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We found that expression of the NAD(P)H oxidase adapter p47<jats:italic>\n<jats:sup>phox<\/jats:sup>\n<\/jats:italic> was suppressed in human colon carcinoma specimens relative to adjacent normal colon. Overexpression of p47<jats:italic>\n<jats:sup>phox<\/jats:sup>\n<\/jats:italic> increased apoptosis in colon cancer cell lines independent of p53 and mismatch\u2010repair competency. p47<jats:italic>\n<jats:sup>phox<\/jats:sup>\n<\/jats:italic> was found to interact with the c\u2010Abl adapter Abl interactor\u20101 (ABI\u20101), and p47<jats:italic>\n<jats:sup>phox<\/jats:sup>\n<\/jats:italic> coprecipitated with both ABI\u20101 and c\u2010Abl. Ectopic expression of p47<jats:italic>\n<jats:sup>phox<\/jats:sup>\n<\/jats:italic> in colon cancer cells increased oxidant production with phosphorylation and activation of nuclear c\u2010Abl and consequent apoptosis. Colonic epithelial p47<jats:italic>\n<jats:sup>phox<\/jats:sup>\n<\/jats:italic> may be specifically targeted to a c\u2010Abl\u2010containing complex that serves a physiologic tumor suppressing function.<\/jats:p>","DOI":"10.1016\/s0014-5793(03)00262-x","type":"journal-article","created":{"date-parts":[[2003,4,7]],"date-time":"2003-04-07T17:25:26Z","timestamp":1049736326000},"page":"195-200","source":"Crossref","is-referenced-by-count":4,"title":["Induction of colonic epithelial cell apoptosis by p47\u2010dependent oxidants<sup>1<\/sup>"],"prefix":"10.1002","volume":"540","author":[{"given":"Ying","family":"Gu","sequence":"first","affiliation":[]},{"given":"Rhonda F","family":"Souza","sequence":"additional","affiliation":[]},{"given":"Ru Feng","family":"Wu","sequence":"additional","affiliation":[]},{"given":"You Cheng","family":"Xu","sequence":"additional","affiliation":[]},{"given":"Lance 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