{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:25:21Z","timestamp":1762673121681},"reference-count":34,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2001,9,1]],"date-time":"2001-09-01T00:00:00Z","timestamp":999302400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computers in Biology and Medicine"],"published-print":{"date-parts":[[2001,9]]},"DOI":"10.1016\/s0010-4825(01)00013-0","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T21:18:16Z","timestamp":1027631896000},"page":"385-398","source":"Crossref","is-referenced-by-count":9,"title":["On preprocessing of protein sequences for neural network prediction of polyproline type II secondary structures"],"prefix":"10.1016","volume":"31","author":[{"given":"Markku","family":"Siermala","sequence":"first","affiliation":[]},{"given":"Martti","family":"Juhola","sequence":"additional","affiliation":[]},{"given":"Mauno","family":"Vihinen","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0010-4825(01)00013-0_BIB1","series-title":"Computational Molecular Biology","author":"Clote","year":"2000"},{"key":"10.1016\/S0010-4825(01)00013-0_BIB2","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/1074-5521(95)90183-3","article-title":"Tyrosine kinases: modular signaling enzymes with tunable specifications","volume":"2","author":"Shokat","year":"1995","journal-title":"Chem. Biol."},{"key":"10.1016\/S0010-4825(01)00013-0_BIB3","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0959-440X(97)80146-7","article-title":"Structures of Src-family tyrosine kinases","volume":"7","author":"Sicheri","year":"1997","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/S0010-4825(01)00013-0_BIB4","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0968-0004(98)01202-X","article-title":"Insights into Src kinase functions: structural comparisons","volume":"23","author":"Williams","year":"1998","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/S0010-4825(01)00013-0_BIB5","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0304-4157(99)00005-2","article-title":"Membrane-targeting of signaling molecules by SH2\/SH3 domain-containing adaptor proteins","volume":"1422","author":"Buday","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S0010-4825(01)00013-0_BIB6","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0898-6568(98)00059-X","article-title":"Regulatory role of SH3 domain-mediated protein\u2013protein interactions in synaptic vesicle endocytosis","volume":"11","author":"McPherson","year":"1999","journal-title":"Cell Signal"},{"key":"10.1016\/S0010-4825(01)00013-0_BIB7","series-title":"Bioinformatics: The Machine Learning Approach","author":"Baldi","year":"1998"},{"key":"10.1016\/S0010-4825(01)00013-0_BIB8","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1093\/bioinformatics\/15.9.723","article-title":"Neural network input representations that produce accurate consensus sequences from DNA fragment assemblies","volume":"15","author":"Allex","year":"1999","journal-title":"Bioinformatics"},{"key":"10.1016\/S0010-4825(01)00013-0_BIB9","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1093\/bioinformatics\/15.11.937","article-title":"Exploiting the past and the future in protein secondary structure prediction","volume":"15","author":"Baldi","year":"1999","journal-title":"Bioinformatics"},{"key":"10.1016\/S0010-4825(01)00013-0_BIB10","first-page":"497","article-title":"Artificial neural network method for discriminating coding regions of eukaryotic genes","volume":"11","author":"Cai","year":"1995","journal-title":"CABIOS"},{"key":"10.1016\/S0010-4825(01)00013-0_BIB11","first-page":"41","article-title":"HTTP: a neural network-based method for predicting the topology of helical transmembrane domains in proteins","volume":"12","author":"Fariselli","year":"1996","journal-title":"CABIOS"},{"key":"10.1016\/S0010-4825(01)00013-0_BIB12","doi-asserted-by":"crossref","unstructured":"D. Frishman, P. Argos, A neural network for recognizing distantly related protein sequences, in: E. Fiesler, R. Beale (Eds.), Handbook of Neural Computation, IOP Publishing and Oxford University Press, Amsterdam, Oxford, 1997, pp. G4.4:1\u20138.","DOI":"10.1887\/0750303123\/b365c116"},{"key":"10.1016\/S0010-4825(01)00013-0_BIB13","first-page":"447","article-title":"Kohonen map as a visualization tool for the analysis of protein sequences: multiple alignments, domains and segments of secondary structures","volume":"12","author":"Henk","year":"1996","journal-title":"CABIOS"},{"key":"10.1016\/S0010-4825(01)00013-0_BIB14","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1093\/bioinformatics\/16.3.245","article-title":"Adaptive encoding neural networks for the recognition of human signal peptide cleavage sites","volume":"16","author":"Jagla","year":"2000","journal-title":"Bioinformatics"},{"key":"10.1016\/S0010-4825(01)00013-0_BIB15","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/0076-6879(92)10031-8","article-title":"Artificial neural networks","volume":"210","author":"Katz","year":"1992","journal-title":"Meth. Enzymology"},{"key":"10.1016\/S0010-4825(01)00013-0_BIB16","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/0167-7799(90)90206-D","article-title":"Training neural networks to analyse biological sequences","volume":"8","author":"Petersen","year":"1990","journal-title":"Trends in Biotechnology."