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In support of this view, several studies have demonstrated that the treatment of cultured neurons with A\u03b2 leads to the hyperphosphorylation of tau protein and neuronal cell death. Here we report that lithium prevents the enhanced phosphorylation of tau protein at the sites recognized by antibodies Tau\u20101 and PHF\u20101 which occurs when cultured rat cortical neurons are incubated with A\u03b2. Interestingly, lithium also significantly protects cultured neurons from A\u03b2\u2010induced cell death. These results raise the possibility of using chronic lithium treatment for the therapy of Alzheimer's disease.<\/jats:p>","DOI":"10.1016\/s0014-5793(99)00685-7","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T17:52:28Z","timestamp":1027619548000},"page":"260-264","source":"Crossref","is-referenced-by-count":206,"title":["Lithium protects cultured neurons against \u03b2\u2010amyloid\u2010induced neurodegeneration"],"prefix":"10.1002","volume":"453","author":[{"given":"Gema","family":"Alvarez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan 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