{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:24:55Z","timestamp":1762143895213},"reference-count":37,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[1997,7,1]],"date-time":"1997-07-01T00:00:00Z","timestamp":867715200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[1997,7]]},"DOI":"10.1016\/s0014-2999(97)01053-4","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T12:18:09Z","timestamp":1027599489000},"page":"155-160","source":"Crossref","is-referenced-by-count":58,"title":["Effect of spinal cyclooxygenase inhibitors in rat using the formalin test and in vitro prostaglandin E2 release"],"prefix":"10.1016","volume":"331","author":[{"given":"David M","family":"Dirig","sequence":"first","affiliation":[]},{"given":"Gabrielle P","family":"Konin","sequence":"additional","affiliation":[]},{"given":"Peter C","family":"Isakson","sequence":"additional","affiliation":[]},{"given":"Tony L","family":"Yaksh","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0014-2999(97)01053-4_BIB1","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.2042-7158.1976.tb04144.x","article-title":"Pharmacological differences between the optical isomers of ibuprofen: Evidence for metabolic inversion of the (\u2212)-isomer","volume":"28","author":"Adams","year":"1976","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/S0014-2999(97)01053-4_BIB2","doi-asserted-by":"crossref","first-page":"16516","DOI":"10.1016\/0014-5793(96)00604-7","article-title":"Up-regulation of cyclooxygenase-2 mRNA in the rat spinal cord following peripheral inflammation","volume":"390","author":"Beiche","year":"1996","journal-title":"FEBS Lett."},{"key":"10.1016\/S0014-2999(97)01053-4_BIB3","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1139\/y80-039","article-title":"Prostaglandin E2 catabolism in the spinal nerve roots of the cat","volume":"58","author":"Bishai","year":"1980","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/S0014-2999(97)01053-4_BIB4","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/cne.903550208","article-title":"Characterization of inducible cyclooxygenase in rat brain","volume":"355","author":"Breder","year":"1995","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/S0014-2999(97)01053-4_BIB5","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/j.2042-7158.1983.tb04345.x","article-title":"Biological activity of indoprofen and its optical isomers","volume":"35","author":"Buttinoni","year":"1983","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/S0014-2999(97)01053-4_BIB6","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0304-3959(87)90023-6","article-title":"Subcutaneous formalin-induced activity of dorsal horn neurones in the rat: Differential response to an intrathecal opiate administered pre or post formalin","volume":"30","author":"Dickenson","year":"1987","journal-title":"Pain"},{"key":"10.1016\/S0014-2999(97)01053-4_BIB7","first-page":"219","article-title":"Intrathecal baclofen and muscimol, but not midazolam, are antinociceptive using the rat-formalin model","volume":"275","author":"Dirig","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/S0014-2999(97)01053-4_BIB8","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1042\/bj3050479","article-title":"Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase","volume":"305","author":"Gierse","year":"1995","journal-title":"Biochem. J."},{"key":"10.1016\/S0014-2999(97)01053-4_BIB9","doi-asserted-by":"crossref","first-page":"15810","DOI":"10.1074\/jbc.271.26.15810","article-title":"A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors","volume":"271","author":"Gierse","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0014-2999(97)01053-4_BIB10","first-page":"119","article-title":"Radioimmunoassay of prostaglandins and thromboxanes","volume":"5","author":"Granstrom","year":"1978","journal-title":"Adv. Prostaglandin Thromboxane Res."},{"key":"10.1016\/S0014-2999(97)01053-4_BIB11","unstructured":"Hammond, D.L., Gregory, S.A., 1996. Intrathecally administered cyclooxygenase-2 inhibitors attenuate carrageenan-induced thermal hyperalgesia in the rat. Soc. Neurosci. Abs. 26th Annual Meeting, 712.17."