{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T23:43:47Z","timestamp":1769125427284,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2000,10,5]],"date-time":"2000-10-05T00:00:00Z","timestamp":970704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2000,10,6]]},"abstract":"<jats:p>The potential use of polypeptides and oligonucleotides for therapeutical purposes has been questioned because of their inherently poor cellular uptake. However, the 16\u2010mer oligopeptide penetratin, derived from the homeodomain of Antennapedia, has been reported to enter cells readily via a non\u2010endocytotic and receptor\u2010 and transporter\u2010independent pathway, even when conjugated to large hydrophilic molecules. We here present the first study where penetratin is shown to traverse a pure lipid bilayer. The results support the idea that the uptake mechanism involves only the interaction of the peptide with the membrane lipids. Furthermore, we conclude that the translocation does not involve pore formation.<\/jats:p>","DOI":"10.1016\/s0014-5793(00)02072-x","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T14:34:24Z","timestamp":1027607664000},"page":"265-268","source":"Crossref","is-referenced-by-count":201,"title":["The Antennapedia peptide penetratin translocates across lipid bilayers \u2013 the first direct observation"],"prefix":"10.1002","volume":"482","author":[{"given":"Per E.G.","family":"Thor\u00e9n","sequence":"first","affiliation":[]},{"given":"Daniel","family":"Persson","sequence":"additional","affiliation":[]},{"given":"Mattias","family":"Karlsson","sequence":"additional","affiliation":[]},{"given":"Bengt","family":"Nord\u00e9n","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2000,10,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-7799(96)30005-X"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(99)01429-7"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(00)01447-4"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(98)80017-2"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1096\/fsb2fasebj.12.1.67"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.25.16010"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0998-857"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(00)00310-5"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(00)00305-7"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.30.18188"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3011.2000.00163.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(96)80095-X"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1996.0372r.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01868880"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4157(98)00014-8"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi971009p"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)54349-0"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00187a044"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(97)78115-3"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(94)90303-4"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(00)01771-2"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2FS0014-5793%2800%2902072-X","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2FS0014-5793(00)02072-X","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/S0014-5793%2800%2902072-X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T09:41:08Z","timestamp":1694857268000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1016\/S0014-5793%2800%2902072-X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,10,5]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,10,6]]}},"alternative-id":["10.1016\/S0014-5793(00)02072-X"],"URL":"https:\/\/doi.org\/10.1016\/s0014-5793(00)02072-x","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,10,5]]}}}