{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:09:49Z","timestamp":1760782189633,"version":"3.44.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2002,8,1]],"date-time":"2002-08-01T00:00:00Z","timestamp":1028160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2002,8,1]],"date-time":"2002-08-01T00:00:00Z","timestamp":1028160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2002,8]]},"DOI":"10.1016\/s0009-2797(02)00037-6","type":"journal-article","created":{"date-parts":[[2002,9,9]],"date-time":"2002-09-09T16:43:49Z","timestamp":1031589829000},"page":"215-229","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Cytotoxicity and DNA damage induced by a new platinum(II) complex with pyridine and dithiocarbamate"],"prefix":"10.1016","volume":"140","author":[{"given":"Cristina","family":"Marzano","sequence":"first","affiliation":[]},{"given":"Dolores","family":"Fregona","sequence":"additional","affiliation":[]},{"given":"Francarosa","family":"Baccichetti","sequence":"additional","affiliation":[]},{"given":"Andrea","family":"Trevisan","sequence":"additional","affiliation":[]},{"given":"Lorena","family":"Giovagnini","sequence":"additional","affiliation":[]},{"given":"Franco","family":"Bordin","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0009-2797(02)00037-6_BIB1","series-title":"Cisplatin. Chemistry and Biochemistry of a Leading Anticancer Drug","first-page":"3","article-title":"Platinum complexes for the treatment of cancer: Why the search goes on","author":"Rosenberg","year":"1999"},{"key":"10.1016\/S0009-2797(02)00037-6_BIB2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/1040-8428(93)90042-3","article-title":"New platinum antitumor complexes","volume":"15","author":"Kelland","year":"1993","journal-title":"Crit. Rev. Oncol.\/Hematol."},{"key":"10.1016\/S0009-2797(02)00037-6_BIB3","first-page":"1013","article-title":"Cisplatin-induced apoptosis by translocation of endogenous Bax in mouse collecting duct cells(1)","volume":"62","author":"Hwa-Lee","year":"2001","journal-title":"J. Biochem. Pharmacol."},{"key":"10.1016\/S0009-2797(02)00037-6_BIB4","first-page":"2745","article-title":"Effect of diethyldithiocarbamate on cis-diamminedichloroplatinum(II)-induced cytotoxicity, DNA cross-linking, and \u03b3-glutamyl transpeptidase inhibition","volume":"46","author":"Bodenner","year":"1986","journal-title":"Cancer Res."},{"key":"10.1016\/S0009-2797(02)00037-6_BIB5","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3109\/08860229409044874","article-title":"Protective effects of dithiocarbamates against renal toxicity of cis-diamminedichloroplatinum in rats","volume":"16","author":"Hidaka","year":"1994","journal-title":"Ren. Fail."},{"key":"10.1016\/S0009-2797(02)00037-6_BIB6","first-page":"242","article-title":"Combination and individual antitumor effects of hyperthermia, cisplatin, and selected dithiocarbamates","volume":"19","author":"Walker","year":"1989","journal-title":"Ann. Clin. Lab. Sci."},{"key":"10.1016\/S0009-2797(02)00037-6_BIB7","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0162-0134(97)00041-X","article-title":"DNA binding studies with cis-dichlorobis (5(6)-non\/chlorosubstituted-2-hydroxymethyl-benzimidazole) platinum(II) complexes","volume":"68","author":"Gumus","year":"1997","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/S0009-2797(02)00037-6_BIB8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0162-0134(00)00133-1","article-title":"Platinum (II) and palladium(II) complexes with dithicarbamates and amines: synthesis, characterization and cell assay","volume":"83","author":"Faraglia","year":"2001","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/S0009-2797(02)00037-6_BIB9","unstructured":"C. Marzano, A. Trevisan, L. Giovagnini, D. Fregona, Synthesis of a new platinum(II)complex: anticancer activity and nephrotoxicity in vitro, Toxicology in vitro, in press."},{"key":"10.1016\/S0009-2797(02)00037-6_BIB10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-642-74760-1_1","article-title":"Metal anti-tumor compounds: the mechanism of action of platinum complexes","volume":"10","author":"Johnson","year":"1989","journal-title":"Prog. Clin. Biochem. Med."},{"key":"10.1016\/S0009-2797(02)00037-6_BIB11","first-page":"35","article-title":"Cellular pharmacology of cisplatin: perspectives on mechanisms of acquired resistance","volume":"2","author":"Andrews","year":"1990","journal-title":"Cancer Cells"},{"key":"10.1016\/S0009-2797(02)00037-6_BIB12","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0009-2797(98)00100-8","article-title":"Synthesis, characterization and DNA modification induced by a novel Pt(IV)-bis(monoglutarate) complex which induces apoptosis in glioma cells","volume":"117","author":"Perez","year":"1999","journal-title":"Chem.-Biol. Interact."},{"key":"10.1016\/S0009-2797(02)00037-6_BIB13","first-page":"281","article-title":"Synthesis, mutagenicity, binding to pBR 322 DNA and antitumor activity of platinum(II) complexes with ethambutol","volume":"11","author":"Coluccia","year":"1991","journal-title":"Anticancer Res."},{"key":"10.1016\/S0009-2797(02)00037-6_BIB14","first-page":"6250","article-title":"Differential potentation of alkylating and platinating agent toxicity in human ovarian carcinoma cells by glutathione depletion","volume":"45","author":"Andrews","year":"1985","journal-title":"Cancer Res."