{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T20:57:02Z","timestamp":1770325022310,"version":"3.49.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2001,10,1]],"date-time":"2001-10-01T00:00:00Z","timestamp":1001894400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal for Parasitology"],"published-print":{"date-parts":[[2001,10]]},"DOI":"10.1016\/s0020-7519(01)00257-0","type":"journal-article","created":{"date-parts":[[2002,10,14]],"date-time":"2002-10-14T17:55:05Z","timestamp":1034618105000},"page":"1293-1302","source":"Crossref","is-referenced-by-count":186,"title":["Microneme proteins: structural and functional requirements to promote adhesion and invasion by the apicomplexan parasite Toxoplasma gondii"],"prefix":"10.1016","volume":"31","author":[{"given":"Dominique","family":"Soldati","sequence":"first","affiliation":[]},{"given":"Jean Francois","family":"Dubremetz","sequence":"additional","affiliation":[]},{"given":"Maryse","family":"Lebrun","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0020-7519(01)00257-0_BIB1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0166-6851(97)00069-8","article-title":"Cloning and characterization of actin depolymerizing factor from Toxoplasma gondii","volume":"88","author":"Allen","year":"1997","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB2","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1093\/emboj\/19.11.2435","article-title":"RAP1 controls rhoptry targeting of RAP2 in the malaria parasite Plasmodium falciparum","volume":"19","author":"Baldi","year":"2000","journal-title":"EMBO. J."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB3","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0960-9822(00)00420-6","article-title":"Fission yeast myosin-II isoforms assemble into contractile rings at distinct times during mitosis","volume":"10","author":"Bezanilla","year":"2000","journal-title":"Curr. Biol."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB4","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.1574-6976.1999.tb00413.x","article-title":"Signaling during the invasion of host cells by Toxoplasma gondii","volume":"23","author":"Bonhomme","year":"1999","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB5","doi-asserted-by":"crossref","first-page":"4119","DOI":"10.1074\/jbc.M008294200","article-title":"The toxoplasma micronemal protein MIC4 is an adhesin composed of six conserved apple domains","volume":"276","author":"Brecht","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB6","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0166-6851(00)00296-6","article-title":"Identification of novel micronemal protein in Toxoplasma gondii and molecular characterization of TgMIC5","volume":"111","author":"Brydges","year":"2000","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB7","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0166-6851(00)00280-2","article-title":"Induction of secretion and surface capping of microneme proteins in Eimeria tenella","volume":"110","author":"Bumstead","year":"2000","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB8","first-page":"114","article-title":"Sequential protein secretion from three distinct organelles of Toxoplasma gondii accompanies invasion of human fibroblasts","volume":"73","author":"Carruthers","year":"1997","journal-title":"Eur. J. Cell. Biol."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB9","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1046\/j.1365-2958.1999.01174.x","article-title":"Mobilization of intracellular calcium stimulates microneme discharge in Toxoplasma gondii","volume":"31","author":"Carruthers","year":"1999","journal-title":"Mol. Microbiol."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB10","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1046\/j.1462-5822.1999.00023.x","article-title":"Secretion of micronemal proteins is associated with toxoplasma invasion of host cells","volume":"1","author":"Carruthers","year":"1999","journal-title":"Cell Microbiol."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB11","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.1128\/IAI.68.7.4005-4011.2000","article-title":"Toxoplasma gondii uses sulfated proteoglycans for substrate and host cell attachment","volume":"68","author":"Carruthers","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB12","doi-asserted-by":"crossref","first-page":"14346","DOI":"10.1074\/jbc.275.19.14346","article-title":"The Toxoplasma adhesive protein MIC2 is proteolytically processed at multiple sites by two parasite-derived proteases","volume":"275","author":"Carruthers","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB13","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF02989882","article-title":"What the granins tell us about the formation of secretory granules in neuroendocrine cells","volume":"19","author":"Chanat","year":"1991","journal-title":"Cell. Biophys."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB14","doi-asserted-by":"crossref","first-page":"7332","DOI":"10.1128\/MCB.20.19.7332-7341.2000","article-title":"Two conserved amino acid motifs mediate protein targeting to the micronemes of the apicomplexan parasite Toxoplasma gondii","volume":"20","author":"Di Cristina","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB15","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1046\/j.1365-2958.1997.5671913.x","article-title":"Participation of myosin in gliding motility and host cell invasion by Toxoplasma gondii","volume":"26","author":"Dobrowolski","year":"1997","journal-title":"Mol. Microbiol."