},{"key":"10.1016\/S0014-2999(97)01053-4_BIB12","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0006-8993(94)91596-2","article-title":"Prostacyclin enhances the evoked-release of substance P and calcitonin gene-related peptide from rat sensory neurons","volume":"655","author":"Hingtgen","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/S0014-2999(97)01053-4_BIB13","doi-asserted-by":"crossref","first-page":"5411","DOI":"10.1523\/JNEUROSCI.15-07-05411.1995","article-title":"Prostaglandins facilitate peptide release from rat sensory neurons by activating the adenosine 3\u2032,5\u2032-cyclic monophosphate transduction cascade","volume":"15","author":"Hingtgen","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/S0014-2999(97)01053-4_BIB14","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/0014-5793(73)80456-9","article-title":"On the specificity of antisera against prostaglandins A2 and E2","volume":"37","author":"Jobke","year":"1973","journal-title":"FEBS Lett."},{"key":"10.1016\/S0014-2999(97)01053-4_BIB15","first-page":"136","article-title":"Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat","volume":"263","author":"Malmberg","year":"1992","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/S0014-2999(97)01053-4_BIB16","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0014-2999(94)90247-X","article-title":"Antinociception produced by spinal delivery of the S and R enantiomers of flurbiprofen in the formalin test","volume":"256","author":"Malmberg","year":"1994","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/S0014-2999(97)01053-4_BIB17","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1523\/JNEUROSCI.15-04-02768.1995","article-title":"Cyclooxygenase inhibition and the spinal release of prostaglandin E2 and amino acids evoked by paw formalin injection: A microdialysis study in unanesthetized rats","volume":"15","author":"Malmberg","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/S0014-2999(97)01053-4_BIB18","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1172\/JCI114850","article-title":"Selective regulation of cellular cyclooxygenase by dexamethasone and endotoxin in mice","volume":"86","author":"Masferrer","year":"1990","journal-title":"J. Clin. Invest."},{"key":"10.1016\/S0014-2999(97)01053-4_BIB19","doi-asserted-by":"crossref","first-page":"10902","DOI":"10.1074\/jbc.270.18.10902","article-title":"Different intracellular locations for prostaglandin endoperoxide synthases-1 and -2","volume":"270","author":"Morita","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0014-2999(97)01053-4_BIB20","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1021\/jm960803q","article-title":"Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: Identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazole-1-yl]benzenesulfonamide (SC-58635 Celecoxib)","volume":"40","author":"Penning","year":"1997","journal-title":"J. Med. Chem."},{"key":"10.1016\/S0014-2999(97)01053-4_BIB21","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0304-3959(95)00121-2","article-title":"Formalin-evoked activity in identified primary afferent fibers: Systematic lidocaine suppresses phase 2 activity","volume":"64","author":"Puig","year":"1996","journal-title":"Pain"},{"key":"10.1016\/S0014-2999(97)01053-4_BIB22","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1016\/S0021-9258(18)69170-7","article-title":"Regulation of fibroblast cyclooxygenase synthesis by interleukin-1","volume":"263","author":"Raz","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0014-2999(97)01053-4_BIB23","doi-asserted-by":"crossref","first-page":"12013","DOI":"10.1073\/pnas.91.25.12013","article-title":"Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain","volume":"91","author":"Seibert","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0014-2999(97)01053-4_BIB24","doi-asserted-by":"crossref","first-page":"6382","DOI":"10.1016\/S0021-9258(18)42706-8","article-title":"Purification and characterization of a novel, distinct isoform of prostaglandin endoperoxide synthase induced by human chorionic gonadotropin in granulosa cells of rat preovulatory follicles","volume":"267","author":"Sirois","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0014-2999(97)01053-4_BIB25","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0065-2776(08)60430-7","article-title":"Prostaglandin Endoperoxide H Synthases-1 and -2","volume":"62","author":"Smith","year":"1996","journal-title":"Adv. Immunol."