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In <jats:italic>Xenopus<\/jats:italic> oocytes TASK\u20104 generated K<jats:sup>+<\/jats:sup> currents displaying a marked outward rectification which was lost by elevation of extracellular K<jats:sup>+<\/jats:sup>. TASK\u20104 currents were efficiently blocked by barium (83% inhibition at 2 mM), only weakly inhibited by 1 mM concentrations of quinine, bupivacaine and lidocaine, but not blocked by tetraethylammonium, 4\u2010aminopyridine and Cs<jats:sup>+<\/jats:sup>. TASK\u20104 was sensitive to extracellular pH, but in contrast to other TASK channels, pH sensitivity was shifted to more alkaline pH. Thus, TASK\u20104 in concert with other TASK channels might regulate cellular membrane potential over a wide range of extracellular pH.<\/jats:p>","DOI":"10.1016\/s0014-5793(01)02222-0","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T19:58:13Z","timestamp":1027627093000},"page":"84-89","source":"Crossref","is-referenced-by-count":114,"title":["Characterization of TASK\u20104, a novel member of the pH\u2010sensitive, two\u2010pore domain potassium channel family"],"prefix":"10.1002","volume":"492","author":[{"given":"Niels","family":"Decher","sequence":"first","affiliation":[]},{"given":"Marcel","family":"Maier","sequence":"additional","affiliation":[]},{"given":"Werner","family":"Dittrich","sequence":"additional","affiliation":[]},{"given":"Johann","family":"Gassenhuber","sequence":"additional","affiliation":[]},{"given":"Andrea","family":"Br\u00fcggemann","sequence":"additional","affiliation":[]},{"given":"Andreas E.","family":"Busch","sequence":"additional","affiliation":[]},{"given":"Klaus","family":"Steinmeyer","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2001,3,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/376690a0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.23.13256"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2000.279.5.F793"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s109-1998-8100-0"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90137-X"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(96)00126-8"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb00437.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.12.7887"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.38.26691"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M000445200"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.12.3297"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-20-07634.1997"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/12.2.857"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb01031.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.13.9340"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.47.30863"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(97)00258-7"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb01077.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.17.5464"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80903-4"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M002822200"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.14.6.863"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.72.4.890"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00582522"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M001948200"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2FS0014-5793%2801%2902222-0","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2FS0014-5793(01)02222-0","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/S0014-5793%2801%2902222-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T02:48:02Z","timestamp":1694832482000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1016\/S0014-5793%2801%2902222-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,3,7]]},"references-count":25,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2001,3,9]]}},"alternative-id":["10.1016\/S0014-5793(01)02222-0"],"URL":"https:\/\/doi.org\/10.1016\/s0014-5793(01)02222-0","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,3,7]]}}}