{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T11:23:48Z","timestamp":1772796228511,"version":"3.50.1"},"reference-count":23,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[1993,11,1]],"date-time":"1993-11-01T00:00:00Z","timestamp":752112000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T00:00:00Z","timestamp":1662940800000},"content-version":"vor","delay-in-days":10542,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","fertstert.org","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fertility and Sterility"],"published-print":{"date-parts":[[1993,11]]},"DOI":"10.1016\/s0015-0282(16)56282-7","type":"journal-article","created":{"date-parts":[[2016,5,6]],"date-time":"2016-05-06T21:56:03Z","timestamp":1462571763000},"page":"820-825","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":205,"title":["Hyperhomocysteinemia: a risk factor in women with unexplained recurrent early pregnancy loss"],"prefix":"10.1016","volume":"60","author":[{"given":"Maurice G.A.J.","family":"Wouters","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Godfried H.J.","family":"Boers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henk J.","family":"Blom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frans J.M.","family":"Trijbels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris M.G.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George F.","family":"Borm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00e9gine P.M.","family":"Steegers-Theunissen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom K.A.B.","family":"Eskes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0015-0282(16)56282-7_bb0005","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/0140-6736(90)92215-4","article-title":"Recurrent miscarriage II: clinical associations, causes, and management","volume":"336","author":"Stirrat","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/S0015-0282(16)56282-7_bb0010","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/0140-6736(92)90725-I","article-title":"Hyperhomocysteinaemia and recurrent spontaneous abortion or abruptio placentae [letter]","volume":"339","author":"Steegers-Theunissen","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/S0015-0282(16)56282-7_bb0015","series-title":"The metabolic basis of inherited diseases","first-page":"693","article-title":"Disorders of transsulfuration","author":"Mudd","year":"1989"},{"key":"10.1016\/S0015-0282(16)56282-7_bb0020","first-page":"1","article-title":"The natural history of homocystinuria due to cystathionine \u03b2-synthase deficiency","volume":"37","author":"Mudd","year":"1985","journal-title":"Am J Hum Genet"},{"key":"10.1016\/S0015-0282(16)56282-7_bb0025","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1172\/JCI108520","article-title":"Homocysteine-induced arteriosclerosis: the role of endothelial injury and platelet response in its genesis","volume":"58","author":"Harker","year":"1976","journal-title":"J Clin Invest"},{"key":"10.1016\/S0015-0282(16)56282-7_bb0030","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJM198509193131201","article-title":"Heterozygosity for homocystinuria in premature peripheral and cerebral occlusive arterial disease","volume":"313","author":"Boers","year":"1985","journal-title":"N Engl J Med"},{"key":"10.1016\/S0015-0282(16)56282-7_bb0035","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1056\/NEJM199104253241701","article-title":"Hyperhomocysteinemia: an independent risk factor for vascular disease","volume":"324","author":"Clarke","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1016\/S0015-0282(16)56282-7_bb0040","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1146\/annurev.nu.12.070192.001431","article-title":"Hyperhomocyst -(e)inemia as a risk factor for occlusive vascular disease","volume":"12","author":"Kang","year":"1992","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/S0015-0282(16)56282-7_bb0045","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1001\/jama.1992.03490070059042","article-title":"A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians","volume":"268","author":"Stampfer","year":"1992","journal-title":"JAMA"},{"key":"10.1016\/S0015-0282(16)56282-7_bb0050","series-title":"Atherosclerotic cardiovascular disease, hemostasis, and endothelial function","first-page":"183","article-title":"Plasma homocysteine and cardiovascular disease","author":"Ueland","year":"1992"},{"key":"10.1016\/S0015-0282(16)56282-7_bb0055","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0010-7824(92)90047-W","article-title":"Effects of sub-50 oral contraceptives on homocysteine