinger","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0006-3495(02)75379-4_bib20","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s000180050498","article-title":"The biology of cell locomotion with three-dimensional extracellular matrix","volume":"57","author":"Friedl","year":"2000","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/S0006-3495(02)75379-4_bib21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s000180050498","article-title":"The biology of cell locomotion within three-dimensional extracellular matrix","volume":"57","author":"Friedl","year":"2000","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/S0006-3495(02)75379-4_bib22","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/0955-0674(92)90099-X","article-title":"Inside-out integrin signalling","volume":"4","author":"Ginsberg","year":"1992","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/S0006-3495(02)75379-4_bib23","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1083\/jcb.141.7.1685","article-title":"Complementary roles for receptor clustering and conformational change in the adhesive and signaling functions of integrin \u03b1IIb\u03b23","volume":"141","author":"Hato","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0006-3495(02)75379-4_bib24","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1083\/jcb.134.6.1551","article-title":"Modulation of cell migration by integrin-mediated cytoskeletal linkages and ligand-binding affinity","volume":"134","author":"Huttenlocher","year":"1996","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0006-3495(02)75379-4_bib25","doi-asserted-by":"crossref","first-page":"M33","DOI":"10.1016\/S0962-8924(99)01667-0","article-title":"Cell adhesion: old and new questions","volume":"24","author":"Hynes","year":"1999","journal-title":"Trends Cell. Biol."},{"key":"10.1016\/S0006-3495(02)75379-4_bib26","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1083\/jcb.95.2.369","article-title":"Fibronectins: multifunctional modular glycoproteins","volume":"95","author":"Hynes","year":"1982","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0006-3495(02)75379-4_bib27","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1021\/bm005584b","article-title":"Nanoscale clustering of RGD peptides at polymer surfaces using comb polymers. I. Synthesis and characterization of comb thin films","volume":"2","author":"Irvine","year":"2001","journal-title":"Biomacromolecules"},{"key":"10.1016\/S0006-3495(02)75379-4_bib28","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/S0960-9822(00)00486-3","article-title":"Visualizing muscle cell migration in situ","volume":"10","author":"Knight","year":"2000","journal-title":"Curr. Biol."},{"key":"10.1016\/S0006-3495(02)75379-4_bib29","doi-asserted-by":"crossref","first-page":"8392","DOI":"10.1073\/pnas.88.19.8392","article-title":"Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta-1 integrins","volume":"88","author":"Kornberg","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/S0006-3495(02)75379-4_bib30","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1083\/jcb.117.2.437","article-title":"Regulation of fibronectin receptor distribution","volume":"117","author":"LaFlamme","year":"1992","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0006-3495(02)75379-4_bib31","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0092-8674(00)81280-5","article-title":"Cell migration: a physically integrated molecular process","volume":"84","author":"Lauffenburger","year":"1996","journal-title":"Cell."},{"key":"10.1016\/S0006-3495(02)75379-4_bib32","series-title":"Receptors: Models for Binding, Trafficking, and Signaling","author":"Lauffenburger","year":"1993"},{"key":"10.1016\/S0006-3495(02)75379-4_bib33","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1083\/jcb.109.4.1795","article-title":"Cell adhesion to fibronectin and tenascin: quantitative measurements of initial binding and subsequent strengthening response","volume":"109","author":"Lotz","year":"1989","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0006-3495(02)75379-4_bib34","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1242\/jcs.113.10.1677","article-title":"Cell adhesion and motility depend on nanoscale RGD clustering","volume":"113","author":"Maheshwari","year":"2000","journal-title":"J. Cell Sci."},{"key":"10.1016\/S0006-3495(02)75379-4_bib35","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1083\/jcb.114.5.1089","article-title":"An RGD spacing of 440nm is sufficient for integrin alpha V beta 3-mediated fibroblast spreading and 140nm for focal contact and stress fiber formation","volume":"114","author":"Massia","year":"1991","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0006-3495(02)75379-4_bib36","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1063\/1.1699114","article-title":"Equations of state calculations by fast computing machines","volume":"21","author":"Metropolis","year":"1953","journal-title":"J. Chem. Phys."},{"key":"10.1016\/S0006-3495(02)75379-4_bib37","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1126\/science.7846531","article-title":"Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function","volume":"267","author":"Miyamoto","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0006-3495(02)75379-4_bib38","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1083\/jcb.131.3.791","article-title":"Integrin function: molecular hierarchies of cytoskeletal and signaling molecules","volume":"131","author":"Miyamoto","year":"1995","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0006-3495(02)75379-4_bib39","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1083\/jcb.135.6.1633","article-title":"Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors","volume":"135","author":"Miyamoto","year":"1996","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0006-3495(02)75379-4_bib40","doi-asserted-by":"crossref","first-page":"32491","DOI":"10.1074\/jbc.273.49.32491","article-title":"Cell binding sequences in the mouse laminin \u03b11 chain","volume":"273","author":"Nomizu","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0006-3495(02)75379-4_bib41","doi-asserted-by":"crossref","first-page":"11805","DOI":"10.1074\/jbc.272.18.11805","article-title":"Multimerization of the cytoplasmic domain of syndecan-4 is required for its ability to activate protein kinase C","volume":"272","author":"Oh","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0006-3495(02)75379-4_bib42","doi-asserted-by":"crossref","first-page":"13661","DOI":"10.1073\/pnas.94.25.13661","article-title":"Cell locomotion and focal adhesions are regulated by substrate flexibility","volume":"94","author":"Pelham","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/S0006-3495(02)75379-4_bib43","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/S0006-3495(98)77807-5","article-title":"Determining force dependence of two-dimensional receptor-ligand binding affinity by centrifugation","volume":"74","author":"Piper","year":"1998","journal-title":"Biophys. J."