{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T14:28:37Z","timestamp":1776263317159,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2001,2]]},"DOI":"10.1016\/s0021-9150(00)00473-1","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T19:45:13Z","timestamp":1027626313000},"page":"269-276","source":"Crossref","is-referenced-by-count":29,"title":["A potential role for sterol 27-hydroxylase in atherogenesis"],"prefix":"10.1016","volume":"154","author":[{"given":"Catherine M.","family":"Shanahan","sequence":"first","affiliation":[]},{"given":"Keri L.H.","family":"Carpenter","sequence":"additional","affiliation":[]},{"given":"Nat R.B.","family":"Cary","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0021-9150(00)00473-1_BIB1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0005-2760(93)90151-X","article-title":"Lipids and oxidised lipids in human atheroma and normal aorta","volume":"1167","author":"Carpenter","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S0021-9150(00)00473-1_BIB2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0005-2760(94)00247-V","article-title":"Lipids and oxidised lipids in human atherosclerotic lesions at different stages of development","volume":"1256","author":"Carpenter","year":"1995","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S0021-9150(00)00473-1_BIB3","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/S0005-2760(96)00152-X","article-title":"Localization of sterol 27-hydroxylase immuno-reactivity in human atherosclerotic plaques","volume":"1344","author":"Crisby","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S0021-9150(00)00473-1_BIB4","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1210\/endo-127-2-738","article-title":"Generation of regulatory oxysterols: 26-hydroxylation of cholesterol by ovarian mitochondria","volume":"127","author":"Rennert","year":"1990","journal-title":"Endocrinology"},{"key":"10.1016\/S0021-9150(00)00473-1_BIB5","doi-asserted-by":"crossref","first-page":"8592","DOI":"10.1073\/pnas.91.18.8592","article-title":"Atherosclerosis and sterol 27-hydroxylase: evidence for a role of this enzyme in elimination of cholesterol from human macrophages","volume":"91","author":"Bj\u00f6rkhem","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0021-9150(00)00473-1_BIB6","doi-asserted-by":"crossref","first-page":"8222","DOI":"10.1016\/S0021-9258(18)83172-6","article-title":"Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme","volume":"264","author":"Andersson","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9150(00)00473-1_BIB7","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1080\/10715769900300391","article-title":"Oxysterols in cap and core of human advanced atherosclerotic lesions","volume":"30","author":"Garcia-Cruset","year":"1999","journal-title":"Free Radic. Res."},{"key":"10.1016\/S0021-9150(00)00473-1_BIB8","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1161\/01.ATV.17.11.2437","article-title":"Identification of osteoglycin as a component of the vascular matrix. Differential expression by vascular smooth muscle cells during neointima formation and in atherosclerotic plaques","volume":"17","author":"Shanahan","year":"1997","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/S0021-9150(00)00473-1_BIB9","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1161\/01.ATV.15.11.2010","article-title":"Osteopontin is not a marker for proliferating human vascular smooth muscle cells","volume":"15","author":"Newman","year":"1995","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/S0021-9150(00)00473-1_BIB10","doi-asserted-by":"crossref","first-page":"7779","DOI":"10.1016\/S0021-9258(20)89518-0","article-title":"Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis","volume":"266","author":"Cali","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9150(00)00473-1_BIB11","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/S0022-2275(20)40096-3","article-title":"Identification of new mutations in sterol 27-hydroxylase gene in Japanese patients with cerebrotendinous xanthomatosis (CTX)","volume":"35","author":"Kim","year":"1994","journal-title":"J. Lipid Res."},{"key":"10.1016\/S0021-9150(00)00473-1_BIB12","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1172\/JCI112633","article-title":"Demonstration of 26-hydroxylation of C27-steroids in human skin fibroblasts, and a deficiency of this activity in cerebrotendinous xanthomatosis","volume":"78","author":"Skrede","year":"1986","journal-title":"J. Clin. Invest."},{"key":"10.1016\/S0021-9150(00)00473-1_BIB13","first-page":"1283","article-title":"Familial diseases with storage of sterols other than cholesterol: cerebrotendinous xanthomatosis and phytosterolemia","volume":"1","author":"Bj\u00f6rkem","year":"1989"},{"key":"10.1016\/S0021-9150(00)00473-1_BIB14","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0925-4439(93)90072-9","article-title":"Differences in 27-hydroxycholesterol concentrations in plasma and liver of baboons with high and low responses to dietary cholesterol and fat","volume":"1182","author":"Hasan","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S0021-9150(00)00473-1_BIB15","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1042\/0264-6021:3380687","article-title":"Phagocytosis stimulates alternative glycosylation of macrosialin (mouse CD68), a macrophage-specific endosomal protein","volume":"338","author":"da Silva","year":"1999","journal-title":"Biochem. J."},{"key":"10.1016\/S0021-9150(00)00473-1_BIB16","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0962-8924(98)01329-4","article-title":"Recognising death: the phagocytosis of apoptotic cells","volume":"8","author":"Platt","year":"1998","journal-title":"Trends Cell Biol."