metabolism","volume":"45","author":"Steegers-Theunissen","year":"1992","journal-title":"Contraception"},{"key":"10.1016\/S0015-0282(16)56282-7_bb0060","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/clinchem\/39.2.263","article-title":"Homocysteine and other thiols determined in plasma and urine: automation and sample stability","volume":"39","author":"Fiskerstrand","year":"1993","journal-title":"Clin Chem"},{"key":"10.1016\/S0015-0282(16)56282-7_bb0065","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0010-7824(91)90018-B","article-title":"Multivitamin supplementation in oral contraceptive users","volume":"44","author":"Mooij","year":"1991","journal-title":"Contraception"},{"key":"10.1016\/S0015-0282(16)56282-7_bb0070","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0015-0282(16)59704-0","article-title":"Early pregnancy wastage: relationship between chorionic vascularization and embryonic development","volume":"49","author":"Meegdes","year":"1988","journal-title":"Fertil Steril"},{"key":"10.1016\/S0015-0282(16)56282-7_bb0075","unstructured":"Aerts LAGJM van, Klaasboer HH, Postma NS, Pertijs JCLM, Copius Peereboom JHJ, Eskes TKAB, et al. Stereo-specific in vitro embryotoxity of L-homocysteine in pre- and post-implantation rodent embryos. Toxicol In Vitro. In press."},{"key":"10.1016\/S0015-0282(16)56282-7_bb0080","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/ajmg.1320250219","article-title":"Neural tube defects in spontaneous abortions","volume":"25","author":"Byrne","year":"1986","journal-title":"Am J Med Genet"},{"key":"10.1016\/S0015-0282(16)56282-7_bb0085","first-page":"199","article-title":"Neural-tube defects and derangement of homocysteine metabolism [letter]","volume":"324","author":"Steegers-Theunissen","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1016\/S0015-0282(16)56282-7_bb0090","series-title":"The metabolic basis of inherited diseases","first-page":"2049","article-title":"Inherited disorders of folate transport and metabolism","author":"Rosenblatt","year":"1989"},{"key":"10.1016\/S0015-0282(16)56282-7_bb0095","series-title":"The metabolic basis of inherited diseases","first-page":"2065","article-title":"Inherited disorders of cobalamin transport and metabolism","author":"Fenton","year":"1989"},{"key":"10.1016\/S0015-0282(16)56282-7_bb0100","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.1471-0528.1964.tb04317.x","article-title":"The role of folic acid in pregnancy \u2014 with particular reference to anaemia, abruption and abortion","volume":"71","author":"Hibbard","year":"1964","journal-title":"J Obstet Gynaecol Br Commonw"},{"key":"10.1016\/S0015-0282(16)56282-7_bb0105","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/0002-9378(67)90412-7","article-title":"Folic acid metabolism in pregnancy","volume":"99","author":"Stone","year":"1967","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/S0015-0282(16)56282-7_bb0110","series-title":"Genetic susceptibility to environmental factors \u2014 a challenge for public intervention","first-page":"35","article-title":"The clinical usefulness of homocysteine determinations","author":"Boers","year":"1988"},{"key":"10.1016\/S0015-0282(16)56282-7_bb0115","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0021-9150(90)90058-Q","article-title":"Impaired homocysteine metabolism in early-onset cerebral and peripheral occlusive arterial disease \u2014 effects of pyridoxine and folic acid treatment","volume":"81","author":"Brattstr\u00f6m","year":"1990","journal-title":"Atherosclerosis"}],"container-title":["Fertility and Sterility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028216562827?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0015028216562827?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T15:26:48Z","timestamp":1663946808000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028216562827"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,11]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1993,11]]}},"alternative-id":["S0015028216562827"],"URL":"https:\/\/doi.org\/10.1016\/s0015-0282(16)56282-7","relation":{},"ISSN":["0015-0282"],"issn-type":[{"value":"0015-0282","type":"print"}],"subject":[],"published":{"date-parts":[[1993,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hyperhomocysteinemia: a risk factor in women with unexplained recurrent early pregnancy loss","name":"articletitle","label":"Article Title"},{"value":"Fertility and Sterility","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0015-0282(16)56282-7","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1993 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}