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We placed a mutated CNG channel with high sensitivity to cAMP in adenovirus to maximize and render facile its expression in numerous cell types. The ready, continuous nature of the readout contrasted with the traditional approach, which yielded similar static information, but lacked any continuous or interactive qualities. It seems fair to predict that this readily adopted approach will broaden the perception of cAMP signaling.<\/jats:p>","DOI":"10.1016\/s0014-5793(01)02564-9","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T16:27:39Z","timestamp":1027614459000},"page":"85-90","source":"Crossref","is-referenced-by-count":28,"title":["Adenovirus encoded cyclic nucleotide\u2010gated channels: a new methodology for monitoring cAMP in living cells"],"prefix":"10.1002","volume":"500","author":[{"given":"Kent A.","family":"Fagan","sequence":"first","affiliation":[]},{"given":"Jerome","family":"Schaack","sequence":"additional","affiliation":[]},{"given":"Adam","family":"Zweifach","sequence":"additional","affiliation":[]},{"given":"Dermot M.F.","family":"Cooper","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2001,6,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.182.4115.933"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/374421a0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)97092-4"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.67.1.305"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1210561"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)95711-X"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/349694a0"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/71345"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.116.2.147"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90074-8"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.18.12445"},{"key":"e_1_2_6_13_1","first-page":"395","volume":"26","author":"Evans T.","year":"1984","journal-title":"Mol. 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