{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T11:26:46Z","timestamp":1772105206760,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1968,6,1]],"date-time":"1968-06-01T00:00:00Z","timestamp":-50025600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental and Molecular Pathology"],"published-print":{"date-parts":[[1968,6]]},"DOI":"10.1016\/s0014-4800(68)80003-6","type":"journal-article","created":{"date-parts":[[2006,3,21]],"date-time":"2006-03-21T12:14:10Z","timestamp":1142943250000},"page":"314-329","source":"Crossref","is-referenced-by-count":41,"title":["The metabolism of free and esterified cholesterol in tissue culture cells: A review"],"prefix":"10.1016","volume":"8","author":[{"given":"George H.","family":"Rothblat","sequence":"first","affiliation":[]},{"given":"David","family":"Kritchevsky","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0014-4800(68)80003-6_bib1","first-page":"30","article-title":"Lipid Metabolism in cultured cells. I. Factors affecting cholesterol uptake","volume":"107","author":"Bailey","year":"1961"},{"key":"10.1016\/S0014-4800(68)80003-6_bib2","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1152\/ajplegacy.1964.207.6.1221","article-title":"Lipid metabolism in cultured cells. III. Cholesterol excretion process","volume":"207","author":"Bailey","year":"1964","journal-title":"Am. J. Physiol."},{"key":"10.1016\/S0014-4800(68)80003-6_bib3","first-page":"747","article-title":"Lipid metabolism in cultured cells. V. Comparative lipid nutrition in serum and in lipid-free chemically defined medium","volume":"115","author":"Bailey","year":"1964"},{"key":"10.1016\/S0014-4800(68)80003-6_bib4","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0014-4827(65)90168-0","article-title":"Lipid metabolism in cultured cells. IV. Serum alpha globulins and cellular cholesterol exchange","volume":"37","author":"Bailey","year":"1965","journal-title":"Exptl. Cell Res."},{"key":"10.1016\/S0014-4800(68)80003-6_bib5","series-title":"Lipid Metabolism in Tissue Culture Cells","first-page":"85","article-title":"Cellular lipid nutrition and lipid transport","volume":"6","author":"Bailey","year":"1967"},{"key":"10.1016\/S0014-4800(68)80003-6_bib6","unstructured":"Bailey, J. M. (1968). Personal Communication."},{"key":"10.1016\/S0014-4800(68)80003-6_bib7","first-page":"686","article-title":"Utilization of serum lipids by cultured mammalian cells","volume":"100","author":"Bailey","year":"1959"},{"key":"10.1016\/S0014-4800(68)80003-6_bib8","first-page":"594","article-title":"Lipid metabolism in culture cells. II. Cholesterol uptake from serum of normal and atherosclerotic human adults","volume":"107","author":"Bailey","year":"1961"},{"key":"10.1016\/S0014-4800(68)80003-6_bib9","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1083\/jcb.9.1.135","article-title":"The source of lipid accumulation in L cells","volume":"9","author":"Bensch","year":"1961","journal-title":"J. Biophys. Biochem. Cytol."},{"key":"10.1016\/S0014-4800(68)80003-6_bib10","first-page":"51","article-title":"Synthesis of cholesterol by a strain of human uterine fibroblasts propagated in vitro","volume":"99","author":"Berliner","year":"1958"},{"key":"10.1016\/S0014-4800(68)80003-6_bib11","first-page":"174","article-title":"Characterization of lipid constituents of human \u201cfibroblasts\u201d cultivated in vitro","volume":"115","author":"Bole","year":"1964"},{"key":"10.1016\/S0014-4800(68)80003-6_bib12","series-title":"Excretion of free cholesterol from L5178Y tissue culture cells: Effect of serum lipids","author":"Burns","year":"1968"},{"key":"10.1016\/S0014-4800(68)80003-6_bib13","series-title":"Research Progress in Organic-Biological and Medicinal Chemistry","article-title":"The biochemistry of human cells in culture","author":"Cristofalo","year":"1968"},{"key":"10.1016\/S0014-4800(68)80003-6_bib14","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/icb.1963.57","article-title":"Application of a tissue culture technique to screen compounds for the prevention of lipid deposition in aorta cells","volume":"41","author":"Curtis","year":"1963","journal-title":"Australian. J. Exptl. Biol. Med. Sci."