{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T17:04:45Z","timestamp":1764349485094,"version":"3.44.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1999,9,1]],"date-time":"1999-09-01T00:00:00Z","timestamp":936144000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1999,9,1]],"date-time":"1999-09-01T00:00:00Z","timestamp":936144000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[1999,9]]},"DOI":"10.1016\/s0006-8993(99)01844-2","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T17:55:17Z","timestamp":1027619717000},"page":"342-350","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["pRb phosphorylation is regulated differentially by cyclin-dependent kinase (Cdk) 2 and Cdk4 in retinoic acid-induced neuronal differentiation of P19 cells"],"prefix":"10.1016","volume":"842","author":[{"given":"Yumi","family":"Watanabe","sequence":"first","affiliation":[]},{"given":"Takeshi","family":"Watanabe","sequence":"additional","affiliation":[]},{"given":"Masatoshi","family":"Kitagawa","sequence":"additional","affiliation":[]},{"given":"Yoichi","family":"Taya","sequence":"additional","affiliation":[]},{"given":"Kei-ichi","family":"Nakayama","sequence":"additional","affiliation":[]},{"given":"Noboru","family":"Motoyama","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0006-8993(99)01844-2_BIB1","doi-asserted-by":"crossref","first-page":"18195","DOI":"10.1074\/jbc.270.31.18195","article-title":"Both p16 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by CDK-activating kinase","volume":"270","author":"Aprelicova","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0006-8993(99)01844-2_BIB2","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/bies.950160509","article-title":"From embryonal carcinoma cells to neurons: the P19 pathway","volume":"16","author":"Bain","year":"1994","journal-title":"Bioessays"},{"key":"10.1016\/S0006-8993(99)01844-2_BIB3","doi-asserted-by":"crossref","first-page":"6474","DOI":"10.1073\/pnas.86.17.6474","article-title":"Structure and expression of the murine retinoblastoma gene and characterization of its encoded protein","volume":"86","author":"Bernards","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/S0006-8993(99)01844-2_BIB4","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1101\/gad.10.21.2794","article-title":"Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C\/EBPs","volume":"10","author":"Chen","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/S0006-8993(99)01844-2_BIB5","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/359328a0","article-title":"Requirement for a functional Rb-1 gene in murine development","volume":"359","author":"Clarke","year":"1992","journal-title":"Nature"},{"key":"10.1016\/S0006-8993(99)01844-2_BIB6","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1091\/mbc.8.2.287","article-title":"Cyclin D1\/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation","volume":"8","author":"Connell-Crowley","year":"1997","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/S0006-8993(99)01844-2_BIB7","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/0092-8674(93)90500-P","article-title":"WAF1, a potential mediator of p53 tumor suppression","volume":"75","author":"El-Deiry","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0006-8993(99)01844-2_BIB8","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1002\/j.1460-2075.1992.tb05493.x","article-title":"Cell cycle regulation of Cdk2 activity by phosphorylation of Thr160 and Tyr15","volume":"11","author":"Gu","year":"1992","journal-title":"EMBO J."},{"key":"10.1016\/S0006-8993(99)01844-2_BIB9","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0092-8674(93)90110-C","article-title":"Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation","volume":"72","author":"Gu","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0006-8993(99)01844-2_BIB10","first-page":"693","article-title":"Regions controlling hyperphosphorylation and conformation of the retinoblastoma gene product are independent of domains required for transcriptional repression","volume":"7","author":"Hamel","year":"1992","journal-title":"Oncogene"},{"key":"10.1016\/S0006-8993(99)01844-2_BIB11","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/0092-8674(93)90499-G","article-title":"The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases","volume":"75","author":"Harper","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0006-8993(99)01844-2_BIB12","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1128\/MCB.15.5.2672","article-title":"Novel INK4 proteins, p19 and p18 are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6","volume":"15","author":"Hirai","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0006-8993(99)01844-2_BIB13","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/359295a0","article-title":"Effects of an Rb mutation in the mouse","volume":"359","author":"Jacks","year":"1992","journal-title":"Nature"},{"key":"10.1016\/S0006-8993(99)01844-2_BIB14","first-page":"2713","article-title":"Regulation of cyclin D-dependent kinase4 (cdk4) by cdk4-activating kinase","volume":"14","author":"Kato","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0006-8993(99)01844-2_BIB15","doi-asserted-by":"crossref","first-page":"7060","DOI":"10.1002\/j.1460-2075.1996.tb01097.x","article-title":"The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A\/E-Cdk2","volume":"15","author":"Kitagawa","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/S0006-8993(99)01844-2_BIB16","doi-asserted-by":"crossref","first-page":"8313","DOI":"10.1074\/jbc.271.14.8313","article-title":"Differential regulation of retinoblastoma protein function by specific Cdk phosphorylation sites","volume":"271","author":"Knudsen","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0006-8993(99)01844-2_BIB17","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.1128\/MCB.17.10.5771","article-title":"Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation","volume":"17","author":"Knudsen","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0006-8993(99)01844-2_BIB18","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1083\/jcb.131.1.227","article-title":"Inhibition of cyclin-dependent kinase activity triggers neuronal differentiation of mouse neuroblastoma cells","volume":"131","author":"Kranenburg","year":"1995","journal-title":"J. Cell. Biol."