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Since these signals are recognized by adaptor proteins, we hypothesized that there could be epithelial\u2010specific adaptors involved in polarized sorting. Here, we report the identification of a novel member of the adaptor medium chain family, named \u03bc1B, which is closely related to the previously described \u03bc1A (79% amino acid sequence identity). Northern blotting and in situ hybridization analyses reveal the specific expression of \u03bc1B mRNA in a subset of polarized epithelial and exocrine cells. Yeast two\u2010hybrid analyses show that \u03bc1B is capable of interacting with generic tyrosine\u2010based sorting signals. These observations suggest that \u03bc1B may be involved in protein sorting events specific to polarized cells.<\/jats:p>","DOI":"10.1016\/s0014-5793(99)00432-9","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T12:18:27Z","timestamp":1027599507000},"page":"215-220","source":"Crossref","is-referenced-by-count":223,"title":["\u03bc1B, a novel adaptor medium chain expressed in polarized epithelial cells<sup>1<\/sup>"],"prefix":"10.1002","volume":"449","author":[{"given":"Hiroshi","family":"Ohno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Tomemori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fubito","family":"Nakatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruben C.","family":"Aguilar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heike","family":"Foelsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ira","family":"Mellman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuji","family":"Shirasawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan S.","family":"Bonifacino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1999,4,23]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.12.1.575"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.110.24.3001"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(97)80029-4"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/42408"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/378096a0"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.7.1919"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1993.tb05866.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.42.26300"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.126.4.991"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.109.8.2133"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.137.6.1255"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.110.5.597"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(96)10057-X"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(97)80024-5"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(96)10048-9"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(98)80065-3"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4889(98)00056-1"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7569928"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.16.9790"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.40.25915"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb00965.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.5.917"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.11.6005"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.15.8638"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.8.2148"},{"key":"e_1_2_5_27_1","doi-asserted-by":"crossref","unstructured":"Lennon G. 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