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Two muscle IGF\u20101 splice variants were measured and found to be differentially regulated at the RNA level. The significant changes associated with the inability of the older muscles to respond to mechanical overload included the considerably lower expression of the local splice variant mechano growth factor, and the failure to up\u2010regulate IGF\u20101 receptor and MyoD mRNA.<\/jats:p>","DOI":"10.1016\/s0014-5793(01)02825-3","type":"journal-article","created":{"date-parts":[[2002,10,14]],"date-time":"2002-10-14T15:56:01Z","timestamp":1034610961000},"page":"259-263","source":"Crossref","is-referenced-by-count":175,"title":["Age\u2010related loss of skeletal muscle function and the inability to express the autocrine form of insulin\u2010like growth factor\u20101 (MGF) in response to mechanical overload"],"prefix":"10.1002","volume":"505","author":[{"given":"Vivian","family":"Owino","sequence":"first","affiliation":[]},{"given":"Shi Yu","family":"Yang","sequence":"additional","affiliation":[]},{"given":"Geoffrey","family":"Goldspink","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2001,8,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1991.tb02700.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1989.256.6.C1262"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/53A.1.B52"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb09892.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BFb0030904"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0047-6374(82)90105-1"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092270407"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.89.4.1365"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0185(200012)260:4<350::AID-AR30>3.0.CO;2-6"},{"key":"e_1_2_6_11_1","first-page":"E268","volume":"268","author":"Yaresheski K.E.","year":"1995","journal-title":"Am. 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