},{"key":"10.1016\/S0006-3495(02)75379-4_bib44","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1146\/annurev.cellbio.12.1.697","article-title":"RGD and other recognition sequences for integrins","volume":"12","author":"Ruoslahti","year":"1996","journal-title":"Annu. Rev. Cell. Dev. Biol."},{"key":"10.1016\/S0006-3495(02)75379-4_bib45","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1083\/jcb.123.4.977","article-title":"Integrin-cytoskeletal interactions in migrating fibroblasts are dynamic, asymmetric, and regulated","volume":"123","author":"Schmidt","year":"1993","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0006-3495(02)75379-4_bib46","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/BF02796136","article-title":"On spatial periodicity in the formation of cell adhesions to a substrate","volume":"5","author":"Segel","year":"1983","journal-title":"Cell Biophys."},{"key":"10.1016\/S0006-3495(02)75379-4_bib47","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1083\/jcb.110.6.2167","article-title":"The activation-dependent adhesion of macrophages to laminin involves cytoskeletal anchoring and phosphorylation of the \u03b16\u03b21 integrin","volume":"110","author":"Shaw","year":"1990","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0006-3495(02)75379-4_bib48","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0092-8674(89)90294-8","article-title":"Two contrary functions of tenascin: dissection of the active sites by recombinant tenascin fragments","volume":"59","author":"Spring","year":"1989","journal-title":"Cell"},{"key":"10.1016\/S0006-3495(02)75379-4_bib49","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/S0006-3495(93)81456-5","article-title":"A theoretical analysis for the effect of focal contact formation on cell-substrate adhesion strength","volume":"64","author":"Ward","year":"1993","journal-title":"Biophys. J."},{"key":"10.1016\/S0006-3495(02)75379-4_bib50","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/BF00163022","article-title":"Focal contact assembly through cytoskeletal polymerization: steady state analysis","volume":"32","author":"Ward","year":"1994","journal-title":"J. Math. Biol."},{"key":"10.1016\/S0006-3495(02)75379-4_bib51","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0092-8674(00)81604-9","article-title":"A requirement for calveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth","volume":"94","author":"Wary","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0006-3495(02)75379-4_bib52","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1126\/science.2911722","article-title":"Structural origins of the high-affinity biotin binding to streptavidin","volume":"243","author":"Weber","year":"1989","journal-title":"Science"},{"key":"10.1016\/S0006-3495(02)75379-4_bib53","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1083\/jcb.144.6.1285","article-title":"A role for caveolin and the urokinase receptor in integrin-mediated adhesion and signaling","volume":"144","author":"Wei","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0006-3495(02)75379-4_bib54","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1016\/S0006-3495(96)79484-5","article-title":"Effect of receptor-ligand affinity on the strength of endothelial cell adhesion","volume":"71","author":"Xiao","year":"1996","journal-title":"Biophys. J."},{"key":"10.1016\/S0006-3495(02)75379-4_bib55","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1242\/jcs.111.5.615","article-title":"EGF receptor regulation of motility: EGF induces disassembly of focal adhesions independently of the motility-associated PLCg signaling pathway","volume":"111","author":"Xie","year":"1998","journal-title":"J. Cell Sci."},{"key":"10.1016\/S0006-3495(02)75379-4_bib56","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1101\/SQB.1992.057.01.025","article-title":"Mechanisms of fibronectin and integrin function during cell adhesion and migration","volume":"57","author":"Yamada","year":"1992","journal-title":"Cold Spring Harbor Symp. Quant. Biol."},{"key":"10.1016\/S0006-3495(02)75379-4_bib57","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1084\/jem.186.8.1347","article-title":"Mutational evidence for control of cell adhesion through integrin diffusion\/clustering, independent of ligand binding","volume":"186","author":"Yauch","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0006-3495(02)75379-4_bib58","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1242\/jcs.112.11.1655","article-title":"Molecular diversity of cell-matrix interactions","volume":"112","author":"Zamir","year":"1999","journal-title":"J. Cell Sci."}],"container-title":["Biophysical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006349502753794?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006349502753794?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T19:49:12Z","timestamp":1738871352000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006349502753794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["S0006349502753794"],"URL":"https:\/\/doi.org\/10.1016\/s0006-3495(02)75379-4","relation":{},"ISSN":["0006-3495"],"issn-type":[{"value":"0006-3495","type":"print"}],"subject":[],"published":{"date-parts":[[2002,1]]}}}