},{"key":"10.1016\/S0021-9150(00)00473-1_BIB17","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/(SICI)1096-9896(199612)180:4<423::AID-PATH677>3.0.CO;2-1","article-title":"Foam cell apoptosis and the development of the lipid core of human atherosclerosis","volume":"180","author":"Hegyi","year":"1996","journal-title":"J. Pathol."},{"key":"10.1016\/S0021-9150(00)00473-1_BIB18","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/(SICI)1096-9896(199607)179:3<294::AID-PATH590>3.0.CO;2-X","article-title":"Apoptosis in human monocyte-macrophages exposed to oxidised low density lipoprotein","volume":"179","author":"Hardwick","year":"1996","journal-title":"J. Pathol."},{"key":"10.1016\/S0021-9150(00)00473-1_BIB19","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0021-9150(94)05463-S","article-title":"Evidence that the death of macrophage foam cells contributes to the lipid core of atheroma","volume":"114","author":"Ball","year":"1995","journal-title":"Atherosclerosis"},{"key":"10.1016\/S0021-9150(00)00473-1_BIB20","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0022-2275(20)41189-7","article-title":"Liver mitochondrial P450 involved in cholesterol catabolism and vitamin D activation","volume":"35","author":"Okuda","year":"1994","journal-title":"J. Lipid Res."},{"key":"10.1016\/S0021-9150(00)00473-1_BIB21","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1042\/0264-6021:3410233","article-title":"The mitochondrial permeability transition pore and its role in cell death","volume":"341","author":"Crompton","year":"1999","journal-title":"Biochem. J."},{"key":"10.1016\/S0021-9150(00)00473-1_BIB22","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/j.1432-1033.1973.tb03233.x","article-title":"Enzymatic characteristics of CO-sensitive 26-hydroxylase system for 5\u03b2-cholestane-3\u03b1,7\u03b1,12\u03b1-triol in rat-liver mitochondria and its intramitochondrial localization","volume":"40","author":"Taniguchi","year":"1973","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/S0021-9150(00)00473-1_BIB23","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1161\/01.ATV.16.2.208","article-title":"Importance of a novel oxidative mechanism of elimination of intracellular cholesterol in humans","volume":"16","author":"Lund","year":"1996","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/S0021-9150(00)00473-1_BIB24","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0021-9150(95)05594-M","article-title":"Toxicity of oxysterols to human monocyte-macrophages","volume":"118","author":"Clare","year":"1995","journal-title":"Atherosclerosis"},{"key":"10.1016\/S0021-9150(00)00473-1_BIB25","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/S0022-2275(20)33383-6","article-title":"Elimination of cholesterol as cholestenoic acid in human lung by sterol 27-hydroxylase; evidence that most of this steroid in the circulation is of pulmonary origin","volume":"40","author":"Babiker","year":"1999","journal-title":"J. Lipid Res."},{"key":"10.1016\/S0021-9150(00)00473-1_BIB26","doi-asserted-by":"crossref","first-page":"18153","DOI":"10.1074\/jbc.273.29.18153","article-title":"Activities of recombinant human cytochrome P450c27 (CYP27) which produce intermediates of alternative bile acid biosynthetic pathways","volume":"273","author":"Pikuleva","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9150(00)00473-1_BIB27","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1172\/JCI2962","article-title":"Identification of a new inborn error in bile acid synthesis: mutation of the oxysterol 7\u03b1-hydroxylase gene causes severe neonatal disease","volume":"102","author":"Setchell","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/S0021-9150(00)00473-1_BIB28","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S0022-2275(20)41198-8","article-title":"Molecular genetic of cerebrotendinous xanthomatosis in Jews of North African origin","volume":"35","author":"Reshef","year":"1994","journal-title":"J Lipid Res."},{"key":"10.1016\/S0021-9150(00)00473-1_BIB29","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1172\/JCI116484","article-title":"Frameshift and splice-junction mutations in the sterol 27-hydroxylase gene cause cerebrotendinous xanthomatosis in Jews of Moroccan origin","volume":"91","author":"Leitersdorf","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1016\/S0021-9150(00)00473-1_BIB30","doi-asserted-by":"crossref","first-page":"7774","DOI":"10.1016\/S0021-9258(20)89517-9","article-title":"Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reactions in bile acid biosynthesis","volume":"266","author":"Cali","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9150(00)00473-1_BIB31","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0024-3205(71)90221-9","article-title":"Cholestanol and 26-hydroxycholesterol in normal and atherosclerotic human aorta","volume":"10","author":"Fumagalli","year":"1971","journal-title":"Life Sci."},{"key":"10.1016\/S0021-9150(00)00473-1_BIB32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0378-4347(87)80479-6","article-title":"Determination of some hydroxycholesterols in human serum samples","volume":"416","author":"Koopman","year":"1987","journal-title":"J. Chromatogr."}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915000004731?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915000004731?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T20:03:37Z","timestamp":1620677017000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915000004731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,2]]}},"alternative-id":["S0021915000004731"],"URL":"https:\/\/doi.org\/10.1016\/s0021-9150(00)00473-1","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2001,2]]}}}