{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:04:39Z","timestamp":1764173079571},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1997,11,7]],"date-time":"1997-11-07T00:00:00Z","timestamp":878860800000},"content-version":"vor","delay-in-days":144,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[1997,6,16]]},"abstract":"<jats:p>FMRFamide\u2010related peptides have been isolated from both invertebrates and vertebrates and exhibit a wide range of biological effects in rats. We show here that in humans 2 FMRFamide\u2010related peptides are encoded by a single gene expressed as a spliced mRNA. The larger predicted peptide (AGEGLNSQFWSLAAPQRFamide) differs from the peptide isolated from bovines (AGEGLSSPFWSLAAPQRFamide) by the substitutions of 2 amino acids. The shorter predicted peptide (NPSF, SQAFLFQPQRFamide) is 3 amino acids longer than the bovine 8 amino\u2010acid NPFF (FLFQPQRFamide) or the human NPFF peptide isolated from serum <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#feb2s0014579397005577-bib-BIB5\">[5]<\/jats:ext-link>, suggesting that the encoded protein is subject to cleavage by a tripeptidyl peptidase or by a novel processing mechanism. On rat spinal cord, the larger peptide is indistinguishable in activity from the equivalent bovine peptide whereas the smaller extended peptide is inactive.<\/jats:p>","DOI":"10.1016\/s0014-5793(97)00557-7","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T15:15:33Z","timestamp":1027610133000},"page":"426-430","source":"Crossref","is-referenced-by-count":192,"title":["A human gene encoding morphine modulating peptides related to NPFF and FMRFamide"],"prefix":"10.1002","volume":"409","author":[{"given":"Stephen J.","family":"Perry","sequence":"first","affiliation":[]},{"given":"Eagle","family":"Yi-Kung Huang","sequence":"additional","affiliation":[]},{"given":"David","family":"Cronk","sequence":"additional","affiliation":[]},{"given":"Jeffery","family":"Bagust","sequence":"additional","affiliation":[]},{"given":"Ram","family":"Sharma","sequence":"additional","affiliation":[]},{"given":"Robert J.","family":"Walker","sequence":"additional","affiliation":[]},{"given":"Shelagh","family":"Wilson","sequence":"additional","affiliation":[]},{"given":"Julian F.","family":"Burke","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[1997,11,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.877582"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.6.1993"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-06-02356.1992"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.22.7757"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(94)00163-4"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(93)90095-Y"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4179(87)90087-4"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4179(90)90054-3"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)90311-9"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(96)00001-9"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)91531-8"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(87)90041-6"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(90)90091-I"},{"key":"e_1_2_6_15_1","unstructured":"Sambrook J. 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