{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:44:39Z","timestamp":1761540279808,"version":"3.44.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[1998,7,1]],"date-time":"1998-07-01T00:00:00Z","timestamp":899251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1998,7,1]],"date-time":"1998-07-01T00:00:00Z","timestamp":899251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Biochemistry"],"published-print":{"date-parts":[[1998,7]]},"DOI":"10.1016\/s0009-9120(98)00027-7","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T08:06:05Z","timestamp":1027584365000},"page":"409-415","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["The effects of age, apolipoprotein E phenotype and gender on the concentration of amyloid-\u03b2 (A\u03b2) 40, A\u03b242, apolipoprotein E and transthyretin in human cerebrospinal fluid"],"prefix":"10.1016","volume":"31","author":[{"given":"Suzanne","family":"Kunicki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pankaj D","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang S","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edith","family":"Zorychta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0009-9120(98)00027-7_BIB1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/oxfordjournals.epirev.a036092","article-title":"Epidemiology of Alzheimer disease","volume":"14","author":"Bretler","year":"1992","journal-title":"Epidemiol Rev"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB2","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/0896-6273(93)90070-8","article-title":"Apolipoprotein E in sporadic Alzheimer\u2019s disease","volume":"11","author":"Rebeck","year":"1993","journal-title":"Neuron"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB3","doi-asserted-by":"crossref","first-page":"9649","DOI":"10.1073\/pnas.90.20.9649","article-title":"Increased amyloid-\u03b2 peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease","volume":"90","author":"Schmechel","year":"1993","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB4","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1073\/pnas.90.5.1977","article-title":"Apolipoprotein E","volume":"90","author":"Strittmatter","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB5","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0022-510X(68)90154-8","article-title":"Observations on the brains of non-demented old people","volume":"7","author":"Tomlinson","year":"1968","journal-title":"J Neurol Sci"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB6","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1212\/WNL.41.4.479","article-title":"The consortium to establish a registry for Alzheimer\u2019s disease (CERAD). II. Standardization of the neuropathologic assessment of Alzheimer\u2019s disease","volume":"41","author":"Mirra","year":"1991","journal-title":"Neurol"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB7","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S0006-291X(84)80190-4","article-title":"Alzheimer\u2019s disease","volume":"120","author":"Glenner","year":"1984","journal-title":"Biochem Biophys Res Comm"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB8","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/0006-291X(90)90635-Z","article-title":"Detection of soluble forms of the \u03b2-amyloid precursor protein in human plasma","volume":"167","author":"Podlisny","year":"1990","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB9","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/359325a0","article-title":"Isolation and quantification of soluble Alzheimer\u2019s \u03b2-peptide from biological fluid","volume":"359","author":"Seubert","year":"1992","journal-title":"Nature"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB10","doi-asserted-by":"crossref","first-page":"6338","DOI":"10.1073\/pnas.86.16.6338","article-title":"The \u03b2-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid","volume":"86","author":"Palmert","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB11","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0304-3940(94)90763-3","article-title":"Apolipoprotein E allele \u03f54 is linked to increased deposition of the amyloid \u03b2-peptide (A\u03b2) in cases with or without Alzheimer\u2019s disease","volume":"178","author":"Berr","year":"1994","journal-title":"Neurosci Lett"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB12","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1056\/NEJM199511093331902","article-title":"Apolipoprotein E, dementia, and cortical deposition of \u03b2-amyloid protein","volume":"333","author":"Polvikoski","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB13","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.1021\/bi00069a001","article-title":"The carboxyl terminus of the \u03b2 amyloid protein is critical for the seeding of amyloid formation","volume":"32","author":"Jarrett","year":"1993","journal-title":"Biochem"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB14","doi-asserted-by":"crossref","first-page":"11993","DOI":"10.1073\/pnas.91.25.11993","article-title":"Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation","volume":"91","author":"Citron","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB15","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1006\/bbrc.1993.1423","article-title":"Apolipoprotein E","volume":"192","author":"Wisniewski","year":"1993","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB16","doi-asserted-by":"crossref","first-page":"8368","DOI":"10.1073\/pnas.91.18.8368","article-title":"Transthyretin sequesters amyloid \u03b2 protein and prevents amyloid formation","volume":"91","author":"Schwarzman","year":"1994","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB17","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0006-8993(91)91092-F","article-title":"Distribution of clusterin in Alzheimer brain tissue","volume":"541","author":"Namba","year":"1991","journal-title":"Brain Res"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB18","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/ana.410380413","article-title":"Reduction of \u03b2-amyloid peptide42 in the cerebrospinal fluid of patients with Alzheimer\u2019s disease","volume":"38","author":"Motter","year":"1995","journal-title":"Ann Neurol"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB19","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1097\/00001756-199412000-00032","article-title":"Cerebrospinal fluid apolipoprotein E is reduced in Alzheimer\u2019s disease","volume":"5","author":"Blennow","year":"1994","journal-title":"Neuroreport"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB20","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1093\/clinchem\/36.11.1871","article-title":"Improved phenotyping of apolipoprotein