{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T23:13:55Z","timestamp":1776467635908,"version":"3.51.2"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1997,2,1]],"date-time":"1997-02-01T00:00:00Z","timestamp":854755200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[1997,2]]},"DOI":"10.1016\/s0021-9150(96)06018-2","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T04:25:23Z","timestamp":1027657523000},"page":"111-118","source":"Crossref","is-referenced-by-count":371,"title":["Systemic endothelial dysfunction is related to the extent and severity of coronary artery disease"],"prefix":"10.1016","volume":"129","author":[{"given":"Thomas","family":"Neunteufl","sequence":"first","affiliation":[]},{"given":"Reinhold","family":"Katzenschlager","sequence":"additional","affiliation":[]},{"given":"Ali","family":"Hassan","sequence":"additional","affiliation":[]},{"given":"Ursula","family":"Klaar","sequence":"additional","affiliation":[]},{"given":"Severin","family":"Schwarzacher","sequence":"additional","affiliation":[]},{"given":"Dietmar","family":"Glogar","sequence":"additional","affiliation":[]},{"given":"Peter","family":"Bauer","sequence":"additional","affiliation":[]},{"given":"Franz","family":"Weidinger","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0021-9150(96)06018-2_BIB1","doi-asserted-by":"crossref","unstructured":"Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980;288:373\u2013376.","DOI":"10.1038\/288373a0"},{"key":"10.1016\/S0021-9150(96)06018-2_BIB2","doi-asserted-by":"crossref","unstructured":"Ross R. The pathogenesis of atherosclerosis: an update. N Engl J Med 1986;314:488\u2013500.","DOI":"10.1056\/NEJM198602203140806"},{"key":"10.1016\/S0021-9150(96)06018-2_BIB3","doi-asserted-by":"crossref","unstructured":"Healy B. Endothelial cell dysfunction: an emerging endocrinopathy linked to coronary disease. J Am Coll Cardiol 1990;16:349\u2013356.","DOI":"10.1016\/0735-1097(90)90585-D"},{"key":"10.1016\/S0021-9150(96)06018-2_BIB4","unstructured":"Meredith IT, Yeung AC, Weidinger FF et al. Role of impaired endothelium-dependent vasodilation in ischemic manifestations of coronary artery disease. Circulation 1993;87(5):56\u201366."},{"key":"10.1016\/S0021-9150(96)06018-2_BIB5","doi-asserted-by":"crossref","unstructured":"Ludmer PL, Selwyn AP, Shook TL et al. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med 1986 23;315:1046\u20131051.","DOI":"10.1056\/NEJM198610233151702"},{"key":"10.1016\/S0021-9150(96)06018-2_BIB6","doi-asserted-by":"crossref","unstructured":"Zeiher AM, Drexler H, Wollschl\u00e4ger H, Just H. Modulation of coronary vasomotor tone in humans: progressive endothelial dysfunction with different early stages of coronary atherosclerosis. Circulation 1991;83:391\u2013401.","DOI":"10.1161\/01.CIR.83.2.391"},{"key":"10.1016\/S0021-9150(96)06018-2_BIB7","doi-asserted-by":"crossref","unstructured":"Werns SW, Walton JA, Hsia HH, Nabel EG, Sanz ML, Pitt B. Evidence of endothelial dysfunction in angiographically normal coronary arteries of patients with coronary artery disease. Circulation 1989;79:287\u2013291.","DOI":"10.1161\/01.CIR.79.2.287"},{"key":"10.1016\/S0021-9150(96)06018-2_BIB8","doi-asserted-by":"crossref","unstructured":"Hodgson JM, Marshall JJ. Direct vasoconstriction and endothelium-dependent vasodilation. Mechanisms of acetylcholine effects on coronary flow and arterial diameter in patients with nonstenotic coronary arteries. Circulation 1989;79:1043\u20131051.","DOI":"10.1161\/01.CIR.79.5.1043"},{"key":"10.1016\/S0021-9150(96)06018-2_BIB9","doi-asserted-by":"crossref","unstructured":"Celermajer DS, Sorensen KE, Gooch VM