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB16","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/(SICI)1097-0169(1997)37:3<253::AID-CM7>3.0.CO;2-7","article-title":"Actin in the parasite Toxoplasma gondii is encoded by a single copy gene, ACT1 and exists primarily in a globular form","volume":"37","author":"Dobrowolski","year":"1997","journal-title":"Cell. Motil. Cytoskeleton"},{"key":"10.1016\/S0020-7519(01)00257-0_BIB17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0166-6851(00)00289-9","article-title":"The toxoplasma homolog of plasmodium apical membrane antigen-1 (AMA-1) is a microneme protein secreted in response to elevated intracellular calcium levels","volume":"111","author":"Donahue","year":"2000","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB18","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1126\/science.286.5446.1882","article-title":"Setting the standards: quality control in the secretory pathway","volume":"286","author":"Ellgaard","year":"1999","journal-title":"Science"},{"key":"10.1016\/S0020-7519(01)00257-0_BIB19","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0166-6851(96)02773-9","article-title":"The MIC1 microneme protein of Toxoplasma gondii contains a duplicated receptor-like domain and binds to host cell surface","volume":"83","author":"Fourmaux","year":"1996","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB20","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0962-8924(00)01745-1","article-title":"Pathways for protein disulphide bond formation","volume":"10","author":"Frand","year":"2000","journal-title":"Trends Cell. Biol."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB21","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S0962-8924(00)01871-7","article-title":"Surfing pathogens and the lessons learned for actin polymerization","volume":"11","author":"Frischknecht","year":"2001","journal-title":"Trends Cell Biol."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB22","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1046\/j.1462-5822.2000.00064.x","article-title":"The microneme protein MIC3 of Toxoplasma gondii is a secretory adhesin, which binds to both the surface of the host cells and the surface of the parasite","volume":"2","author":"Garcia-R\u00e9guet","year":"2000","journal-title":"Cell. Microbiol."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB23","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1091\/mbc.11.4.1385","article-title":"A dibasic motif in the tail of an apicomplexan myosin is an essential determinant of plasma membrane localization","volume":"11","author":"Hettmann","year":"2000","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB24","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/35017090","article-title":"Targeting to rhoptry organelles of Toxoplasma gondii involves evolutionarily conserved mechanisms","volume":"2","author":"Hoppe","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB25","doi-asserted-by":"crossref","first-page":"422\/28","DOI":"10.1016\/S1369-5274(00)00115-6","article-title":"Protein\/targeting determineants in the secertory pathway of apicomplexan parasites","volume":"3","author":"Kaasch","year":"2000","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB26","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1083\/jcb.147.5.937","article-title":"Conservation of a gliding motility and cell invasion machinery in apicomplexan parasites","volume":"147","author":"Kappe","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB27","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1083\/jcb.141.6.1323","article-title":"The protozoan parasite Toxoplasma gondii targets proteins to dense granules and the vacuolar space using both conserved and unusual mechanisms","volume":"141","author":"Karsten","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB28","doi-asserted-by":"crossref","first-page":"12369","DOI":"10.1074\/jbc.M011045200","article-title":"Toxoplasma gondii attachment to host cells is regulated by a calmodulin-like domain protein kinase","volume":"276","author":"Kieschnick","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB29","doi-asserted-by":"crossref","first-page":"15119","DOI":"10.1074\/jbc.273.24.15119","article-title":"Precise timing of expression of a Plasmodium falciparum-derived transgene in Plasmodium berghei is a critical determinant of subsequent subcellular localization","volume":"273","author":"Kocken","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB30","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0166-6851(99)00092-4","article-title":"Differential membrane targeting of the secretory proteins GRA4 and GRA6 within the parasitophorous vacuole formed by Toxoplasma gondii","volume":"102","author":"Labruyere","year":"1999","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB31","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1084\/jem.190.12.1783","article-title":"Invasion by Toxoplasma gondii establishes a moving junction that selectively excludes host cell plasma membrane proteins on the basis of their membrane anchoring","volume":"190","author":"Mordue","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB32","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1042\/bj3130655","article-title":"Acidocalcisomes in Toxoplasma gondii tachyzoites","volume":"313","author":"Moreno","year":"1996","journal-title":"Biochem. J."