{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:46:56Z","timestamp":1777445216630,"version":"3.51.4"},"reference-count":40,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[1998,4,1]],"date-time":"1998-04-01T00:00:00Z","timestamp":891388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[1998,4]]},"DOI":"10.1016\/s0006-8993(98)00085-7","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T22:02:28Z","timestamp":1027634548000},"page":"108-116","source":"Crossref","is-referenced-by-count":78,"title":["The effects of neurosteroids on acquisition and retention of a modified passive-avoidance learning task in mice"],"prefix":"10.1016","volume":"791","author":[{"given":"D.S.","family":"Reddy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.K.","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0006-8993(98)00085-7_BIB1","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1016\/0014-2999(94)90453-7","article-title":"NE-100, a novel potent \u03c3 ligand, preferentially binds to \u03c31 binding sites in guinea pig brain","volume":"251","author":"Chaki","year":"1994","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/S0006-8993(98)00085-7_BIB2","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/0960-0760(94)90284-4","article-title":"The pharmacology of neurosteroidogenesis","volume":"49","author":"Costa","year":"1994","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/S0006-8993(98)00085-7_BIB3","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1037\/0735-7044.111.3.512","volume":"111","author":"Fleshner","year":"1997","journal-title":"Behav. Neurosci."},{"key":"10.1016\/S0006-8993(98)00085-7_BIB4","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1073\/pnas.89.5.1567","article-title":"Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it","volume":"89","author":"Flood","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/S0006-8993(98)00085-7_BIB5","doi-asserted-by":"crossref","first-page":"10806","DOI":"10.1073\/pnas.92.23.10806","article-title":"Pregnenolone sulfate enhances posttraining memory processes when injected in very low doses into limbic system structures: The amygdala is by far the most sensitive","volume":"92","author":"Flood","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/S0006-8993(98)00085-7_BIB6","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/0006-8993(88)91116-X","article-title":"Dehydroepiandrosterone sulfate improves memory in aging mice","volume":"448","author":"Flood","year":"1988","journal-title":"Brain Res."},{"key":"10.1016\/S0006-8993(98)00085-7_BIB7","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1006\/nlme.1995.1046","article-title":"Neurosteroids affect spatial\/reference, working, and long-term memory of female rats","volume":"64","author":"Frye","year":"1995","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/S0006-8993(98)00085-7_BIB8","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/0006-8993(90)91143-5","article-title":"A sigma-like binding site in rat pheochromocytoma (PC12) cells: decreased affinity for (+)-benzomorphans and lower molecular weight suggest a different sigma receptor form from that of guinea pig brain","volume":"527","author":"Hellewell","year":"1990","journal-title":"Brain Res."},{"key":"10.1016\/S0006-8993(98)00085-7_BIB9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0091-3057(88)90431-5","article-title":"Opposite effects induced by low and high doses of apomorphine on single-trial passive-avoidance learning in mice","volume":"30","author":"Ichihara","year":"1988","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/S0006-8993(98)00085-7_BIB10","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0014-2999(92)90688-Z","article-title":"Effects of dopamine receptor agonists on passive-avoidance learning in mice: interaction of dopamine D1 and D2 receptors","volume":"213","author":"Ichihara","year":"1992","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/S0006-8993(98)00085-7_BIB11","first-page":"677","article-title":"Steroid potentiation and inhibition of N-methyl-d-aspartate receptor-mediated intracellular Ca2+ responses: structure-activity studies","volume":"271","author":"Irwin","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/S0006-8993(98)00085-7_BIB12","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0006-8993(95)00493-A","article-title":"The effects of pregnenolone sulfate and ethylestrenol on retention of a passive-avoidance task","volume":"689","author":"Isaacson","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/S0006-8993(98)00085-7_BIB13","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1096\/fasebj.3.7.2541039","article-title":"Differential regulation of \u03c3 and PCP receptors after chronic administration of haloperidol and phencyclidine in mice","volume":"3","author":"Itzhak","year":"1989","journal-title":"FASEB J."