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The role of Trp proteins in store regulation of endothelial membrane conductances was tested by expression of an N\u2010terminal fragment of hTrp3 (N\u2010TRP) which exerts a dominant negative effect on Trp channel function presumably due to suppression of channel assembly. Depletion of intracellular Ca<jats:sup>2+<\/jats:sup> stores with IP<jats:sub>3<\/jats:sub> (100 \u03bcM) or thapsigargin (100 nM) induced a substantial cation conductance in sham\u2010transfected HUVEC as well as in HUVEC transfected with hTrp3. In contrast, HUVEC transfected with N\u2010TRP failed to exhibit store\u2010operated currents. Our results suggest the involvement of Trp related proteins in the store\u2010operated cation conductance of human vascular endothelial cells.<\/jats:p>","DOI":"10.1016\/s0014-5793(98)01212-5","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T12:19:54Z","timestamp":1027599594000},"page":"101-106","source":"Crossref","is-referenced-by-count":135,"title":["Trp proteins form store\u2010operated cation channels in human vascular endothelial cells"],"prefix":"10.1002","volume":"437","author":[{"given":"Klaus","family":"Groschner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Hingel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Lintschinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Balzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Romanin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Schreibmayer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1998,12,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1997.77.4.901"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/355353a0"},{"key":"e_1_2_5_4_1","first-page":"1014","volume":"47","author":"Reinsprecht M.","year":"1995","journal-title":"Mol. 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