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We demonstrate here that the LT\u03b2R signaling to NF\u2010\u03baB activation does not necessarily require NEMO, which is essential for TNFR signaling. In the absence of NEMO, the p50 and RelB, but not RelA subunits of NF\u2010\u03baB are found in the nuclear DNA binding complexes induced by the LT\u03b2R signaling. Our results thus disclose NEMO\u2010independent NF\u2010\u03baB activation by LT\u03b2R.<\/jats:p>","DOI":"10.1016\/s0014-5793(02)03622-0","type":"journal-article","created":{"date-parts":[[2002,12,3]],"date-time":"2002-12-03T11:38:12Z","timestamp":1038915492000},"page":"45-51","source":"Crossref","is-referenced-by-count":65,"title":["Lymphotoxin\u2010\u03b2 receptor mediates NEMO\u2010independent NF\u2010\u03baB activation"],"prefix":"10.1002","volume":"532","author":[{"given":"Tatsuya","family":"Saitoh","sequence":"first","affiliation":[]},{"given":"Hiroyasu","family":"Nakano","sequence":"additional","affiliation":[]},{"given":"Naoki","family":"Yamamoto","sequence":"additional","affiliation":[]},{"given":"Shoji","family":"Yamaoka","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2002,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.17.9302"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80588-9"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80292-7"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00237-9"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80589-0"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.8.4105"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.40.24934"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.15.11121"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1058453"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.909001"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni0302-221"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/41493"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.10.1322"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5412.321"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.14.14.1729"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5339.860"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80406-7"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5381.1360"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5412.313"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/26261"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.14.7.854"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81466-X"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.5.631"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0898-6568(01)00160-7"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104837200"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.15.8570"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.46.28745"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65714-8"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.17.3.1441"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.60.2.181"},{"key":"e_1_2_6_32_1","first-page":"324","volume":"24","author":"Onishi M.","year":"1996","journal-title":"Exp. 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