{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T07:19:25Z","timestamp":1775114365807,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[1999,11,1]],"date-time":"1999-11-01T00:00:00Z","timestamp":941414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,17]],"date-time":"2013-08-17T00:00:00Z","timestamp":1376697600000},"content-version":"vor","delay-in-days":5038,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biophysical Journal"],"published-print":{"date-parts":[[1999,11]]},"DOI":"10.1016\/s0006-3495(99)77079-7","type":"journal-article","created":{"date-parts":[[2009,1,6]],"date-time":"2009-01-06T12:16:48Z","timestamp":1231244208000},"page":"2418-2429","source":"Crossref","is-referenced-by-count":78,"title":["Properties of a Model of Ca++-Dependent Vesicle Pool Dynamics and Short Term Synaptic Depression"],"prefix":"10.1016","volume":"77","author":[{"given":"Sibylle","family":"Weis","sequence":"first","affiliation":[]},{"given":"Ralf","family":"Schneggenburger","sequence":"additional","affiliation":[]},{"given":"Erwin","family":"Neher","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0006-3495(99)77079-7_bib1","doi-asserted-by":"crossref","first-page":"5661","DOI":"10.1523\/JNEUROSCI.16-18-05661.1996","article-title":"Determinants of the time course of facilitation at the granule cell to purkinje cell synapse","volume":"16","author":"Atluri","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/S0006-3495(99)77079-7_bib2","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1113\/jphysiol.1970.sp009034","article-title":"Depression of transmitter release at the neuromuscular junction of the frog","volume":"206","author":"Betz","year":"1970","journal-title":"J. Physiol."},{"key":"10.1016\/S0006-3495(99)77079-7_bib3","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1113\/jphysiol.1995.sp021095","article-title":"Pre- and postsynaptic whole-cell recordings in the medial nucleus of the trapezoid body of the rat","volume":"489","author":"Borst","year":"1995","journal-title":"J. Physiol."},{"key":"10.1016\/S0006-3495(99)77079-7_bib4","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/383431a0","article-title":"Calcium influx and transmitter release in a fast CNS synapse","volume":"383","author":"Borst","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0006-3495(99)77079-7_bib5","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1098\/rstb.1999.0386","article-title":"Effect of changes in action potential shape on calcium currents and transmitter release in a calyx-type synapse of the rat auditory brainstem","volume":"354","author":"Borst","year":"1999","journal-title":"Phil. Trans. R. Soc. Lond. B"},{"key":"10.1016\/S0006-3495(99)77079-7_bib6","series-title":"Taschenbuch der Mathematik","author":"Bronstein","year":"1991"},{"key":"10.1016\/S0006-3495(99)77079-7_bib7","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/S0006-3495(84)84244-7","article-title":"Calcium domains associated with individual channels can account for anomalous voltage relations of Ca-dependent responses","volume":"45","author":"Chad","year":"1984","journal-title":"Biophys. J."},{"key":"10.1016\/S0006-3495(99)77079-7_bib8","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1113\/jphysiol.1982.sp014067","article-title":"Role of presynaptic calcium ions and channels in synaptic facilitation and depression at the squid giant synapse","volume":"323","author":"Charlton","year":"1982","journal-title":"J. Physiol."},{"key":"10.1016\/S0006-3495(99)77079-7_bib9","doi-asserted-by":"crossref","first-page":"5885","DOI":"10.1523\/JNEUROSCI.14-10-05885.1994","article-title":"A quantitative measurement of the dependence of short-term synaptic enhancement on presynaptic residual calcium","volume":"14","author":"Delaney","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1016\/S0006-3495(99)77079-7_bib10","doi-asserted-by":"crossref","first-page":"6147","DOI":"10.1523\/JNEUROSCI.18-16-06147.1998","article-title":"Calcium-dependence and recovery kinetics of presynaptic depression at the climbing fiber to Purkinje cell synapse","volume":"18","author":"Dittman","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/S0006-3495(99)77079-7_bib11","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1113\/jphysiol.1965.sp007639","article-title":"A quantitative study of end-plate potentials in isolated human muscle","volume":"178","author":"Elmquist","year":"1965","journal-title":"J. Physiol."},{"key":"10.1016\/S0006-3495(99)77079-7_bib12","first-page":"170","article-title":"Multiple overlapping processes underlying short-term synaptic enhancement","volume":"20","author":"Fisher","year":"1997","journal-title":"TINS"},{"key":"10.1016\/S0006-3495(99)77079-7_bib13","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1113\/jphysiol.1994.sp020303","article-title":"Direct patch recording from identified presynaptic terminals mediating glutamatergic EPSCs in the rat CNS, in vitro","volume":"479","author":"Forsythe","year":"1994","journal-title":"J. Physiol."},{"key":"10.1016\/S0006-3495(99)77079-7_bib14","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1152\/jn.1985.53.3.652","article-title":"Simulation of synaptic depression, posttetanic potentiation, and presynaptic facilitation of synaptic potentials from sensory neurons mediating Gill-withdrawal reflex in Aplysia","volume":"53","author":"Gingrich","year":"1985","journal-title":"J. Neurophys."