},{"key":"10.1016\/S0014-4800(68)80003-6_bib15","series-title":"Advances in Lipid Research","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/B978-1-4831-9941-2.50011-X","article-title":"Lipid metabolism by macrophages and its relationship to atherosclerosis","author":"Day","year":"1967"},{"key":"10.1016\/S0014-4800(68)80003-6_bib16","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/0014-4827(64)90302-7","article-title":"Chemically defined media for cultivation of long-term cell strains from four mammalian species","volume":"36","author":"Evans","year":"1964","journal-title":"Exptl. Cell Res."},{"key":"10.1016\/S0014-4800(68)80003-6_bib17","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/0014-4827(65)90211-9","article-title":"The limited in vitro lifetime of human diploid cell strains","volume":"37","author":"Hayflick","year":"1965","journal-title":"Exptl. Cell Res."},{"key":"10.1016\/S0014-4800(68)80003-6_bib18","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1083\/jcb.30.3.531","article-title":"An improved chemically defined basal medium (CMRL-1415) for newly explanted mouse embryo cells","volume":"30","author":"Healy","year":"1966","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0014-4800(68)80003-6_bib19","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/infdis\/112.3.213","article-title":"Studies on the nutrition and metabolism of animal cells in serum-free media. I. Serum-free monolayer cultures","volume":"112","author":"Higuchi","year":"1963","journal-title":"J. Infect. Diseases"},{"key":"10.1016\/S0014-4800(68)80003-6_bib20","first-page":"343","article-title":"The lipids of human diploid cell strain WI-38","volume":"44","author":"Kritchevsky","year":"1966","journal-title":"Ann. Med. Exptl. Biol. Fenniae"},{"key":"10.1016\/S0014-4800(68)80003-6_bib21","first-page":"375","article-title":"The lipid content and structure of cells","volume":"23","author":"Mackenzie","year":"1964"},{"key":"10.1016\/S0014-4800(68)80003-6_bib22","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/0014-4827(64)90310-6","article-title":"Regulation of cell lipid metabolism and accumulation. III. The lipid content of mammalian cells and the response to the lipogenic activity of rabbit serum","volume":"36","author":"MacKenzie","year":"1964","journal-title":"Exptl. Cell Res."},{"key":"10.1016\/S0014-4800(68)80003-6_bib23","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1021\/bi00869a002","article-title":"Regulation of cell lipid metabolism and accumulation. IV. The isolation and composition of cytoplasmic lipid-rich particles","volume":"5","author":"MacKenzie","year":"1966","journal-title":"Biochemistry"},{"key":"10.1016\/S0014-4800(68)80003-6_bib24","series-title":"Lipid Metabolism in Tissue Culture Cells","first-page":"63","article-title":"Regulation of cell lipid metabolism and accumulation. V. Quantitative and structural aspects of triglyceride accumulation caused by lipogenic substances","volume":"6","author":"MacKenzie","year":"1967"},{"key":"10.1016\/S0014-4800(68)80003-6_bib25","first-page":"362","article-title":"Effects of acid mucopolysaccharides on growth rates and constituent lipids of tissue cultures","volume":"113","author":"Morrison","year":"1963"},{"key":"10.1016\/S0014-4800(68)80003-6_bib26","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1177\/000331976101201015","article-title":"Effects of heparin on the uptake of lipids by isolated human and animal arterial endothelial type cells","volume":"12","author":"Robertson","year":"1961","journal-title":"Angiology"},{"key":"10.1016\/S0014-4800(68)80003-6_bib27","first-page":"193","article-title":"The uptake of labeled lipoproteins by isolated human and animal endothelial type cells","volume":"vol. 2","author":"Robertson","year":"1963"},{"key":"10.1016\/S0014-4800(68)80003-6_bib28","series-title":"Biophysical Mechanisms in Vascular Homeostatis and Intravascular Thrombosis","first-page":"267","article-title":"Intracellular incorporation of plasma lipoproteins by arterial intima in relation to early stages of intravascular thrombosis","author":"Robertson","year":"1965"},{"key":"10.1016\/S0014-4800(68)80003-6_bib29","series-title":"Lipid Metabolism in Tissue Culture Cells","first-page":"115","article-title":"Transport of plasma lipoproteins and ultrastructure of human arterial intimacytes in culture","volume":"6","author":"Robertson","year":"1967"},{"key":"10.1016\/S0014-4800(68)80003-6_bib30","unstructured":"Robertson, A.L. (1968). Personal communication."