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB33","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1006\/expr.1994.1106","article-title":"Characterization of extreme apical antigens from Toxoplasma gondii","volume":"79","author":"Morrissette","year":"1994","journal-title":"Exp. Parasitol."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB34","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0962-8924(99)01698-0","article-title":"Differential sorting and post-secretory targeting of proteins in parasitic invasion","volume":"10","author":"Ngo","year":"2000","journal-title":"Trends Cell Biol."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB35","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0966-842X(00)01700-5","article-title":"Analysis of a malaria sporozoite protein family required for gliding motility and cell invasion","volume":"8","author":"Nussenzweig","year":"2000","journal-title":"Trends Microbiol."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB36","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1247\/csf.20.415","article-title":"The granin family \u2013 its role in sorting and secretory granule formation","volume":"20","author":"Ozawa","year":"1995","journal-title":"Cell Struct. Funct."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB37","first-page":"4347","article-title":"A post-lysosomal compartment in Dictyostelium discoideum","volume":"261","author":"Padh","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB38","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1091\/mbc.11.1.355","article-title":"Toxofilin, a novel actin-binding protein from Toxoplasma gondii, sequesters actin monomers and caps actin filaments","volume":"11","author":"Poupel","year":"2000","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB39","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1083\/jcb.152.3.563","article-title":"Identification and characterisation of an Escorter for two secretory adhesins in Toxoplasma gondii","volume":"152","author":"Reiss","year":"2001","journal-title":"J. Cell. Biol."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB47","first-page":"1343","article-title":"Endocytosis in different lifestyles of protozoan parasitism: role in nutrient uptake with special reference to Toxoplasma gondii","volume":"31","author":"Robibaro","year":"2001","journal-title":"J. Parasitol."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB40","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1128\/MCB.15.1.87","article-title":"A selector of transcription initiation in the protozoan parasite Toxoplasma gondii.","volume":"15","author":"Soldati","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB41","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0166-6851(00)00379-0","article-title":"Targeting of soluble proteins to the rhoptries and micronemes in Toxoplasma gondii","volume":"113","author":"Striepen","year":"2001","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB42","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S1471-4922(00)01761-X","article-title":"Mix and match modules: structure and function of microneme proteins in apicomplexan parasites","volume":"17","author":"Tomley","year":"2001","journal-title":"Trends Parasitol."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB43","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0014-5793(99)01416-7","article-title":"The PAN module: the N-terminal domains of plasminogen and hepatocyte growth factor are homologous with the apple domains of the prekallikrein family and with a novel domain found in numerous nematode proteins","volume":"461","author":"Tordai","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB44","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0166-6851(99)00182-6","article-title":"Mobilization of intracellular calcium upon attachment of Toxoplasma gondii tachyzoites to human fibroblasts is required for invasion","volume":"106","author":"Vieira","year":"2000","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB45","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0166-6851(96)02796-X","article-title":"Molecular characterisation of an expressed sequence tag locus of Toxoplasma gondii encoding the micronemal protein MIC2","volume":"84","author":"Wan","year":"1997","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/S0020-7519(01)00257-0_BIB46","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/BF02100680","article-title":"Evolution of a family of N-acetylglucosamine binding proteins containing the disulfide-rich domain of wheat germ agglutinin","volume":"33","author":"Wright","year":"1991","journal-title":"J. Mol. Evol."}],"container-title":["International Journal for Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020751901002570?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020751901002570?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T16:23:03Z","timestamp":1556209383000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020751901002570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,10]]},"references-count":47,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2001,10]]}},"alternative-id":["S0020751901002570"],"URL":"https:\/\/doi.org\/10.1016\/s0020-7519(01)00257-0","relation":{},"ISSN":["0020-7519"],"issn-type":[{"value":"0020-7519","type":"print"}],"subject":[],"published":{"date-parts":[[2001,10]]}}}