},{"key":"10.1016\/S0010-4825(01)00013-0_BIB17","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/0022-2836(88)90564-5","article-title":"Predicting the secondary structure of globular proteins using neural network models","volume":"202","author":"Qian","year":"1988","journal-title":"J. Mol. Biol."},{"key":"10.1016\/S0010-4825(01)00013-0_BIB18","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/prot.340190108","article-title":"Combining evolutionary information and neural networks to predict protein secondary structure","volume":"19","author":"Rost","year":"1994","journal-title":"Proteins"},{"key":"10.1016\/S0010-4825(01)00013-0_BIB19","doi-asserted-by":"crossref","unstructured":"B. Rost, A neural network for prediction of protein secondary structure, in: E. Fiesler, R. Beale (Eds.), Handbook of Neural Computation, IOP Publishing and Oxford University Press, Amsterdam, Oxford, 1997, pp. G4.1:1\u20139.","DOI":"10.1887\/0750303123\/b365c113"},{"key":"10.1016\/S0010-4825(01)00013-0_BIB20","doi-asserted-by":"crossref","unstructured":"E.E. Snyder, G.D. Stormo, Neural networks for identification of protein coding regions in genomic DNA sequences, in: E. Fiesler, R. Beale (Eds.), Handbook of Neural Computation, IOP Publishing and Oxford University Press, Amsterdam, Oxford, 1997, pp. G4.2:1\u20138.","DOI":"10.1887\/0750303123\/b365c114"},{"key":"10.1016\/S0010-4825(01)00013-0_BIB21","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1093\/bioinformatics\/16.12.1062","article-title":"Neural network schemes for detecting rare events in human genomic DNA","volume":"16","author":"Choe","year":"2000","journal-title":"Bioinformatics"},{"key":"10.1016\/S0010-4825(01)00013-0_BIB22","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/0022-2836(70)90057-4","article-title":"A general method applicable to search for similarities in amino-acid sequence of two proteins","volume":"48","author":"Needleman","year":"1970","journal-title":"J. Mol. Biol."},{"key":"10.1016\/S0010-4825(01)00013-0_BIB23","unstructured":"PDB: http:\/\/www.rcsb.og\/pdb\/"},{"key":"10.1016\/S0010-4825(01)00013-0_BIB24","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The Protein Data Bank","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleid Acids Res."},{"key":"10.1016\/S0010-4825(01)00013-0_BIB25","series-title":"Applying Neural Networks","author":"Swingler","year":"1996"},{"key":"10.1016\/S0010-4825(01)00013-0_BIB26","series-title":"Atlas of Protein Sequence and Structure, Vol. 5","first-page":"345","article-title":"A model of evolutionary change in proteins, matrices for detecting distant relationships","author":"Dayhoff","year":"1978"},{"key":"10.1016\/S0010-4825(01)00013-0_BIB27","unstructured":"M. Siermala, M. Juhola, M. Vihinen, On preprocessing of protein sequences for neural network prediction of polyproline type II secondary structures, Department of Computer and Information Science, University of Tampere, Finland, Report A-2000-13, 2000."},{"key":"10.1016\/S0010-4825(01)00013-0_BIB28","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1002\/bip.360221211","article-title":"Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features","volume":"22","author":"Kabsch","year":"1983","journal-title":"Biopolymers"},{"key":"10.1016\/S0010-4825(01)00013-0_BIB29","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1109\/10.245628","article-title":"Peptides secondary structure prediction with neural networks: a criterion for building appropriate learning sets","volume":"40","author":"Ruggiero","year":"1993","journal-title":"Trans. Biomed. Eng."},{"key":"10.1016\/S0010-4825(01)00013-0_BIB30","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1006\/jmbi.1993.1047","article-title":"Left-handed polyproline II helices commonly occur in globular proteins","volume":"229","author":"Adzhubei","year":"1993","journal-title":"J. Mol. Biol."},{"key":"10.1016\/S0010-4825(01)00013-0_BIB31","unstructured":"M. Siermala, M. Juhola, M. Vihinen, Neural network prediction of polyproline type II secondary structures, in: A. Hasman, B. Blobel, J. Dudeck, R. Engelbrecht, G. Gell, H.-U. Prokosch (Eds.), Medical Informatics Europe 2000, Hannover, Germany, 27 August\u20131 September, 2000, pp. 475\u2013479."},{"key":"10.1016\/S0010-4825(01)00013-0_BIB32","series-title":"Neural Networks for Pattern Recognition","author":"Bishop","year":"1997"},{"key":"10.1016\/S0010-4825(01)00013-0_BIB33","series-title":"Third Generation Prediction of Secondary Structure","author":"Rost","year":"1998"},{"key":"10.1016\/S0010-4825(01)00013-0_BIB34","unstructured":"J. Laurikkala, M. Juhola, Nearest neighbour classification with heterogeneous proximity functions, in: A. Hasman, B. Blobel, J. Dudeck, R. Engelbrecht, G. Gell, H.-U. Prokosch (Eds.), Medical Informatics Europe 2000, Hannover, Germany, 27 August\u20131 September, 2000, pp. 753\u2013757."}],"container-title":["Computers in Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010482501000130?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010482501000130?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,20]],"date-time":"2019-04-20T13:56:16Z","timestamp":1555768576000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0010482501000130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,9]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,9]]}},"alternative-id":["S0010482501000130"],"URL":"https:\/\/doi.org\/10.1016\/s0010-4825(01)00013-0","relation":{},"ISSN":["0010-4825"],"issn-type":[{"value":"0010-4825","type":"print"}],"subject":[],"published":{"date-parts":[[2001,9]]}}}