{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T20:52:54Z","timestamp":1778014374689,"version":"3.51.4"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1999,6,1]],"date-time":"1999-06-01T00:00:00Z","timestamp":928195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[1999,6]]},"DOI":"10.1016\/s0006-8993(99)01389-x","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T11:59:07Z","timestamp":1027598347000},"page":"226-236","source":"Crossref","is-referenced-by-count":199,"title":["Distribution of cyclooxygenase-1 and cyclooxygenase-2 mRNAs and proteins in human brain and peripheral organs"],"prefix":"10.1016","volume":"830","author":[{"given":"Koji","family":"Yasojima","sequence":"first","affiliation":[]},{"given":"Claudia","family":"Schwab","sequence":"additional","affiliation":[]},{"given":"Edith G.","family":"McGeer","sequence":"additional","affiliation":[]},{"given":"Patrick L.","family":"McGeer","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0006-8993(99)01389-X_BIB1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1046\/j.1471-4159.1996.66010006.x","article-title":"Cyclooxygenase-2 induction in cerebral cortex: an intracellular response to synaptic excitation","volume":"66","author":"Adams","year":"1996","journal-title":"J. Neurochem."},{"key":"10.1016\/S0006-8993(99)01389-X_BIB2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0006-8993(95)00839-I","article-title":"Induction by lipopolysaccharide of cyclooxygenase-2 mRNA in rat brain; its possible role in the febrile response","volume":"697","author":"Cao","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/S0006-8993(99)01389-X_BIB3","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/0197-4580(96)00110-8","article-title":"Prostaglandin G\/H synthase-2 (cyclooxygenase-2) mRNA expression is decreased in Alzheimer's disease","volume":"17","author":"Chang","year":"1996","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/S0006-8993(99)01389-X_BIB4","first-page":"15","article-title":"COX-1 and COX-2 tissue expression: implications and predictions","volume":"24","author":"Crofford","year":"1997","journal-title":"J. Rheumatol."},{"key":"10.1016\/S0006-8993(99)01389-X_BIB5","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/378406a0","article-title":"Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II","volume":"378","author":"Dinchuk","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0006-8993(99)01389-X_BIB6","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0304-3940(98)00755-1","article-title":"Effect of selective inhibition of cyclooxygenase 2 on temporary focal cerebral ischemia in rats","volume":"256","author":"Hara","year":"1998","journal-title":"Neurosci. Lett."},{"key":"10.1016\/S0006-8993(99)01389-X_BIB7","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0165-5728(98)00132-5","article-title":"Induction of cyclooxygenase (COX)-2 but not COX-1 gene expression in apoptotic cell death","volume":"89","author":"Ho","year":"1998","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/S0006-8993(99)01389-X_BIB8","first-page":"65","article-title":"A simple sequentially repetitive multiple test procedure","volume":"6","author":"Holm","year":"1979","journal-title":"Scand. J. Stat."},{"key":"10.1016\/S0006-8993(99)01389-X_BIB9","doi-asserted-by":"crossref","first-page":"24965","DOI":"10.1074\/jbc.270.42.24965","article-title":"Transcriptional regulation of human prostaglandin-endoperoxide synthase-2 gene by lipopolysaccharide and phorbol ester in vascular endothelial cells","volume":"270","author":"Inoue","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0006-8993(99)01389-X_BIB10","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1097\/00001756-199709080-00028","article-title":"Increased levels of cyclooxygenase-2 mRNA in the rat spinal cord after peripheral inflammation: an in situ hybridization study","volume":"8","author":"Ichitani","year":"1997","journal-title":"NeuroReport"},{"key":"10.1016\/S0006-8993(99)01389-X_BIB11","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1073\/pnas.93.6.2317","article-title":"COX-2, a synaptically induced exzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex","volume":"93","author":"Kaufmann","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/S0006-8993(99)01389-X_BIB12","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0387-7604(96)00047-2","article-title":"Cyclooxygenase-2 expression during rat neocortical development and in Rett syndrome","volume":"19","author":"Kaufmann","year":"1997","journal-title":"Brain Develop."},{"key":"10.1016\/S0006-8993(99)01389-X_BIB13","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0006-8993(85)90682-1","article-title":"Modulatory effect of prostaglandin D2, E2 and F2\u03b1 on the postsynaptic actions of inhibitory and excitatory amino acids in cerebellar Purkinje cell dendrites in vitro","volume":"330","author":"Kimura","year":"1985","journal-title":"Brain Res."},{"key":"10.1016\/S0006-8993(99)01389-X_BIB14","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/0092-8674(95)90126-4","article-title":"Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration","volume":"83","author":"Langenbach","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0006-8993(99)01389-X_BIB15","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/(SICI)1097-4547(19980901)53:5<583::AID-JNR8>3.0.CO;2-5","article-title":"Strong nuclear factor-\u03baB-DNA binding parallels cyclooxygenase-2 gene transcription in aging and in sporadic Alzheimer's disease superior temporal lobe neocortex","volume":"53","author":"Lukiw","year":"1998","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/S0006-8993(99)01389-X_BIB16","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1073\/pnas.91.8.3228","article-title":"Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic","volume":"91","author":"Masferrer","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/S0006-8993(99)01389-X_BIB17","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1212\/WNL.50.4.986","article-title":"Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging","volume":"50","author":"Mackenzie","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/S0006-8993(99)01389-X_BIB18","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0165-0173(95)00011-9","article-title":"The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases","volume":"21","author":"McGeer","year":"1995","journal-title":"Brain Res. Rev."