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Cells expressing DN MKK3 respond to rosiglitazone, resulting in adipocyte formation. The effects of rosiglitazone appear to be potentiated through peroxisome proliferator activating receptor\u2010\u03b3. This trans\u2010differentiation is inhibited by the use of the phosphoinositide\u20103 (PI3) kinase inhibitor, LY294002. 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