},{"key":"10.1016\/S0006-8993(98)00085-7_BIB14","first-page":"433","article-title":"Neurosteroids: A new class of neuromodulators","volume":"31","author":"Kulkarni","year":"1995","journal-title":"Drugs Today"},{"key":"10.1016\/S0006-8993(98)00085-7_BIB15","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0926-6410(95)90016-0","article-title":"Reversal of scopolamine induced amnesia in rats by the steroid sulfatase inhibitor estrone-3-O-sulfamate","volume":"2","author":"Li","year":"1995","journal-title":"Cogn. Brain. Res."},{"key":"10.1016\/S0006-8993(98)00085-7_BIB16","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0301-0082(92)90025-A","article-title":"Neurosteroids: Endogenous bimodal modulators of the GABA-A receptor. Mechanism of action and physiological significance","volume":"38","author":"Majewska","year":"1992","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/S0006-8993(98)00085-7_BIB17","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/BF02245063","article-title":"The neurosteroid pregnenolone sulfate blocks NMDA antagonist-induced deficits in a passive-avoidance memory task","volume":"11","author":"Mathis","year":"1994","journal-title":"Psychopharmacology"},{"key":"10.1016\/S0006-8993(98)00085-7_BIB18","first-page":"851","article-title":"Increase in extracellular acetylcholine level by sigma ligands in rat frontal cortex","volume":"265","author":"Matsuno","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/S0006-8993(98)00085-7_BIB19","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0166-4328(97)86061-5","article-title":"Dehydroepiandrosterone sulfate attenuates dizocilpine-induced learning impairment in mice via \u03c31-receptors","volume":"83","author":"Maurice","year":"1997","journal-title":"Behav. Brain Res."},{"key":"10.1016\/S0006-8993(98)00085-7_BIB20","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0278-5846(96)00160-1","article-title":"Neuroprotective and anti-amnesic potentials of sigma (\u03c3) receptor ligands","volume":"21","author":"Maurice","year":"1997","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/S0006-8993(98)00085-7_BIB21","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1002\/(SICI)1097-4547(19961215)46:6<734::AID-JNR10>3.0.CO;2-U","article-title":"Modulation by neurosteroids of the in vivo (+)-[3H]SKF-10,047 binding to \u03c31 receptors in the mouse forebrain","volume":"46","author":"Maurice","year":"1996","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/S0006-8993(98)00085-7_BIB22","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/0006-8993(93)91524-V","article-title":"Infusion of neurosteroids into the nucleus basalis magnocellularis affects cognitive processes in the rat","volume":"607","author":"Mayo","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/S0006-8993(98)00085-7_BIB23","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1037\/0003-066X.38.2.161","article-title":"Preserving the presence of the past: Hormonal influences on memory storage","volume":"38","author":"McGough","year":"1983","journal-title":"Am. Psychologist"},{"key":"10.1016\/S0006-8993(98)00085-7_BIB24","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0006-8993(91)90866-T","article-title":"How long does `memory consolidation' take? New compounds can improve retention performance, even if administered upto 24 hours after the learning experience","volume":"555","author":"Mondadori","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/S0006-8993(98)00085-7_BIB25","doi-asserted-by":"crossref","first-page":"3774","DOI":"10.1073\/pnas.92.9.3774","article-title":"Neurosteroids, via \u03c3 receptors, modulate the [3H]norepinephrine release evoked by N-methyl-d-aspartate in the rat hippocampus","volume":"92","author":"Monnet","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/S0006-8993(98)00085-7_BIB26","first-page":"208","article-title":"Assessment of nootropic and amnestic activity of centrally acting agents","volume":"29","author":"Reddy","year":"1997","journal-title":"Indian J. Pharmacol."