},{"key":"10.1016\/S0014-2999(97)01053-4_BIB26","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/0006-8993(90)90723-O","article-title":"Nociceptive effects induced by intrathecal administration of prostaglandin D2, E2, or F2 alpha to conscious mice","volume":"510","author":"Uda","year":"1990","journal-title":"Brain Res."},{"key":"10.1016\/S0014-2999(97)01053-4_BIB27","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/newbio231232a0","article-title":"Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs","volume":"231","author":"Vane","year":"1971","journal-title":"Nature New Biol."},{"key":"10.1016\/S0014-2999(97)01053-4_BIB28","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0304-3959(90)90073-M","article-title":"The rat paw formalin test: Comparison of noxious agents","volume":"40","author":"Wheeler-Aceto","year":"1990","journal-title":"Pain"},{"key":"10.1016\/S0014-2999(97)01053-4_BIB29","unstructured":"Yaksh, T.L., 1982. Central and peripheral mechanism for the antialgesic action of acetylsalicylic acid. In: Barnet, J.M., Hirsh, J., Mustard, J.F. (Eds), Central and Peripheral Mechanism for the Antialgesic Action of Acetylsalicylic Acid. Raven Press, New York, NY, pp. 137\u2013152."},{"key":"10.1016\/S0014-2999(97)01053-4_BIB30","first-page":"250","article-title":"The spinal pharmacology of facilitation of afferent processing evoked by high-threshold afferent input of the postinjury pain state","volume":"6","author":"Yaksh","year":"1993","journal-title":"Curr. Opin. Neurol. Neurosurg."},{"key":"10.1016\/S0014-2999(97)01053-4_BIB31","unstructured":"Yaksh, T.L., 1997. Pre-clinical models of nociception. In: Biebuyck, J.F., Lynch, C., Maze, M., Saidman, L.J., Yaksh, T.L., Zapol, W. (Eds), Pre-clinical Models of Nociception. Lippincott-Raven, Philadelphia, PA, in press."},{"key":"10.1016\/S0014-2999(97)01053-4_BIB32","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/0031-9384(76)90029-9","article-title":"Chronic catheterization of the spinal sub-arachnoid space","volume":"17","author":"Yaksh","year":"1976","journal-title":"Physiol. Behav."},{"key":"10.1016\/S0014-2999(97)01053-4_BIB33","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/0024-3205(91)90537-L","article-title":"The utility of 2-hydroxypropyl-beta-cyclodextrin as a vehicle for the intracerebral and intrathecal administration of drugs","volume":"48","author":"Yaksh","year":"1991","journal-title":"Life Sci."},{"key":"10.1016\/S0014-2999(97)01053-4_BIB34","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/0896-6273(93)90192-T","article-title":"Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids","volume":"11","author":"Yamagata","year":"1993","journal-title":"Neuron"},{"key":"10.1016\/S0014-2999(97)01053-4_BIB35","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1016\/0024-3205(91)90637-Q","article-title":"Stereospecific effects of a nonpeptidic NK1 selective antagonist, CP-96,345: Antinociception in the absence of motor dysfunction","volume":"49","author":"Yamamoto","year":"1991","journal-title":"Life Sci."},{"key":"10.1016\/S0014-2999(97)01053-4_BIB36","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1097\/00000542-199210000-00021","article-title":"Comparison of the antinociceptive effects of pre- and posttreatment with intrathecal morphine and MK801, an NMDA antagonist, on the formalin test in the rat","volume":"77","author":"Yamamoto","year":"1992","journal-title":"Anesthesiology"},{"key":"10.1016\/S0014-2999(97)01053-4_BIB37","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0304-3959(96)03106-5","article-title":"Characterization of time course of spinal amino acids, citrulline, and PGE2 release after carrageenan\/kaolin-induced knee joint inflammation: A chronic microdialysis study","volume":"67","author":"Yang","year":"1996","journal-title":"Pain"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299997010534?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299997010534?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T16:31:02Z","timestamp":1620232262000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299997010534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,7]]},"references-count":37,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[1997,7]]}},"alternative-id":["S0014299997010534"],"URL":"https:\/\/doi.org\/10.1016\/s0014-2999(97)01053-4","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[1997,7]]}}}