},{"key":"10.1016\/S0014-4800(68)80003-6_bib31","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1172\/JCI104812","article-title":"Plasma lipoprotein metabolism in perfused rat livers. II. Transfer of free and esterified cholesterol into the plasma","volume":"42","author":"Roheim","year":"1963","journal-title":"J. Clin. Invest."},{"key":"10.1016\/S0014-4800(68)80003-6_bib32","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1351\/pac196408030507","article-title":"Comparison of effects of D2O and X-Ray irradiation on lipid composition of tissue culture cells","volume":"8","author":"Rothblat","year":"1964","journal-title":"Pure Appl. Chem."},{"key":"10.1016\/S0014-4800(68)80003-6_bib33","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0005-2760(66)90099-3","article-title":"The uptake of cholesterol by L5178Y tissue culture cells: Studies with free cholesterol","volume":"116","author":"Rothblat","year":"1966","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S0014-4800(68)80003-6_bib34","series-title":"Lipid Metabolism in Tissue Culture Cells","first-page":"129","article-title":"Cholesterol metabolism is tissue culture cells","volume":"6","author":"Rothblat","year":"1967"},{"key":"10.1016\/S0014-4800(68)80003-6_bib35","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/0005-2760(67)90172-5","article-title":"The excretion of free and ester cholesterol by tissue culture cells: Studies with L5178Y and L cells","volume":"144","author":"Rothblat","year":"1967","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S0014-4800(68)80003-6_bib36","first-page":"35","article-title":"Uptake of cholesterol by L5178Y tissue culture cells: Studies with delipidized serum. (Abstract)","volume":"36","author":"Rothblat","year":"1967","journal-title":"Circulation"},{"key":"10.1016\/S0014-4800(68)80003-6_bib37","first-page":"317","article-title":"Cholesterol ester metabolism in tissue culture cells","author":"Rothblat","year":"1968"},{"key":"10.1016\/S0014-4800(68)80003-6_bib38","series-title":"Cholesterol uptake by L5178Y tissue culture cells: Studies with delipidized serum","author":"Rothblat","year":"1968"},{"key":"10.1016\/S0014-4800(68)80003-6_bib39","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0140-6736(58)91191-7","article-title":"Effects of linolenic and stearic acids on cholesterol-induced lipoid deposition in human aortic cells in tissue-culture","volume":"1","author":"Rutstein","year":"1958","journal-title":"Lancet"},{"key":"10.1016\/S0014-4800(68)80003-6_bib40","first-page":"7","article-title":"Further studies on the deletion of the cholesterol feedback system in hepatomas","volume":"26","author":"Siperstein","year":"1966","journal-title":"Cancer Res."},{"key":"10.1016\/S0014-4800(68)80003-6_bib41","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/S0021-9258(18)96165-X","article-title":"Combination of delipidized high density lipoprotein with lipids","volume":"242","author":"Sodhi","year":"1967","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0014-4800(68)80003-6_bib42","series-title":"Biological Properties of Mammalian Surface Membrane","article-title":"The lipid composition of the surface membranes of the L cell","volume":"8","author":"Weinstein","year":"1968"}],"container-title":["Experimental and Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480068800036?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480068800036?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,25]],"date-time":"2021-07-25T02:08:59Z","timestamp":1627178939000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014480068800036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1968,6]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1968,6]]}},"alternative-id":["S0014480068800036"],"URL":"https:\/\/doi.org\/10.1016\/s0014-4800(68)80003-6","relation":{},"ISSN":["0014-4800"],"issn-type":[{"value":"0014-4800","type":"print"}],"subject":[],"published":{"date-parts":[[1968,6]]}}}