{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T03:17:39Z","timestamp":1775186259918,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2000,6,1]],"date-time":"2000-06-01T00:00:00Z","timestamp":959817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2000,6]]},"DOI":"10.1016\/s0016-5085(00)70351-9","type":"journal-article","created":{"date-parts":[[2005,10,28]],"date-time":"2005-10-28T11:22:30Z","timestamp":1130498550000},"page":"1001-1011","source":"Crossref","is-referenced-by-count":374,"title":["Claudins regulate the intestinal barrier in response to immune mediators"],"prefix":"10.1016","volume":"118","author":[{"given":"Tetsushi","family":"Kinugasa","sequence":"first","affiliation":[]},{"given":"Takanori","family":"Sakaguchi","sequence":"additional","affiliation":[]},{"given":"Xuibin","family":"Gu","sequence":"additional","affiliation":[]},{"given":"Hans\u2013Christian","family":"Reinecker","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0016-5085(00)70351-9_bib1","first-page":"G1461","article-title":"IL-2-deficient mice raised under germfree conditions develop delayed mild focal intestinal inflammation","volume":"276","author":"Schultz","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/S0016-5085(00)70351-9_bib2","doi-asserted-by":"crossref","first-page":"5224","DOI":"10.1128\/IAI.66.11.5224-5231.1998","article-title":"Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin- 10-deficient mice","volume":"66","author":"Sellon","year":"1998","journal-title":"Infect Immun"},{"key":"10.1016\/S0016-5085(00)70351-9_bib3","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1146\/annurev.physiol.60.1.143","article-title":"Regulation of the movement of solutes across tight junctions","volume":"60","author":"Madara","year":"1998","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/S0016-5085(00)70351-9_bib4","first-page":"L647","article-title":"Structure, function, and regulation of cellular tight junctions","volume":"262","author":"Schneeberger","year":"1992","journal-title":"Am J Physiol"},{"key":"10.1016\/S0016-5085(00)70351-9_bib5","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1083\/jcb.123.6.1631","article-title":"Breaking through the tight junction barrier","volume":"123","author":"Gumbiner","year":"1993","journal-title":"J Cell Biol"},{"key":"10.1016\/S0016-5085(00)70351-9_bib6","first-page":"G467","article-title":"Tight junctions and the molecular basis for regulation of paracellular permeability","volume":"269","author":"Anderson","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1016\/S0016-5085(00)70351-9_bib7","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1083\/jcb.141.7.1539","article-title":"Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin","volume":"141","author":"Furuse","year":"1998","journal-title":"J Cell Biol"},{"key":"10.1016\/S0016-5085(00)70351-9_bib8","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1083\/jcb.123.6.1777","article-title":"Occludin: a novel integral membrane protein localizing at tight junctions","volume":"123","author":"Furuse","year":"1993","journal-title":"J Cell Biol"},{"key":"10.1016\/S0016-5085(00)70351-9_bib9","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1083\/jcb.133.1.43","article-title":"Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues","volume":"133","author":"Ando-Akatsuka","year":"1996","journal-title":"J Cell Biol"},{"key":"10.1016\/S0016-5085(00)70351-9_bib10","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1083\/jcb.145.3.579","article-title":"Claudin-11\/OSP\u2013based tight junctions of myelin sheaths in brain and Sertoli cells in testis","volume":"145","author":"Morita","year":"1999","journal-title":"J Cell Biol"},{"key":"10.1016\/S0016-5085(00)70351-9_bib11","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.4049\/jimmunol.153.5.2122","article-title":"IL-4 directly modulates function of a model human intestinal epithelium","volume":"153","author":"Colgan","year":"1994","journal-title":"J Immunol"},{"key":"10.1016\/S0016-5085(00)70351-9_bib12","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1172\/JCI113938","article-title":"Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers","volume":"83","author":"Madara","year":"1989","journal-title":"J Clin Invest"},{"key":"10.1016\/S0016-5085(00)70351-9_bib13","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1242\/jcs.112.1.137","article-title":"Tumor necrosis factor-alpha (TNF-\u03b1) regulates the epithelial barrier in the human intestinal cell line HT-29\/B6","volume":"112","author":"Schmitz","year":"1999","journal-title":"J Cell Sci"},{"key":"10.1016\/S0016-5085(00)70351-9_bib14","first-page":"G214","article-title":"Reversible disassembly of an intestinal epithelial monolayer by prolonged exposure to phorbol ester","volume":"266","author":"Hecht","year":"1994","journal-title":"Am J Physiol"},{"key":"10.1016\/S0016-5085(00)70351-9_bib15","doi-asserted-by":"crossref","first-page":"3368","DOI":"10.4049\/jimmunol.164.6.3368","article-title":"Fractalkine is an epithelial and endothelial cell-derived chemoattractant for intraepithelial lymphocytes in the small intestinal mucosa","volume":"164","author":"Muehlhoefer","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/S0016-5085(00)70351-9_bib16","first-page":"G1201","article-title":"Interleukin-15 