},{"key":"10.1016\/S0006-3495(99)77079-7_bib15","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","article-title":"A new generation of Ca2+ indicators with greatly improved fluorescence properties","volume":"260","author":"Grynkiewicz","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0006-3495(99)77079-7_bib16","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/371513a0","article-title":"Calcium dependence of the rate of exocytosis in a synaptic terminal","volume":"371","author":"Heidelberger","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0006-3495(99)77079-7_bib17","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF00374600","article-title":"A two-step model of secretion control in neuroendocrine cells","volume":"424","author":"Heinemann","year":"1993","journal-title":"Pfl\u00fcgers Arch."},{"key":"10.1016\/S0006-3495(99)77079-7_bib18","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/S0006-3495(97)78792-7","article-title":"Calcium dynamics associated with a single action potential in a CNS presynaptic terminal","volume":"72","author":"Helmchen","year":"1997","journal-title":"Biophys. J."},{"key":"10.1016\/S0006-3495(99)77079-7_bib19","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/371603a0","article-title":"Residual Ca2+ and short-term synaptic plasticity","volume":"371","author":"Kamiya","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0006-3495(99)77079-7_bib20","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1113\/jphysiol.1968.sp008469","article-title":"The role of calcium in neuromuscular facilitation","volume":"195","author":"Katz","year":"1968","journal-title":"J. Physiol."},{"key":"10.1016\/S0006-3495(99)77079-7_bib21","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1113\/jphysiol.1975.sp010832","article-title":"Depression and recovery of transmission at the squid giant synapse","volume":"245","author":"Kusano","year":"1975","journal-title":"J. Physiol."},{"key":"10.1016\/S0006-3495(99)77079-7_bib22","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1152\/jn.1953.16.5.509","article-title":"An electrical investigation of effects of repetitive stimulation on mammalian neuromuscular junction","volume":"16","author":"Liley","year":"1953","journal-title":"J. Neurophys."},{"key":"10.1016\/S0006-3495(99)77079-7_bib23","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1073\/pnas.79.7.2415","article-title":"Transmission by presynaptic spike-like depolarization in the squid giant synapse","volume":"79","author":"Llin\u00e1s","year":"1982","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0006-3495(99)77079-7_bib24","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/0028-3908(95)00150-5","article-title":"The concept of calcium concentration microdomains in synaptic transmission","volume":"34","author":"Llin\u00e1s","year":"1995","journal-title":"Neuropharmacology"},{"key":"10.1016\/S0006-3495(99)77079-7_bib25","doi-asserted-by":"crossref","first-page":"6961","DOI":"10.1523\/JNEUROSCI.17-18-06961.1997","article-title":"Linearized buffered Ca2+ diffusion in microdomains and its implications for calculation of [Ca2+] at the mouth of a calcium channel","volume":"17","author":"Naraghi","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/S0006-3495(99)77079-7_bib26","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1113\/jphysiol.1992.sp019127","article-title":"Calcium gradients and buffers in bovine chromaffin cells","volume":"450","author":"Neher","year":"1992","journal-title":"J. Physiol."},{"key":"10.1016\/S0006-3495(99)77079-7_bib27","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0896-6273(00)80983-6","article-title":"Vesicle pools and Ca2+-microdomains: new tools for understanding their roles in neurotransmitter release","volume":"20","author":"Neher","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/S0006-3495(99)77079-7_bib28","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0143-4160(98)90058-6","article-title":"Usefulness and limitations of linear approximations to the understanding of Ca++ signals","volume":"24","author":"Neher","year":"1998","journal-title":"Cell Calcium"},{"key":"10.1016\/S0006-3495(99)77079-7_bib29","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/S0006-3495(97)78709-5","article-title":"The binomial model in fluctuation analysis of quantal neurotransmitter release","volume":"72","author":"Quastel","year":"1997","journal-title":"Biophys. J."},{"key":"10.1016\/S0006-3495(99)77079-7_bib30","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1113\/jphysiol.1968.sp008468","article-title":"A dual effect of calcium ions on neuromuscular facilitation","volume":"195","author":"Rahamimoff","year":"1968","journal-title":"J. Physiol."},{"key":"10.1016\/S0006-3495(99)77079-7_bib31","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1523\/JNEUROSCI.14-02-00523.1994","article-title":"The role of presynaptic calcium in short-term enhancement at the hippocampal mossy fiber synapse","volume":"14","author":"Regehr","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1016\/S0006-3495(99)77079-7_bib32","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.1523\/JNEUROSCI.14-05-03246.1994","article-title":"Localization of calcium signals by a mobile calcium buffer in frog saccular hair cells","volume":"14","author":"Roberts","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1016\/S0006-3495(99)77079-7_bib33","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0896-6273(00)80789-8","article-title":"Released fraction and total size of a pool of immediately available transmitter quanta at a calyx synapse","volume":"23","author":"Schneggenburger","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/S0006-3495(99)77079-7_bib34","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0006-3495(85)83804-2","article-title":"Compartmentalization of the submembrane calcium activity during calcium influx and its significance in transmitter release","volume":"48","author":"Simon","year":"1985","journal-title":"Biophys. J."