},{"key":"10.1016\/S0006-8993(99)01844-2_BIB19","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1432-0436.1992.tb00766.x","article-title":"Retinoic acid resistance of the variant embryonic carcinoma cell line RAC65 is caused by expression of a truncated RAR\u03b1","volume":"49","author":"Kruyt","year":"1992","journal-title":"Differentiation"},{"key":"10.1016\/S0006-8993(99)01844-2_BIB20","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/359288a0","article-title":"Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoesis","volume":"359","author":"Lee","year":"1992","journal-title":"Nature"},{"key":"10.1016\/S0006-8993(99)01844-2_BIB21","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1101\/gad.8.17.2008","article-title":"Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation","volume":"8","author":"Lee","year":"1994","journal-title":"Genes Dev."},{"key":"10.1016\/S0006-8993(99)01844-2_BIB22","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1101\/gad.9.6.639","article-title":"Cloning of p57Kip2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution","volume":"9","author":"Lee","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/S0006-8993(99)01844-2_BIB23","doi-asserted-by":"crossref","first-page":"4279","DOI":"10.1002\/j.1460-2075.1991.tb05006.x","article-title":"The retinoblastoma protein is phosphorylated on multiple sites by human cdc2","volume":"10","author":"Lees","year":"1991","journal-title":"EMBO J."},{"key":"10.1016\/S0006-8993(99)01844-2_BIB24","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/j.1460-2075.1991.tb08018.x","article-title":"Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase","volume":"10","author":"Lin","year":"1991","journal-title":"EMBO J."},{"key":"10.1016\/S0006-8993(99)01844-2_BIB25","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1101\/gad.9.6.650","article-title":"p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene","volume":"9","author":"Matsuoka","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/S0006-8993(99)01844-2_BIB26","first-page":"7265","article-title":"Activation of cyclin dependent-kinase-4 (cdk4) by mouse MO15-associated kinase","volume":"14","author":"Matsuoka","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0006-8993(99)01844-2_BIB27","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/0012-1606(82)90338-4","article-title":"Isolation of male embryonal carcinoma cells and their chromosomal replication patterns","volume":"89","author":"McBurney","year":"1982","journal-title":"Dev. Biol."},{"key":"10.1016\/S0006-8993(99)01844-2_BIB28","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/j.1460-2075.1994.tb06241.x","article-title":"Distinct sub-populations of the retinoblastoma protein show a distinct pattern of phosphorylation","volume":"13","author":"Mittnacht","year":"1994","journal-title":"EMBO J."},{"key":"10.1016\/S0006-8993(99)01844-2_BIB29","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/0092-8674(90)90597-8","article-title":"A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells","volume":"60","author":"Okano","year":"1990","journal-title":"Cell"},{"key":"10.1016\/S0006-8993(99)01844-2_BIB30","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0092-8674(94)90572-X","article-title":"Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals","volume":"78","author":"Polyak","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0006-8993(99)01844-2_BIB31","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/345686a0","article-title":"A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo","volume":"345","author":"Rosner","year":"1990","journal-title":"Nature"},{"key":"10.1016\/S0006-8993(99)01844-2_BIB32","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/366704a0","article-title":"A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D\/CDK4","volume":"366","author":"Serrano","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0006-8993(99)01844-2_BIB33","first-page":"1585","article-title":"Regulated expression of the retinoblastoma gene in differentiating embryonal carcinoma cells","volume":"8","author":"Slack","year":"1993","journal-title":"Oncogene"},{"key":"10.1016\/S0006-8993(99)01844-2_BIB34","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0962-8924(94)90033-7","article-title":"The ins and outs of RB: coupling gene expression to the cell cycle clock","volume":"4","author":"Sherr","year":"1994","journal-title":"Trends Cell Biol."},{"key":"10.1016\/S0006-8993(99)01844-2_BIB35","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1101\/gad.9.10.1149","article-title":"Inhibitors of mammalian G1 cyclin-dependent kinases","volume":"9","author":"Sherr","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/S0006-8993(99)01844-2_BIB36","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0968-0004(96)10070-0","article-title":"RB kinases and RB-binding proteins: new points of view","volume":"22","author":"Taya","year":"1997","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/S0006-8993(99)01844-2_BIB37","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1399-3011.1995.tb01325.x","article-title":"Chemical synthesis of phosphopeptides using the arylthio group of protection of phosphate: application to identification of cdc2 kinase phosphorylation sites","volume":"46","author":"Ueno","year":"1995","journal-title":"Int. J. Pept. Protein Res."},{"key":"10.1016\/S0006-8993(99)01844-2_BIB38","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0092-8674(95)90385-2","article-title":"The retinoblastoma protein and cell cycle control","volume":"81","author":"Weinberg","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0006-8993(99)01844-2_BIB39","doi-asserted-by":"crossref","first-page":"12738","DOI":"10.1074\/jbc.272.19.12738","article-title":"Differential phosphorylation of the retinoblastoma protein by G1\/S cyclin-dependent kinases","volume":"272","author":"Zarkowska","year":"1997","journal-title":"J. Biol. Chem."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899399018442?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899399018442?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T17:20:22Z","timestamp":1757784022000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899399018442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,9]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1999,9]]}},"alternative-id":["S0006899399018442"],"URL":"https:\/\/doi.org\/10.1016\/s0006-8993(99)01844-2","relation":{},"ISSN":["0006-8993"],"issn-type":[{"type":"print","value":"0006-8993"}],"subject":[],"published":{"date-parts":[[1999,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"pRb phosphorylation is regulated differentially by cyclin-dependent kinase (Cdk) 2 and Cdk4 in retinoic acid-induced neuronal differentiation of P19 cells","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0006-8993(99)01844-2","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1999 Elsevier Science B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}