{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:25:05Z","timestamp":1767849905754,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2001,2,20]],"date-time":"2001-02-20T00:00:00Z","timestamp":982627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2001,2,23]]},"abstract":"<jats:p>Chick pineal mitogen\u2010activated protein kinase (MAPK) exhibits circadian activation and light\u2010dependent deactivation at nighttime. Here we report that, in the chick pineal gland, levels of active forms of MAPK, MEK, Raf\u20101 and Ras exhibited synchronous circadian rhythms with peaks during the subjective night, suggesting a sequential activation of components in the classical Ras\u2010MAPK pathway in a circadian manner. In contrast, the light\u2010dependent deactivation of MAPK was not accompanied by any change of MEK activity, but it was attributed to the light\u2010dependent activation of protein phosphatase dephosphorylating MAPK. These results indicate that the photic and clock signals regulate MAPK activity via independent pathways, and suggest a pivotal role of MAPK in photic entrainment and maintenance of the circadian oscillation.<\/jats:p>","DOI":"10.1016\/s0014-5793(01)02153-6","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T19:52:46Z","timestamp":1027626766000},"page":"71-75","source":"Crossref","is-referenced-by-count":29,"title":["Circadian and photic regulation of MAP kinase by Ras\u2010 and protein phosphatase\u2010dependent pathways in the chick pineal gland"],"prefix":"10.1002","volume":"491","author":[{"given":"Yuichiro","family":"Hayashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamon","family":"Sanada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Fukada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,2,20]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.55.030193.000313"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.214852"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.424750"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/372094a0"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)81713-1"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/3695"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-03-00986.2000"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M004706200"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.44.27665"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.3.1487"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(95)55031-3"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.25.14843"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5466.682"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/35003589"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81199-X"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.14.6.645"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/343651a0"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.24.7337"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.0278"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4889(94)00211-V"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2560283"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(91)01043-2"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.11.5292"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1995.65031332.x"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2FS0014-5793%2801%2902153-6","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2FS0014-5793(01)02153-6","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/S0014-5793%2801%2902153-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T03:37:37Z","timestamp":1694835457000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1016\/S0014-5793%2801%2902153-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2,20]]},"references-count":24,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2001,2,23]]}},"alternative-id":["10.1016\/S0014-5793(01)02153-6"],"URL":"https:\/\/doi.org\/10.1016\/s0014-5793(01)02153-6","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,2,20]]}}}