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We have used the enzyme peptide methionine sulfoxide reductase (PMSR) to reverse this damage, and shown by a variety of criteria that enzyme treatment restores the primary, secondary, and tertiary structure and lipid association characteristic of the native unoxidized protein. Lipid\u2010associated as well as lipid\u2010free apolipoprotein A\u2010I reacts with PMSR, suggesting that enzymatic reduction of oxidized apolipoprotein A\u2010I in high density lipoproteins can result in restoration of biological activity and the ability to promote cholesterol efflux from cells.<\/jats:p>","DOI":"10.1016\/s0014-5793(98)00908-9","type":"journal-article","created":{"date-parts":[[2003,4,5]],"date-time":"2003-04-05T00:21:01Z","timestamp":1049502061000},"page":"196-200","source":"Crossref","is-referenced-by-count":38,"title":["Enzymatic repair of oxidative damage to human apolipoprotein A\u2010I"],"prefix":"10.1002","volume":"433","author":[{"given":"Alexander B.","family":"Sigalov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence J.","family":"Stern","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1999,6,28]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198911093211907"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-199106000-00006"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-199604000-00006"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)41914-5"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)38529-1"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.11.6080"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.11.6088"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi962952g"},{"key":"e_1_2_1_10_1","first-page":"395","volume":"35","author":"Sigalov A.B.","year":"1997","journal-title":"Eur. 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