},{"key":"10.1016\/S0006-8993(98)00085-7_BIB27","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/s002130050136","article-title":"Role of GABA-A and mitochondrial diazepam binding inhibitor receptors in the antistress activity of neurosteroids in mice","volume":"128","author":"Reddy","year":"1996","journal-title":"Psychopharmacology"},{"key":"10.1016\/S0006-8993(98)00085-7_BIB28","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0006-8993(96)01447-3","article-title":"Differential anxiolytic effects of neurosteroids in the mirrored chamber behavior test in mice","volume":"752","author":"Reddy","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/S0006-8993(98)00085-7_BIB29","first-page":"395","article-title":"Neurosteroid coadministration prevents development of tolerance and augments recovery from benzodiazepine withdrawal anxiety and hyperactivity in mice","volume":"19","author":"Reddy","year":"1997","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"10.1016\/S0006-8993(98)00085-7_BIB30","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0014-2999(97)01294-6","article-title":"Chronic neurosteroid treatment prevents development of morphine tolerance and attenuates abstinence behavior in mice","volume":"337","author":"Reddy","year":"1997","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/S0006-8993(98)00085-7_BIB31","first-page":"381","article-title":"Neuroprotective effects of neurosteroids against hypoxic stress-induced neurotoxicity in naive and FG 7142-treated mice","volume":"29","author":"Reddy","year":"1997","journal-title":"Indian J. Pharmacol."},{"key":"10.1016\/S0006-8993(98)00085-7_BIB32","unstructured":"D.S. Reddy, S.K. Kulkarni, Reversal of benzodiazepine inverse agonist FG 7142-induced anxiety syndrome by neurosteroids in mice, Methods Find. Exp. Clin. Pharmacol. 19 (1997) (in press)."},{"key":"10.1016\/S0006-8993(98)00085-7_BIB33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0006-2952(94)00258-N","article-title":"Pregnenolone: From Selye to Alzheimer and a model of the pregnenolone sulfate binding site on the GABA-A receptor","volume":"49","author":"Roberts","year":"1995","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/S0006-8993(98)00085-7_BIB34","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1159\/000111391","article-title":"Development and regeneration of the nervous system: A role for neurosteroids","volume":"18","author":"Schumacher","year":"1996","journal-title":"Dev. Neurosci."},{"key":"10.1016\/S0006-8993(98)00085-7_BIB35","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0031-9384(96)00447-7","article-title":"Reduction of the scopolamine-induced impairment of passive-avoidance performance by \u03c3 receptor agonist in mice","volume":"61","author":"Senda","year":"1997","journal-title":"Physiol. Behav."},{"key":"10.1016\/S0006-8993(98)00085-7_BIB36","first-page":"155","article-title":"Effects of MK-801 and Ketamine on short-term memory deficits in passive-avoidance step-down task paradigm in mice","volume":"13","author":"Sharma","year":"1991","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"10.1016\/S0006-8993(98)00085-7_BIB37","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3758\/BF03327231","article-title":"Amphetamine, epinephrine and glucose enhancement of memory retrieval","volume":"18","author":"Stone","year":"1990","journal-title":"Psychobiology"},{"key":"10.1016\/S0006-8993(98)00085-7_BIB38","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1126\/science.2832949","article-title":"Steroid binding at \u03c3 receptors suggests a link between endocrine, nervous and immune systems","volume":"240","author":"Su","year":"1988","journal-title":"Science"},{"key":"10.1016\/S0006-8993(98)00085-7_BIB39","first-page":"355","article-title":"Sigma receptors: biology and function","volume":"42","author":"Walker","year":"1990","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/S0006-8993(98)00085-7_BIB40","first-page":"333","article-title":"Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-d-aspartate receptor","volume":"40","author":"Wu","year":"1991","journal-title":"Mol. Pharmacol."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899398000857?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899398000857?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T02:09:58Z","timestamp":1681438198000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899398000857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,4]]},"references-count":40,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[1998,4]]}},"alternative-id":["S0006899398000857"],"URL":"https:\/\/doi.org\/10.1016\/s0006-8993(98)00085-7","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[1998,4]]}}}