},{"key":"10.1016\/S0006-8993(99)01389-X_BIB19","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1212\/WNL.47.2.425","article-title":"Arthritis and antiinflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiological studies","volume":"47","author":"McGeer","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/S0006-8993(99)01389-X_BIB20","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/0092-8674(95)90125-6","article-title":"Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse","volume":"83","author":"Morham","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0006-8993(99)01389-X_BIB21","doi-asserted-by":"crossref","first-page":"16633","DOI":"10.1074\/jbc.271.28.16633","article-title":"An E-box region within the prostaglandin endoperoxide synthase-2 (PGS-2) promoter is required for transcription in rat ovarian granulosa cells","volume":"271","author":"Morris","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0006-8993(99)01389-X_BIB22","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1097\/00001756-199703240-00020","article-title":"Induction of cyclooxygenase-2 in brains of patients with Down's syndrome and dementia of the Alzheimer type: specific localization in affected neurones","volume":"8","author":"Oka","year":"1997","journal-title":"NeuroReport"},{"key":"10.1016\/S0006-8993(99)01389-X_BIB23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1097-4547(19981001)54:1<1::AID-JNR1>3.0.CO;2-M","article-title":"Cyclooxygenase and inflammation in Alzheimer's disease: experimental approaches and clinical interventions","volume":"54","author":"Pasinetti","year":"1998","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/S0006-8993(99)01389-X_BIB24","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0306-4522(98)00218-8","article-title":"Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain","volume":"87","author":"Pasinetti","year":"1998","journal-title":"Neuroscience"},{"key":"10.1016\/S0006-8993(99)01389-X_BIB25","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0304-3940(95)12108-G","article-title":"Induction of cyclooxygenase-2 mRNA and protein following transient focal ischemia in the rat brain","volume":"200","author":"Planas","year":"1995","journal-title":"Neurosci. Lett."},{"key":"10.1016\/S0006-8993(99)01389-X_BIB26","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0006-8993(98)00402-8","article-title":"Cyclooxygenase 2 mRNA expression in rat brain after peripheral injection of lipopolysaccharide","volume":"802","author":"Quan","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/S0006-8993(99)01389-X_BIB27","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1212\/WNL.43.8.1609","article-title":"Clinical trial of indomethacin in Alzheimer's disease","volume":"43","author":"Rogers","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/S0006-8993(99)01389-X_BIB28","doi-asserted-by":"crossref","first-page":"33157","DOI":"10.1074\/jbc.271.52.33157","article-title":"Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2","volume":"271","author":"Smith","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0006-8993(99)01389-X_BIB29","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0006-8993(97)00849-4","article-title":"Neurons express proteins of the classical complement pathway in Alzheimer disease","volume":"769","author":"Terai","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/S0006-8993(99)01389-X_BIB30","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1006\/exnr.1997.6429","article-title":"Maturational regulation and regional induction of cyclooxygenase-2 in rat brain: implications for Alzheimer's disease","volume":"144","author":"Tocco","year":"1997","journal-title":"Exp. Neurol."},{"key":"10.1016\/S0006-8993(99)01389-X_BIB31","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/newbio231232a0","article-title":"Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs","volume":"231","author":"Vane","year":"1971","journal-title":"Nature, New Biol."},{"key":"10.1016\/S0006-8993(99)01389-X_BIB32","doi-asserted-by":"crossref","first-page":"27622","DOI":"10.1074\/jbc.270.46.27622","article-title":"v-src induces prostaglandin synthase 2 gene expression by activation of the c-Jun N-terminal kinase and the c-Jun transcription factor","volume":"270","author":"Xie","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0006-8993(99)01389-X_BIB33","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/0896-6273(93)90192-T","article-title":"Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids","volume":"11","author":"Yamagata","year":"1993","journal-title":"Neuron"},{"key":"10.1016\/S0006-8993(99)01389-X_BIB34","doi-asserted-by":"crossref","first-page":"31315","DOI":"10.1074\/jbc.270.52.31315","article-title":"Transcriptional roles of nuclear factor \u03baB and nuclear factor-interleukin-6 in the tumour necrosis factor \u03b1-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells","volume":"270","author":"Yamamoto","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0006-8993(99)01389-X_BIB35","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1161\/01.RES.82.11.1224","article-title":"Complement gene expression by rabbit heart: upregulation by ischemia and reperfusion","volume":"82","author":"Yasojima","year":"1998","journal-title":"Circ. Res."},{"key":"10.1016\/S0006-8993(99)01389-X_BIB36","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1161\/01.RES.83.8.860","article-title":"Human heart generates complement proteins that are upregulated and activated after myocardial infarction","volume":"83","author":"Yasojima","year":"1998","journal-title":"Circ. Res."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000689939901389X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000689939901389X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T05:31:33Z","timestamp":1556688693000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000689939901389X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,6]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1999,6]]}},"alternative-id":["S000689939901389X"],"URL":"https:\/\/doi.org\/10.1016\/s0006-8993(99)01389-x","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[1999,6]]}}}