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S1P increased the cytoplasmic free Ca<jats:sup>2+<\/jats:sup> concentration without detectable inositol phosphate production in vector\u2010transfected CHO cells. In the Edg\u20103\u2010transfected cells, however, the S1P\u2010induced Ca<jats:sup>2+<\/jats:sup> response was clearly enhanced, which was associated with a significant production of inositol phosphate. These S1P\u2010induced responses in the Edg\u20103\u2010transfected cells were inhibited by U73122, a potent PLC inhibitor. We conclude that Edg\u20103 may be one of the S1P receptors participating in the activation of the PLC\u2010Ca<jats:sup>2+<\/jats:sup> system.<\/jats:p>","DOI":"10.1016\/s0014-5793(98)01676-7","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T08:19:54Z","timestamp":1027585194000},"page":"25-30","source":"Crossref","is-referenced-by-count":45,"title":["Activation of phospholipase C\u2010Ca<sup>2+<\/sup> system by sphingosine 1\u2010phosphate in CHO cells transfected with Edg\u20103, a putative lipid receptor"],"prefix":"10.1002","volume":"443","author":[{"given":"Koichi","family":"Sato","sequence":"first","affiliation":[]},{"given":"Junko","family":"Kon","sequence":"additional","affiliation":[]},{"given":"Hideaki","family":"Tomura","sequence":"additional","affiliation":[]},{"given":"Mizuho","family":"Osada","sequence":"additional","affiliation":[]},{"given":"Naoya","family":"Murata","sequence":"additional","affiliation":[]},{"given":"Atsushi","family":"Kuwabara","sequence":"additional","affiliation":[]},{"given":"Tomoko","family":"Watanabe","sequence":"additional","affiliation":[]},{"given":"Hideo","family":"Ohta","sequence":"additional","affiliation":[]},{"given":"Michio","family":"Ui","sequence":"additional","affiliation":[]},{"given":"Fumikazu","family":"Okajima","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[1999,1,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.10.12.8903509"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a021865"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)01301-X"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3300605"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5356.1552"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2163543"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)31692-7"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)41846-1"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/365557a0"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/380634a0"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.10.2830"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(95)01526-4"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.44.26332"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.17.10272"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.4.2082"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00168428"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.8.5291"},{"key":"e_1_2_6_19_1","first-page":"G1091","volume":"272","author":"Im D.S.","year":"1997","journal-title":"Am. 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