signals T84 colonic epithelial cells in the absence of the interleukin-2 receptor beta-chain","volume":"272","author":"Stevens","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/S0016-5085(00)70351-9_bib17","first-page":"G1067","article-title":"Epidermal growth factor attenuates jejunal mucosal injury induced by oleic acid: role of mucus","volume":"267","author":"Ishikawa","year":"1994","journal-title":"Am J Physiol"},{"key":"10.1016\/S0016-5085(00)70351-9_bib18","doi-asserted-by":"crossref","first-page":"5337","DOI":"10.4049\/jimmunol.162.9.5337","article-title":"NF-kappa B-inducing kinase is a common mediator of IL-17-, TNF-alpha-, and IL-1 beta-induced chemokine promoter activation in intestinal epithelial cells","volume":"162","author":"Awane","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/S0016-5085(00)70351-9_bib19","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0092-8674(00)80226-3","article-title":"Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras","volume":"89","author":"Rodriguez-Viciana","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0016-5085(00)70351-9_bib20","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1091\/mbc.9.8.2185","article-title":"Activation of both MAP kinase and phosphatidylinositide 3-kinase by Ras is required for hepatocyte growth factor\/scatter factor-induced adherens junction disassembly","volume":"9","author":"Potempa","year":"1998","journal-title":"Mol Biol Cell"},{"key":"10.1016\/S0016-5085(00)70351-9_bib21","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1083\/jcb.143.2.391","article-title":"A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts","volume":"143","author":"Furuse","year":"1998","journal-title":"J Cell Biol"},{"key":"10.1016\/S0016-5085(00)70351-9_bib22","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1073\/pnas.96.2.511","article-title":"Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands","volume":"96","author":"Morita","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/S0016-5085(00)70351-9_bib23","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1083\/jcb.147.1.185","article-title":"Endothelial claudin. Claudin-5\/tmvcf constitutes tight junction strands in endothelial cells","volume":"147","author":"Morita","year":"1999","journal-title":"J Cell Biol"},{"key":"10.1016\/S0016-5085(00)70351-9_bib24","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1083\/jcb.147.1.195","article-title":"Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands. Evidence for direct involvement of claudins in tight junction barrier","volume":"147","author":"Sonoda","year":"1999","journal-title":"J Cell Biol"},{"key":"10.1016\/S0016-5085(00)70351-9_bib25","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1126\/science.285.5424.62","article-title":"Paracellular channels! (comment)","volume":"285","author":"Wong","year":"1999","journal-title":"Science"},{"key":"10.1016\/S0016-5085(00)70351-9_bib26","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1126\/science.285.5424.103","article-title":"Paracellin-1, a renal tight junction protein required for paracellular Mg 21 resorption","volume":"285","author":"Simon","year":"1999","journal-title":"Science"},{"key":"10.1016\/S0016-5085(00)70351-9_bib27","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1083\/jcb.134.4.1031","article-title":"Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein","volume":"134","author":"Balda","year":"1996","journal-title":"J Cell Biol"},{"key":"10.1016\/S0016-5085(00)70351-9_bib28","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1083\/jcb.148.4.791","article-title":"Oncogenic raf-1 disrupts epithelial tight junctions via downregulation of occludin","volume":"148","author":"Li","year":"2000","journal-title":"J Cell Biol"},{"key":"10.1016\/S0016-5085(00)70351-9_bib29","doi-asserted-by":"crossref","first-page":"9188","DOI":"10.1074\/jbc.273.15.9188","article-title":"Regulation of connexin-43 gap junctional intercellular communication by mito-genactivated protein kinase","volume":"273","author":"Warn-Cramer","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/S0016-5085(00)70351-9_bib30","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/S0960-9822(07)00375-2","article-title":"The gap junction protein connexin43 interacts with the second PDZ domain of the zona occludens-1 protein","volume":"8","author":"Giepmans","year":"1998","journal-title":"Curr Biol"},{"key":"10.1016\/S0016-5085(00)70351-9_bib31","doi-asserted-by":"crossref","first-page":"C554","DOI":"10.1152\/ajpcell.1999.277.3.C554","article-title":"PKC-dependent regulation of transepithelial resistance: roles of MLC and MLC kinase","volume":"277","author":"Turner","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/S0016-5085(00)70351-9_bib32","doi-asserted-by":"crossref","first-page":"C1378","DOI":"10.1152\/ajpcell.1997.273.4.C1378","article-title":"Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation","volume":"273","author":"Turner","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/S0016-5085(00)70351-9_bib33","doi-asserted-by":"crossref","first-page":"C1678","DOI":"10.1152\/ajpcell.1996.271.5.C1678","article-title":"Expression