E","volume":"36","author":"Hill","year":"1990","journal-title":"Clin Chem"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB21","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1073\/pnas.76.9.4350","article-title":"Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets","volume":"76","author":"Towbin","year":"1979","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB22","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0009-8981(91)90070-S","article-title":"Clinical relevance of the quantification of apolipoprotein E in cerebrospinal fluid","volume":"196","author":"Carlsson","year":"1991","journal-title":"Clin Chim Acta"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB23","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/0022-510X(94)90140-6","article-title":"Soluble amyloid \u03b2-protein in the cerebrospinal fluid from patients with Alzheimer\u2019s disease, vascular dementia and controls","volume":"127","author":"Pirttil\u00e4","year":"1994","journal-title":"J Neurol Sci"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB24","first-page":"121","article-title":"Production and characterization of monoclonal antibodies reactive to synthetic cerebrovascular amyloid peptide","volume":"2","author":"Kim","year":"1988","journal-title":"Neurosci Res Commun"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB25","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0304-3940(97)00966-X","article-title":"Increased plasma amyloid B protein 1-42 levels in Down Syndrome","volume":"241","author":"Mehta","year":"1998","journal-title":"Neurosci Lett"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB26","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/0022-510X(91)90218-V","article-title":"Age-related changes in cerebrospinal fluid protein concentrations","volume":"104","author":"Garton","year":"1991","journal-title":"J Neurolog Sci"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB27","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1080\/01621459.1995.10476572","article-title":"Bayes factors","volume":"90","author":"Kass","year":"1995","journal-title":"J Amer Statistical Assoc"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB28","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1006\/bbrc.1995.1667","article-title":"An age-related correlation between levels of \u03b2-amyloid precursor protein and \u03b2-amyloid in human cerebrospinal fluid","volume":"210","author":"Carroll","year":"1995","journal-title":"Biochem Biophys Res Comm"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB29","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1046\/j.1471-4159.1996.66010259.x","article-title":"Assessment of amyloid \u03b2 protein in cerebrospinal fluid as an aid in the diagnosis of Alzheimer\u2019s disease","volume":"66","author":"Southwick","year":"1996","journal-title":"J Neurochem"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB30","first-page":"259","article-title":"Amyloid \u03b2 protein deposition in normal aging has the same characteristics as that in Alzheimer\u2019s disease. Predominance of A\u03b242(43) and association of A\u03b240 with cored plaques","volume":"148","author":"Fukumoto","year":"1996","journal-title":"Am J Pathol"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB31","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s004010050506","article-title":"Inconstant apolipoprotein E (ApoE)-like immunoreactivity in amyloid \u03b2 protein deposits","volume":"92","author":"Uchihara","year":"1996","journal-title":"Acta Neuropathol"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB32","first-page":"41","article-title":"Senile cerebral amyloid. Prealbumin as a common constituent in the neuritic plaque, in the neurofibrillary tangle, and in the microangiopathic lesion","volume":"107","author":"Shirahama","year":"1982","journal-title":"Am J Pathol"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB33","doi-asserted-by":"crossref","first-page":"22908","DOI":"10.1074\/jbc.271.37.22908","article-title":"Analysis of heterogeneous \u03b2A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive western blot assay","volume":"271","author":"Ida","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB34","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.1600-0404.1988.tb03687.x","article-title":"Reduced prealbumin (transthyretin) in CSF of severely demented patients with Alzheimer\u2019s disease","volume":"78","author":"Riss\u00f8en","year":"1988","journal-title":"Acta Neurol"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB35","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1212\/WNL.36.7.900","article-title":"Transthyretin","volume":"36","author":"Herbert","year":"1986","journal-title":"Neurol"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB36","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0304-3940(96)12774-9","article-title":"Relevance of the quantification of apolipoprotein E in the cerebrospinal fluid in Alzheimer\u2019s disease","volume":"212","author":"Lefranc","year":"1996","journal-title":"Neurosci Lett"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB37","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1111\/j.1471-4159.1993.tb09841.x","article-title":"Characterization of \u03b2-amyloid peptides from normal cerebral spinal fluid","volume":"61","author":"Vigo-Pelfrey","year":"1994","journal-title":"J Neurochem"},{"key":"10.1016\/S0009-9120(98)00027-7_BIB38","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s004010050452","article-title":"Early-onset dementias","volume":"91","author":"Giannakopoulous","year":"1996","journal-title":"Acta Neuropathol"}],"container-title":["Clinical Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912098000277?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912098000277?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T15:15:02Z","timestamp":1757862902000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009912098000277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,7]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1998,7]]}},"alternative-id":["S0009912098000277"],"URL":"https:\/\/doi.org\/10.1016\/s0009-9120(98)00027-7","relation":{},"ISSN":["0009-9120"],"issn-type":[{"type":"print","value":"0009-9120"}],"subject":[],"published":{"date-parts":[[1998,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effects of age, apolipoprotein E phenotype and gender on the concentration of amyloid-\u03b2 (A\u03b2) 40, A\u03b242, apolipoprotein E and transthyretin in human cerebrospinal fluid","name":"articletitle","label":"Article Title"},{"value":"Clinical Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0009-9120(98)00027-7","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1998 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}