},{"key":"10.1016\/S0009-2797(02)00037-6_BIB15","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1002\/(SICI)1097-0142(19960501)77:9<1797::AID-CNCR7>3.0.CO;2-9","article-title":"Mechanisms of resistance of human small cell lung cancer lines selected in VP-16 and cisplatin","volume":"77","author":"Jain","year":"1996","journal-title":"Cancer"},{"key":"10.1016\/S0009-2797(02)00037-6_BIB16","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folin-phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0009-2797(02)00037-6_BIB17","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0163-7258(91)90022-E","article-title":"Principles and practice of DNA filter elution","volume":"49","author":"Kohn","year":"1991","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/S0009-2797(02)00037-6_BIB18","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/377649a0","article-title":"Crystal structure of double-stranded DNA containing the major adduct of the anticancer drug cisplatin","volume":"377","author":"Takahara","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0009-2797(02)00037-6_BIB19","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0959-8049(96)00507-2","article-title":"Modulation of cis-diamminedichloroplatinum (II) accumulation and cytotoxicity by spermine in sensitive and resistant human ovarian carcinoma cells","volume":"33","author":"Marverti","year":"1997","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/S0009-2797(02)00037-6_BIB20","first-page":"68","article-title":"cis-diamminedichloroplatinum(II) accumulation in sensitive and resistant human ovarian carcinoma cells","volume":"48","author":"Andrews","year":"1988","journal-title":"Cancer Res."},{"key":"10.1016\/S0009-2797(02)00037-6_BIB21","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3109\/02841868809093559","article-title":"cis-diamminedichloroplatinum(II) toxicity in human melanoma cells and lymphocytes as related to cellular platinum accumulation, DNA cross-linking and inhibition of DNA synthesis","volume":"27","author":"Hansson","year":"1988","journal-title":"Acta Oncol."},{"key":"10.1016\/S0009-2797(02)00037-6_BIB22","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/S0006-2952(97)00015-4","article-title":"Serine protease inhibition and mitochondrial dysfunction associated with cisplatin resistance in human tumor cell lines: targets for therapy","volume":"53","author":"Dong","year":"1997","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/S0009-2797(02)00037-6_BIB23","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/S0006-2952(00)00478-0","article-title":"Renal toxicity caused by cisplatinum in glutathione-depleted metallothionein-null mice","volume":"60","author":"Masahiko","year":"2000","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/S0009-2797(02)00037-6_BIB24","first-page":"3237","article-title":"Metallothionein content correlates with the sensitivity of human small cell lung cancer cell lines to cisplatin","volume":"51","author":"Kasahara","year":"1991","journal-title":"Cancer Res."},{"key":"10.1016\/S0009-2797(02)00037-6_BIB25","doi-asserted-by":"crossref","first-page":"4730","DOI":"10.1021\/bi00413a022","article-title":"Enhanced DNA repair as a mechanism of resistance to cis-diamminodichloroplatinum(II)","volume":"27","author":"Eastmant","year":"1988","journal-title":"Biochemistry"},{"key":"10.1016\/S0009-2797(02)00037-6_BIB26","first-page":"850","article-title":"Increased platinum-DNA damage tolerance in associated with cisplatin resistance and cross-resistance to various chemotherapeutic agents in unrelated human ovarian cancer cell lines","volume":"57","author":"Johnson","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/S0009-2797(02)00037-6_BIB27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0162-0134(99)00139-7","article-title":"In vitro and in vivo antitumor activity and cellular pharmacological properties of new platinum-iminoether complexes with different configuration at the iminoether ligands","volume":"77","author":"Coluccia","year":"1999","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/S0009-2797(02)00037-6_BIB28","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/bjc.1993.221","article-title":"Cellular accumulation of the anticancer agent cisplatin: a review","volume":"67","author":"Gately","year":"1993","journal-title":"Br. J. Cancer"},{"key":"10.1016\/S0009-2797(02)00037-6_BIB29","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0027-5107(96)00022-X","article-title":"Mutagenic and carcinogenic properties of platinum-based anticancer drugs","volume":"355","author":"Sanderson","year":"1996","journal-title":"Mut. Res."},{"key":"10.1016\/S0009-2797(02)00037-6_BIB30","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1562\/0031-8655(2000)071<0263:DDIBTF>2.0.CO;2","article-title":"DNA damage induced by 4,6,8,9-tetramethyl-2H-furo[2,3-h]quinolin-2-one, a new furocoumarin analog: biological consequences","volume":"71","author":"Marzano","year":"2000","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/S0009-2797(02)00037-6_BIB31","first-page":"3087","article-title":"Loss of DNA mismatch repair in acquired resistance to cisplatin","volume":"56","author":"Aebi","year":"1996","journal-title":"Cancer Res."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279702000376?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279702000376?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T13:05:22Z","timestamp":1757855122000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279702000376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,8]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,8]]}},"alternative-id":["S0009279702000376"],"URL":"https:\/\/doi.org\/10.1016\/s0009-2797(02)00037-6","relation":{},"ISSN":["0009-2797"],"issn-type":[{"type":"print","value":"0009-2797"}],"subject":[],"published":{"date-parts":[[2002,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cytotoxicity and DNA damage induced by a new platinum(II) complex with pyridine and dithiocarbamate","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0009-2797(02)00037-6","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2002 Elsevier Science Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}