of the catalytic domain of myosin light chain kinase increases paracellular permeability","volume":"271","author":"Hecht","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1016\/S0016-5085(00)70351-9_bib34","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1083\/jcb.137.2.481","article-title":"Regulation of cell motility by mitogen-activated protein kinase","volume":"137","author":"Klemke","year":"1997","journal-title":"J Cell Biol"},{"key":"10.1016\/S0016-5085(00)70351-9_bib35","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1016\/S0016-5085(97)70006-4","article-title":"Enteropathogenic Escherichia coli-induced myosin light chain phosphorylation alters intestinal epithelial permeability","volume":"113","author":"Yuhan","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/S0016-5085(00)70351-9_bib36","first-page":"G965","article-title":"Ethanol modulation of intestinal epithelial tight junction barrier","volume":"276","author":"Ma","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/S0016-5085(00)70351-9_bib37","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1242\/jcs.108.4.1735","article-title":"Epidermal growth factor induces tyrosine phosphorylation and reorganization of the tight junction protein ZO-1 in A431 cells","volume":"108","author":"Van Itallie","year":"1995","journal-title":"J Cell Sci"},{"key":"10.1016\/S0016-5085(00)70351-9_bib38","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1083\/jcb.147.6.1351","article-title":"Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins","volume":"147","author":"Itoh","year":"1999","journal-title":"J Cell Biol"},{"key":"10.1016\/S0016-5085(00)70351-9_bib39","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1126\/science.274.5295.2100","article-title":"Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma","volume":"274","author":"Hu","year":"1996","journal-title":"Science"},{"key":"10.1016\/S0016-5085(00)70351-9_bib40","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/sj.onc.1201485","article-title":"The role of MAP kinase in TPA-mediated cell cycle arrest of human breast cancer cells","volume":"16","author":"Alblas","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/S0016-5085(00)70351-9_bib41","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1073\/pnas.96.5.2077","article-title":"Myogenic signaling of phosphatidylinositol 3-kinase requires the serine-threonine kinase Akt\/protein kinase B","volume":"96","author":"Jiang","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/S0016-5085(00)70351-9_bib42","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1126\/science.286.5445.1741","article-title":"Phosphorylation and regulation of Raf by Akt (protein kinase B)","volume":"286","author":"Zimmermann","year":"1999","journal-title":"Science"},{"key":"10.1016\/S0016-5085(00)70351-9_bib43","doi-asserted-by":"crossref","first-page":"966","DOI":"10.4049\/jimmunol.164.2.966","article-title":"Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing toll-like receptors","volume":"164","author":"Cario","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/S0016-5085(00)70351-9_bib44","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1007\/BF02090367","article-title":"Increased permeability of macroscopically normal small bowel in Crohn's disease","volume":"39","author":"Peeters","year":"1994","journal-title":"Dig Dis Sci"},{"key":"10.1016\/S0016-5085(00)70351-9_bib45","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1136\/gut.38.6.864","article-title":"Assessing the site of increased intestinal permeability in coeliac and inflammatory bowel disease","volume":"38","author":"Teahon","year":"1996","journal-title":"Gut"},{"key":"10.1016\/S0016-5085(00)70351-9_bib46","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0016-5085(99)70126-5","article-title":"Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis","volume":"116","author":"Schmitz","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1016\/S0016-5085(00)70351-9_bib47","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/0016-5085(93)90338-D","article-title":"A novel human macrophage-derived intestinal mucin secretagogue: implications for the pathogenesis of inflammatory bowel disease","volume":"104","author":"Sperber","year":"1993","journal-title":"Gastroenterology"},{"key":"10.1016\/S0016-5085(00)70351-9_bib48","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/S0016-5085(97)70174-4","article-title":"Clustering of increased small intestinal permeability in families with Crohn's disease","volume":"113","author":"Peeters","year":"1997","journal-title":"Gastroenterology"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508500703519?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508500703519?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T06:51:59Z","timestamp":1683269519000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508500703519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,6]]},"references-count":48,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000,6]]}},"alternative-id":["S0016508500703519"],"URL":"https:\/\/doi.org\/10.1016\/s0016-5085(00)70351-9","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2000,6]]}}}