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Here we show in three cases receptor\u00b7RanGTP\u00b7RanBP1 complexes to be the key disassembly intermediates, where RanBP1 stimulates the off\u2010rate at the receptor\/RanGTP interface by more than two orders of magnitude. The transiently released RanGTP\u00b7RanBP1 complex is then induced by RanGAP to hydrolyse GTP, preventing the receptor to rebind RanGTP. The efficient release of importin \u03b2 from RanGTP requires importin \u03b1, in addition to RanBP1.<\/jats:p>","DOI":"10.1016\/s0014-5793(97)01467-1","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T17:53:27Z","timestamp":1027619607000},"page":"249-254","source":"Crossref","is-referenced-by-count":229,"title":["RanBP1 is crucial for the release of RanGTP from importin \u03b2\u2010related nuclear transport factors"],"prefix":"10.1002","volume":"419","author":[{"given":"F.Ralf","family":"Bischoff","sequence":"first","affiliation":[]},{"given":"Dirk","family":"G\u00f6rlich","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[1998,1,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(97)80015-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/mmbr.61.2.193-211.1997"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/386779a0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80361-X"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81315-X"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(96)00583-2"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80372-4"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80173-7"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1996.0369"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.110.11.1325"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80370-0"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80371-2"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/365661a0"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.123.6.1649"},{"key":"e_1_2_6_16_1","unstructured":"Izaurralde E. 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