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Incubation with either H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> or menadione enhanced cardiomyogenesis, whereas the radical scavengers trolox, pyrrolidinedithiocarbamate and <jats:italic>N<\/jats:italic>\u2010acetylcysteine exerted inhibitory effects. The phosphatidylinositol 3\u2010kinase (PI\u20103\u2010kinase) inhibitors LY294002 and wortmannin abolished cardiac commitment and downregulated ROS in embryoid bodies. 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