},{"key":"10.1016\/S0006-3495(99)77079-7_bib35","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/S0896-6273(00)80504-8","article-title":"Cytosolic Ca2+ acts by two separate pathways to modulate the supply of release-competent vesicles in chromaffin cells","volume":"20","author":"Smith","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/S0006-3495(99)77079-7_bib36","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0896-6273(00)80550-4","article-title":"Activity-dependent modulation of the rate at which synaptic vesicles become available to undergo exocytosis","volume":"21","author":"Stevens","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/S0006-3495(99)77079-7_bib37","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/0896-6273(91)90337-Y","article-title":"Role of residual calcium in synaptic depression and posttetanic potentiation: fast and slow calcium signaling in nerve terminals","volume":"7","author":"Swandulla","year":"1991","journal-title":"Neuron"},{"key":"10.1016\/S0006-3495(99)77079-7_bib38","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1073\/pnas.94.2.719","article-title":"The neural code between neocortical pyramidal neurons depends on neurotransmitter release probability","volume":"94","author":"Tsodyks","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0006-3495(99)77079-7_bib39","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1467-842X.1966.tb00164.x","article-title":"Simple stochastic models for the release of quanta of transmitter from a nerve terminal","volume":"8","author":"Vere-Jones","year":"1966","journal-title":"Aust. J. Statist."},{"key":"10.1016\/S0006-3495(99)77079-7_bib40","doi-asserted-by":"crossref","first-page":"8137","DOI":"10.1523\/JNEUROSCI.17-21-08137.1997","article-title":"Presynaptic depression at a calyx synapse: the small contribution of metabotropic glutamate receptors","volume":"17","author":"Gersdorff","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/S0006-3495(99)77079-7_bib41","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/28645","article-title":"High-frequency firing helps replenish the readily releasable pool of synaptic vesicles","volume":"394","author":"Wang","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S0006-3495(99)77079-7_bib42","series-title":"Mechanismen der Kurzzeitplastizit\u00e4t an neuronalen Synapsen. Ph.D. thesis","author":"Weis","year":"1998"},{"key":"10.1016\/S0006-3495(99)77079-7_bib43","doi-asserted-by":"crossref","unstructured":"Wu, L. G., and J. G. G. Borst. 1999. The reduced release probability of releasable vesicles during recovery from short-term synaptic depression. Neuron. (In press).","DOI":"10.1016\/S0896-6273(01)80039-8"},{"key":"10.1016\/S0006-3495(99)77079-7_bib44","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1152\/jn.1997.78.1.417","article-title":"Facilitation at the lobster neuromuscular junction: a stimulus-dependent mobilization model","volume":"78","author":"Worden","year":"1997","journal-title":"J. Neurophys."},{"key":"10.1016\/S0006-3495(99)77079-7_bib45","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0006-3495(92)81872-6","article-title":"Time course of transmitter release calculated from simulations of a calcium diffusion model","volume":"61","author":"Yamada","year":"1992","journal-title":"Biophys. J."},{"key":"10.1016\/S0006-3495(99)77079-7_bib46","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1113\/jphysiol.1974.sp010642","article-title":"Characteristics of crayfish neuromuscular facilitation and their calcium dependence","volume":"241","author":"Zucker","year":"1974","journal-title":"J. Physiol."},{"key":"10.1016\/S0006-3495(99)77079-7_bib47","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/S0896-6273(00)80238-X","article-title":"Exocytosis: A molecular and physiological perspective","volume":"17","author":"Zucker","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/S0006-3495(99)77079-7_bib48","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0959-4388(99)80045-2","article-title":"Calcium- and activity-dependent synaptic plasticity","volume":"9","author":"Zucker","year":"1999","journal-title":"Curr. Op. Neurobiol."}],"container-title":["Biophysical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006349599770797?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006349599770797?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T11:10:34Z","timestamp":1632913834000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006349599770797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,11]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1999,11]]}},"alternative-id":["S0006349599770797"],"URL":"https:\/\/doi.org\/10.1016\/s0006-3495(99)77079-7","relation":{},"ISSN":["0006-3495"],"issn-type":[{"value":"0006-3495","type":"print"}],"subject":[],"published":{"date-parts":[[1999,11]]}}}