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We previously reported that <jats:italic>AGP1<\/jats:italic> induction requires Grr1, the F\u2010box protein part of the SCF<jats:sup>Grr1<\/jats:sup> ubiquitin\u2013ligase complex. We show here that ubiquitin, other components of SCF<jats:sup>Grr1<\/jats:sup> and the ubiquitin\u2010conjugating enzyme Cdc34 are essential for <jats:italic>AGP1<\/jats:italic> and <jats:italic>PTR2<\/jats:italic> induction. This suggests that transduction to these genes of the amino acid signal generated by Ssy1 involves an SCF<jats:sup>Grr1<\/jats:sup>\u2010catalysed ubiquitination step.<\/jats:p>","DOI":"10.1016\/s0014-5793(01)02412-7","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T17:17:04Z","timestamp":1027617424000},"page":"81-85","source":"Crossref","is-referenced-by-count":54,"title":["Ubiquitin and the SCF<sup>Grr1<\/sup> ubiquitin ligase complex are involved in the signalling pathway activated by external amino acids in <i>Saccharomyces cerevisiae<\/i>"],"prefix":"10.1002","volume":"496","author":[{"given":"Florent","family":"Bernard","sequence":"first","affiliation":[]},{"given":"Bruno","family":"Andr\u00e9","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2001,5,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/yea.320111605"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(95)01380-6"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(98)00629-2"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.22.12428"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0061(199701)13:1<9::AID-YEA51>3.0.CO;2-U"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.18.5629"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.9.4.399"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(98)01637-0"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1998.00714.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.2.989"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.8.5405"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0061(19980130)14:2<103::AID-YEA203>3.0.CO;2-C"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.3.814-826.2001"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1970.tb00817.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(80)90055-8"},{"key":"e_1_2_5_17_1","unstructured":"Ausubel F. 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