et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992;340:1111\u20131115.","DOI":"10.1016\/0140-6736(92)93147-F"},{"key":"10.1016\/S0021-9150(96)06018-2_BIB10","doi-asserted-by":"crossref","unstructured":"Pohl U, Holtz J, Busse R, Bassenge E. Crucial role of endothelium in the vasodilator response to increased flow in vivo. Hypertension 1986;8:37\u201344.","DOI":"10.1161\/01.HYP.8.1.37"},{"key":"10.1016\/S0021-9150(96)06018-2_BIB11","doi-asserted-by":"crossref","unstructured":"Holtz J, F\u00f6rstermann U, Pohl U, Giesler M, Bassenge E. Flow-dependent, endothelium-mediated dilation of epicardial coronary arteries in conscious dogs: effects of cyclooxygenase inhibition. J Cardiovasc Pharmacol 1984;6:1161\u20131169.","DOI":"10.1097\/00005344-198406060-00025"},{"key":"10.1016\/S0021-9150(96)06018-2_BIB12","doi-asserted-by":"crossref","unstructured":"Rubanyi GM, Romero JC, Vanhoutte PM. Flow-induced release of endothelium-derived relaxing factor. Am J Physiol 1986; 250:1145\u20131149.","DOI":"10.1152\/ajpheart.1986.250.6.H1145"},{"key":"10.1016\/S0021-9150(96)06018-2_BIB13","unstructured":"Lieberman EH, Knab ST, Creager MA. Nitric oxide mediates the vasodilator response to flow in humans. Circulation 1994; 90(1):138."},{"key":"10.1016\/S0021-9150(96)06018-2_BIB14","doi-asserted-by":"crossref","unstructured":"Joannides R, Haefeli WE, Linder L et al. Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation 1995;91:1314\u20131319.","DOI":"10.1161\/01.CIR.91.5.1314"},{"key":"10.1016\/S0021-9150(96)06018-2_BIB15","doi-asserted-by":"crossref","unstructured":"Celermajer DS, Sorensen KE, Georgakopoulos D et al. Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults. Circulation 1993;88:2149\u20132155.","DOI":"10.1161\/01.CIR.88.5.2149"},{"key":"10.1016\/S0021-9150(96)06018-2_BIB16","doi-asserted-by":"crossref","unstructured":"Celermajer DS, Sorensen KE, Bull C, Robinson J, Deanfield JE. Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction. J Am Coll Cardiol 1994;24:1468\u20131474.","DOI":"10.1016\/0735-1097(94)90141-4"},{"key":"10.1016\/S0021-9150(96)06018-2_BIB17","doi-asserted-by":"crossref","unstructured":"Hirooka Y, Egashira K, Imaizumi T, Tagawa T, Kai H, Sugimachi M, Takeshita A. Effect of l-arginine on acetylcholine-induced endothelium-dependent vasodilation differs between the coronary and forearm vasculatures in humans. J Am Coll Cardiol 1994;24:948\u2013955.","DOI":"10.1016\/0735-1097(94)90854-0"},{"key":"10.1016\/S0021-9150(96)06018-2_BIB18","doi-asserted-by":"crossref","unstructured":"Egashira K, Inou T, Hirooka Y et al. Impaired coronary blood flow response to acetylcholine in patients with coronary risk factors and proximal atherosclerotic lesions. J Clin Invest 1993;91:29\u201337.","DOI":"10.1172\/JCI116183"},{"key":"10.1016\/S0021-9150(96)06018-2_BIB19","doi-asserted-by":"crossref","unstructured":"Wendelhag I, Gustavsson T, Suurkula M, Berglund G, Wikstrand U. Ultrasound measurement of wall thickness in the carotid artery: fundamental principles and description of computerised analysing system. Clin Physiol 1991;11:565\u2013577.","DOI":"10.1111\/j.1475-097X.1991.tb00676.x"},{"key":"10.1016\/S0021-9150(96)06018-2_BIB20","doi-asserted-by":"crossref","unstructured":"Corretti MC, Plotnick GD, Vogel RA. Correlation of cold pressor and flow-mediated brachial artery diameter responses with the presence of coronary artery disease. Am J Cardiol 1995;75:783\u2013787.","DOI":"10.1016\/S0002-9149(99)80411-1"},{"key":"10.1016\/S0021-9150(96)06018-2_BIB21","unstructured":"SAS Institute Inc, SAS\/STAT Users Guide, Version 6, Fourth Edition, Vol. 2, Cary, NC: SAS Institute, 1989:846."},{"key":"10.1016\/S0021-9150(96)06018-2_BIB22","doi-asserted-by":"crossref","unstructured":"DeLong ER, DeLong DM, Clarke-Pearson DL. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 1988;44:837\u2013845.","DOI":"10.2307\/2531595"},{"key":"10.1016\/S0021-9150(96)06018-2_BIB23","doi-asserted-by":"crossref","unstructured":"Anderson TJ, Uehata A, Gerhard MD et al. Close relation of endothelial function in the human coronary and peripheral circulations. J Am Coll Cardiol 1995;26:1235\u20131241.","DOI":"10.1016\/0735-1097(95)00327-4"},{"key":"10.1016\/S0021-9150(96)06018-2_BIB24","doi-asserted-by":"crossref","unstructured":"Creager MA, Cooke JP, Mendelsohn ME et al. Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J Clin Invest 1990;86:228\u2013234.","DOI":"10.1172\/JCI114688"},{"key":"10.1016\/S0021-9150(96)06018-2_BIB25","unstructured":"J\u00fcrgens JL, Bernatz PE. Atherosclerosis of the extremities. In: J\u00fcrgens JL, Spittell JA, Fairbairn II JF (eds). Peripheral Vascular Disease. Philadelphia, PA: Saunders, 1980;253\u2013293."},{"key":"10.1016\/S0021-9150(96)06018-2_BIB26","doi-asserted-by":"crossref","unstructured":"Levine GN, Frei B, Koulouris SN, Gerhard MD, Keaney JF, Vita JA. Ascorbic acid reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation 1996;93:1107\u20131113.","DOI":"10.1161\/01.CIR.93.6.1107"},{"key":"10.1016\/S0021-9150(96)06018-2_BIB27","doi-asserted-by":"crossref","unstructured":"Clarkson P, Adams MR, Powe AJ et al. Oral l-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. J Clin Invest 1996;97:1989\u20131994.","DOI":"10.1172\/JCI118632"},{"key":"10.1016\/S0021-9150(96)06018-2_BIB28","doi-asserted-by":"crossref","unstructured":"St Goar FG, Pinto FJ, Alderman EL, Fitzgerald PJ, Stadius ML, Popp RL. Intravascular ultrasound imaging of angiographically normal coronary arteries: an in vivo comparison with quantitative angiography. J Am Coll Cardiol 1991;18:952\u2013958.","DOI":"10.1016\/0735-1097(91)90753-V"},{"key":"10.1016\/S0021-9150(96)06018-2_BIB29","doi-asserted-by":"crossref","unstructured":"St Goar FG, Pinto FJ, Alderman EL et al. Detection of coronary atherosclerosis in young adult hearts using intravascular ultrasound. Circulation 1992;86:756\u2013763.","DOI":"10.1161\/01.CIR.86.3.756"},{"key":"10.1016\/S0021-9150(96)06018-2_BIB30","doi-asserted-by":"crossref","unstructured":"Zeiher AM, Schachinger V, Hohnloser SH, Saurbier B, Just H. Coronary atherosclerotic wall thickening and vascular reactivity in humans. Elevated high-density lipoprotein levels ameliorate abnormal vasoconstriction in early atherosclerosis. Circulation 1994;89:2525\u20132532.","DOI":"10.1161\/01.CIR.89.6.2525"},{"key":"10.1016\/S0021-9150(96)06018-2_BIB31","doi-asserted-by":"crossref","unstructured":"Vrints CJM, Bult H, Hitter E, Herman AG, Snoek JP. Impaired endothelium-dependent cholinergic coronary vasodilation in patients with angina and normal coronary arteriograms. J Am Coll Cardiol 1992;19:21\u201331.","DOI":"10.1016\/0735-1097(92)90046-P"},{"key":"10.1016\/S0021-9150(96)06018-2_BIB32","doi-asserted-by":"crossref","unstructured":"Egashira K, Inou T, Hirooka Y, Yamada A, Urabe Y, Takeshita A. Evidence of impaired endothelium-dependent coronary vasodilation in patients with angina pectoris and normal coronary angiograms. N Engl J Med 1993;328:1659\u20131664.","DOI":"10.1056\/NEJM199306103282302"}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915096060182?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915096060182?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T15:26:29Z","timestamp":1580916389000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915096060182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,2]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1997,2]]}},"alternative-id":["S0021915096060182"],"URL":"https:\/\/doi.org\/10.1016\/s0021-9150(96)06018-2","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[1997,2]]}}}